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1. 发明申请

WO2009133100A2 ORDERED MESOPOROUS SILICA MATERIAL 审中-公开
标题翻译：有序介孔二氧化硅材料
公开(公告)号：WO2009133100A2
公开(公告)日：2009-11-05
申请号：PCT/EP2009055122
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V , JAMMAER JASPER , AERTS ALEXANDER , VAN DEN MOOTER GUY , MARTENS JOHAN
发明人： JAMMAER JASPER , AERTS ALEXANDER , VAN DEN MOOTER GUY , MARTENS JOHAN
IPC分类号： C01B37/02 , A61K9/16
CPC分类号： A61K9/143 , A61K47/02 , C01B37/02 , Y10T428/249979
摘要： A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.
摘要翻译：在弱酸性或中性pH条件下，使用两亲性嵌段共聚物和任选的四烷基铵化合物的组合合成了一族称为COK-10的有序中孔二氧化硅材料。中孔尺寸基本均匀，在4-30nm范围内，并且可以通过适应合成条件来微调。还在弱酸性或中性pH条件下使用两亲嵌段共聚物和pH大于2且小于8的缓冲剂的组合合成了称为COK-12的2D-六方有序介孔二氧化硅材料的新家族。中孔尺寸是基本均匀的，在4到12nm的范围内并且可以通过调整合成条件来微调。这些有序的中孔二氧化硅材料可用作配制难溶药物分子的载体材料和用于立即释放应用的口服药物制剂。

2. 发明专利

AU2009242175A1 Ordered mesoporous silica material 未知
公开(公告)号：AU2009242175A1
公开(公告)日：2009-11-05
申请号：AU2009242175
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V
发明人： AERTS ALEXANDER , MOOTER GUY VAN DEN , MARTENS JOHAN , JAMMAER JASPER
IPC分类号： A61K9/16 , C01B37/02
摘要： A process for preparing a 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size in the range of 4 to 30 nm comprising the steps of: preparing an aqueous solution comprising an alkali silicate solution; preparing an aqueous solution comprising a poly(alkylene oxide) triblock copolymer and a buffer with a pH greater than 2 and less than 8, adding said aqueous alkali silicate solution to said aqueous solution giving a pH greater than 2 and less than 8 and allowing a reaction between the components to take place at a temperature in the range of 10 to 100° C., and filtering off, drying and calcinating the reaction product to produce said 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size. In an alternative procedure both aqueous solutions are fed as liquid streams into an elongated mixing receptacle having a first and a second opening such that the liquid streams of the solutions are each discharged independently into said first opening of said elongated mixing receptacle such that they directly impinge thereby giving a pH in the resulting mixture of greater than 2 and less than 8 and producing a reaction product at a temperature in the range of 10 to 100° C. in said elongated mixing receptacle, which upon emergence from said second opening of said elongated mixing receptacle is filtered off, dried and the surfactant removed.

3. 发明专利

CA2721485C ORDERED MESOPOROUS SILICA MATERIAL 未知
公开(公告)号：CA2721485C
公开(公告)日：2013-12-24
申请号：CA2721485
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V
发明人： JAMMAER JASPER , AERTS ALEXANDER , VAN DEN MOOTER GUY , MARTENS JOHAN
IPC分类号： C01B37/02 , A61K9/16
摘要： A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.

4. 发明专利

MX2010011670A MATERIAL DE SILICE MESOPOROSO ORDENADO. 未知
公开(公告)号：MX2010011670A
公开(公告)日：2011-05-02
申请号：MX2010011670
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V
发明人： MARTENS JOHAN , JAMMAER JASPER , AERTS ALEXANDER , MOOTER GUY VAN DEN
IPC分类号： C01B37/02 , A61K9/16
摘要： Una nueva familia de materiales de sílice mesoporosos ordenados denotada por COK-10 es sintetizada bajo condiciones de acidez moderada o pH neutro usando una combinación de un copolímero de bloques anfifílico y opcionalmente un compuesto de tetraalquilamonio El tamaño del mesoporo es sustancialmente uniforme, está en el intervalo de 4-30 nm, y puede ser afinado adaptando las condiciones de síntesis. Una nueva familia de materiales de sílice mesoporosos ordenados, hexagonal 2D denotada como COK-12 es sintetizada también bajo condiciones de acidez moderada o pH neutro usando una combinación de un copolímero de bloques anfifílico y un amortiguador con un pH mayor de y menor de 8. El tamaño del mesoporo es sustancialmente uniforme, está en el intervalo de 4 a 12 nm y puede ser afinado adaptando las condiciones de síntesis. Esos materiales de sílice mesoporosos ordenados son útiles como materiales de soporte para la formulación de moléculas de fármaco pobremente solubles y para formulaciones de fármacos orales para aplicaciones de liberación inmediata.

5. 发明专利

AU2009242175B2 Ordered mesoporous silica material 未知
公开(公告)号：AU2009242175B2
公开(公告)日：2013-02-07
申请号：AU2009242175
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V
发明人： VAN DEN MOOTER GUY , JAMMAER JASPER , MARTENS JOHAN , AERTS ALEXANDER
IPC分类号： A61K9/16 , C01B37/02
摘要： A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.

6. 发明专利

ZA201007548B ORDERED MESOPOROUS SILICA MATERIAL 未知
公开(公告)号：ZA201007548B
公开(公告)日：2011-07-27
申请号：ZA201007548
申请日：2010-10-22
申请人： FORMAC PHARMACEUTICALS N V
发明人： AERTS ALEXANDER , JAMMAER JASPER , VAN DEN MOOTER GUY , MARTENS JOHAN
摘要： A process for preparing a 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size in the range of 4 to 30 nm comprising the steps of: preparing an aqueous solution comprising an alkali silicate solution; preparing an aqueous solution comprising a poly(alkylene oxide) triblock copolymer and a buffer with a pH greater than 2 and less than 8, adding said aqueous alkali silicate solution to said aqueous solution giving a pH greater than 2 and less than 8 and allowing a reaction between the components to take place at a temperature in the range of 10 to 100° C., and filtering off, drying and calcinating the reaction product to produce said 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size. In an alternative procedure both aqueous solutions are fed as liquid streams into an elongated mixing receptacle having a first and a second opening such that the liquid streams of the solutions are each discharged independently into said first opening of said elongated mixing receptacle such that they directly impinge thereby giving a pH in the resulting mixture of greater than 2 and less than 8 and producing a reaction product at a temperature in the range of 10 to 100° C. in said elongated mixing receptacle, which upon emergence from said second opening of said elongated mixing receptacle is filtered off, dried and the surfactant removed.

7. 发明专利

CA2721485A1 ORDERED MESOPOROUS SILICA MATERIAL 未知
公开(公告)号：CA2721485A1
公开(公告)日：2009-11-05
申请号：CA2721485
申请日：2009-04-28
申请人： FORMAC PHARMACEUTICALS N V
发明人： JAMMAER JASPER , AERTS ALEXANDER , VAN DEN MOOTER GUY , MARTENS JOHAN
IPC分类号： C01B37/02 , A61K9/16
摘要： A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.

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