专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08883472B2 Process for removing water from aqueous solutions of proteins 有权
标题翻译：从蛋白质水溶液中除去水分的方法
公开(公告)号：US08883472B2
公开(公告)日：2014-11-11
申请号：US10590095
申请日：2005-02-18
申请人： Felipe A. Donate , Timothy C. Frank , Barbara J. Grabowski
发明人： Felipe A. Donate , Timothy C. Frank , Barbara J. Grabowski
IPC分类号： C07K1/00 , C07K1/14
CPC分类号： C07K1/145
摘要： A method for extracting water from an aqueous solution of a protein comprising the steps of: (a) intermixing the aqueous solution of the protein with a sufficient quantity of at least one glycol ether at a temperature at least 30 centigrade degrees above the lower critical solution temperature (LCST), preferably at least 20 centigrade degrees above the LCST, and most preferably at least 10 degrees above the LCST, to form a suspension comprising a concentrated aqueous protein phase and a liquid organic phase comprising said at least one glycol ether and at least 10 percent water extracted from the aqueous solution of the protein, wherein the glycol ether has an inverse solubility in water, with the proviso that the solubility of the glycol ether in water is significantly less than the solubility of water in the glycol ether, and the glycol ether does not significantly deactivate the protein, and (b) separating the concentrated aqueous protein phase formed in step (a) from at least a portion of the liquid organic phase.
摘要翻译：一种从蛋白质水溶液中提取水的方法，包括以下步骤：（a）将蛋白质水溶液与足够量的至少一种二醇醚在比较低临界溶液高至少30摄氏度的温度下混合温度（LCST），优选高于LCST至少20摄氏度，最优选高于LCST至少10度，以形成包含浓缩的蛋白质水相和包含所述至少一种二醇醚的液体有机相的悬浮液，并且在从蛋白质水溶液中提取的最少10％的水，其中乙二醇醚在水中具有相反的溶解度，条件是二醇醚在水中的溶解度显着小于水在乙二醇醚中的溶解度，以及乙二醇醚不会使蛋白质显着失活，和（b）将步骤（a）中形成的浓缩水性蛋白质相从至少一个孔液体有机相。

IPRDB

热门服务

关于我们

友情链接

联系方式