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1. 发明申请

US20070149844A1 Surgical devices for imposing a negative pressure to stabilize the cardiac tissue during surgery 审中-公开
标题翻译：用于在手术期间施加负压以稳定心脏组织的手术装置
公开(公告)号：US20070149844A1
公开(公告)日：2007-06-28
申请号：US11709392
申请日：2007-02-21
申请人： Federico Benetti , Robert Matheny , Charles Taylor
发明人： Federico Benetti , Robert Matheny , Charles Taylor
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61B17/0218 , A61B17/00 , A61B90/40 , A61B2017/00243 , A61B2017/00703 , A61B2017/0243 , A61B2017/306 , A61B2017/3488
摘要： The invention is devices and techniques which use a negative (suction) pressure or vacuum, applied through a surgical instrument, to fix the position of a portion of the surface of a beating heart so that a surgical procedure can be more easily performed. The devices apply a negative pressure at several points on the outer surface of the heart such that a portion of the heart is fixed in place by the suction imposed through the surgical instrument. Because the instrument fixes the position of the tissue, and because the instruments remain at a constant distance from the particular portion of the heart where the surgery is being performed, the device may also serve as a support or platform so that other surgical instruments or devices can be advantageously used at the site. In certain preferred embodiments, the devices described herein have structures to facilitate the use of additional surgical instruments such that the placement of negative pressure device permit the surgeon to advantageously manipulate the other instruments during surgery. The negative pressure is preferably imposed through a plurality of ports which may be disposed in a substantially planar surface of the instrument which contacts the cardiac tissue.
摘要翻译：本发明是使用通过外科器械施加的负（吸力）压力或真空来固定跳动心脏表面的一部分的位置使得外科手术可以更容易地进行的装置和技术。这些装置在心脏的外表面上的几个点处施加负压，使得心脏的一部分通过通过手术器械施加的抽吸被固定就位。因为仪器固定组织的位置，并且因为仪器保持与正在执行手术的心脏的特定部分恒定的距离，所以该装置还可以用作支撑或平台，使得其它手术器械或装置可以有利地在现场使用。在某些优选实施例中，本文所述的装置具有便于使用额外外科器械的结构，使得负压装置的放置允许外科医生在手术期间有利地操纵其他器械。负压优选通过多个端口施加，所述多个端口可以设置在与心脏组织接触的仪器的基本平坦的表面中。

2. 发明申请

US20070014869A1 Compositions for reconstruction, replacement or repair of intracardiac tissue 审中-公开
标题翻译：用于重建，置换或修复心内组织的组合
公开(公告)号：US20070014869A1
公开(公告)日：2007-01-18
申请号：US11334631
申请日：2006-01-18
申请人： Robert Matheny
发明人： Robert Matheny
IPC分类号： A61K35/38 , A61K35/37
CPC分类号： A61K48/00 , A61K9/0019 , A61L27/3633 , A61L27/367 , A61L27/3683 , A61L27/3873 , A61L2400/06 , A61L2430/20
摘要： The invention is to a composition for reconstruction, replacement or repair of a defect in or dsmage to intracardiac tissue comprising a patch, emulsion, injectable solution or other composition comprising extracellular matrix. As extracellular matrix can assimilate with the intracardiac tissue to help generate healthy functioning tissue, using extracellular matrix to address a defect in intracardiac tissue can obviate the need for second or subsequent open heart surgeries, or if the composition can be delivered in a minimally invasive medical procedure, can obviate the need for open heart surgery altogether. Conduction of the intracardiac tissue may also be restored using extracellular matrix material to reconstruct, replace or repair the damaged intracardiac tissue.
摘要翻译：本发明涉及一种用于重组，置换或修复包括贴剂，乳剂，可注射溶液或包含细胞外基质的其它组合物在内的心脏内组织的损伤的组合物。由于细胞外基质可以与心脏内组织同化以帮助产生健康的功能组织，所以使用细胞外基质来解决心内组织中的缺陷可以避免对第二次或随后的开放心脏手术的需要，或者如果组合物可以在微创医学中递送程序，可以完全消除开心手术的需要。也可以使用细胞外基质材料来恢复心脏内组织的传导，以重建，替换或修复损伤的心内组织。

3. 发明授权

US08608796B2 Prosthetic tissue valve 有权
标题翻译：假肢组织瓣膜
公开(公告)号：US08608796B2
公开(公告)日：2013-12-17
申请号：US13801242
申请日：2013-03-13
申请人： Robert Matheny
发明人： Robert Matheny
IPC分类号： A61F2/24
CPC分类号： A61F2/2412
摘要： A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
摘要翻译：本文描述了用于主动脉，肺，二尖瓣或三尖瓣置换的假体组织瓣膜。还描述了与假肢组织瓣一起使用的缝合环。阀可以具有比缺陷阀中的环的圆周大的预定距离的圆周。在连接到环形空间之前，阀可以在非受压位置处基本上是平面的，并且在环形偏压位置处附接时基本上不平面。提供了用于将如本文所述的阀放置在有缺陷阀的环形空间内的偏置位置的方法。

4. 发明申请

US20070014873A1 Compositions for regenerating defective or absent myocardium 审中-公开
公开(公告)号：US20070014873A1
公开(公告)日：2007-01-18
申请号：US11448931
申请日：2006-06-06
申请人： Robert Matheny
发明人： Robert Matheny
IPC分类号： A61K35/38 , A61K35/34 , A61K35/37 , A61K35/44
CPC分类号： A61L27/54 , A61K9/0019 , A61K31/7088 , A61K31/726 , A61K35/22 , A61K35/34 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/50 , A61K35/545 , A61K38/1741 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K48/00 , A61L27/227 , A61L27/3629 , A61L27/3633 , A61L27/367 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/3873 , A61L27/40 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/64 , A61L2400/06 , A61L2430/20 , A61L2430/30
摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition can also have an extracellular matrix scaffold component of any formulation, then including also added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.

5. 发明申请

US20070014872A1 Compositions for regenerating defective or absent myocardium 审中-公开
公开(公告)号：US20070014872A1
公开(公告)日：2007-01-18
申请号：US11448355
申请日：2006-06-06
申请人： Robert Matheny , Beecher Lewis
发明人： Robert Matheny , Beecher Lewis
IPC分类号： A61K35/38 , A61K35/34 , A61K35/37 , A61K35/44
CPC分类号： A61L27/54 , A61K9/0019 , A61K31/7088 , A61K31/726 , A61K35/22 , A61K35/34 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/50 , A61K35/545 , A61K38/1741 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K48/00 , A61L27/227 , A61L27/3629 , A61L27/3633 , A61L27/367 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/3873 , A61L27/40 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/64 , A61L2400/06 , A61L2430/20 , A61L2430/30
摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition can also have an extracellular matrix scaffold component of any formulation, then including also added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.

6. 发明申请

US20070014773A1 Compositions for regenerating defective or absent myocardium 有权
标题翻译：用于再生有缺陷或缺失心肌的组合物
公开(公告)号：US20070014773A1
公开(公告)日：2007-01-18
申请号：US11182551
申请日：2005-07-15
申请人： Robert Matheny , Beecher Lewis
发明人： Robert Matheny , Beecher Lewis
IPC分类号： A61K48/00 , C12N5/08
CPC分类号： A61L27/54 , A61K9/0019 , A61K31/7088 , A61K31/726 , A61K35/22 , A61K35/34 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/50 , A61K35/545 , A61K38/1741 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K48/00 , A61L27/227 , A61L27/3629 , A61L27/3633 , A61L27/367 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/3873 , A61L27/40 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/64 , A61L2400/06 , A61L2430/20 , A61L2430/30
摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.
摘要翻译：用于再生有缺陷或缺失心肌的本发明的组合物包含乳化或可注射的细胞外基质组合物。组合物还可以包括任何制剂的细胞外基质支架组分，并且还包括添加的细胞，蛋白质或其它成分以优化再生过程并恢复心脏功能。用于再生有缺陷或缺失心肌的方法使用适合特定制剂的递送模式将组合物施用于需要再生的心肌部位。

7. 发明申请

US20070014870A1 Compositions for regenerating defective or absent myocardium 审中-公开
公开(公告)号：US20070014870A1
公开(公告)日：2007-01-18
申请号：US11367870
申请日：2006-03-02
申请人： Robert Matheny
发明人： Robert Matheny
IPC分类号： A61K35/38 , A61K35/37
CPC分类号： A61L27/54 , A61K9/0019 , A61K31/7088 , A61K31/726 , A61K35/22 , A61K35/34 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/50 , A61K35/545 , A61K38/1741 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K48/00 , A61L27/227 , A61L27/3629 , A61L27/3633 , A61L27/367 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/3873 , A61L27/40 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/64 , A61L2400/06 , A61L2430/20 , A61L2430/30
摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition can also have an extracellular matrix scaffold component of any formulation, then including also added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.

8. 发明授权

US07052491B2 Vacuum-assisted securing apparatus for a microwave ablation instrument 失效
公开(公告)号：US07052491B2
公开(公告)日：2006-05-30
申请号：US10115115
申请日：2002-04-01
申请人： Lyndall Erb , Dany Berube , Robert Matheny , Robert E. Woodard , Theodore C. Ormsby
发明人： Lyndall Erb , Dany Berube , Robert Matheny , Robert E. Woodard , Theodore C. Ormsby
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/1402 , A61B18/18 , A61B18/1815 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/1437
摘要： A securing apparatus for selectively securing an ablating element of an ablation instrument proximate to a targeted region of a biological tissue. The securing apparatus includes a support base affixed to the ablation instrument relative the ablating element, and having a support face adapted to seat against the biological tissue proximate to the ablation element. The support base further defines a passage having one end communicably coupled to a vacuum source and an opposite end terminating at an orifice at the support face. The support face together with the biological tissue forms a hermetic seal thereagainst during operation of the vacuum source to secure the ablation instrument thereagainst. Essentially, the hermetic seal and the vacuum source cooperate to form a vacuum force sufficient to retain the ablation device against the biological tissue.

9. 发明申请

US20050154250A1 Left and right side heart support 有权
公开(公告)号：US20050154250A1
公开(公告)日：2005-07-14
申请号：US11018872
申请日：2004-12-21
申请人： Walid Aboul-Hosn , William Kanz , Jodi Akin , Michael Guidera , Robert Matheny
发明人： Walid Aboul-Hosn , William Kanz , Jodi Akin , Michael Guidera , Robert Matheny
IPC分类号： A61M1/10 , A61M1/36 , A61N1/362
CPC分类号： A61M1/3621 , A61M1/1008 , A61M1/101 , A61M1/1096 , A61M1/12 , A61M1/122 , A61M1/3663
摘要： A cannulation system for cardiac support uses an inner cannula disposed within an outer cannula. The outer cannula includes a fluid inlet for placement within the right atrium of a heart. The inner cannula includes a fluid inlet extending through the fluid inlet of the outer cannula and the atrial septum for placement within at least one of the left atrium and left ventricle of the heart. The cannulation system also employs a pumping assembly coupled to the inner and outer cannulas to withdraw blood from the right atrium for delivery to the pulmonary artery to provide right heart support, or to withdraw blood from at least one of the left atrium and left ventricle for delivery into the aorta to provide left heart support, or both.

10. 发明申请

US20140277416A1 Seamless Tubular Extracellular Matrix Prosthetic Valve and Method for Forming Same 审中-公开
标题翻译：无缝管状细胞外基质假体瓣膜及其形成方法
公开(公告)号：US20140277416A1
公开(公告)日：2014-09-18
申请号：US13804683
申请日：2013-03-14
申请人： Robert Matheny
发明人： Robert Matheny
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2210/0076 , A61F2250/0036 , A61F2250/0039 , A61L27/3629 , A61L27/3633 , A61L27/54 , A61L2300/402 , A61L2300/41 , A61L2300/414 , A61L2300/64 , A61L2430/20
摘要： A seamless prosthetic valve comprising a continuous tubular member having an outer abluminal surface, a triple walled intermediate portion, and at least a first valve leaflet that is configured to selectively restrict fluid flow through the valve, the triple walled intermediate portion being formed by everting a first end of member over the member, whereby a double walled end is formed, and reverting the first end over the double walled end of the member, the first valve leaflet being formed by suturing the triple walled intermediate portion at a first commissure connection point.
摘要翻译：一种无缝人造瓣膜，包括具有外侧浅层表面的连续管状构件，三壁中间部分和至少第一瓣膜小叶，其被配置为选择性地限制通过所述瓣膜的流体流动，所述三壁中间部分通过构件的第一端部，由此形成双壁端部，并且将第一端部回复到构件的双壁端部上，第一阀瓣通过在第一连合点处缝合三壁中间部分而形成。

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