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1. 发明申请

WO2005116070A9 REPORTER SYSTEM FOR DETECTING SIGNAL PATHWAY ACTIVATION IN MULTIPLE CELL TYPES 审中-公开
标题翻译：用于检测多个细胞类型的信号途径激活的报告器系统
公开(公告)号：WO2005116070A9
公开(公告)日：2006-04-27
申请号：PCT/US2005014199
申请日：2005-04-27
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
发明人： WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
IPC分类号： C12N5/10 , A01K67/027 , C07K14/705 , C12N15/85 , C12N15/87
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N15/8509 , C12N2517/02 , C12N2830/00
摘要： The invention provides a reporter system for studying signal transduction pathways. The reporter system includes a gene encoding a detectable gene product expressed in multiple cell types. A gene of interest can be used to target a specific locus in an embryonic stem cell, for example, the ROSA26 locus. The transformed stem cell is introduced into a blastocyst, which develops into a chimeric animal that produces the gene product of interest in multiple tissues, such that the effect of the gene product on the animal can be determined, both during development and in adulthood. Cell lines can be produced from cells or tissues obtained from the chimeric animal or its progeny. This reporter system can elucidate the components of signal transduction pathways when the reporter gene is activated under the regulatory control of a response element.
摘要翻译：本发明提供了一种用于研究信号转导途径的报告系统。记者系统包括编码以多种细胞类型表达的可检测基因产物的基因。感兴趣的基因可以用于靶向胚胎干细胞中的特定基因座，例如ROSA26基因座。转化的干细胞被引入囊胚，其发育成在多个组织中产生感兴趣的基因产物的嵌合动物，从而可以在发育和成年期间确定基因产物对动物的影响。可以从嵌合动物或其后代获得的细胞或组织产生细胞系。当报告基因在响应元件的调节控制下被激活时，该报道系统可以阐明信号转导途径的组分。

2. 发明申请

WO2004038003A3 HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES AND METHODS OF THEIR USE 审中-公开
标题翻译：多核苷酸编码的人多肽及其使用方法
公开(公告)号：WO2004038003A3
公开(公告)日：2004-12-09
申请号：PCT/US0333947
申请日：2003-10-24
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
IPC分类号： A61K38/00 , A61K39/395 , A61K48/00 , C07K14/00 , C07K14/47 , C07K16/00 , C12N20060101 , C12N5/10 , C12N15/11 , C12N15/63 , G01N33/53
CPC分类号： C07K14/47
摘要： The invention provides novel polynucleotides, related polypeptides related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新颖的多核苷酸，相关的多肽相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性病症，例如癌症以及炎症，免疫，细菌和病毒病症。

3. 发明申请

WO2005116070A3 Reporter system for detecting signal pathway activation in multiple cell types 审中-公开
标题翻译：用于检测多种细胞类型信号通路激活的记录系统
公开(公告)号：WO2005116070A3
公开(公告)日：2006-06-15
申请号：PCT/US2005014199
申请日：2005-04-27
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
发明人： WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
IPC分类号： A01K67/027 , C07K14/705 , C12N15/85 , C12N5/10 , C12N15/87
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N15/8509 , C12N2517/02 , C12N2830/00
摘要： The invention provides a reporter system for studying signal transduction pathways. The reporter system includes a gene encoding a detectable gene product expressed in multiple cell types. A gene of interest can be used to target a specific locus in an embryonic stem cell, for example, the ROSA26 locus. The transformed stem cell is introduced into a blastocyst, which develops into a chimeric animal that produces the gene product of interest in multiple tissues, such that the effect of the gene product on the animal can be determined, both during development and in adulthood. Cell lines can be produced from cells or tissues obtained from the chimeric animal or its progeny. This reporter system can elucidate the components of signal transduction pathways when the reporter gene is activated under the regulatory control of a response element.
摘要翻译：本发明提供了一种用于研究信号转导途径的报告系统。记者系统包括编码以多种细胞类型表达的可检测基因产物的基因。感兴趣的基因可以用于靶向胚胎干细胞中的特定基因座，例如ROSA26基因座。转化的干细胞被引入囊胚，其发育成在多个组织中产生感兴趣的基因产物的嵌合动物，从而可以在发育和成年期间确定基因产物对动物的影响。可以从嵌合动物或其后代获得的细胞或组织产生细胞系。当报告基因在响应元件的调节控制下被激活时，该报道系统可以阐明信号转导途径的组分。

4. 发明申请

WO2004035732A3 HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES AND METHODS OF THEIR USE 审中-公开
标题翻译：多核苷酸编码的人多肽及其使用方法
公开(公告)号：WO2004035732A3
公开(公告)日：2006-01-26
申请号：PCT/US0326780
申请日：2003-08-28
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , HUANG MIN MEI , KOTHAKOTA SRINIVAS , HAISHAN LIN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , HUANG MIN MEI , KOTHAKOTA SRINIVAS , HAISHAN LIN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING
IPC分类号： C07K14/47 , C12N20060101 , C07K14/00 , C07H21/04 , C12N1/20 , C12N1/21 , C12N5/10 , C12N15/11 , C12N15/63 , C12N15/64 , G01N33/50
CPC分类号： C07K14/47
摘要： The invention provides novel polynucleotides, related polypeptides related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供新的多核苷酸，相关多肽相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。

5. 发明申请

WO2004020591A3 METHODS OF USE FOR NOVEL HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES 审中-公开
标题翻译：多核苷酸编码新型人多肽的方法
公开(公告)号：WO2004020591A3
公开(公告)日：2005-03-24
申请号：PCT/US0326864
申请日：2003-08-28
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , HUANG MIN MEI , KOTHAKOTA SRINIVAS , HAISHAN LIN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT FORGAN , HUANG MIN MEI , KOTHAKOTA SRINIVAS , HAISHAN LIN , LINNEMANN THOMAS , PIERCE KRISTEN , WANG YAN , WONG JUSTIN G P , WU GE , ZHANG HONGBING
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，相关多肽，相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。

6. 发明申请

WO2004039952A3 METHODS OF USE FOR NOVEL HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES 审中-公开
标题翻译：多核苷酸编码新型人多肽的方法
公开(公告)号：WO2004039952A3
公开(公告)日：2009-09-11
申请号：PCT/US0333725
申请日：2003-10-24
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT F , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KIRSTEN , WANG YAN , WONG JUSTINE G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT F , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KIRSTEN , WANG YAN , WONG JUSTINE G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
IPC分类号： C07K16/00 , A01N63/00 , A61K39/395 , C07K16/18 , C12N20060101 , C12P21/04
CPC分类号： C07K16/18
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，相关多肽，相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。

7. 发明申请

WO2004039952A8 METHODS OF USE FOR NOVEL HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES 审中-公开
标题翻译：用于多核苷酸编码的新型人多肽的方法
公开(公告)号：WO2004039952A8
公开(公告)日：2005-01-27
申请号：PCT/US0333725
申请日：2003-10-24
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT F , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KIRSTEN , WANG YAN , WONG JUSTINE G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , BEAURANG PIERRE ALVARO , BEHRENS DIRK , HALENBECK ROBERT F , KOTHAKOTA SRINIVAS , LIN HAISHAN , LINNEMANN THOMAS , PIERCE KIRSTEN , WANG YAN , WONG JUSTINE G P , WU GE , ZHANG HONGBING , ZENG CHANGJIANG
IPC分类号： C07K16/18 , C12N20060101 , C12N
CPC分类号： C07K16/18
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，相关的多肽，相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性病症，例如癌症以及炎症，免疫，细菌和病毒病症。

8. 发明申请

WO2006128125A2 METHODS OF AND COMPOSITIONS FOR STIMULATION OF GLUCOSE UPTAKE INTO MUSCLE CELLS AND TREATMENT OF DISEASES 审中-公开
标题翻译：用于刺激葡萄糖摄入到肌肉细胞和治疗疾病的方法和组合物
公开(公告)号：WO2006128125A2
公开(公告)日：2006-11-30
申请号：PCT/US2006020797
申请日：2006-05-30
申请人： FIVE PRIME THERAPEUTICS INC , LIN JUNYU , KOTHAKOTA SRINIVAS , WU GE , DOBERSTEIN STEPHEN , BRENNAN THOMAS , MASUOKA LORIANNE , QIN MINMIN , MARSHALL SHANNON , WANG YAN , HOLLENBAUGH DIANE , WILLIAMS LEWIS T
发明人： LIN JUNYU , KOTHAKOTA SRINIVAS , WU GE , DOBERSTEIN STEPHEN , BRENNAN THOMAS , MASUOKA LORIANNE , QIN MINMIN , MARSHALL SHANNON , WANG YAN , HOLLENBAUGH DIANE , WILLIAMS LEWIS T
CPC分类号： A61K38/1883 , A61K31/155 , A61K31/18 , A61K31/195 , A61K31/197 , A61K38/1808 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/60 , A61K2300/00
摘要： The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.
摘要翻译：本发明涉及ErbB配体（包括β细胞素）的治疗用途。治疗用途包括单独使用ErbB配体家族化合物或与其他药物联合用于降低血糖水平，治疗I型和II型糖尿病，肥胖症，肌肉消瘦疾病和心脏毒性的方法。

9. 发明申请

WO2009140418A3 COMPOSITIONS AND METHODS FOR TREATING ARTHRITIS AND/OR DISEASES INVOLVING CARTILAGE DEGENERATION 审中-公开
标题翻译：用于治疗涉及变性的结核病和/或疾病的组合物和方法
公开(公告)号：WO2009140418A3
公开(公告)日：2009-12-30
申请号：PCT/US2009043834
申请日：2009-05-13
申请人： FIVE PRIME THERAPEUTICS INC , PENTA KALYANI , KOTHAKOTA SRINIVAS , WILLIAMS RUSTY , HESTIR KEVIN , MARSHALL SHANNON , FINER JEFFREY , WANG YAN
发明人： PENTA KALYANI , KOTHAKOTA SRINIVAS , WILLIAMS RUSTY , HESTIR KEVIN , MARSHALL SHANNON , FINER JEFFREY , WANG YAN
IPC分类号： C07K14/00 , C07K16/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.
摘要翻译：本发明提供促进蛋白多糖合成并促进软骨细胞活性，从而治疗关节炎的药物多肽组合物。还提供了提供这些组合物治疗关节炎的方法。

10. 发明申请

WO0038706A2 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
标题翻译：治疗癌症和介导树突状细胞化学治疗的方法
公开(公告)号：WO0038706A2
公开(公告)日：2000-07-06
申请号：PCT/US9931096
申请日：1999-12-28
申请人： CHIRON CORP , KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
发明人： KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
IPC分类号： C12N15/02 , A61K31/711 , A61K38/00 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47
CPC分类号： A61K38/195 , A61K38/2013 , A61K2300/00
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.
摘要翻译：本发明基于本文报道的新观察结果，即SLC在体内抑制肿瘤生长并且是树突细胞（DC）的有效趋化因子。因此，本发明提供了治疗哺乳动物受试者中的癌症或过度增殖性病症的方法，其包括：向所述受试者施用治疗有效量的SLC。用于本发明方法的SLC包括SLC多肽，变体和片段以及相关核酸。本发明的方法可用于治疗癌症和过度增殖性疾病。此外，本发明提供了用于调节哺乳动物的树突细胞功能的方法，所述方法包括向所述哺乳动物施用治疗有效量的SLC试剂，所述试剂选自：SLC多肽，SLC多肽变体，SLC多肽片段，编码SLC多肽的多核苷酸，变体和片段，抗SLC抗体和CCR7受体的配体。这些方法可用于增加或减少哺乳动物的免疫应答，特别是初次免疫应答。该方法在预防移植排斥和治疗自身免疫性疾病方面特别有用。或者，该方法可用于增强免疫应答。

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