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1. 发明申请

US20080210558A1 Electrowetting Pumping Device And Use For Measuring Electrical Activity 有权
标题翻译：电动泵送装置及用于测量电气活动的用途
公开(公告)号：US20080210558A1
公开(公告)日：2008-09-04
申请号：US11917857
申请日：2006-06-16
申请人： Fabien Sauter-Starace , Jean Berthier
发明人： Fabien Sauter-Starace , Jean Berthier
IPC分类号： B01D57/02 , G01N27/26
CPC分类号： B01L3/50273 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N33/48728
摘要： The invention relates to a method for pumping through an orifice (30, 31) of a first substrate (1), a first volume of liquid (2) in contact with a first hydrophobic surface of said substrate, wherein a pressure variation between the first volume of liquid and a second volume of liquid (2′), located in contact with said orifice and a second hydrophobic surface of said substrate, is achieved by electrowetting.
摘要翻译：本发明涉及一种用于泵送通过第一衬底（1）的孔口（30,31）的方法，与所述衬底的第一疏水表面接触的第一体积的液体（2），其中第一通过电润湿实现液体的体积和与所述孔口接触的第二体积的液体（2'）和所述基底的第二疏水性表面。

2. 发明授权

US08349158B2 Electrowetting pumping device and application to electric activity measurements 有权
标题翻译：电动泵送装置和应用于电动活动测量
公开(公告)号：US08349158B2
公开(公告)日：2013-01-08
申请号：US13313537
申请日：2011-12-07
申请人： Fabien Sauter-Starace , Jean Berthier
发明人： Fabien Sauter-Starace , Jean Berthier
IPC分类号： G01N27/26 , G01N33/50 , F04B37/02
CPC分类号： B01L3/50273 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N33/48728
摘要： A method for pumping through an orifice of a first substrate, a first volume of liquid in contact with a first hydrophobic surface of said substrate, wherein a pressure variation between the first volume of liquid and a second volume of liquid, located in contact with said orifice and a second hydrophobic surface of said substrate, is achieved by electrowetting.
摘要翻译：一种用于泵送第一衬底的孔口的方法，与所述衬底的第一疏水表面接触的第一体积的液体，其中所述第一体积液体和第二体积的液体之间的压力变化位于与所述第一衬底接触的位置孔和第二疏水表面，通过电润湿实现。

3. 发明授权

US08075754B2 Electrowetting pumping device and use for measuring electrical activity 有权
标题翻译：电动泵送装置和用于测量电气活动的用途
公开(公告)号：US08075754B2
公开(公告)日：2011-12-13
申请号：US11917857
申请日：2006-06-16
申请人： Fabien Sauter-Starace , Jean Berthier
发明人： Fabien Sauter-Starace , Jean Berthier
IPC分类号： G01N27/26
CPC分类号： B01L3/50273 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N33/48728
摘要： The invention relates to a method for pumping through an orifice (30, 31) of a first substrate (1), a first volume of liquid (2) in contact with a first hydrophobic surface of said substrate, wherein a pressure variation between the first volume of liquid and a second volume of liquid (2′), located in contact with said orifice and a second hydrophobic surface of said substrate, is achieved by electrowetting.
摘要翻译：本发明涉及一种用于泵送通过第一衬底（1）的孔口（30,31）的方法，与所述衬底的第一疏水表面接触的第一体积的液体（2），其中第一通过电润湿实现液体的体积和与所述孔口接触的第二体积的液体（2'）和所述基底的第二疏水性表面。

4. 发明申请

US20080185296A1 Planar Device With Well Addressing Automated By Dynamic Electrowetting 审中-公开
标题翻译：具有良好寻址的平面设备通过动态电泳自动化
公开(公告)号：US20080185296A1
公开(公告)日：2008-08-07
申请号：US11916751
申请日：2006-06-07
申请人： Fabien Sauter-Starace , Yves Fouillet , Nathalie Picollet-D'Hahan , Francois Chatelain
发明人： Fabien Sauter-Starace , Yves Fouillet , Nathalie Picollet-D'Hahan , Francois Chatelain
IPC分类号： G01N27/26
CPC分类号： G01N33/48728 , B01L3/502792 , B01L2300/0645 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , G01N2015/105
摘要： The invention concerns a method to analyse the liquid in a drop (2), comprising: contacting a drop of this liquid with a hydrophobic surface (8), displacing the drop on this surface by electrowetting, to bring it to a site (24, 26, 28) to measure electrical activity in which a conductive solution (42) is arranged, measuring said electrical activity.
摘要翻译：本发明涉及一种分析液滴（2）中的液体的方法，包括：使该液体的一滴与疏水表面（8）接触，通过电润湿使该表面上的液滴移位，使其到达位置（24， 26,28）以测量其中布置导电溶液（42）的电活动，测量所述电活动。

5. 发明申请

US20110264166A1 MULTIPLE ELECTRODE LEAD AND A SYSTEM FOR DEEP ELECTRICAL NEUROSTIMULATION INCLUDING SUCH A LEAD 审中-公开
标题翻译：多电极引线和深潜电子系统，包括这样一个引线
公开(公告)号：US20110264166A1
公开(公告)日：2011-10-27
申请号：US13176109
申请日：2011-07-05
申请人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
发明人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
IPC分类号： A61N1/36 , A61N1/05 , B82Y5/00
CPC分类号： A61N1/0529 , A61N1/0531
摘要： A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod.A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.
摘要翻译：铅的深电神经刺激，铅包括：生物相容性材料棒; 以及还具有生物相容性材料的刀片，其固定到所述杆的一端并与其对齐; 其中所述刀片具有两个主表面和设置在所述两个主面中的至少一个上的多个电极，所述两个主面以二维构型，所述电极连接到设置在所述杆的内部或表面上的导体元件。一种深电神经刺激系统，包括：用于深电神经刺激的电脉冲发生器; 以及上述类型的至少一个引线，其电极与所述电脉冲发生器电连接。

6. 发明申请

US20090012593A1 Multiple electrode lead and a system for deep electrical neurostimulation including such a lead 有权
标题翻译：多电极引线和用于深电神经刺激的系统，包括这样的引线
公开(公告)号：US20090012593A1
公开(公告)日：2009-01-08
申请号：US12216305
申请日：2008-07-02
申请人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
发明人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0531
摘要： A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.
摘要翻译：铅的深电神经刺激，铅包括：生物相容性材料棒; 以及还具有生物相容性材料的刀片，其固定到所述杆的一端并与其对齐; 其中所述刀片具有两个主表面和设置在所述两个主面中的至少一个上的多个电极，所述两个主面以二维构型，所述电极连接到设置在所述杆的内部或表面上的导体元件。一种深电神经刺激系统，包括：用于深电神经刺激的电脉冲发生器; 以及上述类型的至少一个引线，其电极与所述电脉冲发生器电连接。

7. 发明授权

US07991481B2 Multiple electrode lead and a system for deep electrical neurostimulation including such a lead 有权
标题翻译：多电极引线和用于深电神经刺激的系统，包括这样的引线
公开(公告)号：US07991481B2
公开(公告)日：2011-08-02
申请号：US12216305
申请日：2008-07-02
申请人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
发明人： Alim Louis Benabid , Fabien Sauter-Starace , Patrice Caillat
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0531
摘要： A lead for deep electrical neurostimulation comprising a rod of biocompatible material and a blade, also of biocompatible material, secured to one end of the rod and in alignment therewith. The blade presents two main faces and a plurality of electrodes disposed on at least one of the two main faces in a two-dimensional configuration. The electrodes are connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising an electrical pulse generator connected to at least one lead of the above-described type is also disclosed.
摘要翻译：用于深电神经刺激的引线，包括生物相容性材料棒和生物相容性材料的叶片，其固定到杆的一端并与其对齐。叶片具有两个主面和设置在两个主面中的至少一个上的多个电极，二维构型。电极连接到设置在所述杆的内部或表面上的导体元件。还公开了一种深电神经刺激系统，其包括连接到上述类型的至少一个引线的电脉冲发生器。

8. 发明申请

US20110184269A1 IMPLANTABLE PROBE 审中-公开
标题翻译：可植入探头
公开(公告)号：US20110184269A1
公开(公告)日：2011-07-28
申请号：US13003492
申请日：2009-07-10
申请人： Fabien Sauter-Starace , Bibari Olivier , Chabrol Claude , Catherine Pudda
发明人： Fabien Sauter-Starace , Bibari Olivier , Chabrol Claude , Catherine Pudda
IPC分类号： A61B5/0476 , A61N1/05
CPC分类号： A61B5/0478 , A61N1/0536
摘要： An implantable probe for acquiring neural signals or for electrically stimulating neurons, the probe comprising: a support (ES) of flexible polymer material; an inorganic substrate (S′) fastened to said support and having thickness that is sufficiently small to present flexibility comparable to that of the support; at least one electrode (EL) carried by said substrate; and a layer (NC) of conductive material deposited by high temperature growth on a surface of said or each electrode and suitable for improving at least one property thereof selected from: electrical properties; biocompatibility properties; and biostability properties. A method of fabricating such a probe, including making electrodes on said inorganic substrate, thinning it, depositing said conductive layer thereon by growth at high temperature, and subsequently transferring the thinned substrate carrying the coated electrodes onto the support of flexible polymer material.
摘要翻译：一种用于获取神经信号或用于电刺激神经元的可植入探针，所述探针包括：柔性聚合物材料的支撑体（ES）; 固定到所述支撑件的无机基底（S'），其厚度足够小以呈现与支撑件相当的柔性; 由所述衬底承载的至少一个电极（EL）以及通过高温生长沉积在所述或每个电极的表面上并适于改善其至少一种性质的导电材料层（NC），其选自：电性能; 生物相容性; 和生物稳定性。一种制造这种探针的方法，包括在所述无机衬底上制造电极，使其变薄，在高温下通过生长沉积所述导电层，随后将带有涂覆电极的薄化衬底转移到柔性聚合物材料的支撑体上。

9. 发明授权

US08676328B2 Transcranial securing device for deep brain stimulation leads 有权
标题翻译：用于深部脑刺激的经颅固定装置
公开(公告)号：US08676328B2
公开(公告)日：2014-03-18
申请号：US12603062
申请日：2009-10-21
申请人： Fabien Sauter-Starace , Alim-Louis Benabid , Raymond Charles
发明人： Fabien Sauter-Starace , Alim-Louis Benabid , Raymond Charles
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61B5/4082 , A61B5/6864 , A61B5/6865 , A61B5/6882 , A61B2017/3445 , A61B2017/347 , A61B2090/103 , A61N1/0539
摘要： A transcranial securing device for deep brain stimulation leads comprising: a principal part for securing inside an opening formed in the cranium of a patient; and at least one first securing part housed inside said principal part; said or each securing part comprises at least one axial bore adapted to allow the passage of one or more deep brain stimulation leads; said or at least one securing part is arranged so as to be capable of passing from a first position in which the lead or leads can slide axially in the respective bores, to a second position in which it grips the lead or leads in the respective bore or bores, preventing said sliding.
摘要翻译：一种用于深脑刺激引线的经颅固定装置，包括：用于固定在形成于患者颅骨中的开口内的主要部分; 以及容纳在所述主要部分内的至少一个第一固定部分; 所述或每个固定部分包括适于允许一个或多个深部脑刺激引线通过的至少一个轴向孔; 所述或至少一个固定部分布置成能够从其中所述引线或引线在相应的孔中轴向滑动的第一位置通过到第二位置，在所述第二位置，所述第一位置将所述引线或引线夹在相应的孔中或孔，防止所述滑动。

10. 发明申请

US20110147215A1 METHOD AND DEVICE FOR MANIPULATING AND OBSERVING LIQUID DROPLETS 审中-公开
标题翻译：用于操纵和观察液体滴液的方法和装置
公开(公告)号：US20110147215A1
公开(公告)日：2011-06-23
申请号：US13003105
申请日：2009-07-09
申请人： Olivier Fuchs , Fabien Sauter-Starace
发明人： Olivier Fuchs , Fabien Sauter-Starace
IPC分类号： B01D57/02
CPC分类号： F04B19/006 , B01L3/502792 , B01L2200/0678 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0421 , G01N2015/1481
摘要： A device for manipulating and observing suspended particles in a liquid. The device includes: a first substrate including at least one first orifice forming an inlet site for the liquid, an observation site for observing the suspended particles, and a mechanism displacing the liquid from the inlet site to the observation site. The first substrate includes a first hydrophobic layer. The liquid is electrically conducting. The liquid can be displaced as a droplet by electrowetting, the droplet being in contact with the hydrophobic layer.
摘要翻译：用于操纵和观察液体中的悬浮颗粒的装置。该装置包括：第一基板，包括形成液体的入口部位的至少一个第一孔口，用于观察悬浮颗粒的观察部位，以及使液体从入口部位移动到观察部位的机构。第一衬底包括第一疏水层。液体是导电的。液体可以通过电润湿作为液滴移位，液滴与疏水层接触。

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