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1. 发明专利

CA2038066A1 (BENZHYDRYLOXYETHYLPIPERIDYL) ALIPHATIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALLERGIES AND ASTHMA 未知
公开(公告)号：CA2038066A1
公开(公告)日：1992-02-10
申请号：CA2038066
申请日：1991-03-12
申请人： FUKUMI HIROSHI , SAKAMOTO TOSHIAKI , SUGIYAMA MITSUO , YAMAGUCHI TAKESHI , IIZUKA YOSHIO , SANKYO CO
发明人： FUKUMI HIROSHI , SAKAMOTO TOSHIAKI , SUGIYAMA MITSUO , YAMAGUCHI TAKESHI , IIZUKA YOSHIO
IPC分类号： A61K31/445 , A61K31/452 , A61P11/00 , A61P11/08 , A61P37/08 , A61P43/00 , C07D211/34 , C07D405/12
摘要： Compounds of formula (I): (I) in which: R1 and R2 are independently alkyl, alkoxy, trifluoromethyl, nitro or halogen; A is an aliphatic hydrocarbon group having from 2 to 8 carbon atoms whose chain contains at least 2 carbon atoms in a linear chain between the piperidine group and -COOH, said group optionally being unsaturated; and m and n are independently 0, 1, 2 or 3; and pharmaceutically acceptable salts and esters thereof have been found to have valuable anti-histamine properties without the usual side effects of anti-histamines. Methods of preparing the compounds are also provided.

2. 发明专利

CA2026925A1 TETRACYCLIC COMPOUNDS HAVING ANTI-ALLERGIC AND ANTI-ASTHMATIC ACTIVITIES, THEIR PREPARATION AND USE 未知
公开(公告)号：CA2026925A1
公开(公告)日：1991-04-06
申请号：CA2026925
申请日：1990-10-04
申请人： FUKUMI HIROSHI , SAKAMOTO TOSHIAKI , SUGIYAMA MITSUO , IIZUKA YOSHIO , YAMAGUCHI TAKESHI
发明人： FUKUMI HIROSHI , SAKAMOTO TOSHIAKI , SUGIYAMA MITSUO , IIZUKA YOSHIO , YAMAGUCHI TAKESHI
IPC分类号： C07D213/06 , C07D213/60 , C07D223/14 , C07D241/42 , C07D471/14 , C07D487/04 , A61K31/55
摘要： Compounds of formula (I): (I) ¢in which: Q is nitrogen or =CH-; R1 and R2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R3 is various specific substituted alkyl groups! and pharmaceutically acceptable salts thereof have valuable anti-allergic and anti-asthmatic activities. They may be prepared by reacting a corresponding compound where R3 is replaced by a hydrogen atom with a compound to introduce the group R3.

3. 发明专利

CA2045755A1 THIAZOLIDINECARBOXYLIC ACID AMIDE DERIVATIVES HAVING ANTI-ALLERGIC ACTIVITY, THEIR PREPARATION AND THEIR USE 未知
公开(公告)号：CA2045755A1
公开(公告)日：1991-12-28
申请号：CA2045755
申请日：1991-06-26
申请人： HIROSHI FUKUMI , SAKAMOTO TOSHIAKI , MITSUO SUGIYAMA , OSHIMA TAKESHI , IIJIMA YASUTERU , YAMAGUCHI TAKESHI
发明人： FUKUMI HIROSHI , SAKAMOTO TOSHIAKI , SUGIYAMA MITSUO , OSHIMA TAKESHI , IIJIMA YASUTERU , YAMAGUCHI TAKESHI
IPC分类号： C07D277/06 , A61K31/425 , A61K31/426 , A61K31/427 , A61P11/06 , A61P37/08 , C07D215/06 , C07D241/04 , C07D277/04 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/445 , A61K31/495
摘要： Compounds of formula (I): (I) ín which R1 is optionally substituted pyridyl; R2 is hydrogen, alkyl or optionally substituted pyridyl; R3 is hydrogen or various organic groups; R4 is hydrogen or alkyl; A is alkylene; and Z is a substituted piperidyl, piperazinyl or homopiperazinyl group which is substituted at least by a di-substituted methyl, methoxy or methylene group, each substituent being phenyl or heterocyclyl!; and pharmaceutically acceptable salts thereof have anti-allergic, anti-asthma and anti-PAF activities. Methods of making the compounds are also provided.

4. 发明专利

JPH07242246A DEVICE FOR TRANSPORT 失效
公开(公告)号：JPH07242246A
公开(公告)日：1995-09-19
申请号：JP5253894
申请日：1994-02-28
申请人： OSHIMA REIJI , SAKAMOTO TOSHIAKI , JAPAN PAPER IND
发明人： OSHIMA REIJI , SAKAMOTO TOSHIAKI , SEKINE AKIYOSHI
IPC分类号： B65D21/02 , B65D5/00 , B65D25/20
摘要： PURPOSE:To provide a device for transport by which the generation of wastes can be suppressed to a minimum, and which can withstand repeated use for a long period of time. CONSTITUTION:A device for transport has an approx. rectangular shape without bottom, consisting of a pair of confronted lateral crosspieces 5a and a pair of longitudinal crosspieces 5b, and is a built-up container made of a paper with water resisting property, which is equipped with an external frame 2 with an engaging step 6 to receive an internal box 3 on the top and bottom end surfaces. Then, from respective side edges of a bottom plate 8, side surface parts 9 are respectively extended, and at the same time, a sealing part 10 is bendably extended between the side ends of each side surface part 9, and on the outer edge of each side surface part 9, an engaging edge 11 of which the width is wider than the side surface part 9 is formed into a folded back shape, for the internal box 3. For a lid body 4, a standing piece 13 with a low height is provided on the four edges of a top plate 12. The device for transport is constituted of said external frame 2, internal box 3 and lid body 4. When the external frames 2 are stacked, protuberances 17a, 17b, 18a, 18b being provided on the external frame 2 are engaged, and when the internal box 3 is put in the external frame 2, the engaging edge 11 is engaged with the engaging step 6.

5. 发明专利

JP2566531B2 失效
公开(公告)号：JP2566531B2
公开(公告)日：1996-12-25
申请号：JP5253894
申请日：1994-02-28
申请人： OOSHIMA REIJI , SAKAMOTO TOSHIAKI , NIPPON SHIGYO KK
发明人： OOSHIMA REIJI , SAKAMOTO TOSHIAKI , SEKINE AKYOSHI
IPC分类号： B65D21/02 , B65D5/00 , B65D25/20

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