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    • 5. 发明公开
    • CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    • 晶体形成器件和系统的方法进行生产及其用途
    • EP1730489A2
    • 2006-12-13
    • EP05712041.2
    • 2005-01-25
    • Fluidigm Corporation
    • GROSSMAN, RobertUNGER, MarcLAM, PhillipCHOU, Hou-PuKIMBALL, JakePIEPRZYK, Martin
    • G01N15/06G01N33/00G01N33/48
    • C12Q1/68B01L3/0293B01L3/06B01L3/5025B01L3/502715B01L3/50273B01L3/502738B01L3/5635B01L3/565B01L9/527B01L2200/027B01L2200/0605B01L2300/0816B01L2300/14B01L2400/0487B01L2400/0655C30B7/00C30B29/58Y10T436/11
    • The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.
    • 本发明提供一种用于微流体装置和它们的使用方法。 本发明进一步提供的装置和系统,用于使用微流体装置,分析的微流体装置中进行的反应,和系统来生成,存储,组织,并分析从使用所述微流体装置产生的数据。 本发明提供了使用和制备的微流体系统和设备,其在一些实施方案中,可用于晶体形成有用的进一步的方法。 在一个,实施例在其中以装置包括具有压板面具有一个或多个流体端口的压板。 流体端口空间对应于一个或更多个井的微流体装置的表面上。 一种用于相对于压板的微流体装置保持平台被包括在内,用于推动压盘抵靠微流体装置,从而没有压板的流体端口中的至少一个被推向孔之一的压板致动器,以形成一个压力腔 包括阱,端口,如此做了当加压流体通过端口中的一个引入或移除到或从压力室,压力流体在其中发生变化。