专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997010000A1 THERAPEUTIC AND PROPHYLACTIC METHODS USING HEAT SHOCK PROTEINS 审中-公开
标题翻译：使用热休克蛋白的治疗和预防方法
公开(公告)号：WO1997010000A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014556
申请日：1996-09-11
申请人： FORDHAM UNIVERSITY
发明人： FORDHAM UNIVERSITY , SRIVASTAVA, Pramod, K.
IPC分类号： A61K39/385
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/6043 , A61K2039/622 , C07K14/47 , Y02A50/403 , Y02A50/41 , Y02A50/466 , Y02A50/478
摘要： The present invention relates to immunogenic complexes of heat shock proteins (hsp) noncovalently bound to exogenous antigenic molecules which when administered to an individual elicit specific immunological responses in the host. Methods of prevention and treatment of cancer and infectious disease are provided.
摘要翻译：本发明涉及非共价结合于外源抗原分子的热休克蛋白（hsp）的免疫原性复合物，其在给予个体时在宿主中引发特异性免疫应答。提供了预防和治疗癌症和传染病的方法。

2. 发明申请

WO1997010002A1 IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASE USING ANTIGEN-PRESENTING CELLS SENSITIZED WITH HEAT SHOCK PROTEIN-ANTIGEN COMPLEXES 审中-公开
标题翻译：使用抗高温蛋白抗原复合物的抗原细胞免疫癌和感染性疾病的免疫治疗
公开(公告)号：WO1997010002A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014558
申请日：1996-09-11
申请人： FORDHAM UNIVERSITY
发明人： FORDHAM UNIVERSITY , SRIVASTAVA, Pramod, K.
IPC分类号： A61K39/385
CPC分类号： A61K39/0011 , A61K38/191 , A61K38/20 , A61K38/21 , A61K2039/5154 , A61K2039/6043 , A61K2039/622 , Y02A50/403 , Y02A50/41 , Y02A50/466 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or other antigen presenting cells (APC) sensitized with heat shock proteins non-covalently bound to peptide complexes and/or antigenic components. APC are incubated in the presence of hsp-peptide complexes and/or antigenic components in vitro. The sensitized cells are reinfused into the patient with or without treatment with cytokines including but not limited to interferon- alpha , interferon- alpha , interleukin-2, interleukin-4, interleukin-6 and tumor neurosis factor.
摘要翻译：本发明涉及用于增强免疫应答和用于预防和治疗感染性疾病或原发性和转移性肿瘤性疾病的方法和组合物，其基于施用热休克蛋白非特异性的巨噬细胞和/或其他抗原呈递细胞（APC）共价结合肽复合物和/或抗原成分。 APC在体外在hsp-肽复合物和/或抗原成分存在下孵育。致敏细胞用或不用细胞因子包括但不限于干扰素-α，干扰素-α，白介素-2，白细胞介素-4，白细胞介素-6和肿瘤神经元因子治疗而被再灌注入患者。

3. 发明申请

WO1997010001A1 TREATMENT OR PREVENTION OF NEOPLASTIC AND INFECTIOUS DISEASES WITH HEAT SHOCK/STRESS PROTEINS 审中-公开
标题翻译：用热冲击/应激蛋白治疗或预防神经性和感染性疾病
公开(公告)号：WO1997010001A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014557
申请日：1996-09-11
申请人： FORDHAM UNIVERSITY
发明人： FORDHAM UNIVERSITY , SRIVASTAVA, Pramod, K.
IPC分类号： A61K39/385
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/52 , A61K2039/525 , A61K2039/6043 , A61K2039/622 , G01N33/56977 , G01N33/574 , Y02A50/403 , Y02A50/41 , Y02A50/466 , Y02A50/478 , Y10S435/81
摘要： The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases. The methods of the invention comprise administering a composition comprising an effective amount of a complex, in which the complex consists essentially of a heat shock protein (hsp) noncovalently bound to an antigenic molecule. "Antigenic molecule" as used herein refers to the peptides with which the hsps are endogenously associated in vivo as well as exogenous antigens/immunogens (i.e., with which the hsps are not complexed in vivo or antigenic/immunogenic fragments and derivatives thereof. In a preferred embodiment, the complex is autologous to the individual. The effective amounts of the complex are in the range of 100-600 micrograms for complexes comprising hsp70, 50-1000 micrograms for hsp90, and 10-600 micrograms for gp96. The invention also provides a method for measuring tumor rejection in vivo in an individual, preferably a human, comprising measuring the generation by the individual of MHC Class I-restricted CD8+ cytotoxic T lymphocytes specific to the tumor. Methods of purifying hsp70-peptide complexes are also provided.
摘要翻译：本发明涉及引发免疫应答和预防和治疗原发性和转移性肿瘤性疾病和传染病的方法和组合物。本发明的方法包括施用包含有效量的复合物的组合物，其中复合物基本上由非共价结合于抗原分子的热休克蛋白（hsp）组成。本文所用的“抗原分子”是指hsps与体内内源性相关的肽以及外源性抗原/免疫原（即，hsps在体内不复合的肽或其抗原性/免疫原性片段及其衍生物）复合物对于个体是自体的，复合物的有效量对于包含hsp70，hsp90为50-1000微克，gp96为10-600微克的复合物为100-600微克，本发明还提供一种用于测量个体，优选人体内肿瘤排斥反应的方法，包括测量个体对肿瘤特异性的MHC I类限制性CD8 +细胞毒性T淋巴细胞的产生。还提供了纯化hsp70-肽复合物的方法。

4. 发明申请

WO1998015616A1 METHODS FOR GENERATING CYTOTOXIC T CELLS IN VITRO 审中-公开
标题翻译：在体内产生细胞毒素T细胞的方法
公开(公告)号：WO1998015616A1
公开(公告)日：1998-04-16
申请号：PCT/US1997018110
申请日：1997-10-06
申请人： FORDHAM UNIVERSITY
发明人： FORDHAM UNIVERSITY , SRIVASTAVA, Pramod, K. , BINDER, Robert , BLACHERE, Nathalie, E.
IPC分类号： C12N05/06
CPC分类号： A61K39/0011 , A61K2039/5158
摘要： The present invention provides methods for generating antigen-reative cytotoxic T cells in vitro comprising culturing immune cells and antigenic cells that have at least one MHC allele in common (and preferably, are syngeneic), in which the antigenic cells have been treated according to the methods of the invention. The antigenic cells are treated by subjecting them to osmotic shock followed by irradiation. As a result, a subset of T cells are activated and mature into antigen-reactive cytotoxic T cells. The effectiveness of the procedure may be enhanced by repeated restimulations and/or the addition of heat shock protein-peptide complexes. Methods and compositions are also disclosed for the treatment and prevention in a subject of cancer or infectious disease comprising administering to the subject matched cytotoxic T cells that are generated in vitro by the present methods.
摘要翻译：本发明提供了在体外产生抗原性细胞毒性T细胞的方法，包括培养具有至少一种共同（优选是同基因）的MHC等位基因的免疫细胞和抗原性细胞，其中抗原细胞已经根据本发明的方法。通过对抗原细胞进行渗透休克，然后照射进行处理。结果，一部分T细胞被激活并成熟为抗原反应性细胞毒性T细胞。可以通过重复的再刺激和/或加入热休克蛋白 - 肽复合物来增强该程序的有效性。还公开了用于癌症或感染性疾病的受试者的治疗和预防的方法和组合物，包括向受试者施用通过本发明方法在体外产生的匹配的细胞毒性T细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式