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1. 发明申请

WO2013142973A1 ANESTHETIC DELIVERY SYSTEM 审中-公开
标题翻译： ANESTHETIC交付系统
公开(公告)号：WO2013142973A1
公开(公告)日：2013-10-03
申请号：PCT/CA2013/000296
申请日：2013-03-28
申请人： FISHER, Joseph , DUFFIN, James , IRONSTONE, Joel
发明人： FISHER, Joseph , DUFFIN, James , IRONSTONE, Joel
IPC分类号： A61M16/10 , A61B5/08 , A61M16/00 , A61M16/18
CPC分类号： A61M16/183 , A61B5/087 , A61B5/4821 , A61M16/0003 , A61M16/0051 , A61M16/0057 , A61M16/0066 , A61M16/0075 , A61M16/0081 , A61M16/0093 , A61M16/01 , A61M16/024 , A61M16/0833 , A61M16/0891 , A61M16/18 , A61M16/22 , A61M2016/0027 , A61M2016/0039 , A61M2016/102 , A61M2016/1035 , A61M2202/048 , A61M2205/3303 , A61M2205/3334 , A61M2205/3389 , A61M2205/502 , A61M2230/42 , A61M2230/437 , A61M2202/0007
摘要： An anesthetic delivery system for use in conjunction with an anesthetic return system for reutilizing anesthetic exhaled by a subject, the system including a measurement system operatively connected to a breathing circuit for continuously measuring at least one flow parameter and anesthetic content of a gas stream reaching the subject and a control system for receiving input from the measurement system and controlling the amount of anesthetic entering the system, the control system including an input device for inputting a setting that corresponds to a desired amount of anesthetic in the gas stream reaching the subject, and utilizing a control algorithm for controlling the amount of anesthetic entering the system based on said desired amount of anesthetic, and flow and anesthetic content parameters as determined by the measurement system, such that the control algorithm is adapted to supplement anesthetic already in gas stream flowing to the subject to attain a level of anesthetic reaching the subject that correspond to the desired amount set via the input device.
摘要翻译：一种与麻醉返回系统结合使用以麻醉受试者呼出的麻醉剂的麻醉剂递送系统，该系统包括可操作地连接到呼吸回路的测量系统，用于连续地测量至少一个流动参数和到达主体和用于接收来自测量系统的输入并控制进入系统的麻醉剂的量的控制系统，所述控制系统包括用于输入对应于到达对象的气流中的期望量的麻醉剂的设定的输入装置，以及利用控制算法来控制基于所述所需量的麻醉剂进入系统的麻醉剂的量，以及由测量系统确定的流量和麻醉剂含量参数，使得控制算法适于补充已经在气流中流动的麻醉剂达到一定程度的麻醉剂铰接对应于通过输入装置设定的期望量的对象。

2. 发明申请

WO2013082703A1 AN APPARATUS TO ATTAIN AND MAINTAIN TARGET END TIDAL PARTIAL PRESSURE OF A GAS 审中-公开
标题翻译：实现和维护目标的装置终端气体局部压力
公开(公告)号：WO2013082703A1
公开(公告)日：2013-06-13
申请号：PCT/CA2012/001123
申请日：2012-12-05
申请人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James , SLESSAREV, Marat , KESSLER, Cathie , ITO, Shoji
发明人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James , SLESSAREV, Marat , KESSLER, Cathie , ITO, Shoji
IPC分类号： A61M16/10 , A61B5/08
CPC分类号： A61M16/0051 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/4836 , A61M16/0003 , A61M16/0069 , A61M16/026 , A61M16/085 , A61M16/0883 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0021 , A61M2016/0027 , A61M2016/102 , A61M2016/1025 , A61M2016/103 , A61M2205/502 , A61M2230/43 , A61M2230/432 , A61M2230/435
摘要： A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i] T ) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i] T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.
摘要翻译：处理器获得用于一个或多个相应呼吸[i]的气体X（PetX [i] T）的逻辑可达到的末端潮气分压的输入，并且输入需要被受试者启发的气体X的量的预期计算在一个启发的气体中，使用所需的输入来使用质量平衡关系的输入，使PetX [i] T针对相应的呼吸[i]，其中一个或多个值用于控制输送到主体是从质量平衡关系的表达式输出的。质量平衡关系以考虑（前景）的形式表示，对于相应的呼吸，[i]肺泡周围的毛细血管中的气体量X和肺泡中的气体X的量，可选地基于肺的模型，其占肺中气体的子体积，其基本上影响影响传质的肺泡气体X浓度。

3. 发明申请

WO2009137939A1 RELATIVE CONTRIBUTION OF THORACIC MUSCLES TO BREATHING 审中-公开
标题翻译：胸腔积液对呼吸的相关贡献
公开(公告)号：WO2009137939A1
公开(公告)日：2009-11-19
申请号：PCT/CA2009/000679
申请日：2009-05-15
申请人： FISHER, Joseph , VESELY, Alex , BALABAN, Dahlia , DUFFIN, James , WELLS, Greg, D
发明人： FISHER, Joseph , VESELY, Alex , BALABAN, Dahlia , DUFFIN, James , WELLS, Greg, D
IPC分类号： A61B5/08 , A61B5/03 , A61B5/091
CPC分类号： A61B5/036 , A61B5/037 , A61B5/091 , A61B5/205 , A61B5/412 , A61B5/4519
摘要： A method and apparatus for evaluating the relative contribution of the diaphragm versus other thoracic muscles to breathing by obtaining measurements of parameters that correlate with changes in thoracic cavity and intra-abdominal cavity pressures over identical time increments and organizing the measurement data in manner that reveals whether the pressures changes are characteristic of the pattern of contemporaneous pressure changes in those cavities that accompany contraction and/or relaxation of the diaphragm muscles or whether the pressure changes are characteristic of the pattern of contemporaneous pressure changes in those cavities that accompany contraction and/or relaxation of the intercostal muscles.
摘要翻译：通过获得与相同时间增量的胸腔和腹腔压力变化相关的参数的测量值来评估隔膜相对于其他胸肌对呼吸的相对贡献的方法和装置，并以揭示是否压力变化是伴随膈肌收缩和/或放松的那些空腔中的同期压力变化的模式的特征，或压力变化是否伴随伴随收缩和/或松弛的那些空腔中的同期压力变化的模式的特征的肋间肌肉。

4. 发明申请

WO2011143751A1 NON-INVASIVE CARDIAC OUTPUT DETERMINATION 审中-公开
标题翻译：非入侵性心脏输出量测定
公开(公告)号：WO2011143751A1
公开(公告)日：2011-11-24
申请号：PCT/CA2011/000577
申请日：2011-05-18
申请人： FISHER, Joseph , KLEIN, Michael , DUFFIN, James
发明人： FISHER, Joseph , KLEIN, Michael , DUFFIN, James
IPC分类号： A61B5/08 , A61B5/026 , G06F19/00
CPC分类号： A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0813 , A61B5/0836 , A61B5/7225 , A61B5/7278 , A61M16/0057 , A61M16/12
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non- invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a testcriterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.
摘要翻译：一种使用迭代算法来控制气体输送装置的方法，所述方法包括使用迭代算法递送用于非侵入性地确定受试者的肺血流的测试气体（TG）的装置可控变量，所述测试气体包括迭代地生成并评估迭代变量的测试值算法，以便输出满足检验标准的迭代变量的测试值，其中迭代算法的特征在于它定义了至少一个设备可控变量，迭代变量和通过以下步骤获得的测试气体的最终潮汐浓度之间的测试数学关系：设置设备可控变量，使得迭代算法确定测试值上的迭代是否满足测试标准或迭代地生成逐渐改进的测试值。

5. 发明申请

WO2015161363A1 IMAGING ABNORMALITIES IN VASCULAR RESPONSE 审中-公开
标题翻译：血管反应成像异常
公开(公告)号：WO2015161363A1
公开(公告)日：2015-10-29
申请号：PCT/CA2015/000274
申请日：2015-04-27
申请人： FISHER, Joseph , SOBCZYK, Olivia , CRAWLEY, Adrian P. , POUBLANC, Julian , SAM, Kevin , MANDELL, Daniel M. , MIKULIS, David , DUFFIN, James
发明人： FISHER, Joseph , SOBCZYK, Olivia , CRAWLEY, Adrian P. , POUBLANC, Julian , SAM, Kevin , MANDELL, Daniel M. , MIKULIS, David , DUFFIN, James
IPC分类号： A61B5/055 , A61B5/00 , A61B5/026 , G06T7/00
CPC分类号： A61B5/055 , A61B5/0042 , A61B5/026 , A61B5/4064 , A61B2576/026 , G06T7/0012 , G06T7/33 , G06T2207/10088 , G06T2207/20128 , G06T2207/30016 , G06T2207/30104
摘要： The interpretation and assessment of cerebrovascular reactivity (CVR) images relies on a qualitative review of possible abnormalities, which are viewed as inhomogeneities in the CVR maps that appear to differ from the CVR maps of healthy individuals. An imaging system which combines z-maps with a standardized stimulus offers a high resolution image indicating the presence, localization and severity of the pathological CVR. The standardized stimulus is in the form of targeted arterial partial pressures of carbon dioxide which allow one to assess the severity and distribution of an abnormality or reduction in a subject's vascular response to a vasoactive stimulus in at least one region of interest of the subject's brain. Z-maps have been found to be useful to reduce the effects of test- to- test, subject- to- subject and platform- to platform variability for comparison of CVR images.
摘要翻译：脑血管反应性（CVR）图像的解释和评估依赖于对可能的异常的定性评估，这被认为是CVR图中与健康个体的CVR图不同的不均匀性。将z-图与标准刺激相结合的成像系统提供了高分辨率图像，指示病理性CVR的存在，定位和严重程度。标准刺激是二氧化碳靶向动脉分压的形式，其允许评估受试者在受试者脑部的至少一个感兴趣区域中的血管反应性刺激的异常的严重性和分布或减少受试者的血管反应。已经发现Z图可以有效地降低测试，主题与平台对平台变异性的影响，以便比较CVR图像。

6. 发明申请

WO2013163735A1 A NEW METHOD AND APPARATUS TO ATTAIN AND MAINTAIN TARGET ARTERIAL BLOOD GAS CONCENTRATIONS USING RAMP SEQUENCES 审中-公开
标题翻译：使用RAMP序列的新方法和装置来获取和维持靶向血液浓度
公开(公告)号：WO2013163735A1
公开(公告)日：2013-11-07
申请号：PCT/CA2013/000427
申请日：2013-04-30
申请人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James , SLESSAREV, Marat , KESSLER, Cathie , ITO, Shoji , SOBCZYK, Olivia , BATTISTI-CHARBONNEY, Anne , MIKULIS, David , MANDELL, Daniel Michael
发明人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James , SLESSAREV, Marat , KESSLER, Cathie , ITO, Shoji , SOBCZYK, Olivia , BATTISTI-CHARBONNEY, Anne , MIKULIS, David , MANDELL, Daniel Michael
IPC分类号： A61M16/00 , A61B5/021 , A61B5/08 , A61B5/091 , A61M16/06
CPC分类号： A61M16/0066 , A61B5/082 , A61B5/091 , A61M16/0045 , A61M16/026 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: - obtaining input of a series of logistically attainable PetX values for a series of respective breaths: - determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and - controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
摘要翻译：一种用于控制受试者肺中气体X的末端潮气分压的装置和方法，以及用于研究，诊断和治疗目的的这种装置和方法的使用，其中该方法包括： - 获得一系列的输入用于一系列相应呼吸的逻辑上可获得的PetX值： - 确定受激气体中受试者启发的气体X的量，以针对所述相应呼吸中的每一个的PetX;以及 - 控制气体递送装置递送在所述各个呼吸中的每一个中输送到被检体的体积气体中的气体量，以针对该呼吸的各个PetX。

7. 发明申请

WO2013152415A1 ACCURATE TIDAL VOLUME MEASUREMENT 审中-公开
标题翻译：精确的体积测量
公开(公告)号：WO2013152415A1
公开(公告)日：2013-10-17
申请号：PCT/CA2012/000876
申请日：2012-09-05
申请人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James
发明人： KLEIN, Michael , FISHER, Joseph , DUFFIN, James
IPC分类号： A61B5/087 , A61M16/00 , A61M16/20
CPC分类号： A61B5/087 , A61B5/091 , A61M16/024 , A61M16/208 , A61M2016/0039 , A61M2016/0042
摘要： The inventors have found a simple modification of the standard ventilator circuit that allows a flow sensor in the inspiratory limb of the ventilator circuit to directly measure the inspired tidal volume received by the patient. This modification of the ventilator circuit passively redirects the compressible volume around the flow sensor, and yet does not interfere with the function of the ventilator or ventilator breathing circuit.
摘要翻译：本发明人已经发现了标准呼吸机电路的简单修改，其允许呼吸机回路的吸气肢中的流量传感器直接测量由患者接收的吸气潮气量。呼吸机回路的这种修改被动地重定向流量传感器周围的可压缩体积，但不会干扰呼吸机或呼吸机呼吸回路的功能。

8. 发明申请

WO2013138910A1 VIRTUAL RESPIRATORY GAS DELIVERY SYSTEMS AND CIRCUITS 审中-公开
标题翻译：虚拟呼吸气体输送系统和电路
公开(公告)号：WO2013138910A1
公开(公告)日：2013-09-26
申请号：PCT/CA2013/000266
申请日：2013-03-19
申请人： KLEIN, Michael , FISHER, Joseph
发明人： KLEIN, Michael , FISHER, Joseph
IPC分类号： A61M16/10 , A61B5/08 , A61B5/087
CPC分类号： A61M16/0069 , A61B5/091 , A61M16/0003 , A61M16/01 , A61M16/026 , A61M16/0891 , A61M16/12 , A61M16/122 , A61M16/204 , A61M2016/0027 , A61M2016/0039 , A61M2202/02 , A61M2202/0225 , A61M2202/0283 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , A61M2230/432 , A61M2202/0007
摘要： A respiratory gas delivery system monitors gas flow over the course of a breath in real time and uses this parameter to simulate, in whole or part, the function of a reference respiratory gas delivery system, in particular structural features, particularly structural components of parts of the reference system, to overcome a structural limitation of the reference system.
摘要翻译：呼吸气体输送系统实时监测呼吸过程中的气体流量，并且使用该参数全部或部分地模拟参考呼吸气体输送系统的功能，特别是结构特征，特别是结构部件的结构部件参考系，克服了参考系的结构限制。

9. 发明申请

WO2009073606A2 MULTI-DIMENSIONAL SCROLL WHEEL 审中-公开
标题翻译：多维滚轮
公开(公告)号：WO2009073606A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/085137
申请日：2008-12-01
申请人： APPLE INC. , RATHNAM, Lakshman , BOKMA, Louis , ROTHKOPF, Fletcher , MUCIGNAT, Andrea , KOCALAR, Erturk , LYON, Benjamin , FISHER, Joseph
发明人： RATHNAM, Lakshman , BOKMA, Louis , ROTHKOPF, Fletcher , MUCIGNAT, Andrea , KOCALAR, Erturk , LYON, Benjamin , FISHER, Joseph
IPC分类号： G06F3/033 , G06F3/048
CPC分类号： G06F3/041 , G06F3/017 , G06F3/03547 , G06F3/038 , G06F3/0416 , G06F3/044 , G06F3/0482 , G06F3/04847 , G06F3/0485 , G06F3/04883 , G06F2203/04808
摘要： A multi-dimensional scroll wheel is disclosed. Scroll wheel circuitry is provided to detect input gestures that traverse the center of the scroll wheel and to detect multi-touch input. The scroll wheel can include a first plurality of sensor elements arranged in a first closed loop and a second plurality of sensor elements arranged in a second closed loop, the first and second closed loops being concentrically arranged about the center of the scroll wheel.
摘要翻译：公开了一种多维滚轮。提供滚轮电路以检测穿过滚轮中心的输入手势并检测多点触摸输入。滚轮可以包括布置在第一闭环中的第一多个传感器元件和布置在第二闭合回路中的第二多个传感器元件，第一和第二闭环围绕滚轮的中心同心布置。

10. 发明申请

WO2007047286A2 PARTICULATE BLOCKING OXYGEN DELIVERY MASK 审中-公开
标题翻译：颗粒堵塞氧气输送面罩
公开(公告)号：WO2007047286A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/039662
申请日：2006-10-10
申请人： VIASYS HEALTHCARE INC. , FISHER, Joseph , SASANO, Hiroshi , SASANO, Nobuko , AZAMI, Takafumi
发明人： FISHER, Joseph , SASANO, Hiroshi , SASANO, Nobuko , AZAMI, Takafumi
IPC分类号： A62B23/02
CPC分类号： A62B23/025 , A61M16/0087 , A61M16/06 , A61M16/101 , A61M16/1055 , A61M16/1065 , A61M16/107 , A62B18/025
摘要： A particulate blocking oxygen delivery mask includes a face piece constructed at least partially of a filtering material, a securing member such as a strap attached to the face piece, and an gas entry port disposed on the face piece. The gas entry port may include an optional one-way valve. The mask may be coupled to a continuous flow of oxygen or may be used as a partial or non-rebreathing mask. The mask permits the administration of high concentrations of oxygen to the patient while at the same time isolating the patient from any potentially contagious airborne particles in their surroundings. It also isolates any potentially contagious droplets or aerosolized particulate matter exhaled by a patient from entering the environment and potentially infecting others.
摘要翻译：微粒阻塞氧气递送面罩包括至少部分由过滤材料构成的面部件，固定构件（例如附接到面部件的带子）和设置在面部件上的气体入口。进气口可以包括可选的单向阀。面罩可以连接到连续的氧气流，或者可以用作部分或非重复呼吸面罩。该面罩允许向患者施用高浓度的氧气，同时使患者隔离其周围环境中任何潜在传染性的气载微粒。它还隔离患者呼出的任何潜在传染性液滴或雾化颗粒物，以防止其进入环境并可能感染其他人。

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