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1. 发明申请

WO2012076386A1 INSERT AND VIAL FOR THE INFUSION OF LIQUIDS 审中-公开
标题翻译：插入和渗透液体渗透
公开(公告)号：WO2012076386A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/071452
申请日：2011-12-01
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , FINI, Massimo , VENERONI, Alain , WEHMEYER, Wolfgang , HOFMANN, Wolfgang
发明人： FINI, Massimo , VENERONI, Alain , WEHMEYER, Wolfgang , HOFMANN, Wolfgang
IPC分类号： A61J1/14 , A61J1/20 , A61M5/162
CPC分类号： A61M5/162 , A61J1/1406 , A61J1/20 , A61J1/2031 , A61J1/2065 , A61J1/2089 , B65B3/003
摘要： The present invention relates to an insert (40) and a vial (30) for the infusion of a liquid (80). The vial (30) comprises a hollow body (31) for storing the liquid (80), a grasp portion (38) and a head (32). The head comprises a delivery opening (33) defining an axis (X), a closing septum (34) suitable for closing the delivery opening; and at least one circumferential push surface (35) defined next to the head by a protrusion. The circumferential push surface is firmly connected to the grasp portion. The insert (40) according to the invention is suitable to delivery the liquid (80) and to receive the insertion along axis (X) of the vial. The insert comprises a main body (41) and an inner part (42). The main body comprises a lateral wall (410) and a lower delivery portion (411) defining a first lower duct (511) and a second lower duct (521). The inner part comprises an inner wall (420) and a piercing spike (421). The inner wall (420) defines a seat (422) suitable to receive the head of the vial, and comprises at least one slit (423) suitable to engage a radially inner portion (350) of the at least one circumferential push surface of the vial. The piercing spike is suitable to pierce the closing septum of the vial and defines a first upper duct (510) and a second upper duct (520). The inner part is housed inside the main body so as to be able to rotate with respect to the latter around axis (X). In particular, the inner part is able to rotate between: a fluidly open configuration A wherein the upper ducts are in fluid communication with the lower ducts; and a fluidly closed configuration (B) wherein the upper ducts are not in fluid communication with the lower ducts.
摘要翻译：本发明涉及用于液体（80）的注入的插入件（40）和小瓶（30）。小瓶（30）包括用于储存液体（80）的空心体（31），把持部分（38）和头部（32）。头部包括限定轴线（X）的输送开口（33），适于关闭输送口的闭合隔膜（34）; 以及至少一个周向推动表面（35），该周向推动表面（35）由突出部限定在头部附近。周向推动表面牢固地连接到抓握部分。根据本发明的插入件（40）适于输送液体（80）并且沿着小瓶的轴线（X）接收插入物。插入件包括主体（41）和内部部件（42）。主体包括限定第一下部管道（511）和第二下部管道（521）的侧壁（410）和下部输送部分（411）。内部部分包括内壁（420）和穿刺尖（421）。所述内壁（420）限定适于容纳所述小瓶的头部的座（422），并且包括适于接合所述至少一个周向推动表面的径向内部（350）的至少一个狭缝（423）小瓶。穿刺尖端适于刺穿小瓶的闭合隔膜并且限定第一上部管道（510）和第二上部管道（520）。内部容纳在主体内，以能够相对于主体绕轴线（X）旋转。特别地，内部部分能够在以下方面之间旋转：流体打开构型A，其中上部管道与下部管道流体连通; 以及流体关闭的构造（B），其中上部管道不与下部管道流体连通。

2. 发明申请

WO2011054693A1 TUBING SET HAVING A GATE FOR THE CONNECTION OF VIALS 审中-公开
标题翻译：具有连接门的管道
公开(公告)号：WO2011054693A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/066056
申请日：2010-10-25
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , REITER, Reinhold , FINI, Massimo , VENERONI, Alain , BARTHOLOMÄUS, Johannes , WIESEN, Gerhard
发明人： REITER, Reinhold , FINI, Massimo , VENERONI, Alain , BARTHOLOMÄUS, Johannes , WIESEN, Gerhard
IPC分类号： A61M1/34
CPC分类号： A61M1/3672 , A61M1/3621 , A61M1/3627 , A61M2205/07 , A61M2205/3331
摘要： The present invention refers to a tubing set (12) suitable for use in co-operation with a hemodialysis machine (10). The tubing set comprises: an out-tube (14) for supplying the blood from the patient to a filter (16) of the machine; an in-tube (18) for supplying the blood from the filter back to the patient; a drip chamber (20) placed along one of said tubes, adapted to let the blood drip through an air buffer (22); and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the blood. The vial gate (24) according to the invention comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the drip chamber, and a vent lumen (32), suitable for providing air (34) inside the vial in order to replace the delivered drug.
摘要翻译：本发明涉及适用于与血液透析机（10）合作的管组（12）。管组包括：用于将血液从患者提供给机器的过滤器（16）的外管（14）; 用于将来自过滤器的血液提供给患者的管内（18）; 沿着所述管中的一个放置一个适于使血液通过空气缓冲器（22）滴落的滴水室（20）; 以及用于连接含有要输送到血液中的药物的小瓶（26）的小瓶门（24）。根据本发明的小瓶门（24）包括适于将药物（30）从小瓶输送到滴液室的输送腔（28）和适于在内部提供空气（34）的排气腔（32）该小瓶为了更换递送的药物。

3. 发明申请

WO2011092068A1 INSERT FOR THE INFUSION OF DRUGS 审中-公开
标题翻译：插入药物输注
公开(公告)号：WO2011092068A1
公开(公告)日：2011-08-04
申请号：PCT/EP2011/050517
申请日：2011-01-17
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , VENERONI, Alain , FINI, Massimo
发明人： VENERONI, Alain , FINI, Massimo
IPC分类号： A61M39/26 , A61J1/20
CPC分类号： A61M39/26 , A61M5/162 , A61M2039/267 , A61M2039/268
摘要： The present invention relates to an insert 20 for the infusion of drugs. The insert 20 is suitable for connection Io a vial 18 and preferably to a circuit 16 or an infusion line. Moreover the insert comprises a main body 22, a resilient element 24 and a piercing spike 26, The piercing spike has an axis X and defines a first channel 261 and a second channel 262 and is movable relative to the main body along the axis X between a first closed position A and a second open position B. Moreover the resilient element presses against the piercing spike so as to keep it in the first closed position A when no external forces are applied.
摘要翻译：本发明涉及用于输注药物的插入件20。插入件20适于连接到小瓶18并且优选地连接到电路16或输注线。此外，插入件包括主体22，弹性元件24和刺穿尖钉26.刺穿尖钉具有轴线X并且限定第一通道261和第二通道262，并且可相对于主体沿轴线X相对于主体第一关闭位置A和第二打开位置B.此外，弹性元件压靠刺穿尖钉，以便当不施加外力时将其保持在第一关闭位置A。

4. 发明申请

WO2011054497A1 MEDIKAMENTENAPPLIKATIONSADAPTER MIT GASSPERRELEMENT FÜR EIN HÄMODIALYSESCHLAUCHSET 审中-公开
标题翻译：具有气体阻隔元件FOR AHÄMODIALYSESCHLAUCHSET药物应用连接
公开(公告)号：WO2011054497A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/006691
申请日：2010-11-03
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , FINI, Massimo , WEISS, Stefan , TERPIN, Andreas , VENERONI, Alain
发明人： FINI, Massimo , WEISS, Stefan , TERPIN, Andreas , VENERONI, Alain
IPC分类号： A61M5/162
CPC分类号： A61M5/162 , A61M1/14 , A61M1/3621 , A61M1/3627 , A61M5/1411 , A61M5/155 , A61M5/38 , A61M5/385 , A61M5/40 , A61M2005/1623 , A61M2205/7509 , A61M2205/7518 , A61M2205/7527 , A61M2205/7536
摘要： Zur Administration von Medikamenten wird ein Adapter zum Anschluss an ein Hämodialyseschlauchset zur Verfügung gestellt, der den direkten Anschluss einer handelsüblichen Durchstechflasche (22) an den extrakorporalen Kreislauf ermöglicht unter Vermeidung der Einbringung von Luft in den Kreislauf. Der Adapter besitzt zwei Leitungswege (10, 11). Der Leitungsweg zur Medikamentenapplikation enthält ein Gassperrelement (12). Der zweite Leitungsweg dient zur Belüftung der Durchstechflasche.
摘要翻译：对于药物的给药，适配器被提供用于连接到Hämodialyseschlauchset，这允许体外回路标准小瓶（22）的直接连接，同时避免引入空气进入循环。该适配器具有两个导电路径（10，11）。对的含有阻气性部件（12）的药物应用的导通路径。第二传导通路用于泄小瓶中。

5. 发明申请

WO2013079160A1 CONNECTOR WITH DOUBLE LUMEN TUBE 审中-公开
标题翻译：双管连接器
公开(公告)号：WO2013079160A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/004718
申请日：2012-11-14
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , VENERONI, Alain , FINI, Massimo
发明人： VENERONI, Alain , FINI, Massimo
IPC分类号： A61M39/08 , A61M39/10
CPC分类号： F16L9/19 , A61M39/08 , A61M39/105 , A61M2039/082 , Y10T137/0318 , Y10T156/10
摘要： The present invention relates to the invention relates to an assembly of a dual lumen tubing as described above and a dual bore connector as described above having a first flow conduit along the first lumen and the first bore, and having a second flow conduit from the second bore, via a circumferential groove and along the second lumen. Such an assembly may be used in connection with an extracorporeal circuit of a haemodialysis machine or an infusion set.
摘要翻译：本发明涉及如上所述的双腔管组件和如上所述的双孔连接器，其具有沿着第一内腔和第一孔的第一流动管道，并且具有来自第二管腔的第二流动管道通过周向凹槽并沿着第二内腔。这样的组件可以与血液透析机或输液器的体外回路结合使用。

6. 发明申请

WO2011141200A1 TUBING SET HAVING AN IMPROVED GATE FOR THE CONNECTION OF VIALS 审中-公开
标题翻译：管道设有一个改进的门，用于连接六角形
公开(公告)号：WO2011141200A1
公开(公告)日：2011-11-17
申请号：PCT/EP2011/053936
申请日：2011-03-16
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GmbH , FINI, Massimo , VENERONI, Alain
发明人： FINI, Massimo , VENERONI, Alain
IPC分类号： A61M5/162
CPC分类号： A61M5/162 , A61M2005/1623
摘要： The present invention refers to a tubing set (12) suitable for use in co-operation with a medical liquid delivery device (10). The tubing set comprises: a delivery tube (68) suitable for supplying a medical liquid or blood to a patient; and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the medical liquid or blood. The vial gate comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the delivery tube; and a vent lumen (32), suitable for providing a replacement fluid (34, 60) from a location (20, 64) inside the tubing set (12) to the inside of the vial in order to replace the delivered drug. The vial gate according to the invention further comprises at least one one-way valve (70, 72) placed along said vent lumen or said delivery lumen.
摘要翻译：本发明涉及一种适用于与医用液体输送装置（10）配合使用的管道组件（12）。管组包括：适于向患者供应医用液体或血液的输送管（68）以及用于连接含有要输送到医用液体或血液中的药物的小瓶（26）的小瓶门（24）。小瓶门包括适于将药物（30）从小瓶输送到输送管的递送腔（28）; 和排气腔（32），其适于从所述管组（12）内部的位置（20,64）提供到所述小瓶内部的替换流体（34,60），以便替换所递送的药物。根据本发明的小瓶门还包括沿着所述通气腔或所述输送腔放置的至少一个单向阀（70,72）。

7. 发明申请

WO2011134859A1 MEMBRANE FOR A PRESSURE DOME 审中-公开
标题翻译：压力杯的薄膜
公开(公告)号：WO2011134859A1
公开(公告)日：2011-11-03
申请号：PCT/EP2011/056321
申请日：2011-04-20
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GmbH , FINI, Massimo , REITER, Reinhold , DONARINI, Luca
发明人： FINI, Massimo , REITER, Reinhold , DONARINI, Luca
IPC分类号： A61M1/36
CPC分类号： G01L19/14 , A61M1/3639 , A61M1/3641 , G01L7/08
摘要： The present invention relates to a membrane (12) for a pressure dome (10) suitable for cooperation with a pressure sensor (22). The membrane comprises a resilient circular Avail (120) suitable for closing one side of the pressure dome (10) so as to define a partition between the inside of the pressure dome and the outside; and a circular rim (124) suitable for being joined to a main body (16) of the pressure dome. The membrane is characterized in that the resilient circular wall, when there is no difference between the pressures acting respectively on the inner surface (121) and on the outer surface (122), has an outwardly convex form. The invention also relates to a pressure dome comprising the membrane.
摘要翻译：本发明涉及一种用于与压力传感器（22）配合的用于压力圆顶（10）的膜（12）。所述膜包括适于封闭所述压力圆顶（10）的一侧以便限定所述压力圆顶的内部与所述外部之间的间隔的弹性圆形可动（120）; 以及适于连接到压力圆顶的主体（16）的圆形边缘（124）。膜的特征在于，当分别作用在内表面（121）和外表面（122）上的压力之间没有差异时，弹性圆形壁具有向外凸的形式。本发明还涉及包括膜的压力圆顶。

8. 发明申请

WO2010133515A1 SAFETY INSERT FOR EXTRA-CORPOREAL CIRCUITS 审中-公开
标题翻译：安全门禁用于外部电路
公开(公告)号：WO2010133515A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056640
申请日：2010-05-14
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , FINI, Massimo
发明人： FINI, Massimo
IPC分类号： A61M1/36 , G01L19/06
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/15 , A61M2205/16 , A61M2205/7536 , G01L19/003 , G01L19/0636 , Y10T428/13
摘要： The present invention relates to a safety insert 20 for an extra-corporeal circuit 19. The safety insert, comprises: a first half-shell 21 and a second half-shell 22 forming a shell 212 defining an inner duct 221, at least part of the second half-shell being made with a translucent or transparent material; a first tubular connector 25 adapted to be connected to a branch pipe 27 from the extra-corporeal circuit, and a second tubular connector 26 defined by the first half-shell and adapted to be connected to a transducer 28; and a first hydrophobic semi-permeable membrane 23 having a first membrane area A 1 and a second hydrophobic semi-permeable membrane 24 having a second membrane area A 2 , said two membranes being arranged in series along said inner duct 221. In a front view, the extent of an overlapping area A 12 of said membranes is comprised between 0% and 50% of the smaller of said two membrane areas A 1 , A 2 . The inventions further relates to an extra-corporeal circuit 19 comprising the above safety insert.
摘要翻译：本发明涉及一种用于体外电路19的安全插入件20.安全插入件包括：第一半壳体21和第二半壳体22，其形成限定内部管道221的壳体212，至少部分第二半壳由半透明或透明材料制成; 第一管状连接器25，适于从额外的体电路连接到分支管27;以及由第一半壳限定并适于连接到换能器28的第二管状连接器26; 以及具有第一膜面积A1的第一疏水性半透膜23和具有第二膜面积A2的第二疏水性半透膜24，所述两个膜沿着所述内管221串联布置。在正视图中，所述膜的重叠区域A12的程度在所述两个膜区域A1，A2中较小者的0％至50％之间。本发明还涉及一种包括上述安全插入件的超体电路19。

9. 发明申请

WO2012004123A1 DISPOSABLE CONNECTOR FOR HEMOFILTRATION 审中-公开
标题翻译：用于HEMOFILTRATION的替代连接器
公开(公告)号：WO2012004123A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/060314
申请日：2011-06-21
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , REITER, Reinhold , FINI, Massimo , VAIANO, Andrea
发明人： REITER, Reinhold , FINI, Massimo , VAIANO, Andrea
IPC分类号： A61M39/06 , A61M39/10
CPC分类号： A61M39/10 , A61M1/367 , A61M39/06 , A61M2039/1027 , A61M2039/1077 , F16L55/00 , Y10T137/9029
摘要： The present invention refers to a disposable connector 20 suitable for engagement on the substitution port 180 of a hemo filtration machine 18. The connector 20 comprises: a rigid main body 22 defining a duct 220; and a soft element 24 fitted on an end of the main body 22. In the connector 20 according to the invention, the soft element 24 comprises a membrane 240 occluding the duct 220 and performing a valve function; and a seal portion 242 radially expanding outward of the duct 220.
摘要翻译：本发明涉及适于接合血液过滤机18的替代口180的一次性连接器20.连接器20包括：限定管道220的刚性主体22; 以及安装在主体22的端部上的软元件24.在根据本发明的连接器20中，软元件24包括封闭管道220并执行阀功能的膜240; 以及径向向外延伸到管道220的密封部分242。

10. 发明申请

WO2011039306A1 TUBING SET HAVING AN INSERT FOR THE INFUSION OF DRUGS 审中-公开
标题翻译：用于输送药物的插管
公开(公告)号：WO2011039306A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064559
申请日：2010-09-30
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , REITER, Reinhold , FINI, Massimo
发明人： REITER, Reinhold , FINI, Massimo
IPC分类号： A61J1/06 , A61M1/14 , A61M1/34 , A61M39/06 , A61M39/02
CPC分类号： A61M39/02 , A61J1/06 , A61M1/342 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M5/1409 , A61M5/142 , A61M5/162 , A61M2039/0205 , A61M2039/242
摘要： The present invention refers to a tubing set (126) suitable for use in co-operation with a machine (100) for carrying out a hemodialysis treatment of a patient's blood. The tubing set comprises: a blood out-tube (102) for supplying the blood from the patient to a filter (106) of said machine; a blood in-tube (114) for supplying the blood from the filter back to the patient; and a substitution tube (116) connected to one of said blood in-tube or blood out-tube suitable for providing a substitution fluid in the patient's blood. According to the invention, the substitution tube comprises an insert (30) for the infusion of drugs. The invention further refers to the insert and to a vial (34) suitable to co-operate with the insert. The invention finally refers to a method for delivering drugs.
摘要翻译：本发明涉及一种适用于与机器（100）进行血液透析治疗的患者血液进行合作的管组（126）。管组包括：用于将血液从患者供给到所述机器的过滤器（106）的血液输出管（102）; 用于将来自过滤器的血液提供给患者的血管内管（114）以及替代管（116），其连接到适于在患者血液中提供置换液体的所述血管内或血管外管中的一个。根据本发明，替代管包括用于输注药物的插入物（30）。本发明还涉及插入件和适于与插入件配合的小瓶（34）。本发明最终是指用于递送药物的方法。

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