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1. 发明申请

WO1997000259A1 IMPROVED PROCESS FOR PRODUCING PENICILLIN G PHENYL ESTER 审中-公开
标题翻译：生产PENICILLIN G PHENYL ESTER的改进方法
公开(公告)号：WO1997000259A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001604
申请日：1996-06-13
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKAHASHI, Satoru , YAMAMURA, Atsushi , HAYASHIDA, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D499/46
CPC分类号： C07D499/00
摘要： A novel process for producing penicillin G phenyl esters represented by formula (I), or salts thereof by the reaction between a compound represented by formula (II), or a salt thereof and the compound represented by formula (IV) or a salt thereof.
摘要翻译：由式（I）表示的青霉素G苯基酯或其盐通过由式（II）表示的化合物或其盐与式（IV）表示的化合物或其盐的反应生产的新方法。

2. 发明申请

WO1993008196A1 PENICILLIN G ESTER 审中-公开
公开(公告)号：WO1993008196A1
公开(公告)日：1993-04-29
申请号：PCT/JP1992001327
申请日：1992-10-12
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKAHASHI, Satoru , YAMAMURA, Atsushi , HAYASHIDA, Hisashi , TAKAGI, Hirofumi , KANEDA, Shigeo
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D499/46
CPC分类号： C07D499/00
摘要： A compound represented by general formula (I) and a preventive or curative agent for fish diseases containing the same as an active ingredient, wherein A represents a single bond and R represents (a), lower alkenoyl, cyclopropylcarbonyloxymethyl, cyclohexylcarbonyloxymethyl, benzoyloxy, benzoyloxymethyl, (b) (wherein Y represents -O- or -COO-), -Z-COOR (wherein Z represents a single bond, -CH2-, -CH2CH2- or -CH=CH-), -CH2W (wherein W represents hydrogen, hydroxy, lower alkoxy or cyano), -CH2NH2, -CH2NHCH3, (c), -CH2N(C2H5)2, (d), (e), (f) or (g) placed at the 3-position; or alternatively A represents (h) and R represents -COOCH3 placed at the 4-position; or further alternatively A represents -CH2M- (wherein M represents O or S) and R represents halogen, lower alkyl, lower alkoxy, lower alkanoyl, lower alkoxycarbonyl, lower alkoxycarbonyl-lower alkyl, lower alkanoyloxy-lower alkyl, lower alkanoyloxy, hydroxylated lower alkyl, or -O(CH2CH2O)kR (wherein R represents lower alkyl and k represents an integer of 1 to 3); R represents hydrogen, lower alkoxy or lower alkanoyloxy; R represents hydrogen; and X represents N or CH.
摘要翻译：由通式（I）表示的化合物和含有与活性成分相同的鱼病的预防或治疗剂，其中A表示单键，R 1表示（a），低级烯酰基，环丙基羰氧基甲基，环己基羰氧基甲基，苯甲酰氧基，苯甲酰氧基甲基，（b）（其中Y表示-O-或-COO-），-Z-COOR 7（其中Z表示单键，-CH 2 - ， - CH 2 CH 2 - 或-CH = CH-）， - CH2W（其中W表示氢，羟基，低级烷氧基或氰基），-CH2NH2，-CH2NHCH3，（c），-CH2N（C2H5）2，（d），（e），（f）或（g） 3-位; 或者A表示（h），R 1表示置于4-位的-COOCH 3; 或另外地，A表示-CH 2 M-（其中M表示O或S），R 1表示卤素，低级烷基，低级烷氧基，低级烷酰基，低级烷氧基羰基，低级烷氧基羰基 - 低级烷基，低级烷酰氧基 - 低级烷基，低级烷酰氧基，羟基化低级烷基或-O（CH 2 CH 2 O）k R 8（其中R 8表示低级烷基，k表示1〜3的整数）。 R 2表示氢，低级烷氧基或低级烷酰氧基; R 3表示氢; X表示N或CH。

3. 发明申请

WO1998030705A1 GENES ENCODING FLATFISH LYSOZYMES OF BASTARD HALIBUT 审中-公开
标题翻译：编码BASTARD HALIBUT的平滑肌球蛋白的基因
公开(公告)号：WO1998030705A1
公开(公告)日：1998-07-16
申请号：PCT/JP1997004919
申请日：1997-12-26
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , AOKI, Takashi , HIRONO, Ikuo
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C12N15/56
CPC分类号： C12N9/2462 , C12Y302/01017
摘要： Genes encoding lysozymes (a) or (b) originating in the kidney of bastard halibut ( Paralichthys olivaceus ). (a) A lysozyme having the partial amino acid sequence consisting of the 1st to 128th amino acids in the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing. (b) A lysozyme having an amino acid sequence derived from the partial amino acid sequence of the lysozyme (a) by substitution, deletion or addition of one or several amino acids therein and having a lysozyme activity.
摘要翻译：编码来自混合大比目鱼（Paralichthys olivaceus）肾脏的溶菌酶（a）或（b））的基因。（a）具有序列表中SEQ ID NO：1所述氨基酸序列中第1至第128位氨基酸部分氨基酸序列的溶菌酶。（b）具有衍生自溶菌酶的部分氨基酸序列的氨基酸序列的溶菌酶（a），其中通过取代，缺失或添加其中的一个或几个氨基酸并具有溶菌酶活性。

4. 发明申请

WO1998020754A1 REGULATEUR FOR FERMENTATION DURING PREPARATION OF SOY SAUCE, SOY SAUCE, AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：在大豆制备期间发酵的规范，大豆酱及其制备方法
公开(公告)号：WO1998020754A1
公开(公告)日：1998-05-22
申请号：PCT/JP1997003671
申请日：1997-10-14
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKENAWA, Seishi , ISE, Naomi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A23L01/238
CPC分类号： A23L27/50
摘要： A regulator for fermentation during the preparation of a soy sauce containing an alkali metal salt of gluconic acid; a soy sauce characterized by comprising an alkali metal salt of gluconic acid either alone or in combination with common salt; and a process for preparing a soy sauce, characterized by adding an aqueous solution containing an alkali metal salt of gluconic acid to koji for soy sauce before the step of mashing.
摘要翻译：在制备含有葡萄糖酸的碱金属盐的酱油时的发酵调节剂; 一种酱油，其特征在于包含单独的或与普通盐组合的葡萄糖酸的碱金属盐; 以及制备酱油的方法，其特征在于在糖化步骤之前，将含有葡萄糖酸的碱金属盐的水溶液加入到酱油中。

5. 发明申请

WO1998016527A1 BENZOXEPINE DERIVATIVES WHICH PROMOTE RELEASE OF GROWTH HORMONE 审中-公开
标题翻译：促生长激素释放的苯并吡喃衍生物
公开(公告)号：WO1998016527A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003704
申请日：1997-10-15
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TANIGUCHI, Kiyoshi , KURODA, Satoru , TSUBAKI, Kazunori , SHIMIZU, Yasuyo , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/10
CPC分类号： C07D405/06 , C07D471/10 , C07K5/0202 , C07K5/06139 , Y02P20/55
摘要： A pharmaceutically useful benzoxepine compound of formula (I), wherein R is 3-azetidinyl, 4-piperidyl or a group of the formula: -Y-NHR , in which R is hydrogen or amino protective group, and Y is lower alkylene or cyclo(lower) alkylene; R is cyano and R is aryl; R is esterified carboxy and R is ar(lower)alkyl: or R and R are linked together to form formula (a), in which R is acyl, A is -(CH2)n-, in which n is 2, 3 or 4, vinylene or butenylene, X is bond or lower alkylene, and formula (b) is piperidino, and pharmaceutically acceptable salts thereof. The compound or a pharmaceutically acceptable salt thereof of the present invention has excellent promotion activity of growth hormone release for animals and human bodies.
摘要翻译：其中R 1为3-氮杂环丁烷基，4-哌啶基或式-Y-NHR 4的基团，其中R 4为氢或氨基保护基并且Y是低级亚烷基或环（低级）亚烷基; R 2是氰基，R 3是芳基; R 2是酯化羧基，R 3是芳（低级）烷基：或R 2和R 3连接在一起形成式（a），其中R 5是酰基，A是 - （CH 2）n - ，其中n为2,3或4，亚乙烯基或亚丁烯基，X为键或低级亚烷基，式（b）为哌啶子基及其药学上可接受的盐。本发明的化合物或其药学上可接受的盐对于动物和人体具有优异的生长激素释放的促进活性。

6. 发明申请

WO1998015535A1 1,4-BENZODIAZEPINONES AND THEIR USES AS CCK ANTAGONISTS 审中-公开
标题翻译： 1,4-苯并恶嗪酮及其作为CCK拮抗剂的用途
公开(公告)号：WO1998015535A1
公开(公告)日：1998-04-16
申请号：PCT/JP1997003483
申请日：1997-09-29
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NIPPON SHOKUBAI CO., LTD. , SATO, Yoshinari , TABUCHI, Seiichiro , MITSUI, Hitoshi , KATSUMI, Ikuyo , YAMAMOTO, Naoko
发明人： FUJISAWA PHARMACEUTICAL CO., LTD. , NIPPON SHOKUBAI CO., LTD.
IPC分类号： C07D243/14
CPC分类号： C07K5/0821 , A61K38/00 , C07D243/14 , C07D243/18 , C07K5/0205 , C07K5/06139
摘要： Benzodiazepine derivatives of formula (I) wherein R is alkyl or cycloalkyl-alkyl when R is hydrogen, or R is a variety of specified groups when R is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.
摘要翻译：当R 4为氢时R 2为烷基或环烷基 - 烷基的式（I）的苯并二氮杂衍生物，或当R 4为烷基，卤素或二烷基氨基时，R 2为多种规定基团作为缩胆囊素拮抗剂有用。

7. 发明申请

WO1997041128A1 3-PYRAZOLIOMETHYLCEPHEM COMPOUNDS AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：作为抗微生物剂的3-吡唑啉酮化合物
公开(公告)号：WO1997041128A1
公开(公告)日：1997-11-06
申请号：PCT/JP1997001416
申请日：1997-04-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KAWABATA, Kohji , OKUDA, Shinya , KISHI, Kohei , EIKYU, Yoshiteru , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/46
CPC分类号： C07D501/00
摘要： The present invention relates to a cephem compound of formula (I) wherein R is amino, etc; R is halogen, etc; R is a group of formula (a) (wherein R is hydrogen, etc); R is a group of formula (b) (wherein R is hydroxy(lower)alkyl, etc; R is amino, etc; and R is hydrogen, etc), etc; R is -COO , etc; X is -S- etc; Y is an anion, and n is 0 or 1, and a salt thereof, which is useful as a medicament; the processes for the preparation of said cephem compound or a salt thereof; a pharmaceutical composition comprising said cephem compound or a pharmaceutically acceptable salt thereof; etc.
摘要翻译：本发明涉及其中R 1为氨基等的式（I）的头孢烯化合物; R 2是卤素等; R 3是式（a）的基团（其中R 6是氢等）; R 4是式（b）的基团（其中R 7是羟基（低级）烷基等; R 8是氨基等; R 9是氢等）等; R 5是-COOO等; X是-S-等; Y 0为阴离子，n为0或1，及其盐，可用作药物; 制备所述头孢烯化合物或其盐的方法; 包含所述头孢烯化合物或其药学上可接受的盐的药物组合物; 等等

8. 发明申请

WO1997031639A1 TABLETS CONTAINING 'beta'-LACTAM ANTIBIOTIC AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：含有β-LACTAM抗生素及其生产方法的片剂
公开(公告)号：WO1997031639A1
公开(公告)日：1997-09-04
申请号：PCT/JP1997000509
申请日：1997-02-21
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YAMAGUCHI, Hisami
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/545
CPC分类号： A61K31/546 , A61K9/0056 , A61K9/0095 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K31/545 , Y10S514/96 , Y10S514/961
摘要： Tablets containing a beta -lactam antibiotic which can be easily taken as such because they are small and which, for administration to a dysphagic person, e.g., one of an advanced age, can be taken as a dispersion because they readily disintegrate by themselves when dropped into water in a glass. Each tablet comprises 60 to 85 wt.% beta -lactam antibiotic, 1 to 10 wt.% lowly substituted hydroxypropylcellulose and/or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5 to 2 wt.% binder. For producing the tablets, these ingredients are tableted using water or an aqueous solution of ethanol, etc.
摘要翻译：含有β-内酰胺抗生素的片剂，因为它们很小并且对于吞咽困难的人（例如，高龄者）的给药可以容易地服用，因为它们在分解时容易分解进入玻璃水。每个片剂包含60至85重量％的β-内酰胺抗生素，1至10重量％的低取代的羟丙基纤维素和/或交联的聚乙烯吡咯烷酮作为崩解剂，和0.5至2重量％的粘合剂。为了生产片剂，将这些成分用水或乙醇水溶液等进行压片。

9. 发明申请

WO1997025310A1 GUANIDINE DERIVATIVES 审中-公开
标题翻译：胍基衍生物
公开(公告)号：WO1997025310A1
公开(公告)日：1997-07-17
申请号：PCT/JP1996003773
申请日：1996-12-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KUNO, Atsushi , INOUE, Yoshikazu , YAMASAKI, Kumi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C279/22
CPC分类号： C07D295/13 , C07C279/22
摘要： Guanidine derivatives of formula (I) wherein R is [di(lower)alkylamino](lower)alkyl, morpholinyl(lower)alkyl, lower alkylpiperazinyl or [lower alkylpyrrolidinyl](lower)alkyl, R is halogen , lower alkyl or lower alkoxy, and R is halogen, lower alkyl, lower alkoxy or mono(or di or tri)halo(lower)alkyl, and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译：式（I）的胍衍生物其中R 1是[二（低级）烷基氨基]（低级）烷基，吗啉基（低级）烷基，低级烷基哌嗪基或[低级烷基吡咯烷基]（低级）烷基，R 2是卤素，低级烷基或低级烷氧基，R 3是可用作药物的卤素，低级烷基，低级烷氧基或单（或二或三）卤代（低级）烷基及其药学上可接受的盐。

10. 发明申请

WO1997024335A1 PROCESS FOR THE PREPARATION OF 3-DIHALOBENZYL-2,4-QUINAZOLINEDIONE DERIVATIVES 审中-公开
标题翻译：制备3-二氢吲哚-2,4-喹唑啉衍生物衍生物的方法
公开(公告)号：WO1997024335A1
公开(公告)日：1997-07-10
申请号：PCT/JP1996003878
申请日：1996-12-27
申请人： FUJI CHEMICAL INDUSTRY CO., LTD. , FUJISAWA PHARMACEUTICAL CO., LTD. , KAMIYA, Takashi , TAKEHARA, Hiroyuki , INAMOTO, Yoshitaka , TANIGUCHI, Akihito , MASUMOTO, Masayuki
发明人： FUJI CHEMICAL INDUSTRY CO., LTD. , FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D239/96
CPC分类号： C07D239/96 , C07C227/08 , C07C229/56
摘要： A process for preparing 3-dihalobenzyl-2,4-quinazolinedione derivatives of general formula (V) (wherein X , X , and X are each halogeno; and A is alkylene) by reacting a dihalobenzyl derivative of general formula (III) (wherein L is an acid residue; and X and X are each as defined above) with a carboxylalkylated 2,4-quinazolinedione derivative of general formula (I) (wherein X and A are each as defined above) to selectively replace the imino hydrogen atom of the derivative (I). The above process enables the efficient preparation of the compounds of general formula (V) useful as inhibitors against aldose reductases, makes it possible to secure the safety and hygiene of workers, and can facilitate waste disposal to reduce the expenses, thus being industrially extremely advantageous.
摘要翻译：制备通式（V）的3-二卤代苄基-2,4-喹唑啉二酮衍生物（其中X 1，X 2和X 3各自为卤素，A为亚烷基）的方法，通式（III）（其中L是酸残基; X 2和X 3各自如上所定义）的衍生物与通式（I）的羧基烷基化2,4-喹唑酮二酮衍生物（其中X < 1>和A各自如上所定义），以选择性地取代衍生物（I）的亚氨基氢原子。上述方法能够有效地制备可用作抑制醛糖还原酶的通式（Ⅴ）的化合物，使得有可能确保工人的安全和卫生，并且可以促进废物处理以降低费用，从而在工业上极其有利。

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