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1. 发明申请

WO0062048A3 SENSOR ARRANGEMENT WITH ELECTRICALLY CONTROLLABLE ARRAYS 审中-公开
标题翻译：随着电动寻址阵列传感器装置
公开(公告)号：WO0062048A3
公开(公告)日：2001-04-26
申请号：PCT/EP0003404
申请日：2000-04-14
申请人： FRAUNHOFER GES FORSCHUNG , ALBERS JOERG , BERNT HELMUT , BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE
发明人： ALBERS JOERG , BERNT HELMUT , BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE
IPC分类号： G01N27/403
CPC分类号： G01N27/3277
摘要： Disclosed is an electric sensor array which is provided with several sensor positions that consist of at least two microelectrodes and thereby form an array (4). Molecular substances can be detected electrochemically and charged molecules can be transported or handled by means of said array. Measuring procedures, especially between two respective addressing procedures, are possible according to which the sensor positions can be individually addressed and electrochemically or electrically controlled at any moment. A polarisation voltage between two addressing procedures is thus maintained. The arrangement of the wiring (14, 15; 16, 17) is embodied in such a way that individual arrays or groups of arrays can be controlled. For biomolecular assays, affinity-binding molecules are immobilised in each sensor position, between the microelectrodes or on auxiliary surfaces, thereby representing a possible utilisation of the array. The array can also be used for individual and electrical read-out. The array can further be used for subsequently measuring events between the addressing procedures, whereby said events took place before measurement addressing occurs.
摘要翻译：还提出了具有多个传感器位置，其中至少各由作为阵列（4）包括两个微电极的电传感器阵列。与此阵列分子量物质可以电化学检测的，带电荷的分子可以被运输或处理。也可能是两个相应的寻址操作之间后的传感器位置是可单独寻址的，并且每个时间被电化学或电控制，用于保持两种寻址操作之间的偏置电压的测量方法，特别是。所述导管（14，15; 16，17）被形成为使得单独的阵列或阵列的基团来控制。在每个传感器的位置或微电极或辅助表面之间生物分子测定亲和结合分子被固定，这是一个可能的使用阵列。另一种是单独电力读出和寻址操作过去的测量解决之前已经过期的事件之间测量它们的可能性。

2. 发明专利

DE19916867A1 Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employs microelectronic production techniques 未知
公开(公告)号：DE19916867A1
公开(公告)日：2000-10-19
申请号：DE19916867
申请日：1999-04-14
申请人： FRAUNHOFER GES FORSCHUNG , BREDEHORST REINHARD
发明人： BREDEHORST REINHARD , HINTSCHE REINER , SEITZ RENE , GUMBRECHT WALTER
IPC分类号： B01J19/00 , C12M1/40 , C12Q1/68
摘要： Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employing microelectronic production techniques, is new. The molecular arrays are produced with planar surfaces. An Independent claim is also included for the molecular array obtained using the method.

3. 发明专利

DE10080029D2 未知
公开(公告)号：DE10080029D2
公开(公告)日：2001-09-13
申请号：DE10080029
申请日：2000-04-14
申请人： FRAUNHOFER GES FORSCHUNG
发明人： ALBERS JOERG , BERNT HELMUT , DEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE
IPC分类号： G01N27/02 , G01N27/416 , G01N27/447

4. 发明专利

AT364838T 未知
公开(公告)号：AT364838T
公开(公告)日：2007-07-15
申请号：AT00938598
申请日：2000-04-14
申请人： FRAUNHOFER GES FORSCHUNG
发明人： ALBERS JOERG , BERNT HELMUT , BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE
IPC分类号： G01N27/403

5. 发明专利

DE50014414D1 未知
公开(公告)号：DE50014414D1
公开(公告)日：2007-07-26
申请号：DE50014414
申请日：2000-04-14
申请人： FRAUNHOFER GES FORSCHUNG
发明人： ALBERS JOERG , BERNT HELMUT , BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE
IPC分类号： G01N27/403

6. 发明专利

DE50011512D1 未知
公开(公告)号：DE50011512D1
公开(公告)日：2005-12-08
申请号：DE50011512
申请日：2000-04-14
申请人： SIEMENS AG , FRAUNHOFER GES FORSCHUNG
发明人： BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE , GUMBRECHT WALTER
IPC分类号： B01J19/00 , G01N33/543
摘要： The invention relates to a method for producing a detection system for detecting different analytes in a sample, characterised by the following steps: providing a planar or essentially planar substrate which has sensors for chemically, optically or electrically detecting the analytes; applying an already microstructured layer to the substrate or applying a continuous layer to the substrate and microstructuring said layer, the layer being applied in such a way in either case that the areas of the substrate that are separated from each other are not covered by the layer, the layer and substrate being sealingly interconnected at least around the uncovered areas; bringing at least some of the uncovered areas into contact with at least one liquid containing catcher molecules, in such a way that said catcher molecules are able to adhere or bond to the surface of the substrate and/or on the surface of the sensors; removing the non-adhering constituents of the liquid and removing the microstructured layer or parts thereof.

7. 发明专利

AT308753T 未知
公开(公告)号：AT308753T
公开(公告)日：2005-11-15
申请号：AT00920704
申请日：2000-04-14
申请人： FRAUNHOFER GES FORSCHUNG
发明人： BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE , GUMBRECHT WALTER
IPC分类号： B01J19/00 , G01N33/543
摘要： The invention relates to a method for producing a detection system for detecting different analytes in a sample, characterised by the following steps: providing a planar or essentially planar substrate which has sensors for chemically, optically or electrically detecting the analytes; applying an already microstructured layer to the substrate or applying a continuous layer to the substrate and microstructuring said layer, the layer being applied in such a way in either case that the areas of the substrate that are separated from each other are not covered by the layer, the layer and substrate being sealingly interconnected at least around the uncovered areas; bringing at least some of the uncovered areas into contact with at least one liquid containing catcher molecules, in such a way that said catcher molecules are able to adhere or bond to the surface of the substrate and/or on the surface of the sensors; removing the non-adhering constituents of the liquid and removing the microstructured layer or parts thereof.

8. 发明专利

DE10081179D2 未知
公开(公告)号：DE10081179D2
公开(公告)日：2002-03-07
申请号：DE10081179
申请日：2000-04-14
申请人： SIEMENS AG , FRAUNHOFER GES FORSCHUNG
发明人： BREDEHORST REINHARD , HINTSCHE RAINER , SEITZ RENE , GUMBRECHT WALTER
IPC分类号： B01J19/00 , G01N33/543
摘要： The invention relates to a method for producing a detection system for detecting different analytes in a sample, characterised by the following steps: providing a planar or essentially planar substrate which has sensors for chemically, optically or electrically detecting the analytes; applying an already microstructured layer to the substrate or applying a continuous layer to the substrate and microstructuring said layer, the layer being applied in such a way in either case that the areas of the substrate that are separated from each other are not covered by the layer, the layer and substrate being sealingly interconnected at least around the uncovered areas; bringing at least some of the uncovered areas into contact with at least one liquid containing catcher molecules, in such a way that said catcher molecules are able to adhere or bond to the surface of the substrate and/or on the surface of the sensors; removing the non-adhering constituents of the liquid and removing the microstructured layer or parts thereof.

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