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1. 发明授权

US09389221B2 Apparatus for processing biological samples 有权
标题翻译：用于处理生物样品的装置
公开(公告)号：US09389221B2
公开(公告)日：2016-07-12
申请号：US14679024
申请日：2015-04-05
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： G01N33/53 , B01L1/00 , B01L3/00 , G01N1/38 , G01N35/00
CPC分类号： G01N33/5304 , B01L1/00 , B01L3/508 , B01L3/52 , B01L2300/02 , B01L2300/0672 , B01L2300/0841 , G01N1/38 , G01N33/5302 , G01N2035/00524
摘要： The present disclosure provides an automated bioprocessing device, which may comprises a processing machine, one or more removable washing cartridges. The removable washing cartridge may comprise a shell, a sample holder, a washing basin, a waste container, a reagent container, a rotation mechanism, and a poking mechanism. The processing machine may comprise a motor, which may provide power to the inserted removable washing cartridge.
摘要翻译：本公开提供了一种自动生物处理装置，其可以包括处理机器，一个或多个可移除的洗涤筒。可移除的清洗盒可以包括壳体，样本保持器，洗涤盆，废物容器，试剂容器，旋转机构和戳戳机构。加工机器可以包括电机，其可以向插入的可移除的清洗盒提供电力。

2. 发明申请

US20140286885A1 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 有权
标题翻译：基于肽的化合物作为神经递质分泌物的抑制剂
公开(公告)号：US20140286885A1
公开(公告)日：2014-09-25
申请号：US14356387
申请日：2012-11-07
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： A61K8/64 , A61Q19/08
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： The present disclosure is directed to peptide-based compounds, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present disclosure may inhibit neurotransmitter release and muscle contraction as a treatment for wrinkles. The compounds of the disclosure may be used for pathological neuronal exocytosis-mediated cosmetic and/or therapeutic purposes.
摘要翻译：本公开涉及基于肽的化合物，其衍生物，药学上可接受的盐，溶剂合物和水合物。本公开的化合物和组合物可以抑制作为皱纹治疗的神经递质释放和肌肉收缩。本公开的化合物可用于病理性神经元胞吐作用介导的化妆品和/或治疗目的。

3. 发明授权

US09248089B2 Peptide-based compounds as inhibitors of neurotransmitter secretion 有权
标题翻译：基于肽的化合物作为神经递质分泌的抑制剂
公开(公告)号：US09248089B2
公开(公告)日：2016-02-02
申请号：US14356387
申请日：2012-11-07
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： A61K8/64 , C07K7/06 , A61Q19/08 , A61K38/00
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： The present disclosure is directed to peptide-based compounds, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present disclosure may inhibit neurotransmitter release and muscle contraction as a treatment for wrinkles. The compounds of the disclosure may be used for pathological neuronal exocytosis-mediated cosmetic and/or therapeutic purposes.
摘要翻译：本公开涉及基于肽的化合物，其衍生物，药学上可接受的盐，溶剂合物和水合物。本公开的化合物和组合物可以抑制作为皱纹治疗的神经递质释放和肌肉收缩。本公开的化合物可用于病理性神经元胞吐作用介导的化妆品和/或治疗目的。

4. 发明申请

US20150285790A1 APPARATUS FOR PROCESSING BIOLOGICAL SAMPLES 审中-公开
标题翻译：加工生物样品的装置
公开(公告)号：US20150285790A1
公开(公告)日：2015-10-08
申请号：US14679024
申请日：2015-04-05
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： G01N33/53 , B01L3/00 , B01L1/00
CPC分类号： G01N33/5304 , B01L1/00 , B01L3/508 , B01L3/52 , B01L2300/02 , B01L2300/0672 , B01L2300/0841 , G01N1/38 , G01N33/5302 , G01N2035/00524
摘要： The present disclosure provides an automated bioprocessing device, which may comprises a processing machine, one or more removable washing cartridges. The removable washing cartridge may comprise a shell, a sample holder, a washing basin, a waste container, a reagent container, a rotation mechanism, and a poking mechanism. The processing machine may comprise a motor, which may provide power to the inserted removable washing cartridge.
摘要翻译：本公开提供了一种自动生物处理装置，其可以包括处理机器，一个或多个可移除的洗涤筒。可移除的清洗盒可以包括壳体，样本保持器，洗涤盆，废物容器，试剂容器，旋转机构和戳戳机构。加工机器可以包括电机，其可以向插入的可移除的清洗盒提供电力。

5. 发明申请

US20130203072A1 APPARATUS FOR PROCESSING BIOLOGICAL SAMPLES AND METHOD THEREOF 审中-公开
标题翻译：用于处理生物样品的装置及其方法
公开(公告)号：US20130203072A1
公开(公告)日：2013-08-08
申请号：US13879995
申请日：2010-10-29
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： G01N1/31
CPC分类号： G01N1/31 , B01L3/5025 , B01L9/52 , B01L2300/021 , C12Q1/68 , G01N35/00 , G01N35/0099 , G01N35/04 , G01N2035/0477
摘要： The present invention provides devices, apparatuses and methods for automated processing of biological samples. This invention provides automated devices and automated methods of sequentially treating a biological sample with processing fluids in more than one washing basin. In some embodiments, the invention provides automated devices and automated methods of western blot processing. In some embodiments, the invention provides automated devices and automated methods of Southern blot processing. In some embodiments, the invention provides automated devices and automated methods of northern blot processing. In some embodiments, the invention provides automated devices and automated methods of staining biomolecules on solid supports. In some embodiments, the invention provides automated devices and automated methods of nucleic acid separation and isolation.
摘要翻译：本发明提供用于生物样品的自动处理的装置，装置和方法。本发明提供了在多于一个洗涤盆中用处理流体顺序处理生物样品的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和蛋白质印迹法的自动化方法。在一些实施方案中，本发明提供了Southern印迹处理的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和Northern印迹法的自动化方法。在一些实施方案中，本发明提供了在固体支持物上染色生物分子的自动化装置和自动化方法。在一些实施方案中，本发明提供自动化装置和核酸分离和分离的自动化方法。

6. 发明授权

US09121795B2 Apparatus for processing biological samples and method thereof 有权
标题翻译：用于处理生物样品的装置及其方法
公开(公告)号：US09121795B2
公开(公告)日：2015-09-01
申请号：US13879995
申请日：2010-10-29
申请人： Feng Tian , Daniel Liang Zou , Lingyun Ji
发明人： Feng Tian , Daniel Liang Zou , Lingyun Ji
IPC分类号： A61B10/00 , G01N1/31 , G01N35/00 , B01L3/00 , G01N35/04 , B01L9/00 , C12Q1/68
CPC分类号： G01N1/31 , B01L3/5025 , B01L9/52 , B01L2300/021 , C12Q1/68 , G01N35/00 , G01N35/0099 , G01N35/04 , G01N2035/0477
摘要： The present invention provides devices, apparatuses and methods for automated processing of biological samples. This invention provides automated devices and automated methods of sequentially treating a biological sample with processing fluids in more than one washing basin. In some embodiments, the invention provides automated devices and automated methods of western blot processing. In some embodiments, the invention provides automated devices and automated methods of Southern blot processing. In some embodiments, the invention provides automated devices and automated methods of northern blot processing. In some embodiments, the invention provides automated devices and automated methods of staining biomolecules on solid supports. In some embodiments, the invention provides automated devices and automated methods of nucleic acid separation and isolation.
摘要翻译：本发明提供用于生物样品的自动处理的装置，装置和方法。本发明提供了在多于一个洗涤盆中用处理流体顺序处理生物样品的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和蛋白质印迹法的自动化方法。在一些实施方案中，本发明提供了Southern印迹处理的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和Northern印迹法的自动化方法。在一些实施方案中，本发明提供了在固体支持物上染色生物分子的自动化装置和自动化方法。在一些实施方案中，本发明提供自动化装置和核酸分离和分离的自动化方法。

7. 发明授权

US09086921B2 Dynamic database memory management according to swap rates 有权
标题翻译：根据互换率动态数据库内存管理
公开(公告)号：US09086921B2
公开(公告)日：2015-07-21
申请号：US13460547
申请日：2012-04-30
申请人： Boris Weissman , Aleksandr V. Mirgorodskiy , Ganesh Venkitachalam , Feng Tian
发明人： Boris Weissman , Aleksandr V. Mirgorodskiy , Ganesh Venkitachalam , Feng Tian
IPC分类号： G06F12/00 , G06F9/50 , G06F17/30 , G06F9/455
CPC分类号： G06F9/5016 , G06F9/45533 , G06F17/30 , G06F17/30306
摘要： Memory of a database management system (DBMS) that is running in a virtual or physical machine is managed using techniques that that reduce the effect of memory swaps on the performance of the physical or virtual machine. One such technique includes the steps of determining a swap rate while the database application is in an executing state, and decreasing the size of memory space available to the database application if the swap rate is above a threshold.
摘要翻译：在虚拟或物理机器中运行的数据库管理系统（DBMS）的内存使用可以减少内存互换对物理机或虚拟机性能的影响的技术进行管理。一种这样的技术包括在数据库应用处于执行状态时确定交换速率的步骤，以及如果交换速率高于阈值则减小数据库应用可用的存储空间的大小。

8. 发明授权

US09074010B2 Modified human plasma polypeptide or Fc scaffolds and their uses 有权
标题翻译：改良的人血浆多肽或Fc支架及其用途
公开(公告)号：US09074010B2
公开(公告)日：2015-07-07
申请号：US13208136
申请日：2011-08-11
申请人： Joseph Sheffer , Thea Norman , Richard D. Dimarchi , Anna-Maria A. Hays Putnam , Feng Tian , Stephanie Chu , Denise Krawitz , Ho Sung Cho
发明人： Joseph Sheffer , Thea Norman , Richard D. Dimarchi , Anna-Maria A. Hays Putnam , Feng Tian , Stephanie Chu , Denise Krawitz , Ho Sung Cho
IPC分类号： C07K14/765 , C07K14/47 , A61K38/38 , C12N15/14 , C07K19/00 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/765 , C07K19/00 , C07K2319/00
摘要： Modified human plasma polypeptides or Fc and uses thereof are provided.
摘要翻译：提供了修饰的人血浆多肽或Fc及其用途。

9. 发明授权

US09020545B2 Link adaptation method, base station and terminal in LTE system 有权
标题翻译： LTE系统中的链路适配方法，基站和终端
公开(公告)号：US09020545B2
公开(公告)日：2015-04-28
申请号：US13201405
申请日：2010-08-17
申请人： Feng Tian
发明人： Feng Tian
IPC分类号： H04B17/00 , H04L1/00 , H04W52/26
CPC分类号： H04L1/0009 , H04B17/318 , H04L1/0003 , H04L2001/0092 , H04W52/262
摘要： The present invention discloses a link adaptation method, a base station and a terminal in a LTE system, wherein the method comprises: a terminal respectively calculating differences between a measured reference signal received power (RSRP) of a home service cell and the RSRPs of multiple adjacent cells; the terminal reporting the maximum difference in the differences to a base station; and the base station determining a modulation and coding scheme (MCS) for the terminal according to the maximum difference. The present invention does not introduce new overhead of the system, simplifies the flow of the AMC, and therefore improves the frequency spectrum efficiency of the system.
摘要翻译：本发明公开了一种LTE系统中的链路适配方法，基站和终端，其中，所述方法包括：分别计算家庭业务小区的测量参考信号接收功率（RSRP）与多个RSRP之间的差异的终端相邻细胞; 终端报告与基站的差异的最大差异; 并且基站根据最大差异确定终端的调制和编码方案（MCS）。本发明不引入系统的新开销，简化了AMC的流程，从而提高了系统的频谱效率。

10. 发明授权

US08586340B2 Selective posttranslational modification of phage-displayed polypeptides 有权
标题翻译：噬菌体展示多肽的选择性翻译后修饰
公开(公告)号：US08586340B2
公开(公告)日：2013-11-19
申请号：US11580223
申请日：2006-10-11
申请人： Meng-Lin Tsao , Feng Tian , Peter Schultz
发明人： Meng-Lin Tsao , Feng Tian , Peter Schultz
IPC分类号： C12N7/02 , C40B40/02
CPC分类号： C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
摘要： The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.
摘要翻译：本发明涉及噬菌体展示多肽的翻译后修饰。这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮氨基酸如对叠氮基-L-苯丙氨酸或炔基 - 氨基酸如对 - 炔丙氧基苯丙氨酸，其被并入噬菌体展示的融合物通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统，在选定位置上的多肽。这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。

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