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1. 发明授权

US5076097A Method and apparatus for determining concentration of macromolecules and colloids in a liquid sample 失效
标题翻译：用于测定液体样品中大分子和胶体浓度的方法和装置
公开(公告)号：US5076097A
公开(公告)日：1991-12-31
申请号：US546004
申请日：1990-06-28
申请人： Fahimeh Zarrin , Stanley L. Kaufman , Frank D. Dorman
发明人： Fahimeh Zarrin , Stanley L. Kaufman , Frank D. Dorman
IPC分类号： G01N15/06 , G01N30/62
CPC分类号： G01N15/065 , G01N30/62
摘要： An apparatus and method for determining the concentration of macromolecules and colloids in a liquid sample is disclosed. The apparatus preferably includes an electrospray apparatus 16 for forming droplets from the sample. Liquid is removed from the droplets by drying in the electrospray apparatus 16, thereby forming an aerosol. The aerosol of a size greater than a predetermined size is then counted by a condensation nucleus counter 52. In this manner, the target macromolecules and colloids are counted. This apparatus is capable of detecting very small macromolecules and colloids of a wide range of materials in a liquid, for example, individual molecules having molecular weight as small as 10,000.
摘要翻译：公开了一种用于确定液体样品中大分子和胶体浓度的装置和方法。该装置优选地包括用于从样品形成液滴的电喷射装置16。通过在电喷雾装置16中干燥从液滴中除去液体，从而形成气溶胶。然后通过冷凝核计数器52计数尺寸大于预定尺寸的气溶胶。以这种方式计数目标大分子和胶体。该装置能够检测液体中各种材料的非常小的大分子和胶体，例如分子量小至10,000的单个分子。

2. 发明授权

US5121988A Single particle detector method and apparatus utilizing light extinction within a sheet of light 失效
标题翻译：单颗粒检测器方法和装置在光照条件下利用光照
公开(公告)号：US5121988A
公开(公告)日：1992-06-16
申请号：US416958
申请日：1989-10-04
申请人： James L. Blesener , Stanley L. Kaufman , David B. Blackford , Frank D. Dorman , Peter P. Hairston
发明人： James L. Blesener , Stanley L. Kaufman , David B. Blackford , Frank D. Dorman , Peter P. Hairston
IPC分类号： G01N15/00 , G01N15/02 , G01N15/14 , G01N21/03 , G01N21/59
CPC分类号： G01N15/1434 , G01N2015/0046 , G01N2015/0238 , G01N21/031 , G01N21/59 , G01N2201/0612
摘要： A particle flux counter apparatus utilizing light extinction. The apparatus utilizes two oppositely disposed cylindrical mirrors (21a, 21b) to bounce a beam back and forth between them, the beam traversing the length of the cylindrical mirrors (21a, 21b) in incremental steps. A plane mirror (22) is cooperatively located to reflect the beam back between the system to traverse the length of the cylindrical mirrors (21a, 21b) a second time in incremented steps. The two sets of steps interleaving such that the beam forms a sheet of light. A detector (60) monitors the intensity of the beam. As particles in a sample aerosol intersect the beam, the light is extinguished and the beam intensity changes. The detector (60) transmits a signal to a microprocessor (108) analyzation. The apparatus also utilizes a feedback circuit (300) to regulate the beam intensity and alternatively provides for modulating the beam to provide for higher peak power into the detector (60) and elimination of common mode noise.
摘要翻译：利用光消光的粒子通量计数器。该装置利用两个相对设置的圆柱形反射镜（21a，21b）在它们之间来回弹起梁，梁以递增的步长横穿圆柱形反射镜（21a，21b）的长度。平面镜（22）协同地定位成将光束反射回系统之间，以递增步骤第二次穿过柱面镜（21a，21b）的长度。两组步骤交错使得光束形成一张光。检测器（60）监视光束的强度。当样品气溶胶中的颗粒与光束相交时，光被熄灭，光束强度发生变化。检测器（60）将信号发送到微处理器（108）分析。该装置还利用反馈电路（300）来调节光束强度，并且可替代地提供调制光束以向检测器（60）提供更高的峰值功率并消除共模噪声。

3. 发明授权

US4948257A Laser optical measuring device and method for stabilizing fringe pattern spacing 失效
标题翻译：激光光学测量装置和用于稳定条纹图案间距的方法
公开(公告)号：US4948257A
公开(公告)日：1990-08-14
申请号：US372223
申请日：1989-06-23
申请人： Stanley L. Kaufman , Frank D. Dorman , Daniel C. Bjorkquist , Miles R. Finn
发明人： Stanley L. Kaufman , Frank D. Dorman , Daniel C. Bjorkquist , Miles R. Finn
IPC分类号： G01P5/26 , G01S17/58
CPC分类号： G01P5/26 , G01S17/58
摘要： Methods and apparatus for enhancing the accuracy of laser optical measuring instruments using fringe pattern spacing are disclosed. The apparatus in one embodiment includes a laser beam source 10, a beam splitter 14, and mirrors 22 to deflect the beams 18, 20 emitted from the beam splitter 14 to a sensing volume. Alternative embodiments include prisms 42, 44, gratings 62 or other optical devices in lieu of mirrors 22. Objects passing through the sensing volume scatter light which is detected by the instrument to determine, among other things, the velocity of the object. The emitted beams 18, 20 are automatically deflected in response to wavelength changes of the laser beam 16 such that variations in the fringe spacing, due to variations in laser beam 16 wavelength, are compensated by variations in the closing angle K of the emitted, deflected beams. The fringe pattern spacing is thereby held more nearly constant enhancing the accuracy of the instrument. Methods of enhancing the accuracy of measurements taken with laser optical measuring instruments are also disclosed.
摘要翻译：公开了提高使用条纹图案间距的激光光学测量仪器精度的方法和装置。在一个实施例中的装置包括激光束源10，分束器14和反射镜22，以将从分束器14发射的光束18,20偏转到感测体积。替代实施例包括棱镜42,44，光栅62或代替反射镜22的其它光学装置。穿过感测体的物体散射由仪器检测到的光，以确定物体的速度。发射的光束18,20响应于激光束16的波长变化而自动偏转，使得由于激光束16波长的变化引起的条纹间隔的变化由发射的偏转的闭合角度K的变化来补偿梁。因此，条纹图案间隔保持更接近恒定，增加了仪器的精度。还公开了使用激光光学测量仪器提高测量精度的方法。

4. 发明授权

US06544484B1 Aerosol charge adjusting apparatus employing a corona discharge 有权
标题翻译：采用电晕放电的气溶胶电荷调节装置
公开(公告)号：US06544484B1
公开(公告)日：2003-04-08
申请号：US09596159
申请日：2000-06-16
申请人： Stanley L. Kaufman , Frank D. Dorman
发明人： Stanley L. Kaufman , Frank D. Dorman
IPC分类号： B01J1926
CPC分类号： H01J49/168 , G01N15/0266 , G01N2015/0046 , H01J49/165
摘要： A system for analyzing aerosols incorporates a corona discharge ion generator with a positively or negatively charged corona discharge needle formed of platinum or a platinum alloy. A high speed (40-210 meter per second) air flow sweeps the ions away from the corona discharge, and propels the ions into a mixing chamber in a turbulent jet that encounters an aerosol, also provided to the mixing chamber. In one version of the ion generator, the ions are carried into the mixing chamber through an orifice formed in a positively or negatively biased plate. In another alternative, the aerosol droplets are electrostatically generated, and propelled into the mixing chamber as an aerosol jet that confronts the ion jet to enhance a mixing of the charged droplets and the ions. In this version the droplets are advantageously neutralized to leave predominantly singly charged positive and negative particles, to provide a neutralized aerosol particularly well suited for analysis with a mass spectrometer.
摘要翻译：用于分析气溶胶的系统包括具有由铂或铂合金形成的带正或负电荷的电晕放电针的电晕放电离子发生器。高速（40-210米/秒）的空气流将离子从电晕放电中扫除，并将离子推进到混合室中，该混合室在遇到气溶胶的湍流射流中也提供给混合室。在离子发生器的一个版本中，离子通过形成在正或负偏压的板中的孔传送到混合室中。在另一个替代方案中，气溶胶液滴被静电产生，并且作为气溶胶射流推进到混合室中，该气溶胶射流面对离子射流以增强带电液滴和离子的混合。在该版本中，液滴有利地被中和以留下主要单一带电的正和负颗粒，以提供特别适合于用质谱仪分析的中和气雾剂。

5. 发明授权

US5290263A Bidirectional check valve catheter 失效
标题翻译：双向止回阀导管
公开(公告)号：US5290263A
公开(公告)日：1994-03-01
申请号：US919984
申请日：1992-07-27
申请人： Bruce D. Wigness , Frank D. Dorman
发明人： Bruce D. Wigness , Frank D. Dorman
IPC分类号： A61M25/00 , A61M5/00
CPC分类号： A61M25/0075 , A61M2025/0076
摘要： A vascular access system (20) utilizing a catheter (22) having at least one lumen with a bidirectional check valve assembly (24).
摘要翻译：一种使用具有至少一个内腔的导管（22）的血管通路系统（20），其具有双向止回阀组件（24）。

6. 发明授权

US4705503A Metabolite sensor including a chemical concentration sensitive flow controller for a drug delivery system 失效
标题翻译：代谢物传感器包括用于药物输送系统的化学浓度敏感流量控制器
公开(公告)号：US4705503A
公开(公告)日：1987-11-10
申请号：US825211
申请日：1986-02-03
申请人： Frank D. Dorman , Bruce D. Wigness
发明人： Frank D. Dorman , Bruce D. Wigness
IPC分类号： A61B5/00 , A61M5/172 , A61M25/00 , A61M37/00
CPC分类号： A61B5/14532 , A61M37/00 , A61M5/1723 , A61B5/1486 , A61M2025/0057
摘要： A system for the measurement of a metabolite in a physiological fluid is disclosed which comprises a catheter which includes an internal metabolite sensor downstream from a semipermeable region where dynamic equilibrium is attained between the external metabolite and a higher concentration of the same metabolite contained in an infusate which is flowed through the catheter. The changing metabolite concentration also can open and close a chemical valve to control the codelivery of a drug through the catheter.
摘要翻译：公开了一种用于测量生理液体中的代谢物的系统，其包括导管，其包含在半透性区域下游的内部代谢物传感器，其中在外部代谢物与含有在灌注液中的较高浓度的相同代谢物之间达到动态平衡其流过导管。代谢物浓度的变化也可以打开和关闭一个化学阀门，以控制药物通过导管的输送。

7. 发明授权

US4596140A Constant overheat anemometer with sensor lead wire impedance compensation 失效
标题翻译：恒定过热风速计带有传感器引线阻抗补偿
公开(公告)号：US4596140A
公开(公告)日：1986-06-24
申请号：US652717
申请日：1984-09-21
申请人： Frank D. Dorman , Eric W. Nelson
发明人： Frank D. Dorman , Eric W. Nelson
IPC分类号： G01F1/68 , G01F1/698 , G01F15/04 , G01P5/12
CPC分类号： G01P5/12
摘要： An improved bridge-type hot-wire constant overheat anemometer having current controlled temperature compensation circuitry, whereby matched sensors may be employed. Independent voltage sensing and current supply paths along with high impedance cross-coupled velocity sensing circuitry assures device accuracy.
摘要翻译：具有电流控制的温度补偿电路的改进的桥式热线常数过热风速计，由此可以采用匹配的传感器。独立的电压感测和电流供应路径以及高阻抗交叉耦合速度感测电路确保器件精度。

8. 发明授权

US4718893A Pressure regulated implantable infusion pump 失效
标题翻译：压力调节植入式输液泵
公开(公告)号：US4718893A
公开(公告)日：1988-01-12
申请号：US825246
申请日：1986-02-03
申请人： Frank D. Dorman , Henry Buchwald
发明人： Frank D. Dorman , Henry Buchwald
IPC分类号： A61M1/00 , A61M5/142 , A61M5/14
CPC分类号： A61M5/14276 , A61M2005/14264 , A61M2205/3523 , Y10S128/12
摘要： An implantable infusion pump (20) for infusing drugs or other chemical or solutions into the body. A movable diaphragm (26) forming a variable volume drug chamber (22). A fluid piston (32) opposing the force exerted by the diaphragm (26) on the drug solution in the drug chamber (22). The pressure of the fluid piston (32) being controlled by a regulator (33) providing a reference pressure and in fluid communication with the fluid piston (32). The regulator (33) reducing the fluid pressure of the piston fluid (32) as drug solution is expelled from the drug chamber (22) so as to maintain a constant pressure differential between the drug chamber (22) and an infusion site in the body. The implantable infusion pump (20) being readily adaptable to variable or electronic flow control.
摘要翻译：一种用于将药物或其它化学物质或溶液注入体内的可植入输液泵（20）。形成可变容积药物室（22）的活动隔膜（26）。流体活塞（32），其与由隔膜（26）施加在药物室（22）中的药物溶液上的力相反。流体活塞（32）的压力由调节器（33）控制，提供参考压力并与流体活塞（32）流体连通。当药物溶液从药物室（22）排出时，调节器（33）降低活塞流体（32）的流体压力，以便在药物室（22）和体内的输注部位之间保持恒定的压力差。植入式输液泵（20）容易适应于可变或电子流量控制。

9. 发明授权

US06293752B1 Junction for shears sensitive biological fluid paths 有权
标题翻译：用于剪切敏感生物流体路径的连接点
公开(公告)号：US06293752B1
公开(公告)日：2001-09-25
申请号：US09266408
申请日：1999-03-09
申请人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P Sullivan
发明人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P Sullivan
IPC分类号： F01D102
CPC分类号： A61M39/10 , A61M1/101 , A61M2202/0413 , A61M2206/10 , F04D29/428 , Y10S415/90 , Y10T137/2104 , Y10T137/2109 , Y10T137/2115
摘要： A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.
摘要翻译：生物流体输送装置包括在至少两个血流路径的交界处的切割水。切割水基本上是直的，基本垂直的，或两者都是。流体路径中的至少一个可以是管状的，并且在一些实施例中，所有流体路径都是管状的。剪切敏感流体可以是但不限于血液，基于血液的组合，细胞培养基，细胞悬浮液，蛋白质和微胶囊悬浮液。该装置可以是体外循环的一部分（例如在心肺旁路手术或血液处理期间的血液），但是不需要。装置的优选实施例包括但不限于动力泵，传质装置，过滤器，储存器和热交换器。

10. 发明授权

US5561515A Apparatus for measuring particle sizes and velocities 失效
标题翻译：用于测量粒径和速度的装置
公开(公告)号：US5561515A
公开(公告)日：1996-10-01
申请号：US319660
申请日：1994-10-07
申请人： Peter P. Hairston , Frank D. Dorman , Gilmore J. Sem , Jugal K. Agarwal
发明人： Peter P. Hairston , Frank D. Dorman , Gilmore J. Sem , Jugal K. Agarwal
IPC分类号： G01N15/02 , G01P5/22 , G01P5/26 , G01P5/18 , G01N21/00 , G01P5/00
CPC分类号： G01P5/22 , G01P5/26 , G01N2015/0238
摘要： An aerodynamic particle size measuring device includes a laser energy source and beam splitting, shaping and polarizing optics for forming two parallel, peripherally overlapping beams. The beams are caused to intersect a gas stream perpendicular to the direction of gas flow, thus to form a measuring volume at the intersection of the beams and flow. Single particles are carried through the measuring volume with the gas flow, each particle scattering and extinguishing light according to the beam profile, as predetermined by the degree of beam overlap and the Gaussian intensity distribution of each beam. A photodetector, responsive either to scattered light or light extinction, generates a time-dependent voltage profile that tends to replicate the intensity profile. The resulting electrical signal is processed to determine an amplitude, set a threshold for minimally acceptable amplitudes, and to derive two negative-going zero crossings for an unambiguous time/velocity determination. Logic circuitry employs the threshold in combination with the zero crossings to reject velocity readings based on single trigger or coincidence events.
摘要翻译：空气动力学粒度测量装置包括激光能量源和分束，成形和偏振光学器件，用于形成两个平行的外围重叠的光束。使梁与垂直于气流方向的气流相交，从而在梁和流的交叉处形成测量体积。单个颗粒通过气流被传送通过测量体积，每个颗粒根据束轮廓散射和熄灭光，如通过束重叠度和每个光束的高斯强度分布所预定的。响应于散射光或光消失的光电检测器产生倾向于复制强度分布的时间依赖电压分布。对所得到的电信号进行处理以确定振幅，设置最小可接受振幅的阈值，并且为明确的时间/速度确定导出两个负向零交叉。逻辑电路采用阈值与零交叉结合，以基于单个触发或重合事件来拒绝速度读数。

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