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1. 发明授权

US07101553B2 Immune response enhancement methods 失效
标题翻译：免疫反应增强方法
公开(公告)号：US07101553B2
公开(公告)日：2006-09-05
申请号：US10822799
申请日：2004-04-13
申请人： Ferdinand Haschke , Anne-Lise Carrie , Zdenek Kratky , Harriet Link-Amster , Florence Rochat
发明人： Ferdinand Haschke , Anne-Lise Carrie , Zdenek Kratky , Harriet Link-Amster , Florence Rochat
IPC分类号： A61K39/165 , A61K39/20
CPC分类号： A61K31/733
摘要： A prebiotic for enhancement of an immune response, a nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for the prevention or treatment of measles; a method of enhancing an immune response which comprises administering an effective amount of a prebiotic; and a method of prevention or treatment of measles which comprises administering an effective amount of a prebiotic. In preferred embodiments the prebiotic comprises a fructo-oligosaccharide.
摘要翻译：用于增强免疫应答的益生元，用于增强免疫应答的营养组合物; 在制备用于增强免疫应答的药物或营养组合物中使用益生元; 使用益生元制造用于预防或治疗麻疹的药物或营养组合物; 一种增强免疫应答的方法，其包括施用有效量的益生元; 以及预防或治疗麻疹的方法，其包括施用有效量的益生元。在优选的实施方案中，益生元包括低聚果糖。

2. 发明授权

US09414621B2 Probiotics for use in expecting female mammals for enhancing the immunity of their offsprings 有权
标题翻译：用于期待女性哺乳动物增强其子代免疫力的益生菌
公开(公告)号：US09414621B2
公开(公告)日：2016-08-16
申请号：US12935149
申请日：2009-03-11
申请人： Jalil Benyacoub , Stephanie Blum-Sperisen , Florence Rochat , Thierry Von der Weid
发明人： Jalil Benyacoub , Stephanie Blum-Sperisen , Florence Rochat , Thierry Von der Weid
IPC分类号： A61K35/741 , A61K35/745 , A23L1/308 , A23L1/30 , A61K35/00
CPC分类号： A23L33/135 , A23L33/21 , A23V2002/00 , A23V2200/30 , A23Y2220/73 , A61K9/0053 , A61K35/741 , A61K35/745 , A61K35/747 , A61K39/09 , A61K2035/115
摘要： The present invention relates to the use of probiotic on expecting female mammals to boost the immune status of offspring. The use can induce an enhanced response of the offspring after birth to an infectious antigenic exposure. Ultimately the use of probiotic in expecting females can induce a better protection of offspring against infectious diseases.
摘要翻译：本发明涉及益生菌预期雌性哺乳动物增强后代免疫状态的用途。这种使用可以诱导出生后的后代对感染性抗原暴露的反应增强。最终在预期女性中使用益生菌可以更好地保护后代免受传染病的侵害。

3. 发明授权

US07666830B2 Nutritional composition preventing bacterial overgrowth 有权
标题翻译：营养组合物防止细菌过度生长
公开(公告)号：US07666830B2
公开(公告)日：2010-02-23
申请号：US10483892
申请日：2002-07-25
申请人： Clara L. Garcia-Rodenas , Olivier Ballevre , Florence Rochat
发明人： Clara L. Garcia-Rodenas , Olivier Ballevre , Florence Rochat
IPC分类号： A61K38/01
CPC分类号： A23K50/40 , A23L33/18 , A23L33/40 , A61K38/01 , A61K38/018
摘要： Protein hydrolyzates are used for prevention of bacterial overgrowth. In addition it was shown in sucklings mammals that specific protein hydrolyzates promote an intestinal flore pattern which is similar to the one of mammals raised by their mother. Other advantages are that the hydrolyzate is easier to obtain and simpler to administrate than treatment of bacterial overgrowth with the aid of active principles.
摘要翻译：蛋白质水解物用于预防细菌过度生长。此外，在哺乳动物的哺乳动物中显示出特定的蛋白质水解物促进了与其母亲所饲养的哺乳动物相似的肠小花纹。其他优点是借助于主动原理，水解产物比治疗细菌过度生长更容易获得并且更容易施用。

4. 发明申请

US20070104700A1 Nutritional formula for optimal gut barrier function 有权
标题翻译：最佳肠道屏障功能的营养配方
公开(公告)号：US20070104700A1
公开(公告)日：2007-05-10
申请号：US10562243
申请日：2004-06-22
申请人： Clara Garcia-Rodenas , Gabriela Bergonzelli , Florence Rochat , Marco Enrico Turini , Irene Corthesy-Theulaz , Christine Cherbut
发明人： Clara Garcia-Rodenas , Gabriela Bergonzelli , Florence Rochat , Marco Enrico Turini , Irene Corthesy-Theulaz , Christine Cherbut
IPC分类号： A61K35/74 , A61K31/22 , A61K31/715
CPC分类号： A61K31/736 , A23L33/12 , A23L33/135 , A23L33/19 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2220/63 , A23Y2300/55 , A61K31/202 , A61K31/702 , A61K31/733 , A23V2250/71 , A23V2250/712 , A23V2250/708 , A23V2250/714 , A23V2250/704 , A23V2250/54246 , A23V2250/5114 , A23V2250/60 , A23V2250/18 , A23V2250/1638 , A23V2250/70 , A23V2250/0616 , A23V2250/5488 , A23V2250/1614 , A23V2250/16 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/1868 , A23V2250/5062 , A23V2250/156 , A23V2250/0612 , A23V2250/641 , A23V2250/628 , A23V2250/612 , A61K2300/00
摘要： The present invention pertains to a composition for inducing a pattern of gut barrier maturation similar to that observed with breast-feeding and able to improve gut barrier maturation, e.g. during neonatal stress. In particular, the present invention relates to an infant formula containing a combination of specific ingredients designed to provide a synergistic effect all along gastrointestinal tract and barrier function.
摘要翻译：本发明涉及用于诱导肠道屏障成熟模式的组合物，其类似于用母乳喂养观察到的并且能够改善肠道屏障成熟，例如，在新生儿压力。特别地，本发明涉及含有特定成分的组合的婴儿配方，所述特定成分被设计成提供沿着胃肠道和屏障功能的协同作用。

5. 发明申请

US20050053641A1 Method of treating irritable bowel syndrome 有权
标题翻译：治疗肠易激综合征的方法
公开(公告)号：US20050053641A1
公开(公告)日：2005-03-10
申请号：US10942722
申请日：2004-09-16
申请人： Florence Rochat , Olivier Ballevre , Alfred Jann
发明人： Florence Rochat , Olivier Ballevre , Alfred Jann
IPC分类号： A23K1/18 , A23K1/14 , A23K1/16 , A23L1/0522 , A23L1/0528 , A23L1/053 , A23L1/09 , A23L1/30 , A23L1/308 , A61K31/70 , A61K31/715 , A61K31/718 , A61K31/733 , A61P1/00 , A61P1/12 , A61P31/04 , A61P43/00 , A61K47/00 , A61K9/14
CPC分类号： A61K31/70 , A23L5/00 , A23L29/244 , A23L29/25 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/22 , A23V2002/00 , A61K31/715 , A61K2300/00 , A23V2250/28 , A23V2250/5022 , A23V2250/5118 , A23V2250/5062 , A23V2200/32 , A23V2200/3202
摘要： A nutritional composition is disclosed which comprises synergistic functional carbohydrates for preventing or treating infection by pathogenic bacteria and/or promoting gut flora balance and health. The carbohydrates have a synergistic activity on promoting bifidobacteria in the intestine. Also disclosed are a method of production of the composition; and a method of treatment of infection by pathogenic bacteria and/or promoting gut flora balance and health which comprises administering an effective amount of the composition.
摘要翻译：公开了一种营养组合物，其包含用于预防或治疗病原菌感染和/或促进肠道菌群平衡和健康的协同功能性碳水化合物。碳水化合物对促进肠内双歧杆菌有协同作用。还公开了一种生产该组合物的方法; 以及治疗感染病原菌和/或促进肠道菌群平衡和健康的方法，其包括施用有效量的组合物。

6. 发明授权

US06399124B1 Frozen dessert containing lactic acid bacteria 有权
标题翻译：冷冻甜点含有乳酸菌
公开(公告)号：US06399124B1
公开(公告)日：2002-06-04
申请号：US09472931
申请日：1999-12-27
申请人： Corinne Lesens , Andrea M. Pfeifer , Florence Rochat
发明人： Corinne Lesens , Andrea M. Pfeifer , Florence Rochat
IPC分类号： A23C9123
CPC分类号： A23G9/363 , A21D13/33 , A21D13/34 , A21D13/38 , A23G9/42 , A23G9/48 , A23G9/506
摘要： Frozen dessert based on an ice cream containing lactic acid bacteria, the said ice cream being coated over all or part of its surface with, and/or placed in, and/or between, an edible support, characterized in that the support is substantially free of lactic acid bacteria, and in that it comprises fermentable fibers specifically promoting the growth, in the intestinal tract, of the lactic acid bacteria contained initially in the ice cream. The invention also relates to the combined use of lactic acid bacteria and prebiotic fibers, for the preparation of a frozen composition in which the lactic acid bacteria and the fibers are not substantially in contact, for the treatment and/or the prevention of gastrointestinal disorders, for strengthening the human immune system, or for increasing the absorption of minerals.
摘要翻译：基于含有乳酸菌的冰淇淋的冷冻甜点，所述冰淇淋涂覆在其可表面上的全部或部分表面上，和/或放置在可食用支持体中和/或之间，和/或之间，其特征在于，支撑体基本上是空的乳酸菌，并且其中包括特别促进肠道中最初包含在冰淇淋中的乳酸菌生长的可发酵纤维。本发明还涉及乳酸菌和益生元纤维的组合使用，用于制备其中乳酸菌和纤维基本上不接触的冷冻组合物用于治疗和/或预防胃肠道疾病，用于加强人体免疫系统，或增加对矿物质的吸收。

7. 发明授权

US6022568A Ice cream with coating containing lactic acid bacteria 有权
标题翻译：冰淇淋含有乳酸菌的涂层
公开(公告)号：US6022568A
公开(公告)日：2000-02-08
申请号：US254349
申请日：1999-05-21
申请人： Corinne Lesens , Christian Dufort , Andrea M. A. Pfeifer , Florence Rochat
发明人： Corinne Lesens , Christian Dufort , Andrea M. A. Pfeifer , Florence Rochat
IPC分类号： A23G9/00 , A23G9/04 , A23G9/32 , A23G9/34 , A23G9/36 , A23G9/40 , A23G9/44 , A23G9/46 , A23G9/48 , A23G9/52 , A23C9/127
CPC分类号： A23G9/363 , A23G9/322 , A23G9/46 , A23G9/48 , A23G2200/02
摘要： Use of lactic acid bacteria in the preparation of a cream intended to coat all or part of an ice cream. The ice cream is an expanded and chilled cream, coated over all or part of its external surface with a non-expanded coating containing 10.sup.3 to 10.sup.9 cfu/g of lactic acid bacteria. Preferably, the expanded cream includes more than 10.sup.6 cfu/g of lactic acid bacteria, the ratio (e/g) between the number of lactic acid bacteria in the coating (e) and the number of lactic acid bacteria in the expanded cream (g) being greater than 1. The coating may include 1% to 70% of a milk fermented by lactic acid bacteria, 0.5% to 5% of animal or vegetable proteins, a lactic fat content of from 2% to 20% and preferably the strain Lactobacillus acidophilus CNCM I-1225.
摘要翻译： PCT No.PCT / EP97 / 03560 371日期1999年5月21日 102（e）日期1999年5月21日PCT提交1997年7月5日PCT公布。第WO98 / 09535号公报日期1998年3月12日在制备用于涂抹全部或部分冰淇淋的奶油中的乳酸菌。冰淇淋是一种膨胀和冷冻的奶油，用全部或部分外表面涂覆含有103至109cfu / g乳酸菌的非膨胀涂层。优选地，膨胀的奶油包含超过106cfu / g的乳酸菌，涂层（e）中的乳酸菌数与膨胀奶油中的乳酸菌数（g ）大于1.涂层可以包括1％至70％的由乳酸菌发酵的乳，0.5％至5％的动物或植物蛋白，乳酸脂肪含量为2％至20％，优选菌株嗜酸乳杆菌CNCM I-1225。

8. 发明授权

US5603930A Lactobacillus johnsonii CNCM I-1225 失效
公开(公告)号：US5603930A
公开(公告)日：1997-02-18
申请号：US455562
申请日：1995-05-31
申请人： Dominique Brassart , Anne Donnet , Harriet Link , Olivier Mignot , Jean-Richard Neeser , Florence Rochat , Eduardo Schiffrin , Alain Servin
发明人： Dominique Brassart , Anne Donnet , Harriet Link , Olivier Mignot , Jean-Richard Neeser , Florence Rochat , Eduardo Schiffrin , Alain Servin
IPC分类号： A23C9/123 , A23C9/127 , A23K10/18 , A23L1/30 , A61K31/00 , A61K35/74 , A61K35/745 , A61K35/747 , A61P1/00 , A61P1/12 , C12N1/20 , C12R1/225 , C12R1/23 , C12R1/24 , A01N63/08
CPC分类号： C12R1/225 , A23C9/1234 , A23K10/18 , A61K35/745 , A61K35/747 , C12R1/01 , A23Y2220/03 , A23Y2300/55 , Y10S435/854
摘要： Lactobacillus johnsonii strain CNCM I-1225 adheres to Caco-2 cells and inhibits adhesion thereto by enterovirulent and enteroinvasive pathogens.
摘要翻译：约翰逊乳杆菌菌株CNCM I-1225粘附于Caco-2细胞，并通过肠毒素和肠溶病毒病原体抑制粘附。

9. 发明授权

US09456630B2 Use of Bifidobacterium longum for the prevention and treatment of inflammation 有权
标题翻译：使用长双歧杆菌预防和治疗炎症
公开(公告)号：US09456630B2
公开(公告)日：2016-10-04
申请号：US13451837
申请日：2012-04-20
申请人： Annick Mercenier , Stephanie Blum-Sperisen , Florence Rochat
发明人： Annick Mercenier , Stephanie Blum-Sperisen , Florence Rochat
IPC分类号： C12N1/12 , A01N63/00 , A61K47/00 , C12N1/04 , A23C9/12 , C12P19/04 , A23L1/30 , A23L1/29 , A61K35/745
CPC分类号： A23L33/135 , A23K10/18 , A23K50/40 , A23L33/40 , A61K35/745
摘要： The invention relates to the use, in the manufacture of a medicament or a therapeutic nutritional composition for preventing or reducing inflammation in a mammal, of bifidobacterium longum ATCC BAAA-999.
摘要翻译：本发明涉及在制备用于预防或减少哺乳动物双歧杆菌ATCC BAAA-999中的炎症的药物或治疗营养组合物中的用途。

10. 发明授权

US09131721B2 Gut microbiota in infants 有权
标题翻译：婴儿肠道微生物群
公开(公告)号：US09131721B2
公开(公告)日：2015-09-15
申请号：US12326368
申请日：2008-12-02
申请人： Florence Rochat , Marie-Christine Secretin
发明人： Florence Rochat , Marie-Christine Secretin
IPC分类号： A23C9/123 , A23C21/00 , A23L1/29 , A23L1/09 , A23L1/236 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A23L1/00
CPC分类号： A23L1/296 , A23L5/00 , A23L27/33 , A23L29/30 , A23L33/12 , A23L33/125 , A23L33/15 , A23L33/16 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2250/54252 , A23V2250/612 , A23V2250/1618
摘要： The use of a whey predominant protein source and lactose in the manufacture of a nutritional composition for promoting the development of an early bifidogenic intestinal microbiota in infants fed with the nutritional composition wherein the nutritional composition has a protein content of less than 2.1 g protein/100 kcal and a phosphorus content of less than 40 mg/100 kcal.
摘要翻译：使用乳清主要蛋白质来源和乳糖来制造营养组合物，用于促进饲喂营养组合物的婴儿中早期双歧杆菌肠道微生物群的发育，其中营养组合物的蛋白质含量小于2.1g蛋白质/ 100 kcal，磷含量小于40mg / 100kcal。

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