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1. 发明申请

WO2007093962A3 METHOD FOR PRODUCING TERPENES AND MEP-TRANSFORMED MICROORGANISMS THEREFORE 审中-公开
标题翻译：用于生产天然产物和改性微生物的方法
公开(公告)号：WO2007093962A3
公开(公告)日：2007-12-21
申请号：PCT/IB2007050474
申请日：2007-02-13
申请人： FIRMENICH & CIE , CLARK ANTHONY , MAURY JEROME , ASADOLLAHI MOHAMMAD ALI , MOELLER KASPER , NIELSEN JENS , SCHALK MICHEL
发明人： CLARK ANTHONY , MAURY JEROME , ASADOLLAHI MOHAMMAD ALI , MOELLER KASPER , NIELSEN JENS , SCHALK MICHEL
IPC分类号： C12N15/52 , C07K14/245 , C12P7/04 , C12P9/00 , C12P23/00
CPC分类号： C12N15/52 , C12P23/00
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译：本发明涉及能够产生选择的萜烯的微生物。微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。以这种方式，可以从微生物的培养基中分离出大量的萜烯。

2. 发明申请

WO2004031376A3 SESQUITERPENE SYNTHASES AND METHODS OF USE 审中-公开
标题翻译： SESQUITERPENE SYNTHASES和使用方法
公开(公告)号：WO2004031376A3
公开(公告)日：2005-05-26
申请号：PCT/IB0305072
申请日：2003-10-02
申请人： FIRMENICH & CIE , SCHALK MICHEL , CLARK ANTHONY
发明人： SCHALK MICHEL , CLARK ANTHONY
IPC分类号： C12N9/00 , C12N9/88 , C12N15/00 , C12N15/52 , C12P7/22
CPC分类号： C12N9/88
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert famesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta- cadinene.
摘要翻译：本发明涉及倍半萜合酶及其生产和使用方法。在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。例如，本发明的倍半萜烯合酶可用于将焦文磷酸酯转化为各种含氧和脂族倍数萜烯，包括戊烯，双环锗锗，立方体和δ-卡汀。

3. 发明专利

IL167832A SESQUITERPENE SYNTHASES AND METHODS OF USE 未知
公开(公告)号：IL167832A
公开(公告)日：2010-11-30
申请号：IL16783205
申请日：2005-04-03
申请人： FIRMENICH & CIE , SCHALK MICHEL , CLARK ANTHONY
发明人： SCHALK MICHEL , CLARK ANTHONY
IPC分类号： C12N9/00 , C12N9/88 , C12N15/00 , C12N15/52

4. 发明申请

WO2006134523A3 NOVEL SESQUITERPENE SYNTHASES AND METHODS OF THEIR USE 审中-公开
标题翻译：新型合成物的合成及其使用方法
公开(公告)号：WO2006134523A3
公开(公告)日：2007-04-12
申请号：PCT/IB2006051831
申请日：2006-06-08
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12N9/00 , C12N15/52 , C12P1/00
CPC分类号： C12N9/88 , C12P5/007 , C12P7/02 , C12P7/26 , C12P15/00
摘要： The present invention relates to novel terpene synthases. The terpene synthases are capable of synthesising mono-, bi- and/or tri-cyclic sesquiterpenes having a C 2 -C 7 or a C 3 -C 7 bond, starting from an acyclic pyrophosphate terpene precursor, farnesyl- pyrophosphate. Accordingly, for the first time, sesquiterpene synthases catalysing the cyclisation to the santalene and bergamotene carbon skeleton are disclosed. The present invention further relates to nucleic acid sequences encoding the sesquiterpene synthases and to methods for making terpenoids.
摘要翻译：本发明涉及新颖的萜烯合成酶。萜烯合成酶能够合成具有C 2 -C 3 -C 7或C 3 N的单 - ，二 - 和/或三 - 环倍半萜烯从非环状焦磷酸萜烯前体，法呢基焦磷酸酯开始，从-C 3 -C 7键开始。因此，首次公开了催化环化为檀香烃和香叶碳骨架的倍半萜烯合成酶。本发明还涉及编码倍半萜合酶的核酸序列和制备萜类化合物的方法。

5. 发明申请

WO2009044336A2 METHOD FOR PRODUCING DITERPENES 审中-公开
标题翻译：生产二硫吡啶的方法
公开(公告)号：WO2009044336A2
公开(公告)日：2009-04-09
申请号：PCT/IB2008053973
申请日：2008-09-30
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12P7/02 , C12N9/10 , C12P17/06
CPC分类号： C12N9/16 , C12P7/02 , C12P17/06 , C12Y301/07004
摘要： The present invention provides a method of producing diterpene compounds, said method comprising contacting a particular polypeptide having a diterpene synthase activity with the diterpene precursor geranylgeranyl pyrophosphate (GGPP). In particular, said method may be carried out in vitro or in vivo to produce labdenediol diphosphate, labdenediol and/or sclareol, which are very useful compounds in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
摘要翻译：本发明提供了生产二萜化合物的方法，所述方法包括使具有二萜合酶活性的特定多肽与二萜前体ge牛儿基ge牛儿基焦磷酸（GGPP）接触。具体地说，所述方法可以在体外或体内进行以产生二烯丙二醇，二氢青蒿琥酯和/或香紫苏醇，它们在香料和调味剂领域是非常有用的化合物。本发明还提供了该方法中使用的多肽的氨基酸序列。衍生自Salvia sclarea并编码本发明多肽的核酸，含有所述核酸的表达载体，以及非人生物体或经转化以携带相同核酸的细胞也是本发明的一部分。

6. 发明申请

WO2009109597A8 METHOD FOR PRODUCING ALPHA- SANTALENE 审中-公开
标题翻译：生产阿托沙坦的方法
公开(公告)号：WO2009109597A8
公开(公告)日：2010-12-02
申请号：PCT/EP2009052546
申请日：2009-03-04
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12N15/52 , C12N9/88 , C12P7/22 , C12P7/26
CPC分类号： C12N9/88 , C12P5/007 , C12P15/00 , C12Y402/03082
摘要： The present invention provides a method of producing a-santalene, said method comprising contacting at least one polypeptide with farnesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce a-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing a-santalene is also an object of the present invention.
摘要翻译：本发明提供了一种生产ant ene烯的方法，所述方法包括使至少一种多肽与法呢基磷酸（FPP）接触。特别地，所述方法可以在体外或体内进行以产生香茅素，在香料和香料领域中非常有用的化合物。本发明还提供了可用于本发明方法的多肽的氨基酸序列。编码本发明多肽的核酸和含有该核酸的表达载体也是本发明的一部分。非人宿主生物或转化用于生产ant the烯的方法的细胞也是本发明的一个目的。

7. 发明申请

WO2009101126A9 METHOD FOR PRODUCING SCLAREOL 审中-公开
标题翻译：生产SCLAREOL的方法
公开(公告)号：WO2009101126A9
公开(公告)日：2010-08-26
申请号：PCT/EP2009051620
申请日：2009-02-12
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12N15/52 , C07D307/92 , C12N15/62
CPC分类号： C12P7/18 , C07D307/92 , C07D311/92 , C07K2319/00 , C12N9/88
摘要： The present invention provides a method of producing sclareol, said method comprising a) contacting a particular polypeptide having a LPP synthase activity with GGPP and b) contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP) produced in step a). In particular, said method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptides used in the method. Nucleic acids derived from Salvia sclarea and encoding the polypeptides of the invention, expression vectors containing said nucleic acids, as well as a non-human host organism or a cell transformed to harbor the same nucleic acids, are also part of the present invention.
摘要翻译：本发明提供了生产香紫苏醇的方法，所述方法包括a）使具有LPP合成酶活性的特定多肽与GGPP接触，和b）使具有香紫苏醇合成酶活性的特定多肽与步骤a）中制备的实验二烯丙基二磷酸酯（LPP）接触。特别地，所述方法可以在体外或体内进行以产生香紫苏醇，香料和香料领域中非常有用的化合物。本发明还提供了该方法中使用的多肽的氨基酸序列。衍生自丹参的核酸编码本发明的多肽，含有所述核酸的表达载体以及非人宿主生物体或转化成携带相同核酸的细胞也是本发明的一部分。

8. 发明申请

WO2009044336A3 METHOD FOR PRODUCING DITERPENES 审中-公开
标题翻译：用于生产甲苯的方法
公开(公告)号：WO2009044336A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008053973
申请日：2008-09-30
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12P7/02 , C12N9/10 , C12P17/06
CPC分类号： C12N9/16 , C12P7/02 , C12P17/06 , C12Y301/07004
摘要： The present invention provides a method of producing diterpene compounds, said method comprising contacting a particular polypeptide having a diterpene synthase activity with the diterpene precursor geranylgeranyl pyrophosphate (GGPP). In particular, said method may be carried out in vitro or in vivo to produce labdenediol diphosphate, labdenediol and/or sclareol, which are very useful compounds in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
摘要翻译：本发明提供了一种生产双萜化合物的方法，所述方法包括使具有双萜合酶活性的特定多肽与二萜前体er牛儿基焦磷酸（GGPP）接触。特别地，所述方法可以在体外或体内进行以产生二苯二酚二磷酸，实二苯二酚和/或香紫苏醇，这是香料和调味品领域中非常有用的化合物。本发明还提供了该方法中使用的多肽的氨基酸序列。编码本发明多肽的编码本发明多肽的核酸，含有所述核酸的表达载体以及转化成携带相同核酸的非人生物体或细胞也是本发明的一部分。

9. 发明申请

WO2005052163A3 SESQUITERPENE SYNTHASES FROM PATCHOULI 审中-公开
标题翻译：来自PATCHOULI的SESQUITERPENE SYNTHASES
公开(公告)号：WO2005052163A3
公开(公告)日：2005-12-01
申请号：PCT/IB2004003836
申请日：2004-11-19
申请人： FIRMENICH & CIE , SCHALK MICHEL
发明人： SCHALK MICHEL
IPC分类号： C12N9/88 , C12N15/60 , C12N1/21 , C12N5/10
CPC分类号： C12P7/22 , C12N9/88 , C12P5/007 , C12P15/00
摘要： The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthase. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various sesquiterpenes including patchoulol, gamma-curcumene and other germacrane-type sesquiterpenes.
摘要翻译：本发明涉及广藿香植物（Pogostemon cablin）的倍半萜合酶及其生产和使用方法。在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。例如，本发明的倍半萜烯合成酶可用于将焦亚基法呢基转化为各种倍半萜烯，包括patchoulol，γ-姜黄素和其他锗类倍半萜烯。

10. 发明专利

IL175728A SESQUITERPENE SYNTHASES FROM PATCHOULI 未知
公开(公告)号：IL175728A
公开(公告)日：2011-05-31
申请号：IL17572806
申请日：2006-05-17
申请人： FIRMENICH & CIE , SCHALK MICHEL , DEGUERRY FABIENNE
发明人： SCHALK MICHEL , DEGUERRY FABIENNE
IPC分类号： C12N9/88

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