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1. 发明授权

US11000638B2 Method of monitoring the bicarbonate content and the sodium content of a dialysis solution 有权
公开(公告)号：US11000638B2
公开(公告)日：2021-05-11
申请号：US16321834
申请日：2017-08-03
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Alfred Gagel , Tilman Stablein , Jochen Popp
IPC分类号： A61M1/16 , A61K33/00 , G01N27/07
摘要： The present invention relates to a method of monitoring the bicarbonate content and the sodium content of a dialysis solution, wherein the dialysis solution is prepared while adding a bicarbonate component and an acidic sodium component, and wherein the method comprises the following steps: a. adding the acidic sodium component and measuring the conductivity (LFist,Na); b. adding the bicarbonate component and measuring the increase in conductivity (ΔLFist,BiC) caused by adding the bicarbonate component; c. determining the increase in conductivity (ΔLFexp,Bic) expected due to the addition of the bicarbonate component; d. checking whether the measured increase in conductivity (ΔLFist,Bic) lies in an expected range of the increase in conductivity (ΔLFexp,Bic); e. determining the total conductivity (LFexp,D) expected after the addition of the bicarbonate component and of the acidic sodium component; f. measuring the total conductivity (LFist,D) after the addition of the bicarbonate component and of the acidic sodium component; and g. checking whether the measured total conductivity (LFist,D) lies in an expected range of the total conductivity (LFexp,D), wherein the measurement of the conductivity in accordance with step a.; the measurement of the increase in conductivity in accordance with step b.; and the measurement of the total conductivity in accordance with step f. are carried out by one and the same conductivity measurement cell.

2. 发明授权

US10322219B2 Method of determining the pressure in an extracorporeal circuit 有权
公开(公告)号：US10322219B2
公开(公告)日：2019-06-18
申请号：US14785217
申请日：2014-04-14
申请人： Fresenius Medical Care Deutschland GmbH
发明人： Alfred Gagel , Benedict Glaser , Haitham Ibrahim , Pascal Kopperschmidt
IPC分类号： A61M1/36 , A61M1/14 , A61M1/30 , F04B43/12 , G01L7/00 , A61M1/10
摘要： The present invention relates to a method of determining the pressure or of a parameter correlated with the pressure in an extracorporeal circuit of a blood treatment apparatus, in particular of a dialyzer, wherein at least one blood pump which is driven by at least one motor is located in the blood circuit, wherein the motor current of the named motor and the blood flow or a parameter correlated therewith is measured for determining the pressure or the parameter correlated therewith and wherein the pressure p or the parameter correlated therewith is calculated from the measured values.

3. 发明授权

US10940258B2 Dialysis device having means for recognizing a shunt recirculation 有权
公开(公告)号：US10940258B2
公开(公告)日：2021-03-09
申请号：US16064220
申请日：2016-12-23
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Pascal Kopperschmidt , Alfred Gagel
IPC分类号： A61M1/34 , A61M1/36
摘要： A dialysis device having an extracorporeal blood circuit which has an arterial line having a blood pump and an arterial needle for connection to a patient, a venous line having a venous needle for connection to a patient and a dialyzer arranged between the arterial line and the venous line and having a blood chamber and a dialysis fluid chamber is provided. The dialysis device furthermore has a control unit and an extracorporeal blood pressure sensor which is arranged at the suction side of the blood pump. The control unit is configured such that a signal output takes place which indicates the presence of recirculation when a change in the signal of the sensor following a trigger event exceeds a threshold value.

4. 发明授权

US11883572B2 Dialysis machine and method of operating a dialysis machine 有权
公开(公告)号：US11883572B2
公开(公告)日：2024-01-30
申请号：US17042271
申请日：2019-03-26
申请人： Fresenius Medical Care Deutschland GmbH
发明人： Tobias Irrgang , Tilman Stäblein , Alfred Gagel , Peter Klöffel
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1603 , A61M1/168 , A61M2205/3317
摘要： The present invention relates to a dialysis machine that is configured to be equipped with an extracorporeal blood system comprising a dialysis solution system that is configured to be equipped with a dialyzer, wherein a mixing region, in particular a mixing chamber, is provided in which the fresh dialysis solution or a component thereof is located in the operation of the dialysis machine, with a concentrate line being in fluid communication with the mixing region, through which concentrate line concentrate can be conducted from a concentrate container into the mixing region, wherein at least two electrically conductive elements are arranged spaced apart from one another in or at the concentrate line or lines; that a measuring device is provided which is electrically connected to the conductive elements and which is configured to measure the conductance or a value correlated therewith between them; and that a control unit is provided which is configured to compare the measured value with a desired value, with a limit value, or with a desired value range.

5. 发明授权

US10967114B2 Dialysis machine 有权
公开(公告)号：US10967114B2
公开(公告)日：2021-04-06
申请号：US15513325
申请日：2015-09-25
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Alfred Gagel , Pascal Kopperschmidt , Thomas Nuernberger
IPC分类号： A61M1/34 , A61M1/36 , A61M1/26 , A61M1/16 , A61M1/14
摘要： A dialysis machine has a blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit. The control unit can operate the blood pump in a first operating mode and in a special operating mode, and start the special operating mode after a trigger event. In the special operating mode, a blood pump conveying rate is controlled via a default value or regulated to a desired value, with the default or desired value being derived from a value determined before the started special mode or corresponding to the value. The presence of an obstacle is polled before the special mode, and depending on the presence thereof, the start of the special mode is blocked or delayed and/or the selection of the default value or the desired value on the presence of the obstacle differs from the selection without the presence of the obstacle.

6. 发明授权

US10155077B2 Dialysis machine, and method of determining the calcification in a dialysis machine 有权
公开(公告)号：US10155077B2
公开(公告)日：2018-12-18
申请号：US14542947
申请日：2014-11-17
申请人： Fresenius Medical Care Deutschland GmbH , Christiane Koch
发明人： Andreas Maierhofer , Alfred Gagel , Malte Gross , Michael Koch
IPC分类号： A61M1/16
摘要： A dialysis machine has at least one filter for the filtration of dialysis liquid and a device for determining calcification of the dialysis machine. The device has one or more sensors configured and arranged to detect either downstream, or upstream and downstream, of the at least one filter an ion concentration or a parameter representative of the ion concentration or of its change of the dialysis liquid, of a solution serving the decalcification or of another measuring solution. The device for determining the calcification of the dialysis machine has an evaluation or calcification unit configured to determine the calcification of the dialysis machine based on the ion concentration or parameter value detected by the sensor or sensors.

7. 发明授权

US10010289B2 Method and device for monitoring an extracorporeal blood treatment of a patient 有权
公开(公告)号：US10010289B2
公开(公告)日：2018-07-03
申请号：US13917944
申请日：2013-06-14
申请人： Fresenius Medical Care Deutschland GmbH
发明人： Alfred Gagel , Andreas Maierhofer
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , A61M1/16 , A61B5/05 , A61M1/28 , A61M1/34
CPC分类号： A61B5/4848 , A61B5/0071 , A61B5/05 , A61B5/14546 , A61B5/1455 , A61B5/14558 , A61B5/4836 , A61B5/6866 , A61B5/7225 , A61M1/16 , A61M1/1609 , A61M1/1619 , A61M1/28 , A61M1/3406 , A61M2205/3306
摘要： The present invention pertains to Method for monitoring a dialysis treatment of a patient, preferably for monitoring a haemodialysis, haemodiafiltration and/or peritoneal dialysis treatment of a patient, the method including the steps of: irradiating a sample of a dialysis fluid used in the dialysis treatment with linearly polarized irradiation light; detecting the intensity of the fluorescence light emitted by the dialysis fluid in a first polarization plane; detecting the intensity of the fluorescence light emitted by the dialysis fluid in a second polarization plane which is different from the first polarization plane; determining the anisotropy of the fluorescence light emitted by the dialysis fluid; and determining the concentration of at least one fluorophore in the dialysis fluid on the basis of both, the determined anisotropy and the intensity of the fluorescence light emitted by the dialysis fluid.

8. 发明申请

US20170224897A1 Device And Method For Determining An Optimum Dialysate Flow For An Extracorporeal Blood Treatment With An Extracorporeal Blood Treatment Device 审中-公开
公开(公告)号：US20170224897A1
公开(公告)日：2017-08-10
申请号：US15501180
申请日：2015-07-20
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Pascal Kopperschmidt , Andreas Maierhofer , Alfred Gagel , Andreas Wupper , Ulrich Moissl
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/1615 , A61M1/1617 , A61M1/341 , A61M1/3413 , A61M2205/3334 , A61M2205/70
摘要： The invention relates to a method and to a device for determining an optimum dialysate flow Qdopt for an extracorporeal blood treatment and to a blood treatment device comprising a device 18 for determining an optimum dialysate flow Qdopt. The optimum dialysate flow Qdopt is determined on the basis of a relationship describing the dependence of the clearance K on the dialysate flow Qd. The device according to the invention comprises a measurement device 18B for measuring at least one value which is characteristic of the clearance K, a calculation and/or evaluation unit 18A of the device according to the invention being configured in such a way that the clearance K is determined on the basis of the at least one value which is characteristic of the clearance. The calculation and/or evaluation unit 18A is configured in such a way that the optimum dialysate flow Qdopt is determined from the relationship describing the dependence of the clearance K on the dialysate rate Qd on the basis of the measured clearance K, or the optimum dialysate flow Qdopt is determined from the measured clearance K.

9. 发明授权

US10881776B2 Control unit for detecting blood in a dialysate discharge line of a blood treatment device, and blood treatment device 有权
公开(公告)号：US10881776B2
公开(公告)日：2021-01-05
申请号：US16314643
申请日：2017-06-28
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Alfred Gagel
IPC分类号： A61M1/16 , A61M1/34
摘要： The invention relates to a control unit (30) for detecting an overshoot of a first limit value (G1) of a first blood concentration (B1) in a first portion (17a) of a dialysate discharge line (17) downstream of a dialysate chamber (7) of a dialyser (4) of a blood treatment device and upstream of a node point (110) at which a bypass line (100) bypassing the dialyser (4) leads into the dialysate discharge line (17), wherein the bypass line (100) branches off, upstream of the dialysate chamber (7), from a dialysate supply line (15) suitable for supplying dialysate from a dialysate source (16) to the dialysate chamber (7).

10. 发明授权

US10569001B2 Device and method for determining an optimum dialysate flow for an extracorporeal blood treatment with an extracorporeal blood treatment device 有权
公开(公告)号：US10569001B2
公开(公告)日：2020-02-25
申请号：US15501180
申请日：2015-07-20
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Pascal Kopperschmidt , Andreas Maierhofer , Alfred Gagel , Andreas Wupper , Ulrich Moissl
IPC分类号： A61M1/16 , A61M1/34
摘要： The invention relates to a method and to a device for determining an optimum dialysate flow Qdopt for an extracorporeal blood treatment and to a blood treatment device comprising a device 18 for determining an optimum dialysate flow Qdopt. The optimum dialysate flow Qdopt is determined on the basis of a relationship describing the dependence of the clearance K on the dialysate flow Qd. The device according to the invention comprises a measurement device 18B for measuring at least one value which is characteristic of the clearance K, a calculation and/or evaluation unit 18A of the device according to the invention being configured in such a way that the clearance K is determined on the basis of the at least one value which is characteristic of the clearance. The calculation and/or evaluation unit 18A is configured in such a way that the optimum dialysate flow Qdopt is determined from the relationship describing the dependence of the clearance K on the dialysate rate Qd on the basis of the measured clearance K, or the optimum dialysate flow Qdopt is determined from the measured clearance K.

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