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1. 发明申请

US20080097521A1 APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译：用于密封血管内窥镜的装置和方法
公开(公告)号：US20080097521A1
公开(公告)日：2008-04-24
申请号：US11929972
申请日：2007-10-30
申请人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
发明人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译：用于密封与血管连通的穿刺的装置包括由冻干的水凝胶或其它材料形成的多孔载体。插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子穿刺的地方

2. 发明申请

US20080058864A1 OCCLUSION MEMBER AND TENSIONER APPARATUS AND METHODS OF THEIR USE FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译： OCCLUSION会员和张力器装置及其用于密封血管的使用方法
公开(公告)号：US20080058864A1
公开(公告)日：2008-03-06
申请号：US11929762
申请日：2007-10-30
申请人： Celso Bagaoisan , Juan Domingo , Nicanor Domingo , Farhad Khosravi , Suresh Pai
发明人： Celso Bagaoisan , Juan Domingo , Nicanor Domingo , Farhad Khosravi , Suresh Pai
IPC分类号： A61B17/03 , A61M25/10
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00557 , A61B2017/00637 , A61B2017/0065 , A61M25/10182 , A61M25/10187 , A61M2025/0681
摘要： Apparatus for sealing a puncture includes an elongate occlusion member having a balloon attached to distal ends of telescoping inner and outer members. A housing on the proximal end of the outer member includes a piston coupled to the inner member and slidable within a chamber communicating with a fluid reservoir. A switch on the housing is actuated to direct fluid from the reservoir through the outer member into the balloon to expand the balloon and into the chamber to move the piston and pull the inner member, shortening the balloon as it expands. During use, the distal end of the occlusion member is introduced into a puncture communicating with a vessel until the collapsed balloon is disposed within the vessel. The balloon is expanded, and a tensioner is connected to the housing to apply a proximal force holding the balloon against the vessel wall to seal the puncture.
摘要翻译：用于密封穿刺的装置包括具有附接到伸缩的内部和外部构件的远端的气囊的细长闭塞构件。外部构件的近端上的壳体包括联接到内部构件并可在与流体储存器连通的腔室内滑动的活塞。启动壳体上的开关以将流体从储存器引导通过外部构件进入气囊，以使气囊膨胀并进入腔室中，以移动活塞并拉动内部构件，从而在气囊膨胀时缩短气囊。在使用期间，将阻塞构件的远端引入到与血管连通的穿刺件中，直到将收缩的气囊设置在血管内。气囊膨胀，并且张紧器连接到壳体以施加将气囊保持抵靠血管壁的近侧力以密封穿刺。

3. 发明申请

US20070060950A1 Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis 审中-公开
标题翻译：用于在经皮操作过程中输送密封材料以便于止血的装置和方法
公开(公告)号：US20070060950A1
公开(公告)日：2007-03-15
申请号：US10975205
申请日：2004-10-27
申请人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan , Scott Sershen
发明人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan , Scott Sershen
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2090/062
摘要： An apparatus for sealing a puncture extending through tissue to a blood vessel includes a guidewire including an expandable tamp, a retaining sheath for covering the tamp, and a delivery sheath including a primary lumen for receiving the guidewire therethrough and a secondary lumen for delivering sealing compound into the puncture. The guidewire is advanced into the puncture with the tamp in a contracted condition, the tamp is expanded within the vessel after retracting the retaining sheath, and the guidewire is retracted to seal the puncture from the vessel. The delivery sheath is advanced over the guidewire, and sealing compound is introduced into the puncture through the delivery sheath. After introducing the sealing compound, the delivery sheath is removed, and an introducer sheath is advanced over the guidewire to provide access to perform a medical procedure via the vessel after removing the guidewire.
摘要翻译：用于将延伸穿过组织的穿刺密封到血管的装置包括：导丝，包括可膨胀的夯，用于覆盖夯的保持护套;以及输送护套，其包括用于接收导丝的主腔，以及用于输送密封化合物的第二内腔进入穿刺。导丝在收缩状态下用夯实进入穿刺中，在缩回保持护套之后，在容器内膨胀，并且引导线缩回以密封穿孔。输送护套在引导线上前进，并且密封化合物通过输送护套引入穿刺。在引入密封化合物之后，移除输送护套，并且引导器护套在引导线上前进，以在移除引导线之后提供通过血管执行医疗程序的通路。

4. 发明申请

US20080082122A1 APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译：用于密封血管内窥镜的装置和方法
公开(公告)号：US20080082122A1
公开(公告)日：2008-04-03
申请号：US11854534
申请日：2007-09-12
申请人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan , Scott Sershen , Marlon Moreno , Juan Domingo
发明人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan , Scott Sershen , Marlon Moreno , Juan Domingo
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654
摘要： An apparatus for sealing a puncture through tissue to a vessel includes an elongate occlusion member including an expandable member, a cartridge carried on the occlusion member, and a sealant carried within the cartridge. The cartridge includes an outer member and a pusher member within the outer member. The sealant is disposed within the outer member adjacent the expandable member distal to the pusher member. During use, the occlusion member is introduced into a puncture until the expandable member and the sealant extend from the puncture into the vessel. The expandable member is expanded, and withdrawn until the expanded expandable member contacts the vessel wall, thereby withdrawing the sealant back into the puncture. The outer member is withdrawn to expose the sealant within the puncture, while the pusher member prevents removal of the sealant, and then the cartridge, occlusion member, and pusher member are successively removed.
摘要翻译：用于将通过组织的穿刺密封到容器的装置包括包括可扩张构件的细长阻塞构件，承载在闭塞构件上的药筒和在药筒内承载的密封剂。该盒在外部构件内包括外部构件和推动构件。密封剂设置在外部构件中，邻近可推动构件远离推动构件。在使用期间，将阻塞构件引入穿刺中，直到可膨胀构件和密封剂从穿刺件延伸到容器中。可膨胀构件被膨胀并且被抽出直到膨胀的可膨胀构件接触血管壁，从而将密封剂抽回到穿刺中。取出外部构件以在穿刺中露出密封剂，同时推动器构件防止密封剂的移除，然后连续地移除盒，遮挡构件和推动构件。

5. 发明申请

US20060100664A1 Apparatus and methods for sealing a vascular puncture 有权
公开(公告)号：US20060100664A1
公开(公告)日：2006-05-11
申请号：US10982385
申请日：2004-11-05
申请人： Suresh Pai , Celso Bagaoisan , Farhad Khosravi
发明人： Suresh Pai , Celso Bagaoisan , Farhad Khosravi
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00672
摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

6. 发明申请

US20060099238A1 Apparatus and methods for sealing a vascular puncture 有权
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：US20060099238A1
公开(公告)日：2006-05-11
申请号：US10982384
申请日：2004-11-05
申请人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
发明人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
IPC分类号： A61F2/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译：用于密封与血管连通的穿刺的装置包括由冻干的水凝胶或其它材料形成的多孔载体。插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子穿刺的地方

7. 发明申请

US20070123817A1 Apparatus and Methods for Sealing a Vascular Puncture 有权
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：US20070123817A1
公开(公告)日：2007-05-31
申请号：US11627318
申请日：2007-01-25
申请人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
发明人： Farhad Khosravi , Suresh Pai , Celso Bagaoisan
IPC分类号： A61M31/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译：用于密封与血管连通的穿刺的装置包括由冻干的水凝胶或其它材料形成的多孔载体。插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子穿刺的地方

8. 发明申请

US20050149117A1 Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis 审中-公开
标题翻译：用于在经皮手术过程中输送密封材料以便于止血的装置和方法
公开(公告)号：US20050149117A1
公开(公告)日：2005-07-07
申请号：US10745946
申请日：2003-12-24
申请人： Farhad Khosravi , Celso Bagaoisan , Suresh Pai , Scott Sershen
发明人： Farhad Khosravi , Celso Bagaoisan , Suresh Pai , Scott Sershen
IPC分类号： A61B17/00 , A61B17/08 , A61M5/178
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065
摘要： Apparatus and methods are provided for sealing a puncture extending through tissue to a blood vessel. A delivery sheath is introduced-into the puncture, and a sealing compound, e.g., precursor polymers that mix to create a hydrogel, is introduced through the delivery sheath into the puncture. The delivery sheath is then removed, an introducer sheath is advanced through the puncture into the vessel, and instruments are introduced through the introducer sheath into the vessel to perform a medical procedure. After completing the procedure, the introducer sheath is withdrawn. The sealing compound may expand into the puncture and/or tissue recoil of the surrounding tissue may cause the sealing compound to at least partially occlude the puncture to facilitate sealing and/or hemostasis.
摘要翻译：提供了用于将延伸穿过组织的穿刺密封到血管的装置和方法。将输送护套引入穿刺中，并且通过输送护套将密封化合物（例如混合以产生水凝胶的前体聚合物）引入穿刺中。然后移出输送鞘，引导器护套穿过穿刺进入血管，并且将器械通过导引器鞘导入血管以执行医疗程序。完成该程序后，引导器护套被取出。密封化合物可能膨胀到周围组织的穿刺和/或组织反冲中，可能导致密封化合物至少部分地阻塞穿刺以便于密封和/或止血。

9. 发明申请

US20080058862A1 APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译：用于密封血管内窥镜的装置和方法
公开(公告)号：US20080058862A1
公开(公告)日：2008-03-06
申请号：US11929728
申请日：2007-10-30
申请人： Farhad Khosravi , Celso Bagaoisan , Stephen Ramee
发明人： Farhad Khosravi , Celso Bagaoisan , Stephen Ramee
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00557 , A61B2017/00637 , A61B2017/0065 , A61M25/10182 , A61M25/10187 , A61M2025/0681
摘要： An apparatus for sealing a puncture communicating with a blood vessel includes an inner member slidable within an outer member, and a balloon coupled to distal ends of the inner and outer members. A proximal end of the outer member includes a port for delivering fluid into the balloon, and a cylinder that communicates with the port. A piston coupled to the inner member is slidable and biased to move distally within the cylinder. The apparatus is introduced into the puncture until the collapsed balloon is disposed within the vessel. Fluid is introduced into the port, moving the inner member proximally to shorten the balloon as it expands. The balloon is withdrawn to seal the puncture, and a hydrogel is introduced into the puncture. Fluid is removed via the port, moving the inner member distally to extend the balloon as it collapses, and the apparatus is withdrawn.
摘要翻译：用于密封与血管连通的穿刺的装置包括可在外部构件内滑动的内部构件和联接到内部构件和外部构件的远端的气囊。外部构件的近端包括用于将流体输送到气囊中的端口和与端口连通的气缸。联接到内部构件的活塞可滑动并且被偏压以在气缸内向远侧移动。该装置被引入到穿刺中，直到塌陷的气囊被置于血管内。将流体引入端口中，使内部构件向近端移动，以在气囊膨胀时缩短气囊。撤回气囊以密封穿刺，并将水凝胶引入穿刺中。通过端口移除流体，使内部构件向远端移动，以在气囊塌缩时延伸气囊，并且退出设备。

10. 发明授权

US08926639B2 Apparatus and methods for tissue closure 有权
标题翻译：用于组织闭合的装置和方法
公开(公告)号：US08926639B2
公开(公告)日：2015-01-06
申请号：US13144291
申请日：2010-01-11
申请人： Celso Bagaoisan , Suresh Pai , James Dreher
发明人： Celso Bagaoisan , Suresh Pai , James Dreher
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/29
CPC分类号： A61B17/0482 , A61B17/0057 , A61B17/0469 , A61B17/0493 , A61B2017/00637 , A61B2017/00663 , A61B2017/00672 , A61B2017/00858 , A61B2017/0472 , A61B2017/06042 , A61B2017/2911 , A61B2017/2946
摘要： Apparatus and methods are provided for treating a tissue opening, for example a trocar opening used in a minimally invasive surgical procedure. In a tissue closure device, a finger guard or shield can be used, handle or holding area or areas can be used, and positioning indicators can be used. A resiliently flexible target material can also be used for reliably holding a suture during the procedure. Introducers can be used having a suture holder, an alignment indicator and insertion limits.
摘要翻译：提供了用于治疗组织开口的装置和方法，例如用于微创外科手术的套管针开口。在组织闭合装置中，可以使用手指护罩或护罩，可以使用手柄或保持区域或区域，并且可以使用定位指示器。弹性柔性的目标材料也可用于在手术过程中可靠地保持缝合线。引导者可以使用缝合线夹，对准指示器和插入限制。

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