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1. 发明申请

US20120068076A1 PORTABLE PET SCANNER FOR IMAGING OF A PORTION OF THE BODY 审中-公开
标题翻译：便携式PET扫描仪用于成像身体部位
公开(公告)号：US20120068076A1
公开(公告)日：2012-03-22
申请号：US13023475
申请日：2011-02-08
申请人： Farhad Daghighian
发明人： Farhad Daghighian
IPC分类号： G01T1/164
CPC分类号： A61B6/037 , A61B6/4405 , A61B6/5235 , A61B6/5247 , A61B17/3403 , A61B34/20 , A61B2017/3413 , A61B2034/2051 , A61B2034/2055 , A61B2034/2059 , A61B2090/365 , A61B2090/378
摘要： A mobile PET scanner for use in bed side or a surgical environment comprises a mobile support base, with first and a second arm arms extending therefrom. The first arm is configured for placement under a table supporting an individual while the second arm is substantially parallel to and above said first arm with the individual being located between the first and second arms. Multiple module blocks are positioned along the length of the first and second arm. Each modules block comprises scintillators with solid state silicone multipliers or multi-pixel photon counters attached thereto. Positrons emitted from radiation labeled tissue within the individual's body impinge on the multiple scintillators to generate. The photons from each of the scintillator are received by each of a solid state silicone multipliers or multi-pixel photon counters associated therewith and an electrical signal representative of the received photons is then generated. The electrical signal output from each of the solid state silicone multipliers or multi-pixel photon counters is then transmitted to a computerized data collection and analysis system, which substantially instantaneously generates a visual image on a screen showing the location within the individuals body emitted the photons. This image can be coordinated with a photo image or a CT image showing the same portion of the individual's body.
摘要翻译：用于床侧或手术环境的移动PET扫描器包括移动支撑基座，第一和第二臂臂从其延伸。第一臂构造成用于放置在支撑个人的桌子下方，而第二臂基本上平行于所述第一臂并且位于所述第一臂之上，而个体位于第一和第二臂之间。沿着第一和第二臂的长度定位多个模块块。每个模块块包括具有固态硅胶乘法器的闪烁器或附着于其上的多像素光子计数器。从个体身体辐射标记的组织发射的正电子撞击到多个闪烁体上以产生。来自每个闪烁体的光子由固态硅胶乘法器或与其相关联的多像素光子计数器中的每一个接收，并且然后产生表示所接收的光子的电信号。然后，将每个固态硅胶乘法器或多像素光子计数器输出的电信号传送到计算机化的数据收集和分析系统，其基本上瞬间在屏幕上产生视觉图像，显示个体内发射光子的位置。该图像可以与照片图像或CT图像协调，显示个体身体的相同部分。

2. 发明申请

US20100219346A1 NOVEL POSITRON EMISSION DETECTORS AND CONFIGURATIONS 有权
标题翻译：新的POSITRON排放检测器和配置
公开(公告)号：US20100219346A1
公开(公告)日：2010-09-02
申请号：US12776777
申请日：2010-05-10
申请人： Farhad Daghighian
发明人： Farhad Daghighian
IPC分类号： G01T1/164
CPC分类号： A61B8/0833 , A61B6/037 , A61B6/5247 , A61B8/0841 , A61B8/4245 , A61B8/4254 , A61B8/4263 , A61B8/5238 , A61B17/3403 , A61B34/20 , A61B2017/3413 , A61B2034/2051 , A61B2034/2055 , A61B2034/2059 , A61B2090/365 , A61B2090/378
摘要： A three-dimensional detector module for use in detecting annihilation photons generated by positrons emitted from radio-labeled sites within a body is formed from multiple solid state photo-detectors attached to one or more scintillators. Each photo-detector can be attached to a scintillator to form a photo-detector/scintillator combination and multiple photo-detector/scintillator combinations can be arranged in an array. Alternatively, multiple photo-detectors can be attached to the surface of a single scintillator to form an array. Multiple arrays are then stacked to form a photo-detector module. The modules can then be assembled to form a sheet of photo-detector modules. Multiple sheets or multiple modules can then be arranged around a body to detect emissions from radio-labeled sites in the body. Multiple position sensors attached to the photo-detectors, arrays or modules provide the ability to locate the source of the positron emissions from the labeled sites in the body and generate an image of the emission site. A series of novel PET configurations can be constructed from these detector modules, making PET scanners portable, more sensitive and flexible to be used in numerous different operational configurations, such as operating room, emergency rooms, critical care units, or battlefield.
摘要翻译：用于检测由身体内的放射标记位点发射的正电子产生的湮灭光子的三维检测器模块由连接到一个或多个闪烁体的多个固态光检测器形成。每个光检测器可以连接到闪烁体以形成光检测器/闪烁体组合，并且多个光检测器/闪烁体组合可以排列成阵列。或者，可以将多个光电检测器附接到单个闪烁体的表面以形成阵列。然后堆叠多个阵列以形成光电检测器模块。然后可以组装模块以形成一张光电检测器模块。然后可以在身体周围布置多张或多个模块，以检测体内放射性标记位点的排放。连接到光电检测器，阵列或模块的多位置传感器提供了从体内标记位点定位正电子发射源并产生发射位点的图像的能力。可以从这些检测器模块构建一系列新颖的PET配置，使PET扫描仪便携，更灵敏和灵活，可用于许多不同的操作配置，如手术室，急诊室，重症监护室或战场。

3. 发明授权

US06602488B1 Use of radiopharmaceuticals and intraoperative radiation probe for delivery of medicinal treatments 有权
标题翻译：使用放射性药物和术中辐射探针进行药物治疗
公开(公告)号：US06602488B1
公开(公告)日：2003-08-05
申请号：US09518457
申请日：2000-03-03
申请人： Farhad Daghighian
发明人： Farhad Daghighian
IPC分类号： A61K5055
CPC分类号： G01T1/161 , A61B2034/2051 , A61K49/18 , A61K51/1282

4. 发明申请

US20120032086A1 HAND-HELD GAMMA RAY SCANNER 审中-公开
标题翻译：手持伽马射线扫描仪
公开(公告)号：US20120032086A1
公开(公告)日：2012-02-09
申请号：US13023469
申请日：2011-02-08
申请人： Farhad Daghighian
发明人： Farhad Daghighian
IPC分类号： G01T1/166
CPC分类号： G01T1/166 , A61B6/4258 , G01T1/161
摘要： A hand held gamma ray scanner comprises a one dimensional array of SSPM detectors coupled to a scintillator slab or an array of scintillators. A position tracker is attached to this “scanner” enabling software in a support system to acquire the position of the scanner, as well as 1-D images of the distribution of gamma rays received from radiation labeled tissue and generate an output signal in real time.
摘要翻译：手持式伽马射线扫描器包括耦合到闪烁体板或闪烁体阵列的SSPM检测器的一维阵列。一个位置跟踪器被连接到这个“扫描器”上，使得支持系统中的软件能够获取扫描仪的位置，以及从辐射标记的组织接收的γ射线分布的1-D图像，并实时产生输出信号。

5. 发明授权

US07809428B2 Devices for detection and therapy of atheromatous plaque 有权
标题翻译：用于动脉粥样硬化斑块检测和治疗的装置
公开(公告)号：US07809428B2
公开(公告)日：2010-10-05
申请号：US10215600
申请日：2002-08-09
申请人： David Elmaleh , Farhad Daghighian
发明人： David Elmaleh , Farhad Daghighian
IPC分类号： A61B6/00 , A61F2/06
CPC分类号： A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B6/4258 , A61B18/20 , A61B2017/00057 , A61B2017/00079 , A61B2018/00904 , A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61K47/643 , A61K51/0474 , A61K51/0491 , A61N5/0601 , A61N5/062 , A61N2005/0602
摘要： The present invention relates to devices for detection of active atheromatous plaque and/or thin-capped fibro-atheroma (“vulnerable plaque”) using selectively targeted radiolabeled compositions, such as beta-emitting compositions.
摘要翻译：本发明涉及使用选择性靶向放射性标记的组合物，例如β发射组合物来检测活性动脉粥样硬化斑块和/或薄盖纤维动脉粥样硬化（“易损斑块”）的装置。

6. 发明申请

US20060106306A1 Method and instrument for minimally invasive sentinel lymph node location and biopsy 有权
标题翻译：微创前哨淋巴结位置和活检的方法和仪器
公开(公告)号：US20060106306A1
公开(公告)日：2006-05-18
申请号：US11270906
申请日：2005-11-10
申请人： Richard Essner , Farhad Daghighian , Henry Daghighian
发明人： Richard Essner , Farhad Daghighian , Henry Daghighian
IPC分类号： A61B5/05
CPC分类号： A61B8/0841 , A61B6/4258 , A61B8/0833 , A61B17/3403 , A61B34/20 , A61B90/361 , A61B2017/3413 , A61B2090/378 , A61B2090/392
摘要： The present invention is directed to instruments and instrumental techniques for locating cancer cells in lymph nodes which utilize a radiation detector operatively connected to an ultrasound probe for locating the exact position of radiation tagged tissue, particularly in sentinel lymph nodes followed by placement of a biopsy device. Also described are unique new interoperative radiation detection probes for use in these techniques which include structure for placement of a biopsy device or biopsy needle into the located lymph node and procedures for removal of small portions of detected radiation emitting sentinel lymph nodes for evaluation in a pathology laboratory by measurement of expressed genes located in the removed tissue. The instruments and instrumental techniques also facilitate the subsequent delivery of materials to reverse the unfavorable immune response or environment conducive for metastasis in the sentinel lymph node once cancer cells are located therein.
摘要翻译：本发明涉及用于定位在淋巴结中的癌细胞的仪器和仪器技术，其利用可操作地连接到超声探头的放射线检测器来定位辐射标记的组织的确切位置，特别是在前哨淋巴结中，随后放置活组织检查装置。还描述了用于这些技术的独特的新的术中放射线检测探针，其包括用于将活检装置或活检针放置到所述定位的淋巴结中的结构以及用于去除检测到的发射前哨淋巴结的小部分的步骤以用于病理学评估通过测量位于去除的组织中的表达基因的实验室。一旦癌细胞位于其中，仪器和仪器技术还有助于后续的材料输送以逆转前哨淋巴结转移不利的免疫应答或有利于转移的环境。

7. 发明授权

US5338937A Radiation imaging device having an enlarged uniform field of view 失效
标题翻译：具有放大的均匀视野的放射成像装置
公开(公告)号：US5338937A
公开(公告)日：1994-08-16
申请号：US77015
申请日：1993-06-14
申请人： Farhad Daghighian , Saul Miodownik , Peter Shenderov , Behzad Eshaghian
发明人： Farhad Daghighian , Saul Miodownik , Peter Shenderov , Behzad Eshaghian
IPC分类号： G01T1/164 , G01T1/208 , G01T1/20
CPC分类号： G01T1/1644 , G01T1/208 , A61B6/4258
摘要： A radiation imaging device of the type employing a scintillator and a position-sensitive photomultiplier tube eliminates or reduces edge effects and thereby increases the linear field of view by compensating for nonlinearities which distort an image close to the edge. Specifically, (1) a light guide is placed about the edge of the scintillator to channel light that would otherwise be reflected from the edge of scintillator to a light absorbing material so that edge reflected light is not detected by the position-sensitive photomultiplier tube and (2) variable resistors are employed to compensate for distortions in the image caused by current leakage along the edge of the position-sensitive photomultiplier tube.
摘要翻译：使用闪烁体和位置敏感光电倍增管的类型的放射线成像装置消除或减少边缘效应，从而通过补偿使靠近边缘的图像失真的非线性来增加线性视场。具体地说，（1）在闪烁器的边缘周围放置一个光导通道，以将否则将从闪烁器的边缘反射到光吸收材料的光，使得边缘反射光不被位置敏感的光电倍增管检测到，（2）可变电阻器用于补偿沿位置敏感光电倍增管边缘的电流泄漏引起的图像失真。

8. 发明授权

US5325855A Flexible intraoperative radiation imaging camera 失效
标题翻译：灵活的术中放射成像摄像机
公开(公告)号：US5325855A
公开(公告)日：1994-07-05
申请号：US927156
申请日：1992-08-07
申请人： Farhad Daghighian , Saul Miodownik , Peter Shenderov , Behzad Eshaghian
发明人： Farhad Daghighian , Saul Miodownik , Peter Shenderov , Behzad Eshaghian
IPC分类号： G01T1/161 , A61B5/05
CPC分类号： G01T1/161 , A61B6/4258
摘要： An imaging apparatus with a flexible light guide which a surgeon can easily manipulate within the patient to control the field of view. Specifically, a scintillator receives radiation rays and converts these radiation rays into light signals at a position inside the body. A flexible bundle of optical fibers optically connected to the scintillator, channels the light signals from the scintillator to a position sensitive light signal detector located outside the body. The position sensitive light signal detector creates a digital signal to relay the position information about the detected event to a computer which accumulates these digital signals, converts these digital signals into images and displays the images.
摘要翻译：具有柔性光导的成像装置，外科医生可以容易地在患者内操纵以控制视野。具体地说，闪烁体接收辐射线，并将这些辐射线转换成身体内部位置的光信号。光学连接到闪烁体的柔性光纤束将来自闪烁体的光信号传送到位于身体外部的位置敏感的光信号检测器。位置敏感光信号检测器创建一个数字信号，将有关检测到的事件的位置信息中继到累积这些数字信号的计算机，将这些数字信号转换为图像并显示图像。

9. 发明授权

US10547340B1 Mobile phone case with an integrated charging and data communication apparatus 有权
公开(公告)号：US10547340B1
公开(公告)日：2020-01-28
申请号：US15627453
申请日：2017-06-20
申请人： Nicole Daghighian , Farhad Daghighian , Paul B. Thomas
发明人： Nicole Daghighian , Farhad Daghighian , Paul B. Thomas
IPC分类号： H04M1/00 , H04B1/3888 , H04M1/02 , H04M1/21 , H04B1/3883 , H02J7/00
摘要： A mobile phone case includes an integrated charging and data communication apparatus, thereby forgoing the need to carry a separate charging and communication cable. The mobile phone case further includes an integrated cable storage compartment for storing the charging and data communication apparatus. The charging and communication apparatus includes a circuit board for electrically connecting a USB connector and a Lightning connector. A first flat cable has one end connected to the USB connector and the other end connect to the circuit board. A second flat cable has one end connected to the Lightning connector and the other end connected to the circuit board to provide electrically connection between the USB connector and the Lightning connector. The storage compartment further includes a USB side slot, a Lightning bottom slot, and a lid for opening and closing the storage compartment.

10. 发明申请

US20170049518A1 REAL-TIME MOLECULAR IMAGING AND MINIMALLY-INVASIVE DETECTION IN INTERVENTIONAL CARDIOLOGY 审中-公开
标题翻译：传统心理学中的实时分子成像和微量入侵检测
公开(公告)号：US20170049518A1
公开(公告)日：2017-02-23
申请号：US15239757
申请日：2016-08-17
申请人： Albert J. Sinusas , Farhad Daghighian
发明人： Albert J. Sinusas , Farhad Daghighian
IPC分类号： A61B34/20 , A61B6/00 , A61B1/04 , A61M25/01 , A61B1/015 , A61B5/042 , A61M25/00 , A61B18/14 , A61B1/018
CPC分类号： A61B34/20 , A61B1/018 , A61B1/043 , A61B5/0071 , A61B5/0084 , A61B5/0422 , A61B6/4258 , A61B6/481 , A61B18/1477 , A61B18/1492 , A61B2010/045 , A61B2018/00357 , A61B2018/00839 , A61B2018/00904 , A61B2018/00982 , A61B2018/1425 , A61B2018/1475 , A61B2034/2051 , A61B2034/2072 , A61B2090/392 , A61B2090/3966 , A61B2090/3987 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A catheter is disclosed for locating radiation tagged tissue within a mammalian body and treating tagged tissue or untagged tissue adjacent to the tagged tissue in a single procedure. The catheter includes in or on a distal end thereof one or more detectors for locating labeled tissue. A lumen extending from a proximal end of said tube to the distal end of said tube, includes a retractable and extendable needle positioned adjacent the distal end of said tube for delivering a liquid treatment modality. I the alternative the injector for delivering the treatment modality may be placed adjacent to the catheter for delivery of the treatment.
摘要翻译：公开了用于定位哺乳动物体内的辐射标记组织的导管，并且在单个过程中处理与标记组织相邻的标记组织或未标记组织。导管包括在其远端中或其远端上的一个或多个检测器，用于定位标记的组织。从所述管的近端延伸到所述管的远端的内腔包括邻近所述管的远端定位的用于输送液体处理模式的可伸缩的针。替代地，用于递送治疗方式的注射器可以放置在与导管相邻以用于递送治疗。

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