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1. 发明申请

WO0232974A3 POLYMER AND ITS USE FOR THE TREATMENT AND/OR PREVENTION OF HYPERPHOSPHOREMIA 审中-公开
标题翻译：聚合物及其用于治疗和/或预防高磷血症的用途
公开(公告)号：WO0232974A3
公开(公告)日：2003-02-20
申请号：PCT/JP0107958
申请日：2001-09-13
申请人： FUJISAWA PHARMACEUTICAL CO , YAMADA AKIRA , SHIMAZAKI NORIHIKO , NAKAYAMA OSAMU , SHOBO MIWAKO , NAKAJIMA YOSHIMITSU , SAWADA HIDEO
发明人： YAMADA AKIRA , SHIMAZAKI NORIHIKO , NAKAYAMA OSAMU , SHOBO MIWAKO , NAKAJIMA YOSHIMITSU , SAWADA HIDEO
IPC分类号： A61K31/74 , C08F220/00 , C08F226/00 , C08F230/08 , C08F251/02 , C08F20/00 , C08F26/00 , C08F30/08
CPC分类号： C08F220/00 , A61K31/74 , C08F226/00 , C08F230/08 , C08F251/02
摘要： A polymer or its salt which is obtainable by polymerization of a monomer of the formula (I) or its salt in the presence of a radical initiator, or by polymerization of a monomer of the formula (I) or its salt with a monomer of the formula (II) or its salt in a molar ratio of (I): (II) being 1:0.1 to 1:25 in the presence of a radical initiatorwherein R1 and R3 are each hydrogen atom or lower alkyl group, R2 and R4 are each acyl group,aliphatic silyl group,amino lower alkyl group which may have one or more suitable substituent(s),heterocyclic group which may have one or more suitable substituent(s) orcarboxy group esterified by the residue of cellulose optionally substituted with one or more lower alkyl and/or lower alkenoyl.
摘要翻译：聚合物或其盐，其可以通过在自由基引发剂的存在下聚合式（I）的单体或其盐，或通过式（I）的单体或其盐与单体的聚合式（II）或其盐在自由基引发剂存在下为（I）：（II）的摩尔比为1:0.1至1:25，其中R 1和R 3各自为氢原子或低级烷基，R 2和R 4为每个酰基，脂族甲硅烷基，可具有一个或多个合适取代基的氨基低级烷基，可具有一个或多个合适的取代基的杂环基或被任选被一个或多个取代基取代的纤维素残基的羧基残基酯化的羧基，更低级烷基和/或低级烯酰基。

2. 发明申请

WO03028739A2 COMPOSITION FOR PREVENTING OR TREATING HYPERLIPIDEMIA OR HYPERGLYCEMIA 审中-公开
标题翻译：用于预防或治疗高脂血症或高脂血症的组合物
公开(公告)号：WO03028739A2
公开(公告)日：2003-04-10
申请号：PCT/JP0209181
申请日：2002-09-09
申请人： FUJISAWA PHARMACEUTICAL CO , NAKAYAMA OSAMU , MURAMATSU YUKO , NAKAJIMA YOSHIMITSU , YAMADA AKIRA , SAWADA HIDEO
发明人： NAKAYAMA OSAMU , MURAMATSU YUKO , NAKAJIMA YOSHIMITSU , YAMADA AKIRA , SAWADA HIDEO
IPC分类号： A61K31/717 , A61K31/75 , A61K31/755 , A61K31/765 , A61K31/78 , A61K31/785 , A61K31/795 , A61K31/80 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10
CPC分类号： A61K31/717 , A61K31/75 , A61K31/755 , A61K31/765 , A61K31/78 , A61K31/785 , A61K31/795 , A61K31/80
摘要： A composition for preventing or treating hyperlipidemia (e.g., hypercholesterolemia, hypertriglyceridemia) or hyperglycemia comprising a polymer or its salt which is obtainable by polymerization of a monomer of the formula (I) or its salt in the presence of a radical initiator, or by polymerization of a monomer of the formula (I) or its salt with a monomer of the formula (II) or its salt in a molar ratio of (I) : (II) being 1:0.1 to 1:25 in the presence of a radical initiator wherein R1, R2, R3, R4 are as defined in the description as an active ingredient, in association with a pharmaceutically acceptable, non-toxic carrier or excipient.
摘要翻译：用于预防或治疗高脂血症（例如，高胆固醇血症，高甘油三酯血症）或高血糖的组合物，其包含通过在自由基引发剂存在下聚合式（I）或其盐的单体或通过聚合获得的聚合物或其盐的式（I）的单体或其盐与式（II）的单体或其盐的摩尔比为（I）：（II）的摩尔比为1:0.1至1:25，在基团存在下引发剂，其中R 1，R 2，R 3，R 4如说明书中所定义为活性成分，与药学上可接受的无毒载体或赋形剂结合。

3. 发明申请

WO0187845A3 N-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS 5-HT ANTAGONISTS 审中-公开
标题翻译：含N-杂环化合物及其作为5-HT拮抗剂使用
公开(公告)号：WO0187845A3
公开(公告)日：2002-08-29
申请号：PCT/JP0104002
申请日：2001-05-14
申请人： FUJISAWA PHARMACEUTICAL CO , YAMADA AKIRA , SPEARS GLEN , HAYASHIDA HISASHI , TOMISHIMA MASAKI , ITO KIYOTAKA , IMANISHI MASASHI
发明人： YAMADA AKIRA , SPEARS GLEN , HAYASHIDA HISASHI , TOMISHIMA MASAKI , ITO KIYOTAKA , IMANISHI MASASHI
IPC分类号： A61P43/00 , C07D217/08 , C07D237/26 , C07D261/20 , C07D277/60 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D521/00 , C07D217/22 , A61K31/395 , C07D237/34
CPC分类号： C07D277/60 , C07D217/08 , C07D231/12 , C07D233/56 , C07D237/26 , C07D249/08 , C07D261/20 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04
摘要： A compound of the formula (I): wherein A is a hydrogen atom, an optionally substituted, unsaturated, N-containing heterocyclic group or a group of the formula (a) : wherein R is an optionally substituted aryl group or an optionally substituted heterocyclic group;M is -(CH2)n-, -(CH2)n-O-(CH2)m- or -(CH2)n-NH-(CH2)m-, wherein n and m are independently 0,1 or 2; Q is an optionally substituted cycloalkylene group, an optionally substituted arylene group or an optionally substituted divalent heterocyclic group; andthe moiety of the formula (b): is an optionally substituted, unsaturated, mono-, di-, tri- or tetra-cyclic, N-containing heterocyclic group which may contain additional hetero atom(s) selected from the group consisting of nitrogen, oxygen and sulfur atoms as the ring member(s), its prodrug or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的化合物：其中A是氢原子，任选取代的，不饱和的含N杂环基或式（a）的基团：其中R是任选取代的芳基或任选取代的杂环基团; M是 - （CH 2）n - ， - （CH 2）n O-（CH 2）m - 或 - （CH 2）n -NH-（CH 2）m - ，其中n和m独立地为0,1或2; Q是任选取代的亚环烷基，任选取代的亚芳基或任选取代的二价杂环基; 和式（b）的部分：是任选取代的，不饱和的，单，二，三或四环的含N的杂环基团，其可以含有另外的选自氮的杂原子，作为环成员的氧和硫原子，其前药或其药学上可接受的盐。

4. 发明申请

WO9531887A2 EXOTHERMIC FATIGUE MEASUREMENT METHOD OF VISCOELASTIC BODY AND HYDRAULIC SERVO SYSTEM FLEXOMETER 审中-公开
标题翻译：粘弹性和液压伺服系统柔性仪的超热疲劳测量方法
公开(公告)号：WO9531887A2
公开(公告)日：1995-11-30
申请号：PCT/JP9501762
申请日：1995-09-05
申请人： BRIDGESTONE CORP , ONO SHIGEKI , SATOH CHIKAHIRO , YAMADA AKIRA
发明人： ONO SHIGEKI , SATOH CHIKAHIRO , YAMADA AKIRA
IPC分类号： G01N25/20 , G01N3/00 , G01N3/34 , G01N3/36 , G01N33/44
CPC分类号： G01N3/36 , G01N33/44 , G01N2203/0016 , G01N2203/0048 , G01N2203/0073 , G01N2203/0094 , G01N2203/0222
摘要： It is a main object of the present invention to provide an exothermic fatigue measurement method of viscoelastic body and a hydraulic servo system flexometer which make it possible to directly measure a strain (displacement) applied to a testpiece and a stress (load), control the stress acting on the testpiece by hydraulic servo feedback control on the basis of the strain and the stress so measured, and accomplish high precision measurement. The hydraulic servo system flexometer according to the present invention includes an upper anvil (22) and a lower anvil (18) whose mutually opposing parallel planes form testpiece retaining surfaces, a hydraulic servo cylinder (19) whose piston rod (21) is connected to the upper or lower anvil (22 or 18) and operates in a direction perpendicular to the testpiece retaining surfaces, and a hydraulic servo mechanism for applying static and dynamic loads to the testpiece (23).
摘要翻译：本发明的主要目的是提供一种粘弹性体的放热疲劳测量方法和液压伺服系统挠度计，其可以直接测量施加于试件的应变（位移）和应力（载荷），控制通过液压伺服反馈控制，在应变和应力测量的基础上作用在试件上，实现高精度测量。根据本发明的液压伺服系统挠度计包括相互相对的平行平面形成试件保持面的上砧座（22）和下砧座（18），其活塞杆（21）连接到上部或下部砧座（22或18）并且在垂直于试件保持表面的方向上操作，以及用于向试件（23）施加静态和动态载荷的液压伺服机构。

5. 发明专利

CA2610879A1 JOINING DEVICE OF PASSAGE BLOCK 未知
公开(公告)号：CA2610879A1
公开(公告)日：2006-12-14
申请号：CA2610879
申请日：2005-06-09
申请人： YAMADA AKIRA
发明人： YAMADA AKIRA
IPC分类号： F17D1/08 , F17D1/02
摘要： A joining device of a passage block, comprising bolt insertion holes (13) and pin insertion holes (14) formed in an upper passage block (3), screw holes (15) and non-screw holes (16) formed in a lower passage block (4), bolts (11) inserted into the bolt insertion holes (13) and threaded with the screw holes (15), and positioning pins (12) inserted into the pin insertion holes (14) and fitted to the non-screw holes (16) at their lower end parts. A cutout part (17) is formed in the positioning pin (12) near its lower end, and a projected part (18) fitted to the cutout part (17) is formed at the opening part of the non-screw hole (16). Since the tightening force of the bolt (11) and a force applied to the projected part (18) of the non-screw hole (16) by the positioning pin (12) when the lower end part of the positioning pin (12) pushes the projected part upward are balanced each other, uniform tightening can be achieved and the passage blocks (3) and (4) can be joined to each other.

6. 发明申请

WO2008052066A3 METHOD AND APPARATUS FOR ACCESS POINT SELECTION IN WIRELESS LAN 审中-公开
标题翻译：用于无线局域网中接入点选择的方法和装置
公开(公告)号：WO2008052066A3
公开(公告)日：2008-07-10
申请号：PCT/US2007082403
申请日：2007-10-24
申请人： NTT DOCOMO INC , DU LEI , BAI YONG , CHEN LAN , WATANABE FUJIO , YAMADA AKIRA
发明人： DU LEI , BAI YONG , CHEN LAN , WATANABE FUJIO , YAMADA AKIRA
IPC分类号： H04W48/20
CPC分类号： H04W48/20
摘要： A method and an apparatus select an access point (AP) in a wireless LAN to associate or reassociate, based on considerations that take into account the quality-of-service (QoS) status of the stations (STAs) and the potential hidden terminal effect. The method utilizes advertised or requested information obtained from an AP which includes the QoS status in each basic service set (BSS) and estimates the potential hidden terminal (HT) effect based on local channel sensing by the STA. The method selects the AP in a manner that reduces the possibility of collision from equal and higher priority HTs, thus providing greater transmission throughput and improving performance.
摘要翻译：一种方法和设备基于考虑到站（STA）的服务质量（QoS）状态和潜在的隐藏终端效应的考虑因素来选择无线LAN中的接入点（AP）以关联或重新关联。该方法利用从AP获得的广告或请求的信息，该信息包括每个基本服务集（BSS）中的QoS状态，并且基于STA的本地信道感测来估计潜在的隐藏终端（HT）效应。该方法以降低来自同等和更高优先级HT的冲突可能性的方式来选择AP，从而提供更大的传输吞吐量并改善性能。

7. 发明公开

EP1264820A4 NOVEL AMIDE COMPOUNDS 审中-公开
标题翻译：酰胺化合物
公开(公告)号：EP1264820A4
公开(公告)日：2004-09-15
申请号：EP01912338
申请日：2001-03-13
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： YAMADA AKIRA , TOMISHIMA MASAKI , HAYASHIDA HISASHI , IMANISHI MASASHI , SPEARS GLEN W , ITO KIYOTAKA , TAKAHASHI FUMIE , MIYAKE HIROSHI
IPC分类号： C07C205/12 , C07C233/75 , C07C257/18 , C07C311/08 , C07D209/08 , C07D209/18 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/82 , C07D213/89 , C07D215/38 , C07D217/22 , C07D233/54 , C07D235/18 , C07D235/30 , C07D237/20 , C07D239/26 , C07D239/42 , C07D249/14 , C07D253/07 , C07D261/14 , C07D261/20 , C07D263/32 , C07D277/30 , C07D277/42 , C07D277/64 , C07D285/12 , C07D285/135 , C07D295/185 , C07D311/22 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/33 , A61P25/28
CPC分类号： C07C205/12 , C07C233/75 , C07C257/18 , C07C311/08 , C07D209/08 , C07D209/18 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/82 , C07D213/89 , C07D215/38 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/18 , C07D235/30 , C07D237/20 , C07D239/26 , C07D239/42 , C07D249/08 , C07D249/14 , C07D253/07 , C07D261/14 , C07D261/20 , C07D263/32 , C07D277/30 , C07D277/42 , C07D277/64 , C07D285/135 , C07D295/185 , C07D311/22 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： A compound represented by the general formula (I) and a salt thereof: R1-A-X-NHCO-Y-R2 wherein R1 is an optionally substituted heterocyclic group or optionally substituted phenyl; R2 is optionally substituted fused phenyl, optionally substituted phenyl, or optionally substituted thienyl; A is a group represented by the formula -(CH¿2?)t-(O)m- or (wherein R?3 and R4¿ each is hydrogen or R?3 and R4¿ in combination form imino; R5 is hydrogen or lower alkyl; t is 0, 1, or 2; and p, m, and n each is 0 or 1); X is optionally substituted phenylene or an optionally substituted, divalent, nitrogenous heterocyclic group; and Y is a bond, lower alkylene, or lower alkenylene.

8. 发明专利

JP2001220375A NEW AMIDE COMPOUND 失效
公开(公告)号：JP2001220375A
公开(公告)日：2001-08-14
申请号：JP2000359201
申请日：2000-11-27
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： ITO KIYOTAKA , GLEN W SPEARS , YAMADA AKIRA , TOMIJIMA MASANORI , KATO MASAYUKI
IPC分类号： C07D213/36 , A61K31/167 , A61K31/335 , A61K31/403 , A61K31/404 , A61K31/4402 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07C257/18 , C07D209/42 , C07D209/88 , C07D209/94 , C07D313/08
摘要： PROBLEM TO BE SOLVED: To obtain a new amide compound or its salt, in detail, a new amide compound having a pharmacological activity such as 5-hydroxytryptamine (5-HT) antagonism, etc., or its salt. SOLUTION: This compound is represented by general formula (I) R1-A- X-NHCO-R2 (I) (R1 is an aryl group which may contain a substituent group or a heterocyclic group which may contain a substituent group; R2 is a condensed phenyl group which may contain a substituent group, a phenyl group which may contain a substituent group or an indolin-1-yl group substituted with a lower alkylthio group and a trihalo (lower) alkyl group; A is a group of formula (II) or group (III) (R3, R4 and R5 are each a hydrogen atom or a lower alkyl group); X is a phenylene group or a lower alkylene group) or its salt.

9. 发明专利

JPH021490A 3-ALKENYL-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUND 失效
公开(公告)号：JPH021490A
公开(公告)日：1990-01-05
申请号：JP4276989
申请日：1989-02-22
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MURATA MASAYOSHI , CHIBA TOSHIYUKI , YAMADA AKIRA
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/14
摘要： NEW MATERIAL:The compound of formula I [R is (protected) carboxy; R is (protected) hydroxy-lower alkyl; R and R are H or lower alkyl; R is (substituted) aliphatic heterocyclic group]. EXAMPLE:(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(E)-2-{(2S)pyrrolidin -2-yl}-1- methylethenyl]-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid. USE:An antibacterial agent effective against Gram-positive bacteria and Gram-negative bacteria. It is stable to dehydropeptidase and discharged in urine at a high ratio. PREPARATION:A compound of formula II (R is aryl or lower alkoxy) is cyclized. The starting compound of formula II is a novel substance which can be produced, e.g., by reacting a compound of formula III with a compound of formula IV.

10. 发明专利

JPH11349572A NEW AMIDE DERIVATIVE AND SALT THEREOF 失效
公开(公告)号：JPH11349572A
公开(公告)日：1999-12-21
申请号：JP9896999
申请日：1999-04-06
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： ITO KIYOTAKA , GLEN W SPEARS , TAKAHASHI FUMIE , YAMADA AKIRA , TOMIJIMA MASANORI , MIYAKE HIROSHI
IPC分类号： C07D249/08 , C07D233/56 , C07D233/61 , C07D233/64 , C07D233/88 , C07D235/08 , C07D263/32 , C07D277/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07D521/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject new compound having pharmacological activities such as a hydroxytryptamine antagonistic activity, etc. SOLUTION: This pyrazole is a compound of formula I [R is a (substituted) heterocyclic ring; R is H, a lower alkyl; a lower alkoxy or the like], e.g. N-(2,2- dimethoxyethyl)-3-nitroaniline. The compound of formula I is obtained by reacting a compound of formula II or its reactive derivative at its amino group (e.g.; a Schiff base type imino or its enamine-type tautomer or the like formed by a reaction of the compound of formula II with a carbonyl compound) with a compound of the formula: R -COOH or its reactive derivative at its carboxy group (acid chloride, acid azide or the like). The above compound has a 5- hydroxytryptamine antagonistic activity, and useful for the prevention and treatment of anxiety, depression, obsessive-compulsive neurosis, migraine, etc. In order to administer the above compound as an active ingredient, it is preferable to use the compound by approximately 0.01-500 mg daily.

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