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1. 发明申请

WO2009145842A9 THERAPEUTIC DEVICE FOR PAIN MANAGEMENT AND VISION 审中-公开
标题翻译：用于疼痛管理和视力的治疗设备
公开(公告)号：WO2009145842A9
公开(公告)日：2010-11-18
申请号：PCT/US2009002166
申请日：2009-04-06
申请人： FORSIGHT LABS LLC , DE JUAN EUGENE , REICH CARY J , BOYD STEPHEN , ALSTER YAIR , SIERRA DAVID , GIFFORD HANSON S , ALEJANDRO JOSE D , LINDSTROM RICHARD L , MACFARLANE K ANGELA , SUTTON DOUGLAS , SCHOLL JOHN ANTHONY
发明人： DE JUAN EUGENE , REICH CARY J , BOYD STEPHEN , ALSTER YAIR , SIERRA DAVID , GIFFORD HANSON S , ALEJANDRO JOSE D , LINDSTROM RICHARD L , MACFARLANE K ANGELA , SUTTON DOUGLAS , SCHOLL JOHN ANTHONY
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
摘要翻译：用于治疗上皮缺陷的治疗镜片包括设置在基质和/或鲍曼膜上的一层治疗材料，以抑制水从泪液流向基质和/或鲍曼膜，使得角膜失去光泽可以恢复到减少角膜肿胀和光散射。该层可以覆盖并保护神经纤维以减轻疼痛。该层可以包括折射率以抑制光从基质和/或鲍曼膜的前表面散射。该镜片可以包括弯曲的前表面，其在上皮再生时为患者提供功能性视力。治疗材料层可以以多种方式定位在眼睛上，例如用喷雾固化以将该层粘附到基质和/或鲍曼膜的暴露表面上。

2. 发明专利

AU2012308317A1 Ocular insert apparatus and methods 未知
公开(公告)号：AU2012308317A1
公开(公告)日：2014-03-27
申请号：AU2012308317
申请日：2012-09-14
申请人： FORSIGHT LABS LLC
发明人： DE JUAN EUGENE , ALSTER YAIR , REICH CARY J , MACFARLANE K ANGELA , CHANG JANELLE , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , SUTTON DOUGLAS
IPC分类号： A61F9/00 , A61M31/00
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

3. 发明申请

WO2013040426A3 OCULAR INSERT APPARATUS AND METHODS 审中-公开
标题翻译： OCULAR插入装置和方法
公开(公告)号：WO2013040426A3
公开(公告)日：2013-05-10
申请号：PCT/US2012055532
申请日：2012-09-14
申请人： FORSIGHT LABS LLC , DE JUAN EUGENE , ALSTER YAIR , REICH CARY J , MACFARLANE K ANGELA , CHANG JANELLE , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , SUTTON DOUGLAS
发明人： DE JUAN EUGENE , ALSTER YAIR , REICH CARY J , MACFARLANE K ANGELA , CHANG JANELLE , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , SUTTON DOUGLAS
IPC分类号： A61F9/00 , A61M31/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

4. 发明专利

CA2764063C ANTERIOR SEGMENT DRUG DELIVERY 未知
公开(公告)号：CA2764063C
公开(公告)日：2019-05-14
申请号：CA2764063
申请日：2010-06-03
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN EUGENE , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F9/00 , A61M31/00
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

5. 发明专利

AU2015203456A1 Anterior segment drug delivery 未知
公开(公告)号：AU2015203456A1
公开(公告)日：2015-07-16
申请号：AU2015203456
申请日：2015-06-23
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN JR EUGENE , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F2/00 , A61F13/00
摘要： ANTERIOR SEGMENT DRUG DELIVERY An ocular insert (31) for use in an eye (2). The eye having upper and lower lids extendable along an anterior eye surface with an optical zone therebetween. The insert comprising a first structure (32) comprising an annulus disposable along the anterior surface of the eye of a patient outside the optical zone; a second structure (34) supported by and disposed over a length of the first structure, wherein the second structure comprises at least a first cushioning structure around a first discrete portion and a second cushioning structure around a second discrete portion of the length of the first structure, respectively; and at least one drug included in a delivery matrix of the first cushioning structure and at least one drug included in a delivery matrix of the second cushioning structure so as release a safe and therapeutically effective quantity of the at least one drug from the first and second cushioning structures of the second structure to the eye for each of the plurality of days, and wherein the ocular insert is configured to activate after being inserted onto the anterior surface of the eye to reconfigure from an insertion configuration to a deployed configuration that conforms the first and second structures of the ocular insert to the anterior surface of the eye to maintain the ocular insert in contact with the eye for the plurality of days.

6. 发明专利

AU2014200016A1 Anterior segment drug delivery 未知
公开(公告)号：AU2014200016A1
公开(公告)日：2014-01-23
申请号：AU2014200016
申请日：2014-01-03
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN JR EUGENE , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F2/00 , A61F13/00
摘要： ANTERIOR SEGMENT DRUG DELIVERY A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

7. 发明专利

AU2010256558B2 Anterior segment drug delivery 未知
公开(公告)号：AU2010256558B2
公开(公告)日：2013-10-03
申请号：AU2010256558
申请日：2010-06-03
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN JR EUGENE , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F2/00 , A61F13/00
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

8. 发明专利

SG173167A1 POSTERIOR SEGMENT DRUG DELIVERY 未知
公开(公告)号：SG173167A1
公开(公告)日：2011-08-29
申请号：SG2011054350
申请日：2010-01-29
申请人： FORSIGHT LABS LLC
发明人： DE JUAN JR EUGENE , ALSTER YAIR , CHAMOW STEVEN M , COGAN FARINAS KATHLEEN , GIFFORD III HANSON S , MACFARLANE K ANGELA , REICH CARY J , BARRETT MICHAEL , CAMPBELL RANDOLPH E , GEORGE ROBERT , SUTTON DOUGLAS
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The therapeutic device may comprise a retention structure and a reservoir, such that the device can be delivered from a lumen of a delivery device. The therapeutic device may comprises a port to inject therapeutic agent into the device when implanted in the patient.

9. 发明专利

AU2014200016B2 Anterior segment drug delivery 未知
公开(公告)号：AU2014200016B2
公开(公告)日：2015-04-09
申请号：AU2014200016
申请日：2014-01-03
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN JR EUGENE , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F2/00 , A61F13/00
摘要： ANTERIOR SEGMENT DRUG DELIVERY A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

10. 发明专利

CA2764063A1 ANTERIOR SEGMENT DRUG DELIVERY 未知
公开(公告)号：CA2764063A1
公开(公告)日：2010-12-09
申请号：CA2764063
申请日：2010-06-03
申请人： FORSIGHT LABS LLC
发明人： ALSTER YAIR , DE JUAN EUGENE JR , REICH CARY J , BOYD STEPHEN , SIERRA DAVID , ALEJANDRO JOSE D , MACFARLANE K ANGELA , SUTTON DOUGLAS
IPC分类号： A61F2/00 , A61F13/00
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

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