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1. 发明申请

US20050251243A1 Stent body sock 有权
标题翻译：支架体袜
公开(公告)号：US20050251243A1
公开(公告)日：2005-11-10
申请号：US11181533
申请日：2005-07-14
申请人： Jan Seppala , Fernando DiCaprio , Raed Rizq
发明人： Jan Seppala , Fernando DiCaprio , Raed Rizq
IPC分类号： A61F2/06 , A61F2/84
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A stent delivery system which includes a stent delivery catheter, the stent delivery catheter having a stent mounting region, the stent mounting region having an inflatable portion. A stent is disposed about the stent mounting region, the stent having an unexpanded position and an expanded position. At least one stent retaining sleeve is also included having first and second ends, the first end being attached to the stent delivery catheter, the at least one stent retaining sleeve disposed about at least a portion of the stent in the unexpanded position, the stent retaining sleeve being constructed and arranged to retract toward the attached first end when the stent is expanded.
摘要翻译：一种支架输送系统，其包括支架输送导管，所述支架输送导管具有支架安装区域，所述支架安装区域具有可充气部分。支架围绕支架安装区域设置，支架具有未展开位置和展开位置。还包括至少一个支架保持套筒，其具有第一和第二端，所述第一端附接到支架输送导管，所述至少一个支架保持套筒围绕未扩张位置的支架的至少一部分设置，支架保持套筒被构造和布置成当支架膨胀时朝着附接的第一端部缩回。

2. 发明授权

US08206431B2 Stent body sock 有权
标题翻译：支架体袜
公开(公告)号：US08206431B2
公开(公告)日：2012-06-26
申请号：US11181533
申请日：2005-07-14
申请人： Jan Seppala , Fernando DiCaprio , Raed Rizq
发明人： Jan Seppala , Fernando DiCaprio , Raed Rizq
IPC分类号： A61F2/06 , A61F11/00
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A stent delivery system which includes a stent delivery catheter, the stent delivery catheter having a stent mounting region, the stent mounting region having an inflatable portion. A stent is disposed about the stent mounting region, the stent having an unexpanded position and an expanded position. At least one stent retaining sleeve is also included having first and second ends, the first end being attached to the stent delivery catheter, the at least one stent retaining sleeve disposed about at least a portion of the stent in the unexpanded position, the stent retaining sleeve being constructed and arranged to retract toward the attached first end when the stent is expanded.
摘要翻译：一种支架输送系统，其包括支架输送导管，所述支架输送导管具有支架安装区域，所述支架安装区域具有可充气部分。支架围绕支架安装区域设置，支架具有未展开位置和展开位置。还包括至少一个支架保持套筒，其具有第一和第二端，所述第一端附接到支架输送导管，所述至少一个支架保持套筒围绕未扩张位置的支架的至少一部分设置，支架保持套筒被构造和布置成当支架膨胀时朝着附接的第一端部缩回。

3. 发明授权

US07001419B2 Stent delivery system with membrane 有权
公开(公告)号：US07001419B2
公开(公告)日：2006-02-21
申请号：US09970459
申请日：2001-10-02
申请人： Fernando DiCaprio , Jan Seppala , Raed Rizq
发明人： Fernando DiCaprio , Jan Seppala , Raed Rizq
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A stent delivery system comprising a catheter. The catheter having a catheter shaft, and a balloon mounted thereto. A stent is disposed about at least a portion of the balloon. The stent having an unexpanded state and an expanded state. The stent being retained on the balloon in the unexpanded state by at least one sleeve. The at least one sleeve having a first portion engaged to the catheter and a second portion at least partially overlaying an end of the stent when the stent is in the unexpanded state. At least one membrane is disposed about a portion of the stent. The at least one membrane constructed and arranged to prevent portions of the stent thereunder from flaring out during advancement of the catheter.

4. 发明授权

US06837897B2 Lumen support for welding 有权
标题翻译：流明支持焊接
公开(公告)号：US06837897B2
公开(公告)日：2005-01-04
申请号：US09939276
申请日：2001-08-24
申请人： Thomas J. Holman , Kristi Flury , Scott A. Olson , Jan Seppala , Richard Dunn , Gina L. Sandvick , Fernando DiCaprio , Justin E. Plessel
发明人： Thomas J. Holman , Kristi Flury , Scott A. Olson , Jan Seppala , Richard Dunn , Gina L. Sandvick , Fernando DiCaprio , Justin E. Plessel
IPC分类号： A61F2/84 , A61F2/06 , A61F2/82 , A61M25/00 , B23K26/00 , B23K26/18 , B23K26/20 , B29C65/00 , B29C65/14 , B29C65/16 , A61M29/00
CPC分类号： A61F2/958 , A61F2002/9583 , B23K26/009 , B23K26/18 , B23K2101/06 , B29C65/14 , B29C65/16 , B29C65/1619 , B29C65/1641 , B29C66/1122 , B29C66/53241 , B29C66/5344 , B29C66/636 , B29C66/71 , B29C66/73921 , B29C66/81267 , B29C66/81268 , B29K2995/0027 , B29L2031/7542 , B29L2031/7543 , B29K2021/003 , B29K2023/06 , B29K2023/065 , B29K2055/02 , B29K2067/00 , B29K2067/003 , B29K2069/00 , B29K2075/00 , B29K2077/00 , B29K2081/04 , B29K2083/00 , B29K2096/005
摘要： A medical device comprising a support member adjacent to a first member and a second member, the first and second members may be laser welded to one another by directing radiation absorbable by the first and second members at the first and second members. The support member is provided adjacent to the first member and is constructed and arranged to substantially reflect or substantially transmit radiation at one or more frequencies absorbable by at least one of the first member and the second member.
摘要翻译：包括与第一构件和第二构件相邻的支撑构件的医疗装置，第一构件和第二构件可以通过引导第一构件和第二构件在第一构件和第二构件可吸收的辐射而彼此激光焊接。支撑构件设置成与第一构件相邻并且被构造和布置成在由第一构件和第二构件中的至少一个可吸收的一个或多个频率处基本上反射或基本上透射辐射。

5. 发明申请

US20130131765A1 FIBROUS MATRIX COATING MATERIALS 审中-公开
标题翻译：纤维基质涂料
公开(公告)号：US20130131765A1
公开(公告)日：2013-05-23
申请号：US13680590
申请日：2012-11-19
申请人： Jeannette C. Polkinghorne , Devon N. Arnholt , James P. Rohl , Brian L. Schmidt , Jan Seppala , Richard L. Tadsen , Patrick Willoughby , Steve Zhang , Shrojalkumar Desai , Joseph T. Delaney, JR. , David R. Wulfman
发明人： Jeannette C. Polkinghorne , Devon N. Arnholt , James P. Rohl , Brian L. Schmidt , Jan Seppala , Richard L. Tadsen , Patrick Willoughby , Steve Zhang , Shrojalkumar Desai , Joseph T. Delaney, JR. , David R. Wulfman
IPC分类号： A61N1/04
CPC分类号： A61N1/04 , A61L29/085 , A61L29/14 , A61L2400/12 , A61N1/05 , C08L75/04
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a polyisobutylene urethane, urea or urethane/urea copolymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚异丁烯氨基甲酸酯，脲或氨基甲酸酯/脲共聚物形成。

6. 发明申请

US20050147734A1 Method and system for coating tubular medical devices 审中-公开
标题翻译：管状医疗器械的涂敷方法及系统
公开(公告)号：US20050147734A1
公开(公告)日：2005-07-07
申请号：US10752021
申请日：2004-01-07
申请人： Jan Seppala , Jeffrey Sewell
发明人： Jan Seppala , Jeffrey Sewell
IPC分类号： A61F2/86 , A61L31/10 , B05C11/10 , A61L2/00 , B05D3/00 , B05D5/12
CPC分类号： A61L31/10 , A61F2/86 , B05C11/1039
摘要： A system and method for application of therapeutic and protective coatings to multiple tubular medical devices in a high volume production process. One or more tubular medical devices, such as stents, are placed on a coating-absorbent core, and coating is applied to the device(s), for example, as when the device-carrying core is passed through an extrusion coating machine to apply the coating in a uniform manner. Once coated, the medical device(s) may be quickly and efficiently removed from the core by causing the core diameter to decrease, such as by applying elongating tension to the core to cause the core diameter to radially contract, thereby allowing the coated device(s) to be simultaneously freed from the core. Improved coating uniformity, increased coated device removal ease and minimized bridging of openings in the tubular medical device may be obtained with a core that absorbs excess coating.
摘要翻译：一种用于在大量生产过程中将治疗和保护性涂层应用于多个管状医疗装置的系统和方法。一个或多个管状医疗装置（例如支架）被放置在涂层吸收芯上，并且涂层被施加到装置上，例如当装置承载芯通过挤压涂布机以施加时涂层均匀。一旦被涂覆，医疗设备可以通过使芯直径减小而快速有效地从芯中去除，例如通过对纤芯施加伸长张力以使芯部直径径向收缩，从而允许涂覆的装置（ s）同时摆脱核心。通过吸收多余涂层的芯可以获得改进的涂层均匀性，增加的涂覆装置去除容易性并且使管状医疗装置中的开口的最小化桥接。

7. 发明申请

US20080206304A1 Medical devices having polymeric regions based on styrene-isobutylene copolymers 有权
标题翻译：具有基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗装置
公开(公告)号：US20080206304A1
公开(公告)日：2008-08-28
申请号：US12070806
申请日：2008-02-21
申请人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
发明人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
IPC分类号： A61K9/00 , A61K47/32 , A61F2/82 , A61F2/01 , A61F2/02 , A61F2/06 , A61F2/18 , A61F2/24 , A61M29/00 , A61N1/05 , A61M25/10 , A61M25/09 , A61M25/01
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

8. 发明授权

US06953470B2 Catheter support 有权
标题翻译：导管支持
公开(公告)号：US06953470B2
公开(公告)日：2005-10-11
申请号：US10241138
申请日：2002-09-11
申请人： Thomas J. Holman , Richard Dunn , Jan Seppala
发明人： Thomas J. Holman , Richard Dunn , Jan Seppala
IPC分类号： A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/0043 , A61M25/0054 , A61M25/0069 , A61M2025/1063
摘要： A balloon catheter comprises a balloon, an inner shaft, an outer shaft and a transition shaft. The transition shaft has a proximal portion and a distal portion joined by a tapered portion. The proximal portion has a diameter greater than the distal portion. The proximal portion has a first end portion engaged to at least a portion of the outer shaft at a first engagement site. At least a portion of the proximal waist is engaged to the proximal portion of the transition shaft at a second engagement site. At least a portion of the end region of the inner shaft is engaged to the distal portion of the transition shaft at a third engagement site. The distal portion extends through the balloon wherein at least a portion of the distal waist of the balloon is engaged to the distal portion of the transition shaft at a forth engagement site.
摘要翻译：球囊导管包括球囊，内轴，外轴和过渡轴。过渡轴具有通过锥形部分连接的近端部分和远端部分。近端部分的直径大于远端部分。近端部分具有在第一接合位置处接合到外轴的至少一部分的第一端部。近端腰部的至少一部分在第二接合位置处接合到过渡轴的近侧部分。内轴的端部区域的至少一部分在第三配合位置处接合到过渡轴的远端部分。远端部分延伸穿过球囊，其中球囊的远端腰部的至少一部分在第四接合位置处接合到过渡轴的远侧部分。

9. 发明授权

US07887830B2 Medical devices having polymeric regions based on styrene-isobutylene copolymers 有权
标题翻译：具有基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗装置
公开(公告)号：US07887830B2
公开(公告)日：2011-02-15
申请号：US12070806
申请日：2008-02-21
申请人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
发明人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
IPC分类号： A61F2/00
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

10. 发明申请

US20080286333A1 Medical devices having coating with improved adhesion 有权
标题翻译：具有改善粘附性的涂层的医疗装置
公开(公告)号：US20080286333A1
公开(公告)日：2008-11-20
申请号：US11803433
申请日：2007-05-15
申请人： Steven Kangas , Jan Seppala , Peter G. Edelman
发明人： Steven Kangas , Jan Seppala , Peter G. Edelman
IPC分类号： A61F2/01 , A61L31/02 , A61L31/08 , A61L31/16 , C08L23/00 , C08L31/00 , C08L33/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： According to an aspect of the present invention, a medical device is provided which comprises a metallic substrate and polymeric region disposed over and in contact with the metallic substrate. The polymeric region comprises (a) a block copolymer that comprises (i) a hard polymer block that comprises a high Tg monomer and (ii) a soft polymer block that comprises a low Tg monomer, (b) an adhesion promoting copolymer that comprises (i) a first monomer that covalently or non-covalently bonds with the metallic substrate and (ii) a second monomer that is compatible with the low Tg monomer and/or the high Tg monomer and (c) a therapeutic agent. The polymeric region may further comprise an optional polymer that is used to tailor the release rate of the therapeutic agent.
摘要翻译：根据本发明的一个方面，提供一种医疗装置，其包括金属基底和设置在金属基底上并与金属基底接触的聚合物区域。聚合物区域包括（a）嵌段共聚物，其包含（i）包含高Tg单体的硬聚合物嵌段和（ii）包含低Tg单体的软聚合物嵌段，（b）粘合促进共聚物，其包含（ i）与金属基底共价或非共价键合的第一单体和（ii）与低Tg单体和/或高Tg单体相容的第二单体和（c）治疗剂。聚合物区域还可以包含任选的聚合物，其用于定制治疗剂的释放速率。

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