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1. 发明授权

US07798999B2 Adjustable length catheter 有权
标题翻译：可调长导管
公开(公告)号：US07798999B2
公开(公告)日：2010-09-21
申请号：US11758543
申请日：2007-06-05
申请人： Frances Kristen Bailey , Jessica L. Burke , Grant T. Hoffman , Ram H. Paul, Jr.
发明人： Frances Kristen Bailey , Jessica L. Burke , Grant T. Hoffman , Ram H. Paul, Jr.
IPC分类号： A61M5/178
CPC分类号： A61M25/0097 , A61M25/0029 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037
摘要： An adjustable length catheter device, a kit and a method of providing the adjustable length catheter device to a patient are provided. The catheter device includes an elongate shaft having a proximal portion, a distal portion, a first lumen and a second lumen extending at least partially therethrough. The catheter device further includes a manifold operably connected to the shaft. The manifold is configured to longitudinally move along the shaft towards the distal portion for separating the proximal portion of the shaft into a first proximal shaft portion including the first lumen and a second proximal shaft portion including the second lumen.
摘要翻译：提供了一种可调节长度的导管装置，套件以及将可调节长度的导管装置提供给患者的方法。导管装置包括细长轴，其具有近端部分，远端部分，第一内腔和至少部分延伸穿过其中的第二内腔。导管装置还包括可操作地连接到轴的歧管。歧管被构造成沿着轴朝向远端部分纵向移动，用于将轴的近端部分分离成包括第一管腔的第一近侧轴部分和包括第二管腔的第二近侧轴部分。

2. 发明授权

US07678144B2 Prosthetic valve with slanted leaflet design 有权
标题翻译：假体瓣带有倾斜小叶设计
公开(公告)号：US07678144B2
公开(公告)日：2010-03-16
申请号：US12019987
申请日：2008-01-25
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, Jr.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, Jr.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet. The at least one semi-rigid leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one semi-rigid leaflet is slanted in a retrograde direction from the second portion to the first portion. The at least one flexible leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one flexible leaflet is slanted in a retrograde direction from the first portion to the second portion when at rest.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。至少一个半刚性小叶包括第一部分和第二部分，第一部分附接到框架，第二部分没有框架。至少一个半刚性小叶从第二部分向第一部分沿逆行方向倾斜。所述至少一个柔性小叶包括第一部分和第二部分，所述第一部分附接到所述框架并且所述第二部分没有所述框架。当静止时，至少一个柔性小叶在从第一部分到第二部分的逆行方向上倾斜。

3. 发明授权

US08313526B2 Valve frame 有权
标题翻译：阀框
公开(公告)号：US08313526B2
公开(公告)日：2012-11-20
申请号：US12273168
申请日：2008-11-18
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul, Jr.
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul, Jr.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.
摘要翻译：本公开涉及用于假体植入式阀的支撑框架。支撑框架可以包括多个对称排列的互连的U形构件结构。优选的支撑框架是包围纵向轴线并且包括面向支撑框架的远端或近端的多个U形构件结构的管状结构。每个U形构件结构可以连接到面向相反纵向方向的单个纵向相邻的U形构件以及两个横向相邻的U形构件。

4. 发明授权

US10226264B2 Apparatus and method for destruction of vascular thrombus 有权
公开(公告)号：US10226264B2
公开(公告)日：2019-03-12
申请号：US13555685
申请日：2012-07-23
申请人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
发明人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
IPC分类号： A61H1/00 , A61B17/22 , A61M25/10 , A61M37/00
摘要： A device for thrombolytic therapy is provided. The device includes an elongate catheter with a distal end portion and a proximal end portion and a first lumen extending through both distal and proximal end portions. The distal end portion of the catheter includes an echogenic tubular potion that defines or surrounds a portion of the first lumen. An expandable balloon coaxially surrounds the tubular portion. The tubular portion additionally includes a plurality of indentations defined upon an outer surface thereof.

5. 发明授权

US07717952B2 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US07717952B2
公开(公告)日：2010-05-18
申请号：US11586285
申请日：2006-10-25
申请人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
发明人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

6. 发明授权

US09277904B2 Devices and methods useful for sealing bodily openings 有权
公开(公告)号：US09277904B2
公开(公告)日：2016-03-08
申请号：US13111338
申请日：2011-05-19
申请人： Ram H. Paul, Jr. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean Chambers
发明人： Ram H. Paul, Jr. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean Chambers
IPC分类号： A61B17/00 , A61B17/34 , A61B17/04 , A61B17/06
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

7. 发明授权

US08540760B2 Tubular devices having reversible components for deployment of endoluminal occluders and related methods and systems 有权
标题翻译：具有用于部署腔内封堵器的可逆组件的管状装置及相关方法和系统
公开(公告)号：US08540760B2
公开(公告)日：2013-09-24
申请号：US12164520
申请日：2008-06-30
申请人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/84
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

8. 发明授权

US08506583B2 Method for open surgical placement 有权
标题翻译：开放手术放置方法
公开(公告)号：US08506583B2
公开(公告)日：2013-08-13
申请号：US13593088
申请日：2012-08-23
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61B17/22
CPC分类号： A61F2/95 , A61F2/06 , A61F2/064 , A61F2002/8483 , A61F2002/9517
摘要： A method for open surgical repair of a damaged portion of an artery or vein. A tubular medical assembly may include one or more shaped members, such as microbarbs, configured to anchor into the tunica intima and the tunica media of the vessel wall, and not to the tunic adventitia and vasa vasorum. The medical assembly is delivered to the damaged vessel portion via a delivery device through an open air pathway, and forms a conduit between transected ends of the damaged vessel.
摘要翻译：一种用于开放性手术修复动脉或静脉损伤部分的方法。管状医疗组件可以包括一个或多个成形构件，例如微巴，构造成锚定到血管壁的内膜和中膜，而不是外套和血管充血。医疗组件经由输送装置通过开放空气通道输送到损坏的容器部分，并且在损坏的容器的横截面之间形成导管。

9. 发明授权

US08403979B2 Monocuspid prosthetic valve having a partial sinus 有权
标题翻译：具有部分窦的Monocuspid人工瓣膜
公开(公告)号：US08403979B2
公开(公告)日：2013-03-26
申请号：US12121453
申请日：2008-05-15
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054
摘要： The disclosure relates to an expandable valve prosthesis for regulating flow through a body vessel. The prosthesis comprises a frame configured to form a laterally asymmetric partial sinus and a valve member.
摘要翻译：本公开涉及一种用于调节通过身体血管的流动的可扩张瓣膜假体。假体包括构造成形成横向不对称的部分窦和瓣膜构件的框架。

10. 发明授权

US09192463B2 Blood perfusion device 有权
标题翻译：血液灌注装置
公开(公告)号：US09192463B2
公开(公告)日：2015-11-24
申请号：US13197511
申请日：2011-08-03
申请人： Ram H. Paul, Jr. , Richard A. Swift , Oliver Bach , Ralf Steiner
发明人： Ram H. Paul, Jr. , Richard A. Swift , Oliver Bach , Ralf Steiner
IPC分类号： A61F2/06 , A61F2/07 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61B17/11
CPC分类号： A61F2/07 , A61B2017/1107 , A61B2017/1132 , A61F2/06 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要： A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
摘要翻译：灌注装置和用于修复身体血管损伤部分的输送系统。灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。一个或多个串联的倒钩可以沿着中间部分周向设置。倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。移植物可以与管状体相关联。移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。移植物也可以在近端部分和远端部分沿管状体的外表面延伸。可以沿着中间部分施加可重塑的覆盖物。还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

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