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    • 4. 发明申请
    • BIODEGRADABLE MEDICAL IMPLANTS, POLYMER COMPOSITIONS AND METHODS OF USE
    • 生物可降解医用植入物,聚合物组合物和使用方法
    • WO2010138212A2
    • 2010-12-02
    • PCT/US2010/001609
    • 2010-06-01
    • INCUBE LABS, LLCIMRAN, MirPATEL, SanjayHARRIS, Joel
    • IMRAN, MirPATEL, SanjayHARRIS, Joel
    • A61L27/14A61L27/40A61L27/38A61F2/82A61F2/04
    • A61L27/14A61F2/04A61F2/06A61F2/07A61F2/82A61F2210/0004A61L27/26A61L27/58A61L31/041A61L31/148
    • Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.
    • 本发明的实施方案提供了包含生物可降解聚合物,由这些组合物制造的医疗植入物和使用这种植入物的方法的组合物。 许多实施方案提供医学植入物,其包含具有第一生物降解速率的第一聚合物主链和具有比第一速率快的第二生物降解速率的第二聚合物主链。 在一些实施例中,第二主干被配置为由天然组织层代替。 第一个骨架提供植入物的支架,而第二个骨架降解。 该支架可以增强植入物的机械性能,包括机械强度的各个方面,例如拉伸,弯曲,箍和屈服强度; 和弹性。 支架还用于在第二主骨架的退化期间或植入物的整个寿命期间保持植入物的最小结构支撑水平,使得植入物不机械地失效。