专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005014050A3 CONJUGATES OF HYDROXYALKYL STARCH AND G-CSF 审中-公开
标题翻译：羟烷基淀粉和G-CSF的共轭物
公开(公告)号：WO2005014050A3
公开(公告)日：2005-04-14
申请号：PCT/EP2004008818
申请日：2004-08-06
申请人： FRESENIUS KABI DE GMBH , EICHNER WOLFRAM , KNOLLER HELMUT , LUTTERBECK KATHARINA , ZANDER NORBERT , FRANK RONALD , SOMMERMEYER KLAUS , CONRADT HARALD S , GRABENHORST ECKART
发明人： EICHNER WOLFRAM , KNOLLER HELMUT , LUTTERBECK KATHARINA , ZANDER NORBERT , FRANK RONALD , SOMMERMEYER KLAUS , CONRADT HARALD S , GRABENHORST ECKART
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a granulocyte colony stimulating factor protein (G-CSF) wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the methods of producing these conjugates and the use of these conjugates.
摘要翻译：本发明涉及羟烷基淀粉和粒细胞集落刺激因子蛋白（G-CSF）的缀合物，其中这些缀合物通过羟烷基淀粉或羟烷基淀粉的衍生物与蛋白质之间的共价键形成。本发明还涉及生产这些缀合物的方法以及这些缀合物的用途。

2. 发明申请

WO2005092369A3 CONJUGATES OF HYDROXYETHYL STARCH AND ERYTHROPOIETIN 审中-公开
标题翻译：羟乙基淀粉和蛋氨酸的结合
公开(公告)号：WO2005092369A3
公开(公告)日：2007-11-15
申请号：PCT/EP2005002639
申请日：2005-03-11
申请人： FRESENIUS KABI DE GMBH , EICHNER WOLFRAM , LUTTERBECK KATHARINA , ZANDER NORBERT , FRANK RONALD , KNOLLER HELMUT , CONRADT HARALD
发明人： EICHNER WOLFRAM , LUTTERBECK KATHARINA , ZANDER NORBERT , FRANK RONALD , KNOLLER HELMUT , CONRADT HARALD
IPC分类号： A61K38/18 , A61K47/48 , A61P7/06 , C08B31/00 , C08B31/12
CPC分类号： C08B31/00 , A61K38/1816 , A61K47/61 , C08B31/006
摘要： The present invention relates to conjugates of hydroxyethyl starch and erythropoietin, wherein these conjugates comprise a linking compound which is covalently linked to erythropoietin and covalently linked to hydroxyethyl starch. The present invention also relates to the method of producing these conjugates, and their use.
摘要翻译：本发明涉及羟乙基淀粉和促红细胞生成素的缀合物，其中这些缀合物包含与促红细胞生成素共价连接并与羟乙基淀粉共价连接的连接化合物。本发明还涉及生产这些共轭物的方法及其应用。

3. 发明申请

WO2005092390A9 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 审中-公开
标题翻译：羟丙基淀粉和蛋白质的结合
公开(公告)号：WO2005092390A9
公开(公告)日：2006-12-28
申请号：PCT/EP2005002637
申请日：2005-03-11
申请人： FRESENIUS KABI DE GMBH , EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , LANGER KLAUS , ORLANDO MICHELE , SOMMERMEYER KLAUS
发明人： EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , LANGER KLAUS , ORLANDO MICHELE , SOMMERMEYER KLAUS
IPC分类号： A61K47/48
CPC分类号： A61K47/61 , A61K47/50
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a protein wherein these conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the method of producing these conjugates and the use of these conjugates.
摘要翻译：本发明涉及羟烷基淀粉和蛋白质的缀合物，其中这些缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价键形成。本发明还涉及生产这些缀合物的方法和这些共轭物的用途。

4. 发明申请

WO2005014655A3 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 审中-公开
标题翻译：羟丙基淀粉和蛋白质的结合
公开(公告)号：WO2005014655A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004008821
申请日：2004-08-06
申请人： FRESENIUS KABI DE GMBH , EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , SOMMERMEYER KLAUS
发明人： EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , SOMMERMEYER KLAUS
IPC分类号： A61K47/48 , A61P9/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K47/61 , A61K47/50
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a protein wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the method of producing these conjugates and the use of these conjugates.
摘要翻译：本发明涉及羟烷基淀粉和蛋白质的缀合物，其中这些缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价键形成。本发明还涉及生产这些缀合物的方法和这些共轭物的用途。

5. 发明申请

WO2005092390A3 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 审中-公开
标题翻译：羟烷基淀粉和蛋白质的结合物
公开(公告)号：WO2005092390A3
公开(公告)日：2006-06-08
申请号：PCT/EP2005002637
申请日：2005-03-11
申请人： FRESENIUS KABI DE GMBH , EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , LANGER KLAUS , ORLANDO MICHELE , SOMMERMEYER KLAUS
发明人： EICHNER WOLFRAM , SCHIMMEL MARTIN , HACKET FRANK , KRAUS ELMAR , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD , LANGER KLAUS , ORLANDO MICHELE , SOMMERMEYER KLAUS
IPC分类号： A61K47/48
CPC分类号： A61K47/61 , A61K47/50
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a protein wherein these conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the method of producing these conjugates and the use of these conjugates.
摘要翻译：本发明涉及羟烷基淀粉和蛋白质的缀合物，其中这些缀合物通过羟烷基淀粉或羟烷基淀粉的衍生物与蛋白质之间的共价键形成。本发明还涉及生产这些缀合物的方法以及这些缀合物的用途。

6. 发明申请

WO2006094810A2 PRODUCTION OF BIOACTIVE GLYCOPROTEINS FROM INACTIVE STARTING MATERIAL 审中-公开
标题翻译：从不活动起始材料生产生物糖蛋白
公开(公告)号：WO2006094810A2
公开(公告)日：2006-09-14
申请号：PCT/EP2006002179
申请日：2006-03-09
申请人： FRESENIUS KABI DE GMBH , FRANK RONALD , CONRADT HARALD , GRABENHORST ECKART , ZANDER NORBERT
发明人： FRANK RONALD , CONRADT HARALD , GRABENHORST ECKART , ZANDER NORBERT
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： The present invention relates to a method for preparing a conjugate comprising a glycoprotein and a polymer or a derivative of said polymer, wherein the polymer is a hydroxyalkylstarch (HAS), the method comprising the steps a) reacting said glycoprotein with a modified polyol carrying attached thereto, by a covalent linkage, a functional group Z, in the presence of a transferase capable of catalysing formation of a covalent linkage between the glycoprotein and said modified polyol, yielding a glycoprotein covalently linked to a polyol carrying attached thereto, by a covalent linkage, at least one functional group Z, and b) reacting at least one functional group A of the polymer or the derivative thereof with the at least one functional group Z of the glycoprotein added to said glycoprotein during step a), and thereby forming a covalent linkage.
摘要翻译：本发明涉及一种制备包含糖蛋白和所述聚合物的聚合物或衍生物的缀合物的方法，其中所述聚合物是羟烷基淀粉（HAS），所述方法包括以下步骤：a）使所述糖蛋白与带有附着物的改性多元醇反应通过共价连接，在能够催化糖蛋白与所述修饰的多元醇之间形成共价键的转移酶的存在下，通过共价连接，通过共价连接产生与携带有多元醇共价连接的糖蛋白，至少一个官能团Z，和b）在步骤a）期间使聚合物或其衍生物的至少一个官能团A与加入到所述糖蛋白的糖蛋白的至少一个官能团Z反应，从而形成共价连锁。

7. 发明申请

WO2005092391A3 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 审中-公开
标题翻译：羟丙基淀粉和蛋白质的结合
公开(公告)号：WO2005092391A3
公开(公告)日：2006-07-20
申请号：PCT/EP2005002640
申请日：2005-03-11
申请人： FRESENIUS KABI DE GMBH , ZANDER NORBERT , FRANK RONALD
发明人： ZANDER NORBERT , FRANK RONALD
IPC分类号： A61K47/48
CPC分类号： C08H1/00 , A61K47/61 , C07K1/13 , C08B31/185
摘要： The present invention relates to an active substance and hydroxyalklyl starch, preferably hydroxyalkyl starch, wherein the conjugates are prepared by native chemical ligation via covalently linking the hydroxyalkyl stach and the active substance by reacting a thioester group with an alpha-X beta-amino group, wherein X is selected from the group consisting of -SH and NH-N. The present invention also relates to the method of producing these conjugates and the use of the conjugates.
摘要翻译：本发明涉及活性物质和羟基烷基淀粉，优选羟烷基淀粉，其中通过使硫酯基与α-Xβ-氨基反应，共价连接羟基烷基和活性物质，通过天然化学连接来制备缀合物，其中X选自-SH和NH-N。本发明还涉及生产这些缀合物的方法和共轭物的用途。

8. 发明申请

WO2005014024A2 CONJUGATES OF A POLYMER AND A PROTEIN LINKED BY AN OXIME LINKING GROUP 审中-公开
标题翻译：聚合物和蛋白质与氨基酸连接的链接
公开(公告)号：WO2005014024A2
公开(公告)日：2005-02-17
申请号：PCT/EP2004008820
申请日：2004-08-06
申请人： FRESENIUS KABI DE GMBH , SOMMERMEYER KLAUS , FRANK RONALD , ZANDER NORBERT
发明人： SOMMERMEYER KLAUS , FRANK RONALD , ZANDER NORBERT
IPC分类号： A61K47/48 , C08B31/00 , C08B37/02 , A61K38/18 , A61K38/19 , C07K1/107 , C07K2/00 , C07K14/505 , C07K14/52
CPC分类号： A61K38/1816 , A61K38/193 , A61K38/215 , A61K38/37 , A61K38/4846 , A61K38/4866 , A61K38/57 , A61K47/60 , A61K47/61 , C08B31/00 , C08B37/0021
摘要： The present invention relates to polymers functionalized by an aminooxy group or a derivative thereof, conjugates, wherein the functionalized polymers are covalently coupled with a protein by an oxime linking group, a process for preparing the functionalized polymers, a process for preparing the conjugates, functionalized polymers as obtainable by the process of the present invention, conjugates as obtainable by the process of the present invention, and pharmaceutical compositions comprising at least one conjugate of the present invention and the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
摘要翻译：本发明涉及由氨基氧基或其衍生物官能化的聚合物，缀合物，其中官能化聚合物通过肟连接基团与蛋白质共价偶联，制备官能化聚合物的方法，制备共轭物的方法，官能化通过本发明的方法可获得的聚合物，可通过本发明的方法获得的缀合物和包含本发明的至少一种缀合物的药物组合物以及用于预防或治疗人的所述缀合物和组合物的用途或动物体。

9. 发明申请

WO9955455A3 DEVICE FOR GENERATING FREELY DEFINABLE LIBRARIES OF ELEMENTS IN THE FORM OF LIGAND AND ACCEPTOR STRUCTURES FOR COMBINATORIAL SYNTHESIS 审中-公开
标题翻译：设备技术产生元件可自由定义的剧目配体的形式，并与受体的结构组合合成
公开(公告)号：WO9955455A3
公开(公告)日：1999-12-23
申请号：PCT/EP9902811
申请日：1999-04-26
申请人： BIOTECHNOLOG FORSCHUNG GMBH , FRANK RONALD , ZANDER NORBERT , MELBERG YVONNE , ADLER FRANK , ZINECKER KLAUS , THOMAE VOLKER
发明人： FRANK RONALD , ZANDER NORBERT , MELBERG YVONNE , ADLER FRANK , ZINECKER KLAUS , THOMAE VOLKER
IPC分类号： B01J19/00 , C07B61/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/0049 , B01J2219/00495 , B01J2219/00536 , B01J2219/00538 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： The invention relates to a device for generating freely definable libraries of elements (8; 34; 54) in the form of ligand and acceptor structures for combinatorial synthesis, for example in active ingredient research. Said elements are regularly arranged on a substrate (6; 30; 50) along a first and a second coordinate (10; 36; 54 or 12; 38; 58) and a dosing head (14; 42) comes into contact with each element separately and in a controlled manner. In each position the dosing head places a metered quantity of a reagent or solvent onto a corresponding element. The substrate (6; 30; 50) is configured as a rotating body which can be turned about its axis of rotational symmetry (2; 32; 52), which serves as its axis of rotation, in the direction of the first coordinate (10; 36; 54). At least one dosing head (14; 42) can be displaced in relation to the substrate along the second coordinate (12; 38; 58) and parallel to the surface of the substrate, and can be controlled in accordance with its momentary position so as to release a defined quantity of the relevant reagent or solvent.
摘要翻译：本发明涉及一种装置，用于产生元件的可自由定义的所有组成成分（8; 34; 54）中的配体和受体的结构的用于组合合成例如在活性成分的研究，的形式，其中基片（6; 30; 50）上的元素经常沿第一和第二坐标（10; 58 36; 54或12; 38）布置，并从一个头单独控制（14; 42）在接近时，计量在相应的位置上的试剂或溶剂到相应的元件。如在第一坐标旋转体可转动壳体的方向的旋转轴，所述基板具有（30; 6 50）的大约对称（52 2 ;; 32）的其旋转轴线的形状（10; 54; 36）。至少一个计量头（14; 42）相对于所述基板沿所述第二坐标（12; 38; 58）平行于移动的基片的表面，并根据其特定的瞬时位置，以分配一定量的所述相关试剂或溶剂可控的。

10. 发明申请

WO2004071151A3 ELECTRICALLY CONDUCTIVE PLASTICS MOULDED ARTICLE 审中-公开
标题翻译：导电塑料模塑制品
公开(公告)号：WO2004071151A3
公开(公告)日：2004-10-28
申请号：PCT/EP2004001283
申请日：2004-02-11
申请人： BIOTECHNOLOG FORSCHUNG GMBH , FRANK RONALD , ZANDER NORBERT , DIKMANS ANTONIUS
发明人： FRANK RONALD , ZANDER NORBERT , DIKMANS ANTONIUS
IPC分类号： C08F255/02 , C08F257/02 , C08F291/00 , C08J7/12 , C08K3/04 , C08K3/08 , C08L23/10 , C08L25/02 , C08L25/06 , C08L51/00 , C08L51/06 , C08L51/08 , C08L67/02 , C08L69/00 , C08L77/00 , H01B1/24 , B01J19/00 , C08J7/16
CPC分类号： H01B1/24 , C08F255/02 , C08F257/02 , C08F291/00 , C08J7/12 , C08K3/04 , C08K3/08 , C08L23/10 , C08L25/02 , C08L25/06 , C08L51/003 , C08L51/06 , C08L51/08 , C08L67/02 , C08L69/00 , C08L77/00 , C08L2666/02
摘要： The invention relates to a moulded article based on plastics which is electrically conductive.
摘要翻译：本发明涉及基于导电塑料的模塑制品。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式