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1. 发明申请

US20100035260A1 Compositions, devices, systems, for using a Nanopore 有权
标题翻译：使用Nanopore的组合，设备，系统
公开(公告)号：US20100035260A1
公开(公告)日：2010-02-11
申请号：US12459059
申请日：2009-06-26
申请人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
发明人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
IPC分类号： C12Q1/68 , C12M1/34 , C07H21/00 , C07K2/00 , C12N9/96
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在不需要终止核苷酸的情况下在纳米孔中被另一种化合物（例如酶）作用的装置和方法。所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。本发明特别用于药物发现，分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

2. 发明授权

US08679747B2 Compositions, devices, systems, for using a nanopore 有权
标题翻译：用于使用纳米孔的组合物，器件，系统
公开(公告)号：US08679747B2
公开(公告)日：2014-03-25
申请号：US12459059
申请日：2009-06-26
申请人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
发明人： Felix Olasagasti , Kate Lieberman , Seico Benner , Mark A. Akeson
IPC分类号： C12Q1/68 , C12M1/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12M3/00
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在不需要终止核苷酸的情况下在纳米孔中被另一种化合物（例如酶）作用的装置和方法。所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。本发明特别用于药物发现，分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

3. 发明申请

US20110174625A1 COMPOSITIONS, DEVICES, SYSTEMS, AND METHODS FOR USING A NANOPORE 有权
标题翻译：组合物，设备，系统和使用纳米级的方法
公开(公告)号：US20110174625A1
公开(公告)日：2011-07-21
申请号：US12450633
申请日：2008-04-04
申请人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Daniel Branton , William B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Daniel Branton , William B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
IPC分类号： G01N27/447
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在纳米孔中被另一种化合物（例如酶）作用的装置和方法。所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

4. 发明申请

US20110005918A1 Compositions, devices, systems, and methods for using a nanopore 审中-公开
标题翻译：使用纳米孔的组合物，器件，系统和方法
公开(公告)号：US20110005918A1
公开(公告)日：2011-01-13
申请号：US12080684
申请日：2008-04-04
申请人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Wiliam B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Roger Jinteh Arrigo Chen , Seico Benner , Wiliam B. Dunbar , Noah A. Wilson , Kate Lieberman , Robin Abu-Shumays , Nicholas Hurt
IPC分类号： G01N27/26 , G01N27/40
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在纳米孔中被另一种化合物（例如酶）作用的装置和方法。所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

5. 发明授权

US08314209B2 Lipid-assisted synthesis of polymer compounds and methods for their use 有权
标题翻译：脂质辅助合成高分子化合物及其使用方法
公开(公告)号：US08314209B2
公开(公告)日：2012-11-20
申请号：US12316515
申请日：2008-12-12
申请人： Sudha Rajamani , Felix Olasagasti , David W. Deamer , Seico Benner
发明人： Sudha Rajamani , Felix Olasagasti , David W. Deamer , Seico Benner
IPC分类号： C07H1/00 , C07H21/00 , C07K1/02
CPC分类号： C07H1/00 , C07K1/02
摘要： The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The method comprises providing an aqueous solution having a plurality of phospholipid molecules and monomer molecules; subjecting the aqueous solution to fluctuating temperature conditions; subjecting the aqueous solution to fluctuating cycles of drying and hydrating conditions; subjecting the aqueous solution to fluctuating [H+] conditions; the fluctuating conditions thereby allowing formation of a chemical bond between at least two monomers to create a polymer. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了用于从单体合成聚合物的方法。特别地，该方法提供了在没有催化酶的情况下从单核苷酸合成多核苷酸。该方法包括提供具有多个磷脂分子和单体分子的水溶液; 使水溶液经受波动的温度条件; 使水溶液经历干燥和水合条件的波动循环; 使水溶液发生波动[H +]条件; 波动条件由此允许在至少两种单体之间形成化学键以产生聚合物。本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

6. 发明申请

US20090264621A1 Lipid-assisted synthesis of polymer compounds and methods for their use 有权
标题翻译：脂质辅助合成高分子化合物及其使用方法
公开(公告)号：US20090264621A1
公开(公告)日：2009-10-22
申请号：US12316515
申请日：2008-12-12
申请人： Sudha Rajamani , Felix Olasagasti , David W. Deamer , Seico Benner
发明人： Sudha Rajamani , Felix Olasagasti , David W. Deamer , Seico Benner
IPC分类号： C07K1/02 , C07H1/00
CPC分类号： C07H1/00 , C07K1/02
摘要： The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了用于从单体合成聚合物的方法。特别地，该方法提供了在不存在催化酶的情况下从单核苷酸合成多核苷酸。本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

7. 发明申请

US20130118902A1 METHODS FOR USING A NANOPORE 审中-公开
标题翻译：使用NANOPORE的方法
公开(公告)号：US20130118902A1
公开(公告)日：2013-05-16
申请号：US13615183
申请日：2012-09-13
申请人： Mark A. Akeson , David W. Deamer , Seico Benner , William B. Dunbar , Noah A. Wilson , Kathy Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Seico Benner , William B. Dunbar , Noah A. Wilson , Kathy Lieberman , Robin Abu-Shumays , Nicholas Hurt
IPC分类号： C25B3/10
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译：本文公开的本发明提供了可以检测和控制混合物中的单个聚合物在纳米孔中被另一种化合物（例如酶）作用的装置和方法。所述装置和方法还用于在反馈控制下或使用通过多核苷酸和纳米孔之间的相互作用产生的信号来快速（〜> 50Hz）确定多核苷酸的核苷酸碱基序列。本发明特别用于分子生物学，结构生物学，细胞生物学，分子开关，分子电路和分子计算装置及其制造领域。

8. 发明授权

US10059988B2 Methods for using a nanopore 有权
公开(公告)号：US10059988B2
公开(公告)日：2018-08-28
申请号：US13615183
申请日：2012-09-13
申请人： Mark A. Akeson , David W. Deamer , Seico Benner , William B. Dunbar , Noah A. Wilson , Kathy Lieberman , Robin Abu-Shumays , Nicholas Hurt
发明人： Mark A. Akeson , David W. Deamer , Seico Benner , William B. Dunbar , Noah A. Wilson , Kathy Lieberman , Robin Abu-Shumays , Nicholas Hurt
IPC分类号： C12Q1/68 , C12Q1/6874 , C12Q1/6869 , G01N33/487 , C25B3/10 , C12Q1/54 , G01N27/327 , G01N27/416
CPC分类号： C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要： Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

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