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1. 发明申请

WO2012068549A3 THERAPEUTIC AGENT FORMULATIONS FOR IMPLANTED DEVICES 审中-公开
标题翻译：植入装置的治疗剂配方
公开(公告)号：WO2012068549A3
公开(公告)日：2012-07-19
申请号：PCT/US2011061535
申请日：2011-11-18
申请人： FORSIGHT VISION4 INC , DE JUAN EUGENE JR , ALSTER YAIR , CHAMOW STEVEN M , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , ERICKSON SIGNE , BUECHE BLAINE
发明人： DE JUAN EUGENE JR , ALSTER YAIR , CHAMOW STEVEN M , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , ERICKSON SIGNE , BUECHE BLAINE
IPC分类号： A61K9/16 , A61K9/10 , A61K31/573 , A61P27/02
CPC分类号： A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1652 , A61K31/573
摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.
摘要翻译：治疗剂的可注射制剂可以包含治疗剂和稳定剂，使得当治疗剂从治疗装置释放时，大部分稳定剂保留在治疗装置中以稳定治疗剂。可注射制剂可以包含一种或多种粘合剂颗粒或可侵蚀材料颗粒，使得制剂可以注射到治疗装置中。结合剂颗粒可以与治疗剂可逆结合以调节治疗剂的释放，并且可侵蚀材料颗粒可以产生酸的质子，从而增加治疗剂的稳定性并且可以调节治疗剂的释放。治疗剂可以与稳定剂，粘合剂颗粒或可侵蚀颗粒中的一种或多种组合以增加治疗剂的稳定性并可调节释放。

2. 发明公开

EP2349339A4 SUSTAINED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：具有长期效应的活性聚集体系统
公开(公告)号：EP2349339A4
公开(公告)日：2015-01-07
申请号：EP09821290
申请日：2009-10-15
申请人： FARINAS KATHLEEN COGAN , CHAMOW STEVEN M
发明人： FARINAS KATHLEEN COGAN , CHAMOW STEVEN M
IPC分类号： A61K47/36 , A61K39/395 , A61K47/12 , A61K47/26 , A61K47/48
CPC分类号： A61K9/0048 , A61K47/645

3. 发明申请

WO2010045506A2 SUSTAINED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：持续性药物递送系统
公开(公告)号：WO2010045506A2
公开(公告)日：2010-04-22
申请号：PCT/US2009060918
申请日：2009-10-15
申请人： FARINAS KATHLEEN COGAN , CHAMOW STEVEN M
发明人： FARINAS KATHLEEN COGAN , CHAMOW STEVEN M
IPC分类号： A61K47/36 , A61K39/395 , A61K47/12 , A61K47/26
CPC分类号： A61K9/0048 , A61K47/645
摘要： A drug composition comprising a charged moiety coupled to a therapeutic compound is disclosed. The charged moiety is configured to interact with at least one type of component of opposite charge in a biological tissue to create an in situ depot for prolonged drug delivery. The biological tissue may be eye tissue or any tissue containing charged components. Further, a method of treating the human body is disclosed. The method is for introducing into a human body a drug composition comprising a charged moiety coupled to a therapeutic compound. Introduction may be through injection. A method of manufacturing a drug composition comprising a charged moiety coupled to a therapeutic compound is also disclosed.
摘要翻译：公开了包含与治疗性化合物偶联的荷电部分的药物组合物。带电部分被配置为与生物组织中的至少一种类型的带相反电荷的成分相互作用，以产生用于延长药物递送的原位贮库。生物组织可以是眼组织或含有带电成分的任何组织。此外，公开了一种治疗人体的方法。该方法用于将包含与治疗性化合物偶联的带电部分的药物组合物引入人体。介绍可能是通过注射。还公开了制造包含与治疗性化合物偶联的带电部分的药物组合物的方法。

4. 发明专利

CA2757037A1 POSTERIOR SEGMENT DRUG DELIVERY 未知
公开(公告)号：CA2757037A1
公开(公告)日：2010-08-05
申请号：CA2757037
申请日：2010-01-29
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN EUGENE JR , ALSTER YAIR , CHAMOW STEVEN M , COGAN FARINAS KATHLEEN , GIFFORD III HANSON S , MACFARLANE K ANGELA , REICH CARY J , BARRETT MICHAEL , CAMPBELL RANDOLPH E , GEORGE ROBERT , SUTTON DOUGLAS
IPC分类号： A61M35/00
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The therapeutic device may comprise a retention structure and a reservoir, such that the device can be delivered from a lumen of a delivery device. The therapeutic device may comprises a port to inject therapeutic agent into the device when implanted in the patient.

5. 发明专利

PL2391419T3 Dostarczanie leku do tylnego odcinka 未知
公开(公告)号：PL2391419T3
公开(公告)日：2019-12-31
申请号：PL10736495
申请日：2010-01-29
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN JR EUGENE , ALSTER YAIR , CHAMOW STEVEN M , COGAN FARINAS KATHLEEN , GIFFORD III HANSON S , MACFARLANE K ANGELA , REICH CARY J , BARRETT MICHAEL , CAMPBELL RANDOLPH E , GEORGE ROBERT , SUTTON DOUGLAS
IPC分类号： A61M35/00 , A61F9/00 , A61K9/00

6. 发明专利

AU2017202212A1 THERAPEUTIC AGENT FORMULATIONS FOR IMPLANTED DEVICES 未知
公开(公告)号：AU2017202212A1
公开(公告)日：2017-04-27
申请号：AU2017202212
申请日：2017-04-04
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN JR EUGENE , ALSTER YAIR , CHAMOW STEVEN M , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , ERICKSON SIGNE , BUECHE BLAINE
IPC分类号： A61K9/10 , A61K9/16 , A61K31/573 , A61P27/02
摘要： A flowable formulation for use with a therapeutic device implanted to treat an eye, the formulation comprising: a therapeutic agent having a molecular weight; and a stabilizer to maintain stability of the therapeutic agent, wherein the stabilizer is selected based on the stabilizer comprising a molecular weight that is at least 10% of the molecular weight of the therapeutic agent, wherein the formulation is suitable for providing the therapeutic agent to an eye from within a therapeutic device implanted in the eye, the therapeutic device having a reservoir chamber and a porous structure, wherein the stabilizer diffuses through the porous structure at a rate that leaves an amount of the stabilizer that is sufficient to stabilize for at least one month therapeutic agent remaining in the reservoir chamber.

7. 发明专利

ES2747755T3 Administración de un fármaco al segmento posterior 未知
公开(公告)号：ES2747755T3
公开(公告)日：2020-03-11
申请号：ES10736495
申请日：2010-01-29
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN JR , ALSTER YAIR , CHAMOW STEVEN M , COGAN FARINAS KATHLEEN , GIFFORD III HANSON S , MACFARLANE K ANGELA , REICH CARY J , BARRETT MICHAEL , CAMPBELL RANDOLPH E , GEORGE ROBERT , SUTTON DOUGLAS
IPC分类号： A61M35/00 , A61F9/00 , A61K9/00
摘要： Dispositivo terapéutico (100) para administrar un agente terapéutico (110) a un ojo (10) que tiene esclerótica (24), conjuntiva (16) sobre la esclerótica (24) y humor vítreo (30), comprendiendo el dispositivo (100): un recipiente (130) configurado para contener el agente terapéutico, en el que el recipiente (130) comprende: un depósito rellenable (140) configurado para tener un volumen (142) dimensionado para contener una formulación líquida del agente terapéutico (110); una barrera (160) que define un tamaño del depósito rellenable (140) y formada de un material para inhibir la liberación del agente terapéutico desde el recipiente (130); y una estructura porosa rígida(150, 158), en la que el depósito (140) y la estructura porosa rígida(150, 158) están ajustadas para liberar cantidades terapéuticas del agente terapéutico (110) durante un tiempo prolongado en el humor vítreo; un puerto de inyección (180) que se extiende al recipiente (130) y que tiene un canal que está configurado para extenderse a través de la esclerótica (24), cuando el recipiente se implanta al menos parcialmente dentro del humor vítreo (30) y configurado para recibir una inyección de agente terapéutico (110) para volver a llenar el recipiente (130); y una estructura de retención (120) acoplada al recipiente (130) configurada para acoplarse a la esclerótica (24) y retener el recipiente (130) al menos parcialmente dentro del ojo (10), comprendiendo la estructura de retención (120) una brida (122) que se extiende hacia el exterior para su colocación, en uso, entre la esclerótica (24) y la conjuntiva (16), estando la brida (122) acoplada al recipiente (130) mediante una parte estrecha (120N), en el que la parte estrecha (120N) está dimensionada de forma más pequeña que la brida (122) y tiene una sección transversal alargada dimensionada para ajustarse dentro de una incisión alargada en la esclerótica (24), en el que el volumen (142) del depósito (140) permanece sustancialmente fijo y la estructura porosa rígida (150, 158) permanece rígida cuando se inyecta el agente terapéutico (110) en el depósito (142) con al menos algo de presión.

8. 发明专利

AU2011329656B2 Therapeutic agent formulations for implanted devices 未知
公开(公告)号：AU2011329656B2
公开(公告)日：2017-01-05
申请号：AU2011329656
申请日：2011-11-18
申请人： FORSIGHT VISION4 INC
发明人： CAMPBELL RANDOLPH E , ERICKSON SIGNE , BUECHE BLAINE , DE JUAN JR EUGENE , ALSTER YAIR , CHAMOW STEVEN M , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J
IPC分类号： A61K9/10 , A61K9/16 , A61K31/573 , A61P27/02
摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.

9. 发明专利

AU2010208046B2 Posterior segment drug delivery 未知
公开(公告)号：AU2010208046B2
公开(公告)日：2014-10-02
申请号：AU2010208046
申请日：2010-01-29
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN JR EUGENE , ALSTER YAIR , CHAMOW STEVEN M , COGAN FARINAS KATHLEEN , GIFFORD III HANSON S , MACFARLANE K ANGELA , REICH CARY J , BARRETT MICHAEL , CAMPBELL RANDOLPH E , GEORGE ROBERT , SUTTON DOUGLAS
IPC分类号： A61M35/00
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The therapeutic device may comprise a retention structure and a reservoir, such that the device can be delivered from a lumen of a delivery device. The therapeutic device may comprises a port to inject therapeutic agent into the device when implanted in the patient.

10. 发明专利

CA2818612C THERAPEUTIC AGENT FORMULATIONS FOR IMPLANTED DEVICES 未知
公开(公告)号：CA2818612C
公开(公告)日：2020-12-29
申请号：CA2818612
申请日：2011-11-18
申请人： FORSIGHT VISION4 INC
发明人： DE JUAN EUGENE , ALSTER YAIR , CHAMOW STEVEN M , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , ERICKSON SIGNE , BUECHE BLAINE
IPC分类号： A61K9/10 , A61K31/573 , A61P27/02
摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.

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