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1. 发明申请

WO2011142836A9 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 审中-公开
标题翻译：用于检测基因型，突变和/或缺失的测定
公开(公告)号：WO2011142836A9
公开(公告)日：2012-01-05
申请号：PCT/US2011000887
申请日：2011-05-16
申请人： FLUIDIGM CORP , JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
发明人： JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , G01N33/52 , G06F19/18
CPC分类号： C12Q1/6851 , C12Q1/6855 , C12Q1/6858 , G01N33/542 , G01N33/582 , G01N33/6893 , G01N2800/368 , C12Q2521/301 , C12Q2521/501 , C12Q2525/155 , C12Q2535/131 , C12Q2537/143 , C12Q2537/16 , C12Q2563/173
摘要： The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.
摘要翻译：本发明提供了用于检测基因型，突变和/或非整倍性的基于扩增的方法。这些方法具有广泛的适用性，但特别适合于检测和定量存在于母体液样品中的游离胎儿DNA中的靶核酸。

2. 发明专利

SG185543A1 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 未知
公开(公告)号：SG185543A1
公开(公告)日：2012-12-28
申请号：SG2012083424
申请日：2011-05-16
申请人： FLUIDIGM CORP , PIEPRZYK MARTIN
发明人： JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
摘要： The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.

3. 发明公开

EP2569447A4 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 审中-公开
标题翻译：用于检测基因型，突变或缺失的测定
公开(公告)号：EP2569447A4
公开(公告)日：2013-11-27
申请号：EP11780930
申请日：2011-05-16
申请人： FLUIDIGM CORP , PIEPRZYK MARTIN
发明人： PIEPRZYK MARTIN , JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , G01N33/52 , G06F19/18
CPC分类号： C12Q1/6851 , C12Q1/6855 , C12Q1/6858 , G01N33/542 , G01N33/582 , G01N33/6893 , G01N2800/368 , C12Q2521/301 , C12Q2521/501 , C12Q2525/155 , C12Q2535/131 , C12Q2537/143 , C12Q2537/16 , C12Q2563/173

4. 发明申请

WO2011142836A3 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 审中-公开
标题翻译：用于检测基因组，突变和/或异常的测定
公开(公告)号：WO2011142836A3
公开(公告)日：2012-07-05
申请号：PCT/US2011000887
申请日：2011-05-16
申请人： FLUIDIGM CORP , JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
发明人： JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , G01N33/52 , G06F19/18
CPC分类号： C12Q1/6851 , C12Q1/6855 , C12Q1/6858 , G01N33/542 , G01N33/582 , G01N33/6893 , G01N2800/368 , C12Q2521/301 , C12Q2521/501 , C12Q2525/155 , C12Q2535/131 , C12Q2537/143 , C12Q2537/16 , C12Q2563/173
摘要： The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.
摘要翻译：本发明提供用于检测基因型，突变和/或非整倍体的基于扩增的方法。这些方法具有广泛的适用性，但是特别适合于检测和定量存在于母体体液样品中的游离胎儿DNA中的靶核酸。

5. 发明申请

WO2010115044A3 SELECTIVE TAGGING OF SHORT NUCLEIC ACID FRAGMENTS AND SELECTIVE PROTECTION OF TARGET SEQUENCES FROM DEGRADATION 审中-公开
标题翻译：选择性标记短核酸片段和选择性保护目标序列从降解
公开(公告)号：WO2010115044A3
公开(公告)日：2011-03-31
申请号：PCT/US2010029690
申请日：2010-04-01
申请人： FLUIDIGM CORP , ZIMMERMANN BERNHARD G
发明人： ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12N15/10 , C12N15/11
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/1065 , C12N15/1072 , C12Q1/6846 , C12Q2521/307 , C12Q2521/325 , C12Q2537/159
摘要： Methods are provided for selective tagging of short nucleic acids comprising a short target nucleotide sequence over longer nucleic acids comprising the same target nucleotide sequence. The methods can involve performing one or two cycles of amplification of a sample comprising long nucleic acids and short nucleic acids, each comprising the same target nucleotide sequence with at least two target-specific primers or primer pairs under suitable annealing conditions, wherein the primer pairs comprise: an inner primer or primer pair that can amplify the target nucleotide sequence on long and short nucleic acids (wherein each inner primer comprises a 5' nucleotide tag; and an outer primer or primer pair that amplifies the target nucleotide sequence on long nucleic acids, but not on short nucleic acids); whereby the amplification after a second cycle produces at least one tagged target nucleotide sequence that comprises two nucleotide tags, one from each inner primer, with the target nucleotide sequence located between the nucleotide tags.
摘要翻译：提供了用于在包含相同靶核苷酸序列的较长核酸上选择性标记包含短目标核苷酸序列的短核酸的方法。所述方法可以包括在合适的退火条件下进行包含长核酸和短核酸的样品的一个或两个循环的扩增，每个循环包含相同的靶核苷酸序列与至少两个靶特异性引物或引物对，其中引物对包括：可以扩增长和短核酸上的靶核苷酸序列的内部引物或引物对（其中每个内引物包含5'核苷酸标签;以及扩增长核酸上的靶核苷酸序列的外引物或引物对，但不在短核酸上）; 由此在第二周期之后的扩增产生至少一个标记的靶核苷酸序列，其包含两个核苷酸标签，每个内引物中的一个，靶核苷酸序列位于核苷酸标签之间。

6. 发明申请

WO2010088288A2 DETERMINATION OF COPY NUMBER DIFFERENCES BY AMPLIFICATION 审中-公开
标题翻译：通过放大确定复制数字差异
公开(公告)号：WO2010088288A2
公开(公告)日：2010-08-05
申请号：PCT/US2010022258
申请日：2010-01-27
申请人： FLUIDIGM CORP , DUBE SIMANT , MIR ALAIN , RAMAKRISHNAN RAMESH , WEAVER LESLEY SUZANNE , ZIMMERMANN BERNHARD G
发明人： DUBE SIMANT , MIR ALAIN , RAMAKRISHNAN RAMESH , WEAVER LESLEY SUZANNE , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6853 , C12Q1/6809 , C12Q1/6886 , C12Q2600/16 , C12Q2561/113 , C12Q2545/10 , C12Q2527/107
摘要： The present invention provides for determining relative copy number difference for one or more target nucleic acid sequences between a test sample and a reference sample or reference value derived therefrom. The methods facilitate the detection of copy number differences less than 1.5-fold.
摘要翻译：本发明提供了确定测试样品和参考样品之间的一个或多个目标核酸序列的相对拷贝数差异或其衍生的参考值。该方法有助于检测小于1.5倍的拷贝数差异。

7. 发明申请

WO2010027870A3 ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS 审中-公开
标题翻译：用于增加样品和/或目标物的测定方法
公开(公告)号：WO2010027870A3
公开(公告)日：2010-07-01
申请号：PCT/US2009055083
申请日：2009-08-26
申请人： FLUIDIGM CORP , MIR ALAIN , RAMAKRISHNAN RAMESH , UNGER MARC , ZIMMERMANN BERNHARD G
发明人： MIR ALAIN , RAMAKRISHNAN RAMESH , UNGER MARC , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/686 , C12N15/1065 , C12Q1/6853 , Y10T436/143333 , C12Q2537/143 , C12Q2525/161
摘要： The present invention provides assay methods that increase the number of samples and/or target nucleic acids that can be analyzed in a single assay.
摘要翻译：本发明提供了增加可以在单次测定中分析的样品和/或靶核酸数量的测定方法。

8. 发明专利

CA2734868C ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS 未知
公开(公告)号：CA2734868C
公开(公告)日：2019-09-10
申请号：CA2734868
申请日：2009-08-26
申请人： FLUIDIGM CORP
发明人： MIR ALAIN , RAMAKRISHNAN RAMESH , UNGER MARC , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12Q1/6844 , C12Q1/6848 , C40B70/00
摘要： The present disclosure relates to methods for detecting a plurality of target nucleic acids in a plurality of samples comprising providing S samples that will be mixed together prior to assay, where S is an integer greater than 1; separately subjecting each of said S samples to an encoding reaction that produces a set of T tagged target nucleotide sequences, each tagged target nucleotide sequence comprising a sample-specific nucleotide tag and a target nucleotide sequence; wherein T is the number of target nucleic acids to be detected, T being an integer greater than one; mixing together tagged target nucleotide sequences from said S samples to form an assay mixture; dividing the assay mixture into up to S × T amplification mixtures, and separately subjecting each of said amplification mixtures to amplification using a unique pair of amplification primers.

9. 发明专利

CA2734868A1 ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS 未知
公开(公告)号：CA2734868A1
公开(公告)日：2010-03-11
申请号：CA2734868
申请日：2009-08-26
申请人： FLUIDIGM CORP
发明人： MIR ALAIN , RAMAKRISHNAN RAMESH , UNGER MARC , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12N15/11
摘要： The present invention provides assay methods that increase the number of samples and/or target nucleic acids that can be analyzed in a single assay.

10. 发明公开

EP2326732A4 ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS 审中-公开
标题翻译： TESTVERFAHRENFÜRERHÖHTENDURCHSATZ VON PROBEN UND / ODER TARGETS
公开(公告)号：EP2326732A4
公开(公告)日：2012-11-14
申请号：EP09812052
申请日：2009-08-26
申请人： FLUIDIGM CORP
发明人： MIR ALAIN , RAMAKRISHNAN RAMESH , UNGER MARC , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/686 , C12N15/1065 , C12Q1/6853 , Y10T436/143333 , C12Q2537/143 , C12Q2525/161

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