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1. 发明授权

US07783345B2 Impedance-based measuring method for hemodynamic parameters 有权
标题翻译：基于阻抗的血液动力学参数测量方法
公开(公告)号：US07783345B2
公开(公告)日：2010-08-24
申请号：US11101358
申请日：2005-04-07
申请人： Falko Skrabal , Jürgen Fortin
发明人： Falko Skrabal , Jürgen Fortin
IPC分类号： A61B5/05
CPC分类号： A61B5/0535 , A61B5/0002 , A61B5/0205 , A61B5/04085 , A61B5/0537
摘要： A method is provided for measuring the volume, the composition and the movement of electroconductive body fluids, based on the electrical impedance of the body or a body segment, especially for performing electromechanocardiography (ELMEC) or impedance cardiography (IKG) measurements for determining hemodynamic parameters. According to the method, an alternating measuring current of at least one frequency is introduced into the body, and the impedance and temporal variations thereof of essentially the same body segment through which the alternating measuring current flows are measured for at least two different measuring lengths (L, L2, L3, L4, L5), essentially in the longitudinal direction of the body.
摘要翻译：提供一种基于身体或身体部分的电阻抗来测量导电体液体的体积，组成和运动的方法，特别是用于执行用于确定血液动力学参数的电子机械心电图（ELMEC）或阻抗心动描记术（IKG）测量。根据该方法，将至少一个频率的交替的测量电流引入到身体中，并测量交替的测量电流所流动的基本相同的主体段的阻抗和时间变化为至少两个不同的测量长度（ L，L2，L3，L4，L5），基本上在身体的纵向方向上。

2. 发明授权

US07390301B2 Device and method for the continuous non-invasive measurement of blood pressure 失效
标题翻译：用于连续无创测量血压的装置和方法
公开(公告)号：US07390301B2
公开(公告)日：2008-06-24
申请号：US10551189
申请日：2004-04-01
申请人： Falko Skrabal , Jürgen Fortin
发明人： Falko Skrabal , Jürgen Fortin
IPC分类号： A61B5/02
CPC分类号： A61B5/02255 , A61B5/02241 , A61B5/0295 , A61B5/6806
摘要： A method for the continuous non-invasive measurement of blood pressure includes at least one first pressure cuff and one second pressure cuff of comparable or identical size, each cuff including an inflatable pressure measuring chamber applicable to a first and a second body part or region containing an artery. The first pressure cuff has a first plethysmographic sensor connected to a regulating and control device used to regulate the pressure in a first pressure measuring chamber by means of a measuring signal of the plethysmographic sensor. The first pressure measuring chamber is connected to a pressure sensor in order to obtain a pressure measuring signal. The second pressure measuring chamber is a reference pressure chamber that can be regulated at the same time as the first pressure measuring chamber, independently therefrom, and can be regulated by the regulating and control device according to a pre-determinable pressure function.
摘要翻译：用于连续非侵入性测量血压的方法包括至少一个具有相当或相同尺寸的第一压力袖带和一个第二压力袖带，每个袖带包括可充气的压力测量室，其可应用于第一和第二身体部位或区域，其包含动脉第一压力袖带具有连接到调节和控制装置的第一体积描记传感器，其用于通过体积描记传感器的测量信号来调节第一压力测量室中的压力。第一压力测量室连接到压力传感器以获得压力测量信号。第二压力测量室是可以与第一压力测量室同时被调节的参考压力室，并且可以根据预先确定的压力函数由调节和控制装置调节。

3. 发明授权

US06669648B1 Continuous non-invasive sphygmomanometer 有权
标题翻译：连续非侵入式血压计
公开(公告)号：US06669648B1
公开(公告)日：2003-12-30
申请号：US09937826
申请日：2001-11-21
申请人： Jürgen Fortin , Falko Skrabal
发明人： Jürgen Fortin , Falko Skrabal
IPC分类号： A61B502
CPC分类号： A61B5/02233
摘要： According to the invention a sphygmomanometer for continuous plethysmographic measurement of blood pressure includes at least one inflatable pressure pad which is attachable to a body part containing an artery, arterial signal sensors for determining arterial blood flow, and a valve-controlled pressure chamber connected to a gas source and to the inflatable pressure pad and including a pressure sensor for measuring the pressure in the pressure chamber or in the pressure pad. The pressure chamber has separate inlet and outlet valves which are controlled dependent on signals of the arterial signal sensors.
摘要翻译：根据本发明，用于血压连续体积描记测量的血压计包括至少一个可附接到包含动脉的身体部分的可充气压力垫，用于确定动脉血流的动脉信号传感器以及连接到气体源和可充气压力垫，并且包括用于测量压力室或压力垫中的压力的压力传感器。压力室具有单独的入口和出口阀，其依赖于动脉信号传感器的信号。

4. 发明授权

US08114025B2 Device and method for controlling the pressure in an inflatable cuff of a blood pressure manometer 有权
标题翻译：用于控制血压计的充气袖带中的压力的装置和方法
公开(公告)号：US08114025B2
公开(公告)日：2012-02-14
申请号：US10576513
申请日：2004-08-19
申请人： Juergen Fortin , Rupert Gruellenberger , Alexander Hacker , Falko Skrabal
发明人： Juergen Fortin , Rupert Gruellenberger , Alexander Hacker , Falko Skrabal
IPC分类号： A61B5/02
CPC分类号： A61B5/02255
摘要： The invention relates to a method and a device for regulating the pressure in at least one inflatable cuff, preferably a finger cuff (6), of a blood pressure manometer comprising a plethysmographic sensor device (8, 9) for detecting a plethysmographic signal PG and a pressure sensor (7) for detecting a cuff pressure signal BP. According to the invention, two control loops (1, 2) acting on a differential amplifier (10) are used to independently regulate different operating parameters, the first, inner control loop (1) using the cuff pressure signal BP as the first regulating variable, and the second, outer control loop (2) comprising a regulating device (12), preferably a PID regulator, which generates a nominal value SW as a second regulating variable from the plethysmographic signal PG. The differential amplifier (10) is connected, on the output side, to at least one valve connected to a pressure source (4), preferably a proportional valve (3; 25, 27), for regulating the pressure in the cuff (6). Additional outer control loops (16 to 21) can be used to respectively set a parameter of the device to a determined nominal value.
摘要翻译：本发明涉及一种用于调节血压计的至少一个可充气袖带（优选为手指套）（6）中的压力的方法和装置，其包括用于检测体积描记信号PG的体积描记传感器装置（8,9）用于检测袖带压力信号BP的压力传感器（7）。根据本发明，使用作用在差分放大器（10）上的两个控制回路（1,2）来独立地调节不同的操作参数，第一内部控制回路（1）使用袖带压力信号BP作为第一调节变量，并且第二外部控制回路（2）包括调节装置（12），优选地是PID调节器，其从体积描记信号PG产生作为第二调节变量的标称值SW。差动放大器（10）在输出侧连接至至少一个连接到压力源（4）的阀门，优选为比例阀（3; 25,27），用于调节袖带（6）中的压力，。可以使用附加的外部控制环路（16至21）来将设备的参数分别设置为确定的标称值。

5. 发明授权

US10517499B2 ECG device 有权
公开(公告)号：US10517499B2
公开(公告)日：2019-12-31
申请号：US14769560
申请日：2014-02-21
申请人： Falko Skrabal
发明人： Falko Skrabal
IPC分类号： A61B5/0402 , A61B5/0408 , A61B5/053 , A61B5/04 , A61B5/00 , A61B5/01 , A61B5/02 , A61B5/022 , A61B5/024 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/11
摘要： An ECG device comprising limb leads and chest wall leads is described which is also suitable for deriving the hemodynamic activity of the heart and the function of the vessels and, respectively, also for evaluating the fluid equilibrium. This is achieved in that at least part of the electrodes of the multichannel ECG is developed with additional embodiments for physical emissions and measurements, for example, electric current and voltage, pressure, sound vibrations, light, and that an electrode is provided for the current supply and, respectively, the voltage measurement at the upper thorax aperture. Furthermore, an alternating current field is built up between the electrodes or, respectively, the distance between the electrodes is used as an ion conductor. Thus, during the conventional ECG writing, the acceleration of the blood and hence the cardiac output, the valve closure and the valve opening, as well as the mechanics of individual circulation sections, for example, also the pulse wave transit time, the blood flow in body sections, the body composition etc. can also be registered and output simultaneously with the routine ECG.

6. 发明授权

US5237993A Process and device for determining parameters of interest in living organisms 失效
标题翻译：确定生物体感兴趣参数的方法和装置
公开(公告)号：US5237993A
公开(公告)日：1993-08-24
申请号：US794244
申请日：1991-11-19
申请人： Falko Skrabal
发明人： Falko Skrabal
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/155 , A61B10/00 , A61F2/02 , A61M1/00 , A61M5/00 , A61M5/14 , A61M5/172
CPC分类号： A61M5/1723 , A61B10/0045 , A61B5/14525 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B5/15003 , A61B5/150244 , A61B5/150251 , A61B5/150396 , A61B5/150511 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M1/0058 , A61M1/0084 , A61B10/007 , A61B5/1486 , A61M2230/201 , A61M2230/65 , Y10S128/13
摘要： In order to determine at least one parameter of interest in a living organism, a perfusion is directly introduced in the tissues. After its partial balancing by the tissue parameter of interest, the perfusion fluid is collected and analyzed for the parameter of interest, as well as for endogenous or exogenous marker properties indicative of the degree of interaction between the perfusion fluid and the tissue, in such a way that the parameters of interest can be determined with the help of such characteristic properties. Contrary to usual processes, used exclusively inside blood vessels or other body cavities filled with liquid, this process creates in the tissues, i.e. in the closed cellular structure, a previously inexistent cavity, in which the perfusion fluid introduced in the tissue interacts directly with the organic tissue, with no intervening membranes. The transfer of the measurement site into the tissue completely eliminates the risk of the thromboses and embolies, besides strongly reducing the risk of infection.
摘要翻译：为了确定活体中至少一个感兴趣的参数，灌注被直接引入到组织中。在通过感兴趣的组织参数的部分平衡之后，收集灌注液并分析感兴趣的参数，以及用于指示灌注液和组织之间的相互作用程度的内源或外源性标记物质，可以借助于这些特征来确定感兴趣的参数。与通常的方法相反，仅在血管或填充有液体的其他体腔内使用，该过程在组织中产生，即在闭合的细胞结构中，先前不存在的空腔，其中引入到组织中的灌注流体直接与有机组织，没有介入膜。测量部位转移到组织中，除了大大降低感染风险外，完全消除了血栓形成和栓塞的风险。

7. 发明授权

US5372582A Probe for dialysis 失效
标题翻译：探查透析
公开(公告)号：US5372582A
公开(公告)日：1994-12-13
申请号：US842138
申请日：1992-03-23
申请人： Falko Skrabal , Erich Kleinhappl
发明人： Falko Skrabal , Erich Kleinhappl
IPC分类号： A61M25/00 , A61M3/00 , A61M5/178
CPC分类号： A61M25/0026 , A61B5/14528 , A61M2025/0031 , A61M25/0032
摘要： A dialytic probe is provided with an insertion needle sharpened at one end, which is surrounded by a flexible plastic cannula, and may be removed after introduction of the probe. The plastic cannula is covered at least partly by a tubular dialyzing membrane which is bonded to the plastic cannula at the distal end and to a handle at the other end, thus forming a fluid-tight seal. The space between the plastic cannula and dialyzing membrane is divided along the length of the probe, such that two passages or lumens of essentially crescent-shaped cross-section are formed, with a flow-connection at the distal end of the plastic cannula, and with a connection to one of separate ingoing and outgoing lines each. The lumen of the plastic cannula may be connected to a drug feeder line. The handle holds the ingoing and outgoing lines and a potential drug feeder line of the probe.
摘要翻译： PCT No.PCT / AT91 / 00092 Sec。 371日期：1992年3月23日 102（e）1992年3月23日PCT PCT 1991年7月30日PCT公布。出版物WO92 / 02270 日期：1992年2月20日。透析探针设有插入针，其一端在柔性塑料套管周围被锐化，并且可以在引入探针之后去除。至少部分地由管状透析膜覆盖塑料插管，管状透析膜在远端结合到塑料插管并在另一端与手柄结合，从而形成流体密封。塑料插管和透析膜之间的空间沿着探头的长度分开，使得形成基本上月牙形横截面的两个通道或内腔，在塑料插管的远端具有流动连接，以及连接到每个独立的输入和输出线之一。塑料插管的管腔可以连接到药物输送管线。手柄保持进出线和探针的潜在药物输送线。

8. 发明授权

US5193545A Device for determining at least one medical variable 失效
标题翻译：用于确定至少一个医疗变量的设备
公开(公告)号：US5193545A
公开(公告)日：1993-03-16
申请号：US476360
申请日：1990-02-07
申请人： Hermann Marsoner , Falko Skrabal , Helmut List
发明人： Hermann Marsoner , Falko Skrabal , Helmut List
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/14528 , A61B5/14532 , A61B5/1473 , A61B5/686 , Y10S128/13
摘要： A device designed for determining one or more medical variables in living organisms, comprises a part to be inserted into the tissue of the organism, which has an exchange channel with openings into the tissue. The device comprising a delivery unit connected with the exchange channel for the delivery of a perfusion fluid and its drainage after partial equilibration with the medical variable or quantity to be measured, i.e., preferably glucose concentration, and comparatively constant endogenous or exogenous marker variables. The device further comprising an analyzing unit for measuring the medical variable and one marker variable, and an evaluation unit for determining the actual concentration of the medical variable with the use of the marker variables. The proposal is put forward that the part to be inserted into the tissue is configured as a flexible plastic cannula, and that this cannula is provided with a puncturing needle on one end, and that the two ends of the cannula are connected to feeder and drainage tubes of the delivery unit both on the pressure and suction side.
摘要翻译：设计用于确定活生物体中的一个或多个医学变量的装置包括要插入生物体的组织的部分，其具有与组织中的开口的交换通道。该装置包括与用于输送灌注流体的交换通道连接的递送单元，以及在与待测量的医学变量或待测量的部分平衡之后的排水，即优选葡萄糖浓度，以及相对恒定的内源或外源标记变量。该装置还包括用于测量医疗变量和一个标记变量的分析单元，以及用于使用标记变量来确定医疗变量的实际浓度的评估单元。提出的是，要插入组织的部分被配置为柔性塑料插管，并且该套管在一端设有穿刺针，套管的两端连接到给料器和排水管输送单元的管在压力和吸力侧。

9. 发明授权

US5097834A Process for determining parameters of interest in living organisms 失效
标题翻译：确定生活有机体利益参数的方法
公开(公告)号：US5097834A
公开(公告)日：1992-03-24
申请号：US415267
申请日：1989-08-02
申请人： Falko Skrabal
发明人： Falko Skrabal
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/155 , A61B10/00 , A61F2/02 , A61M1/00 , A61M5/00 , A61M5/14 , A61M5/172
CPC分类号： A61M5/1723 , A61B10/0045 , A61B5/14525 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B5/15003 , A61B5/150244 , A61B5/150251 , A61B5/150396 , A61B5/150511 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M1/0058 , A61M1/0084 , A61B10/007 , A61B5/1486 , A61M2230/201 , A61M2230/65 , Y10S128/13
摘要： In order to determine at least one parameter of interest in a living organism, a perfusion fluid is directly introduced in the tissues. After its partial balancing by the tissue parameter of interest, the perfusion fluid is collected and analyzed for the parameter of interest, as well as for endogenous or exogenous marker properties indicative of the degree of interaction between the perfusion fluid and the tissue, in such a way that the parameter of interest can be determined with the help of such characteristic properties. Contrary to usual processes, used exclusively inside blood vessels or other body cavities filled with liquid, this process creates in the tissues, i.e. in the closed cellular structure, a previously inexistent cavity, in which the perfusion fluid introduced in the tissue interacts directly with the organic tissue, with no intervening membranes. The transfer of the measurement site into the tissue completely eliminates the risk of the thromboses and embolies, besides strongly reducing the risk of infection.
摘要翻译：为了确定活体中至少一个感兴趣的参数，将灌注液直接引入组织中。在通过感兴趣的组织参数的部分平衡之后，收集灌注液并分析感兴趣的参数，以及用于指示灌注液和组织之间的相互作用程度的内源或外源性标记物质，可以借助于这些特征来确定感兴趣的参数。与通常的方法相反，仅在血管或填充有液体的其他体腔内使用，该过程在组织中产生，即在闭合的细胞结构中，先前不存在的空腔，其中引入组织的灌注流体直接与有机组织，没有介入膜。测量部位转移到组织中，除了大大降低感染风险外，完全消除了血栓形成和栓塞的风险。

10. 发明授权

US5066283A Device for the withdrawal and storage of individual fluid fractions lathered at given intervals 失效
$Device for the withdrawal and storage of individual fluid fractions lathered at given intervals$
标题翻译：提供和储存在生成间隔的个体流体分段的装置
公开(公告)号：US5066283A
公开(公告)日：1991-11-19
申请号：US348488
申请日：1989-03-08
申请人： Falko Skrabal
发明人： Falko Skrabal
IPC分类号： A61B5/00 , A61B5/155 , A61B10/00 , A61M1/00 , A61M5/172
CPC分类号： A61B5/14542 , A61B10/0045 , A61B5/14532 , A61B5/1473 , A61B5/15003 , A61B5/150389 , A61B5/150511 , A61B5/150755 , A61B5/155 , A61B5/4839 , A61M1/0058 , A61M5/1723 , A61B10/007 , A61B5/1486 , A61M1/0084
摘要： A device for withdrawing body fluids such as blood, urine and tissue fluid includes a withdrawal unit, a suction unit, and a storage system receiving the body fluid between the withdrawal unit and the suction unit, the storage system being divided into separate areas holding the fluid fractions gathered at given intervals and permitting the individual fluid fractions to be identified with regard to their time of withdrawal. In this way tests requiring repeated sampling at short intervals are made easier for doctor and patient.
摘要翻译： PCT No.PCT / AT88 / 00051 Sec。 371日期：1989年3月8日 102（e）日期1989年3月8日PCT提交1988年7月11日PCT公布。出版物WO89 / 00397 一种用于取出体液（例如血液，尿液和组织液）的装置，包括抽出单元，抽吸单元和在抽出单元和抽吸单元之间接收体液的存储系统，存储系统被分成保持以给定间隔收集的流体级分的单独区域，并允许根据其抽出时间识别各个流体分数。以这种方式，对于医生和患者来说，以短时间间隔重复采样的测试变得更容易。

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