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1. 发明申请

US20050079170A1 Dimeric and multimeric antigen binding structure 审中-公开
标题翻译：二聚体和多聚体抗原结合结构
公开(公告)号：US20050079170A1
公开(公告)日：2005-04-14
申请号：US10489626
申请日：2002-09-13
申请人： Fabrice Le Gall , Sergey Kipriyanov , Uwe Reusch , Gerhard Moldenhauer , Melvyn Little
发明人： Fabrice Le Gall , Sergey Kipriyanov , Uwe Reusch , Gerhard Moldenhauer , Melvyn Little
IPC分类号： G01N33/531 , A61P31/00 , C07K16/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , A61K39/395 , C07K16/44
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/28 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to dimeric and multimeric antigen binding structures, expression vectors encoding said structures, and diagnostic, as well as therapeutic, uses of said structures. The antigen binding structures are preferably in the form of a Fv-antibody construct.
摘要翻译：本发明涉及二聚和多聚抗原结合结构，编码所述结构的表达载体，以及所述结构的诊断和治疗用途。抗原结合结构优选为Fv抗体构建体的形式。

2. 发明授权

US09035026B2 Anti-CD16 binding molecules 有权
标题翻译：抗CD16结合分子
公开(公告)号：US09035026B2
公开(公告)日：2015-05-19
申请号：US11921123
申请日：2006-05-26
申请人： Karin Hoffmann , Sergey Kipriyanov , Stefan Knackmuss , Fabrice Le Gall , Melvyn Little , Uwe Reusch
发明人： Karin Hoffmann , Sergey Kipriyanov , Stefan Knackmuss , Fabrice Le Gall , Melvyn Little , Uwe Reusch
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K16/28 , A61K47/48 , C07K17/00
CPC分类号： C07K16/283 , A61K47/6879 , C07K16/18 , C07K16/2878 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and in particular binding molecules that specifically bind the A form FcγRIII but do not bind to the B form of FcγRIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells.
摘要翻译：本发明涉及与天然杀伤（NK）细胞和巨噬细胞（即FcγRIIIA）表面上表达的人Fcγ受体特异性结合的结合分子，特别是特异性结合A型FcγRIII但不结合的结合分子到FcγRIII的B形式，以及在诊断和治疗疾病中使用这种结合分子。本发明进一步延伸到编码这种结合分子的多核苷酸，包含这种多核苷酸的宿主细胞和使用这种宿主细胞产生本发明的结合分子的方法。

3. 发明授权

US07901677B1 Use of an antibody against the laminin receptor or laminin receptor precursor for the treatment or diagnosis of several cancer types 有权
标题翻译：使用针对层粘连蛋白受体或层粘连蛋白受体前体的抗体用于治疗或诊断多种癌症类型
公开(公告)号：US07901677B1
公开(公告)日：2011-03-08
申请号：US11910478
申请日：2006-04-05
申请人： Melvyn Little , Stefan Knackmuss , Uwe Reusch , Sergey Kipriyanov , Fabrice Le Gall , Vera Mick , Karin Hoffmann , Peter Röttgen
发明人： Melvyn Little , Stefan Knackmuss , Uwe Reusch , Sergey Kipriyanov , Fabrice Le Gall , Vera Mick , Karin Hoffmann , Peter Röttgen
IPC分类号： A61K39/395 , A61K35/12
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： Described is the use of a recombinant antibody comprising a binding site specific for an epitope of the laminin receptor or laminin receptor precursor for the treatment or diagnosis of various cancers, particularly B-CLL. Preferably, this antibody additionally comprises a binding site for at least one particular cell surface antigen.
摘要翻译：描述了包含对层粘连蛋白受体或层粘连蛋白受体前体的表位特异的结合位点用于治疗或诊断各种癌症，特别是B-CLL的重组抗体的用途。优选地，该抗体另外包含至少一种特定细胞表面抗原的结合位点。

4. 发明申请

US20090214574A1 Anti-cd16 binding molecules 有权
标题翻译：抗cd16结合分子
公开(公告)号：US20090214574A1
公开(公告)日：2009-08-27
申请号：US11921123
申请日：2006-05-26
申请人： Karin Hoffmann , Sergey Kipriyanov , Stefan Knackmuss , Fabrice Le Gall , Melvyn Little , Uwe Reusch
发明人： Karin Hoffmann , Sergey Kipriyanov , Stefan Knackmuss , Fabrice Le Gall , Melvyn Little , Uwe Reusch
IPC分类号： A61K39/395 , C07K16/28 , C12N9/00 , C07K19/00 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/15 , C12N1/21 , C12P21/02 , G01N1/30 , C12Q1/02
CPC分类号： C07K16/283 , A61K47/6879 , C07K16/18 , C07K16/2878 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and in particular binding molecules that specifically bind the A form FcγRIII but do not bind to the B form of FcγRIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells.
摘要翻译：本发明涉及与天然杀伤（NK）细胞和巨噬细胞（即FcgammaRIIIA）表面上表达的人Fcγ受体特异性结合的结合分子，特别是特异性结合A型FcγRIII但不结合的结合分子到FcγRIII的B形式，以及这种结合分子在疾病的诊断和治疗中的用途。本发明进一步延伸到编码这种结合分子的多核苷酸，包含这种多核苷酸的宿主细胞和使用这种宿主细胞产生本发明的结合分子的方法。

5. 发明申请

US20080145362A1 ANTIBODY COMBINATION USEFUL FOR TUMOR THERAPY 审中-公开
标题翻译：用于肿瘤治疗的抗体组合
公开(公告)号：US20080145362A1
公开(公告)日：2008-06-19
申请号：US12036229
申请日：2008-02-23
申请人： Sergey Kipriyanov , Fabrice Le Gall , Bjorn Cochlovius , Melvyn Little
发明人： Sergey Kipriyanov , Fabrice Le Gall , Bjorn Cochlovius , Melvyn Little
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , A61P43/00 , A61K31/70 , C12N15/00 , C12P21/04
CPC分类号： C07K16/2809 , C07K16/283 , C07K16/2878 , C07K2317/626 , C07K2319/00
摘要： Described is a combination of at least two antibodies, characterized by the following properties: (a) it comprises at least two different multivalent antibodies, each one having at least two specificities and being characterized by features (b) and (d) or (b) and (c) as defined below, (b) an antigen-binding domain specific to a tumor antigen, (c) an antigen-binding domain specific to an antigen present on human T cells, or (d) an antigen-binding domain specific to an antigen present on CD3-epsilon negative human effector cells. Also described are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions, preferably pharmaceutical and diagnostic compositions, are described comprising the above mentioned polynucleotides, antibodies or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B-cell malignancies, B-cell mediated autoimmune diseases and diseases associated with depletion of B-cells.
摘要翻译：描述了至少两种抗体的组合，其特征在于以下性质：（a）其包含至少两种不同的多价抗体，每种抗体具有至少两种特异性，并且特征在于（b）和（d）或（b ）和（c）如下所定义，（b）对肿瘤抗原特异性的抗原结合结构域，（c）对存在于人T细胞上的抗原特异性的抗原结合结构域，或（d）抗原结合结构域对存在于CD3-ε阴性人效应细胞上的抗原具有特异性。还描述了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，用其转化的宿主细胞及其在产生所述抗体中的用途。最后，描述包含上述多核苷酸，抗体或载体的组合物，优选药物和诊断组合物。药物组合物可用于免疫治疗，优选抗B细胞恶性肿瘤，B细胞介导的自身免疫性疾病和与B细胞耗竭相关的疾病。

6. 发明申请

US20050176934A1 Antibody combination useful for tumor therapy 审中-公开
标题翻译：抗体组合可用于肿瘤治疗
公开(公告)号：US20050176934A1
公开(公告)日：2005-08-11
申请号：US10510881
申请日：2003-04-15
申请人： Sergey Kipriyanov , Fabrice Le Gall , Bjorn Cochlovius , Melvyn Little
发明人： Sergey Kipriyanov , Fabrice Le Gall , Bjorn Cochlovius , Melvyn Little
IPC分类号： A61P35/00 , C07K16/28 , C12N1/21 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2809 , C07K16/283 , C07K16/2878 , C07K2317/626 , C07K2319/00
摘要： Described is a combination of at least two antibodies, characterized by the following properties: (a) it comprises at least two different multivalent antibodies, each one having at least two specificities and being characterized by features (b) and (d) or (b) and (c) as defined below, (b) an antigen-binding domain specific to a tumor antigen, (c) an antigen-binding domain specific to an antigen present on human T cells, or (d) an antigen-binding domain specific to an antigen present on CD3-epsilon negative human effector cells. Also described are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions, preferably pharmaceutical and diagnostic compositions, are described comprising the above mentioned polynucleotides, antibodies or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B-cell malignancies, B-cell mediated autoimmune diseases and diseases associated with depletion of B-cells.
摘要翻译：描述了至少两种抗体的组合，其特征在于以下性质：（a）其包含至少两种不同的多价抗体，每种抗体具有至少两种特异性，并且特征在于（b）和（d）或（b ）和（c）如下所定义，（b）对肿瘤抗原特异性的抗原结合结构域，（c）对存在于人T细胞上的抗原特异性的抗原结合结构域，或（d）抗原结合结构域对存在于CD3-ε阴性人效应细胞上的抗原具有特异性。还描述了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，用其转化的宿主细胞及其在产生所述抗体中的用途。最后，描述包含上述多核苷酸，抗体或载体的组合物，优选药物和诊断组合物。药物组合物可用于免疫治疗，优选抗B细胞恶性肿瘤，B细胞介导的自身免疫性疾病和与B细胞耗竭相关的疾病。

7. 发明申请

US20110206672A1 Antigen-Binding Molecule And Uses Thereof 审中-公开
标题翻译：抗原结合分子及其用途
公开(公告)号：US20110206672A1
公开(公告)日：2011-08-25
申请号：US13034920
申请日：2011-02-25
申请人： Melvyn Little , Fabrice Le Gall
发明人： Melvyn Little , Fabrice Le Gall
IPC分类号： A61K39/395 , C07K16/28 , A61P37/02
CPC分类号： C07K16/30 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2896 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/62 , C07K2317/626 , C07K2317/73 , C07K2317/92
摘要： In one aspect, the present invention relates to an antigen-binding molecule specific for albumin and CD3 which may comprise two polypeptide chains, each polypeptide chain having at least four variable domains in an orientation preventing Fv formation and the two polypeptide chains are dimerized with one another thereby forming a multivalent antigen-binding molecule. On each of the two polypeptide chains the four variable domains may be arranged in the order VLA-VHB-VLB-VHA from the N-terminal to the C-terminal of the polypeptide. Compositions of the antigen-binding molecule and the methods of using the antigen-binding molecule or the compositions thereof for treatment of various diseases are also provided herein.
摘要翻译：一方面，本发明涉及对白蛋白和CD3特异性的抗原结合分子，其可以包含两条多肽链，每个多肽链在阻止Fv形成的方向中具有至少四个可变结构域，并且两个多肽链与一个二聚体从而形成多价抗原结合分子。在两个多肽链中的每一个上，四个可变结构域可以按照VLA-VHB-VLB-VHA的顺序从多肽的N末端到C末端排列。本文还提供了抗原结合分子的组成以及使用抗原结合分子或其组合物治疗各种疾病的方法。

8. 发明申请

US20050089519A1 Bispecific anti-cd19x anti-cd16 antibodies and uses thereof 审中-公开
标题翻译：双特异性抗cd19x抗CD16抗体及其用途
公开(公告)号：US20050089519A1
公开(公告)日：2005-04-28
申请号：US10495508
申请日：2002-11-14
申请人： Sergey Kipriyanov , Fabrice LeGall , Melvyn Little , Holger Schafer , Gerhard Moldanhauer , Bjorn Cochlovius
发明人： Sergey Kipriyanov , Fabrice LeGall , Melvyn Little , Holger Schafer , Gerhard Moldanhauer , Bjorn Cochlovius
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/74 , A61K35/76 , A61K36/06 , A61K39/00 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/283 , C07K2317/34 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Described are multivalent multimeric antibodies comprising at least two binding sites specific for the human B cell marker CD19 and human Fcγ receptor III (CD16). Also described are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions are described comprising any of above mentioned antibodies, polynucleotides or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B cell malignancies such as non-Hodgkin's lymphoma.
摘要翻译：描述了包含至少两个对人B细胞标记CD19和人Fcγ受体III（CD16）特异的结合位点的多价多聚体抗体。还描述了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，用其转化的宿主细胞及其在产生所述抗体中的用途。最后，描述包含任何上述抗体，多核苷酸或载体的组合物。药物组合物可用于免疫治疗，优选抗B细胞恶性肿瘤，例如非霍奇金淋巴瘤。

9. 发明授权

US5911987A Cell surface protein and effector cell bonding reagent 失效
标题翻译：细胞表面蛋白和效应细胞结合试剂
公开(公告)号：US5911987A
公开(公告)日：1999-06-15
申请号：US702712
申请日：1997-02-21
申请人： Schirrmacher Volker , Khashayarsha Khazaie , Claudia Haas , Gerd Moldenhauer , Melvyn Little , Stefan Dubel , Frank Breitling , Sergey Kipriyanov , Stefanie Gotter , Hans-Jurgen Rode
发明人： Schirrmacher Volker , Khashayarsha Khazaie , Claudia Haas , Gerd Moldenhauer , Melvyn Little , Stefan Dubel , Frank Breitling , Sergey Kipriyanov , Stefanie Gotter , Hans-Jurgen Rode
IPC分类号： C12N15/09 , A61K35/12 , A61K39/00 , A61P31/00 , A61P35/00 , C07H21/04 , C07K14/465 , C07K14/705 , C07K16/10 , C07K16/28 , C12P21/00 , A61K39/395 , A61K39/42 , C07K16/24
CPC分类号： A61K39/0011 , C07K16/1027 , C07K16/2818 , A61K2039/6056
摘要： The present invention relates to a bonding reagent, which is characterized in that it comprises a first bonding component specific for the hemagglutinin-neuraminidase molecule of a Newcastle Disease Virus and a second bonding component specific for a costimulatorily acting molecule of an effector cell.Furthermore, this invention concerns a process for the production of the bonding reagent as well as a vaccine containing the bonding reagent and inactivated tumor cells.
摘要翻译： PCT No.PCT / EP95 / 00843 Sec。 371日期1997年2月21日 102（e）日期1997年2月21日PCT提交1995年3月7日PCT公布。公开号WO95 / 24490 日期1995年9月14日本发明涉及一种粘合试剂，其特征在于它包含对新城疫病毒的血细胞凝集素 - 神经氨酸酶分子特异的第一结合成分和特异于一种共刺激作用分子的第二结合成分效应细胞。此外，本发明涉及生产粘合试剂的方法以及含有结合试剂和灭活的肿瘤细胞的疫苗。

10. 发明授权

US09365647B2 Compounds for use in the treatment of Alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的化合物
公开(公告)号：US09365647B2
公开(公告)日：2016-06-14
申请号：US14345770
申请日：2012-09-19
申请人： Stefan Franz Thomas Weiss , Katarina Jovanovic , Danielle Gonsavles , Bianca Da Costa Dias , Stefan Knackmuss , Uwe Reusch , Melvyn Little , Marc Saul Weinberg
发明人： Stefan Franz Thomas Weiss , Katarina Jovanovic , Danielle Gonsavles , Bianca Da Costa Dias , Stefan Knackmuss , Uwe Reusch , Melvyn Little , Marc Saul Weinberg
IPC分类号： C07K16/28 , A61K31/7105 , A61K39/395 , C12N15/113 , C07K16/26
CPC分类号： A61K39/3955 , A61K31/7105 , A61K2039/505 , C07K16/26 , C07K16/28 , C07K2317/76 , C12N15/1138
摘要： The invention relates to a method of modulating concentration of Alzheimer's Disease (AD) relevant proteins amyloid precursor protein (APP), beta (β) and gamma (γ) secretases and amyloid beta peptide (Aβ), and also relates to a method of reducing Aβ shedding. Furthermore, this invention extends to a compound for use in the treatment of AD, and also to a method of treating AD.
摘要翻译：本发明涉及调节阿尔茨海默病（AD）相关蛋白淀粉样蛋白前体蛋白（APP），β（＆bgr）和γ（γ）分泌酶和淀粉样蛋白β肽（A＆bgr））的浓度的方法，还涉及一种方法减少A＆bgr 脱落此外，本发明延伸到用于治疗AD的化合物，还涉及治疗AD的方法。

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