会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • TETRATHIOL LIGANDS, METAL COMPLEXES, CONJUGATES, AND KITS, THE USE THEREOF IN NUCLEAR MEDICINE DIAGNOSTICS AND ENDORADIONUCLIDE THERAPY, AND METHOD FOR PRODUCING THE TETRATHIOL LIGANDS AND METAL COMPLEXES
    • Tetrathiol配体,金属配合物,结合物和试剂盒,它们在核医学诊断和ENDORADIONUKLIDTHERAPIE及其制造方法Tetrathiol配体和金属络合物
    • WO2010043218A3
    • 2011-01-27
    • PCT/DE2009050056
    • 2009-10-16
    • FORSCHUNGSZENTR DD ROSSENDORFFOERSTER CHRISTIANPIETZSCH HANS-JUERGENSUHR MATTHIAS
    • FOERSTER CHRISTIANPIETZSCH HANS-JUERGENSUHR MATTHIAS
    • C07D295/185A61K51/04A61K51/08C07D273/01C07F1/08C07F5/00C07F7/22C07F13/00
    • C07D295/185C07D273/01C07F13/005
    • The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1') are substituted or non-substituted methylene bridges; the individual R1 and R1', and R3 and R3', are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive whole numbers, where m represents the number of (CH-R1') groups and n represents the number of (CH-R1) groups; wherein the sum of m and n is in the range from 4 to 10; R2 and R2' are selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted carboxyl groups, substituted or non-substituted aryl groups, or Z; X is a substituted or non-substituted methylene bridge having the formula CHR4 or a non-substituted amino group (N-H) or substituted amino group (N-Z); wherein Z stands for -(CH-R5)p-A, where (CH-R5) represents a substituted or non-substituted methylene bridge, and p is a whole number standing for the number of the (CH-R5) groups, wherein p is in the range from 2 through 8; A represents a linkable unit, wherein R4 and the individual R5 are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups.
    • 式(I),其中(CH-R 1)和(CH-R1“)代表取代或未取代的亚甲基桥,每个R 1和R 1”是,以及R 3和R 3“的配位体各自独立地选自氢,取代的或未取代的烷基 ,取代或未取代的芳基,m和n是正整数,其中m表示基团(CH-R1“)的数目,n是基团(CH-R 1)的数量,m,其中与n之和为4的范围内 是如图10所示,具有式CHR 4基团或一个取代的氨基取代或未取代的亚甲基桥是R2和R2“独立地选自氢,取代的或未取代的烷基,取代或未取代的羧基,取代或未取代的芳基,或Z,X(NH)或取代的 氨基(NZ),其中Z是 - (CH-R5)p,其中(CH-R 5)取代的或未取代的亚甲基 表示桥且p为基团(CH-R 5),其中p为2至8的数量的整数,A是一个能够耦合单元,其中,R 4和每个R 5各自独立地选自 氢,取代或未取代的烷基,取代或未取代的芳基。