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1. 发明申请

US20130330710A1 SILK BASED BIOPHOTONIC SENSORS 审中-公开
标题翻译：基于SILK的生物传感器
公开(公告)号：US20130330710A1
公开(公告)日：2013-12-12
申请号：US13813288
申请日：2011-07-30
申请人： Fiorenzo Omenetto , David Kaplan , Jason Amsden , Luca Dal Negro
发明人： Fiorenzo Omenetto , David Kaplan , Jason Amsden , Luca Dal Negro
IPC分类号： G01N21/25
CPC分类号： G01N21/25 , B82Y30/00 , G01N21/4788 , G01N33/54373
摘要： The present disclosure relates to biophotonic sensors. An example of a biophotonic sensor may be an apparatus for analyzing a sample. The apparatus may include a substrate, aperiodic nanostructured protrusions disposed on the substrate, and a silk material deposited between the protrusions.
摘要翻译：本发明涉及生物光子传感器。生物光子传感器的实例可以是用于分析样品的装置。该装置可以包括衬底，设置在衬底上的非周期纳米结构化突起和沉积在突起之间的丝材料。

2. 发明申请

US20120121820A1 FABRICATION OF SILK FIBROIN PHOTONIC STRUCTURES BY NANOCONTACT IMPRINTING 有权
标题翻译：通过纳米压印制造丝光纤光电结构
公开(公告)号：US20120121820A1
公开(公告)日：2012-05-17
申请号：US12741066
申请日：2008-11-05
申请人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Luca Dal Negro
发明人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Luca Dal Negro
IPC分类号： C08J7/18 , B29C59/16
CPC分类号： G03F7/0002 , B29D11/00 , B29D11/00346 , B82Y10/00 , B82Y20/00 , B82Y40/00 , C07K14/435 , G02B6/1225
摘要： A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution, depositing the biopolymer matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with the nanopattern mask, or a nanopattern is machined directly on a surface of the film using E-beam lithograpy such that the biopolymer film exhibits a spectral signature corresponding to the E-beam lithograpy nanopattern. The resulting bio-compatible nanopatterned biophotonic structures may be made from silk, may be biodegradable, and may be bio-sensing devices. The biophotonic structures may employ nanopatterned masks based on non-periodic photonic lattices, and the biophotonic structures may be designed with specific spectral signatures for use in probing biological substances, including displaying optical activity in the form of opalescence.
摘要翻译：制造纳米图案生物光子结构的方法包括使用电子束光刻在基底上形成定制的纳米图案掩模，提供生物聚合物基质溶液，将生物聚合物基质溶液沉积在基材上，以及干燥生物聚合物基质溶液以形成固化的生物聚合物膜。用纳米图案掩模形成膜的表面，或者使用电子束光刻直接在膜的表面上加工纳米图案，使得生物聚合物膜显示对应于电子束光刻纳米图案的光谱特征。所得的生物相容纳米图案的生物光子结构可以由丝制成，可以是可生物降解的，并且可以是生物感测装置。生物光子结构可以使用基于非周期性光子晶格的纳米图案掩模，并且生物光子结构可以被设计成用于探测生物物质的特定光谱特征，包括以乳光的形式显示光学活性。

3. 发明申请

US20130240251A1 SILK ELECTRONIC COMPONENTS 有权
标题翻译：丝光电子元件
公开(公告)号：US20130240251A1
公开(公告)日：2013-09-19
申请号：US13641000
申请日：2011-04-12
申请人： David Kaplan , Fiorenzo Omenetto , Jason Amsden , Hu Tao , Richard Averitt , Andrew Strikwerda , Xin Zhang , Konstantinos Tsioris
发明人： David Kaplan , Fiorenzo Omenetto , Jason Amsden , Hu Tao , Richard Averitt , Andrew Strikwerda , Xin Zhang , Konstantinos Tsioris
IPC分类号： H05K1/03
CPC分类号： H05K1/032 , G02B1/002 , H01Q7/00
摘要： The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.
摘要翻译：本发明涉及丝电子部件及其制造方法。丝电子部件可以用作可植入生物电离和/或生物光子装置，生物传感器，监视装置，隐形斗篷，电磁集中器或天线的新型装置。

4. 发明授权

US08339597B2 Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces 有权
标题翻译：化学/生物传感器在纳米图案非周期表面中使用散射色彩成分
公开(公告)号：US08339597B2
公开(公告)日：2012-12-25
申请号：US13192757
申请日：2011-07-28
申请人： Luca Dal Negro , Svetlana V. Boriskina , Fiorenzo Omenetto
发明人： Luca Dal Negro , Svetlana V. Boriskina , Fiorenzo Omenetto
IPC分类号： G01J3/44
CPC分类号： G01N21/4738 , G01N21/253 , G01N21/78 , G01N2021/4735
摘要： A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting” colorimetric signatures can be used as a transduction mechanism. Aperiodic sensing platforms can operate in the infrared to provide an overlap with spectral fingerprints of biological molecules. Miniaturized optical biosensors may be based on engineered colorimetric scattering signatures (structural color), sharp spectral features, non-uniform angular distributions of scattered light, and broadband manipulation of the local density of states in nano-textured scattering surfaces with deterministic aperiodic order. The biosensors can be fabricated in semiconductor, metal, low- and high-index dielectric platforms using standard nanofabrication techniques such as electron-beam lithography, ion-beam milling, etc, and can be replicated over large areas by standard nano-imprint lithography.
摘要翻译：无标签的多路复用传感平台基于与非周期性光子结构的光相互作用，具有宽带操作的优点。多重散射诱导的指纹图谱可用作转导机制。非周期感测平台可以在红外线中操作，以提供与生物分子的光谱指纹的重叠。小型化的光学生物传感器可以基于工程化的比色散射特征（结构颜色），尖锐的光谱特征，散射光的非均匀角分布以及宽带处理具有确定性非周期性的纳米纹理散射表面中的局部状态密度。生物传感器可以使用标准的纳米制造技术如电子束光刻，离子束铣削等制造在半导体，金属，低折射率和高折射率的介质平台中，并且可以通过标准的纳米压印光刻在大面积上进行复制。

5. 发明授权

US08666471B2 Implantable biomedical devices on bioresorbable substrates 有权
标题翻译：可植入生物医学装置在生物可吸收底物上
公开(公告)号：US08666471B2
公开(公告)日：2014-03-04
申请号：US12892001
申请日：2010-09-28
申请人： John A. Rogers , Dae-Hyeong Kim , Fiorenzo Omenetto , David L. Kaplan , Brian Litt , Jonathan Viventi , Yonggang Huang , Jason Amsden
发明人： John A. Rogers , Dae-Hyeong Kim , Fiorenzo Omenetto , David L. Kaplan , Brian Litt , Jonathan Viventi , Yonggang Huang , Jason Amsden
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04 , A61B5/05 , A61B5/6867 , A61B2562/0285 , A61L31/047 , A61L31/148 , A61N1/0529 , A61N1/0551 , B82Y15/00 , H01L2924/0002 , H05K1/0283 , H05K3/20 , H01L2924/00
摘要： Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.
摘要翻译：本文提供了植入式生物医学装置，可植入生物医学装置的施用方法，制造可植入生物医学装置的方法，以及使用可植入生物医学装置致动靶组织或感测与生物环境中的靶组织相关的参数的方法。每个可植入的生物医学装置包括生物可再吸收的基底，具有由生物可再吸收的基底支撑的多个无机半导体组分的电子器件，以及封装至少一部分无机半导体组分的阻挡层。在与生物环境接触时，生物可再吸收底物至少部分吸收，从而在生物环境中建立可植入生物医学装置与靶组织之间的共形接触。

6. 发明授权

US09761789B2 Silk-based piezoelectric materials 有权
公开(公告)号：US09761789B2
公开(公告)日：2017-09-12
申请号：US13876472
申请日：2011-09-27
申请人： Fiorenzo Omenetto , David Kaplan , Tuna Yucel
发明人： Fiorenzo Omenetto , David Kaplan , Tuna Yucel
IPC分类号： H01L41/193 , H01L21/02 , H01L41/45 , A61N1/365 , A61N1/378 , H01L41/113 , H02N2/18
CPC分类号： H01L41/193 , A61N1/36578 , A61N1/3785 , H01L21/02 , H01L41/1132 , H01L41/45 , H02N2/18
摘要： The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.

7. 发明申请

US20140145365A1 SILK-BASED PIEZOELECTRIC MATERIALS 有权
标题翻译：基于SILK的压电材料
公开(公告)号：US20140145365A1
公开(公告)日：2014-05-29
申请号：US13876472
申请日：2011-09-27
申请人： Fiorenzo Omenetto , David Kaplan , Tuna Yucel
发明人： Fiorenzo Omenetto , David Kaplan , Tuna Yucel
IPC分类号： H01L41/193 , H01L21/02
CPC分类号： H01L41/193 , A61N1/36578 , A61N1/3785 , H01L21/02 , H01L41/1132 , H01L41/45 , H02N2/18
摘要： The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.
摘要翻译：本发明涉及用于制备丝基压电材料的方法和组合物以及用于增加丝基质中的压电性的方法。

8. 发明授权

US08574461B2 Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same 有权
标题翻译：电活性生物聚合物光学和电光器件及其制造方法
公开(公告)号：US08574461B2
公开(公告)日：2013-11-05
申请号：US12513392
申请日：2007-11-05
申请人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
发明人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
IPC分类号： H01B1/12
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
摘要翻译：制造生物聚合物光学器件的方法包括提供聚合物，提供基底，将聚合物浇注到基底上，以及将有机化合物酶促聚合以在所提供的聚合物和基底之间产生导电聚合物。聚合物可以是诸如丝的生物聚合物，并且可以使用有机化合物如酪氨酸进行改性，以通过酪氨酸 - 酶聚合提供生物聚合物光学器件的所提供的本体生物聚合物与底物或其它导电层之间的分子水平界面。酶促聚合可包括用过氧化物酶反应催化有机化合物。结果是碳 - 碳共轭骨架提供用于聚合物和生物聚合物光学器件的聚合物“丝线”。由此提供了提供光学功能和特征的全部有机生物聚合物电活性材料。

9. 发明授权

US09969134B2 Nanopatterned biopolymer optical device and method of manufacturing the same 有权
公开(公告)号：US09969134B2
公开(公告)日：2018-05-15
申请号：US12513394
申请日：2007-11-05
申请人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
发明人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： B29D11/00 , G02B1/04 , Y10T428/24479 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00
摘要： A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.

10. 发明申请

US20110223153A1 MODIFIED SILK FILMS CONTAINING GLYCEROL 审中-公开
标题翻译：含有GLYCEROL的改性丝状膜
公开(公告)号：US20110223153A1
公开(公告)日：2011-09-15
申请号：US13122837
申请日：2009-10-09
申请人： Shenzhou Lu , Xiaoqin Wang , Fiorenzo Omenetto , David Kaplan
发明人： Shenzhou Lu , Xiaoqin Wang , Fiorenzo Omenetto , David Kaplan
IPC分类号： A61K39/395 , C12N5/071 , A61K47/42 , A61K35/12 , A61K38/02 , A61K31/7088 , A61K38/43 , A61K35/76 , A61P31/00 , A61P31/04 , A61P35/00 , B29D11/00
CPC分类号： A61L27/3604 , A61L27/3804 , A61L27/50 , A61L27/54 , A61L2420/06 , B05D1/30 , B05D3/0254 , B05D3/107 , C08J3/18 , C08J5/18 , C08J2389/00 , C08K5/053 , C12N11/02 , C08L89/00
摘要： The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
摘要翻译：本发明提供了制备水不溶性，韧性，柔韧性丝素蛋白膜的组合物和方法。丝膜包括丝素蛋白和约10％至约50％（w / w）甘油，并且通过完全水性方法制备。可以通过从丝膜中提取甘油并重新干燥来进一步处理延性丝膜。活性剂可以嵌入或沉积在甘油改性丝膜上用于各种医疗应用。膜可以是三维结构，或者作为标签或涂层放置在支撑表面上。本发明的甘油改性丝膜可用于各种应用，例如组织工程，医疗装置或植入物，药物递送，以及食用药物或食品标签。

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