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1. 发明申请

WO2006092718A2 CARTILAGINIFORM AND OSTEOCHONDRAL SUSTITUTE COMPRISING A MULTILAYER STRUCTURE AND USE THEREOF 审中-公开
标题翻译：包含多层结构的纤维素和骨质疏松及其使用
公开(公告)号：WO2006092718A2
公开(公告)日：2006-09-08
申请号：PCT/IB2006/000452
申请日：2006-03-02
申请人： FIN-CERAMICA FAENZA S.P.A. , TAMPIERI, Anna , PRESSATO, Daniele , DE LUCA, Claudio , DI FEDE, Sergio
发明人： TAMPIERI, Anna , PRESSATO, Daniele , DE LUCA, Claudio , DI FEDE, Sergio
CPC分类号： A61L27/425 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/32 , A61L27/34 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , C08L89/06
摘要： The present invention relates to a multilayer structure (1) including a first upper layer (2) consisting of an organic matrix including collagen and at least a lower layer (3, 4, ... 10) consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure (1) as well as an osteochondral substitute including said multilayer structure (1) . Finally, the present invention relates to the use of said multilayer structure (1) for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.
摘要翻译：本发明涉及一种多层结构（1），其包括由包含胶原的有机基质和至少一层由3,4,5，...组成的复合基质构成的第一上层（2），所述复合基质包括羟基磷灰石和胶原。此外，本发明涉及包括所述多层结构（1）的软骨替代物以及包括所述多层结构（1）的骨软骨替代物。最后，本发明涉及所述多层结构（1）用于制备所述软骨替代物和所述骨软骨替代物用于治疗软骨缺损和骨软骨缺损或用于软骨组织和/或软骨下骨组织。

2. 发明申请

WO2007029276A3 PIN FOR ANCHORAGE OF ARTICULAR PROSTEHSIS, ARTICULAR PROSTHESIS COMPRISING SAID PIN, TIBIAL COMPONENT AND ARTICULAR PROSTHESIS FOR THE KNEE COMPRISING SAID TIBIAL COMPONENT 审中-公开
公开(公告)号：WO2007029276A3
公开(公告)日：2007-03-15
申请号：PCT/IT2006/000639
申请日：2006-09-04
申请人： FIN-CERAMICA FAENZA S.P.A. , MARCACCI, Maurilio , TAMPIERI, Anna , DI FEDE, Sergio , PRESSATO, Daniele , DE LUCA, Claudio
发明人： MARCACCI, Maurilio , TAMPIERI, Anna , DI FEDE, Sergio , PRESSATO, Daniele , DE LUCA, Claudio
IPC分类号： A61F2/00 , A61F2/30
摘要： A pin for the anchoring of articular prostheses includes a connecting portion (4) with a prosthesis (2) and an engagement portion (5) in a hole obtained within a bone. The engagement portion (5) is at least partly deformable in a radial direction and in a resilient way, in order to allow the instantaneous blocking of the pin (1) in the hole and the primary fixing of the prosthesis (2) on the bone, so as to al low an easy primary fixing of the prosthesis by simply introducing with a pressure the connecting portion in the hole obtained within the bone itself.

3. 发明申请

WO2008146113A2 PROCESS FOR COATING A SURFACE OF A METAL ELEMENT TO INCREASE OSTEOINTEGRATION THEREOF AND PROSTHETIC DEVICE INCLUDING SAID ELEMENT 审中-公开
标题翻译：用于涂覆金属元素表面以增加其软化和包括实体元素在内的前置装置的方法
公开(公告)号：WO2008146113A2
公开(公告)日：2008-12-04
申请号：PCT/IB2008/001229
申请日：2008-05-19
申请人： FIN-CERAMICA FAENZA S.P.A. , PAOLUCCI, Francesco , MARCACCIO, Massimo , ROVERI, Norberto , MANARA, Silvia , TAMPIERI, Anna , PRESSATO, Daniele , DE LUCA, Claudio , DI FEDE, Sergio
发明人： PAOLUCCI, Francesco , MARCACCIO, Massimo , ROVERI, Norberto , MANARA, Silvia , TAMPIERI, Anna , PRESSATO, Daniele , DE LUCA, Claudio , DI FEDE, Sergio
IPC分类号： C25D9/04 , C25D15/02 , A61L27/00 , C25D7/00
CPC分类号： C25D9/04 , A61L27/04 , A61L27/34 , A61L2420/04 , C25D7/00 , C25D15/02 , C08L89/06
摘要： A process for coating a surface of a metal element, in particular a metal element of a prosthetic device, comprising: providing an electrolytic bath comprising: at least one collagen, calcium ions and phosphate ions; immersing into said electrolytic bath at least one cathode and at least one anode, said at least one cathode comprising the metal element to be coated; applying electric direct current to said electrolytic bath so as to obtain on said surface an electrolytic co-deposition of collagen with a calcium-phosphate compound comprising hydroxyapatite. The coating layer thus obtained has a high biocompatibility, so as to obtain an interface between metal element and bone structure which enables a faster new bone formation and a bone integration strengthening in time.
摘要翻译：一种用于涂覆金属元件的表面，特别是假体装置的金属元件的表面的方法，包括：提供电解浴，其包括：至少一种胶原，钙离子和磷酸根离子; 将至少一个阴极和至少一个阳极浸入所述电解浴中，所述至少一个阴极包括待涂覆的金属元素; 向所述电解槽施加电直流电，以在所述表面上获得包含羟基磷灰石的磷酸钙化合物的胶原电解共沉积。由此获得的涂层具有高的生物相容性，从而获得金属元素和骨结构之间的界面，其能够更快地新骨形成和时间上的骨整合强化。

4. 发明申请

WO2007045953A2 A COMPOSITE BASED ON AN APATITE AND A POLYSACCHARIDE, METHOS FOR ITS PREPARATION AND USES THEREOF 审中-公开
标题翻译：基于APATITE和多糖的复合材料，其制备及其用途的METHOS
公开(公告)号：WO2007045953A2
公开(公告)日：2007-04-26
申请号：PCT/IB2006/002843
申请日：2006-10-12
申请人： FIN-CERAMICA FAENZA S.P.A. , C.N.R. CONSIGLIO NAZIONALE DELLE RICERCHE , LANDI, Elena , TAMPIERI, Anna , SANDRI, Monica , DI FEDE, Sergio , PRESSATO, Daniele
发明人： LANDI, Elena , TAMPIERI, Anna , SANDRI, Monica , DI FEDE, Sergio , PRESSATO, Daniele
CPC分类号： C01B25/322 , A61K9/0024 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/602
摘要： The present invention relates to a reticulated hybrid inorganic-organic composite based on an apatite and on a polysaccharide of vegetable origin, for the transport and controlled release of drugs and/or biologically active molecules. Moreover, the present invention relates to a method for preparing said composite and to the uses thereof.
摘要翻译：本发明涉及一种基于磷灰石和植物来源的多糖的网状混合无机 - 有机复合材料，用于运输和控释药物和/或生物活性分子。此外，本发明涉及一种制备所述复合材料的方法及其用途。

5. 发明申请

WO2007045954A1 A PLURISUBSTITUTED HYDROXYAPATITE AND THE COMPOSITE THEREOF WITH A NATURAL AND/OR SYNTHETIC POLYMER, THEIR PREPARATION AND USES THEREOF 审中-公开
标题翻译：一种多羟基化合物及其与天然和/或合成聚合物的复合物，其制备及其用途
公开(公告)号：WO2007045954A1
公开(公告)日：2007-04-26
申请号：PCT/IB2006/002844
申请日：2006-10-12
申请人： FIN-CERAMICA FAENZA S.P.A. , C.N.R. CONSIGLIO NAZIONALE DELLE RICERCHE , LANDI, Elena , TAMPIERI, Anna , CELOTTI, Giancarlo , SPRIO, Simone , PRESSATO, Daniele , DE LUCA, Claudio
发明人： LANDI, Elena , TAMPIERI, Anna , CELOTTI, Giancarlo , SPRIO, Simone , PRESSATO, Daniele , DE LUCA, Claudio
IPC分类号： C01B25/32 , C01B25/16 , A61L27/00 , A61L31/12 , A61F2/28
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treat¬ ing bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses .
摘要翻译：本发明涉及一种多羟基磷灰石，其与生理上相容的离子物质及其与天然和/或合成聚合物的生物杂交复合物多取代，其可用于制备用于治疗骨组织缺陷的仿生骨替代物。此外，本发明涉及其制备方法和用途。

6. 发明申请

WO2007010347A2 PROCESS FOR THE PREPARATION OF A BIOMIMETIC BONE SUBSTITUTE AND ITS USES 审中-公开
标题翻译：制备生物骨代用品的方法及其用途
公开(公告)号：WO2007010347A2
公开(公告)日：2007-01-25
申请号：PCT/IB2006/001925
申请日：2006-07-12
申请人： FIN-CERAMICA FAENZA S.P.A. , MARTINETTI, Roberta , PRESSATO, Daniele , DOLCINI, Laura , DI FEDE, Sergio
发明人： MARTINETTI, Roberta , PRESSATO, Daniele , DOLCINI, Laura , DI FEDE, Sergio
IPC分类号： C01B25/32 , C01B25/34
CPC分类号： A61L27/56 , A61L27/12 , C01B25/327
摘要： The object of the present invention is a process for obtaining a bone substitute of given chemical and physical characteristics and entirely similar to those of the mineral portion of natural bone tissue.
摘要翻译：本发明的目的是用于获得具有给定化学和物理特性并且完全类似于天然骨组织的矿物部分的骨替代物的方法。

7. 发明申请

WO2012014172A1 INTRINSICALLY MAGNETIC HYDROXYAPATITE 审中-公开
标题翻译：本征磁性羟基磷灰石
公开(公告)号：WO2012014172A1
公开(公告)日：2012-02-02
申请号：PCT/IB2011/053362
申请日：2011-07-28
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , FIN-CERAMICA FAENZA S.P.A. , UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , TAMPIERI, Anna , LANDI, Elena , SANDRI, Monica , PRESSATO, Daniele , RIVAS REY, José , BANOBRE LOPEZ, Manuel , MARCACCI, Maurilio
发明人： TAMPIERI, Anna , LANDI, Elena , SANDRI, Monica , PRESSATO, Daniele , RIVAS REY, José , BANOBRE LOPEZ, Manuel , MARCACCI, Maurilio
IPC分类号： C01B25/32 , C01B25/45 , A61L27/12
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64
摘要： The present invention relates to hydroxyapatite doped with Fe 2 + ions and Fe 3 + ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.
摘要翻译：本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。由于在HA的晶格中存在磁性纳米域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，给定有限量的磁性次级目前，少于约3％（体积）。本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。

8. 发明申请

WO2009125282A1 METHOD FOR PERFUSING A BIOCOMPATIBLE MATERIAL GRAFT WITH A LIQUID AND PERFUSION KIT 审中-公开
标题翻译：用液体和香料包装填充生物成分材料的方法
公开(公告)号：WO2009125282A1
公开(公告)日：2009-10-15
申请号：PCT/IB2009/005208
申请日：2009-04-08
申请人： FIN-CERAMICA FAENZA S.P.A. , FIORINI, Mauro , PRESSATO, Daniele
发明人： FIORINI, Mauro , PRESSATO, Daniele
IPC分类号： A61F2/46
CPC分类号： A61F2/4644
摘要： A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of : introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3). A perfusion kit includes a perfusion chamber (2) apt to contain a graft (100) to be perfused with a liquid (101) and a transfer chamber (3) apt to contain a liquid (101) to be perfused, the perfusion chamber (2) being connectable in a tight manner with the transfer chamber (3) for allowing a fluid exchange between the two chambers (2, 3) and inhibiting a fluid exchange between the two chambers (2, 3) and the external environment.
摘要翻译：一种用灌注液灌注生物相容性材料移植物的方法包括以下步骤：将移植物（100）引入灌注室（2），将部分填充有灌注液（101）的转移室（3）灌注室（2）和传送室（3）的紧密方式，用于在它们之间建立流体连通，降低传送室（3）中的压力，用于将存在于灌注室（2）中的部分空气转移，增加传送室（3）内的压力，用于在灌注腔（2）中注入存在于传送室（3）中的灌注液（101）。灌注试剂盒包括适于容纳要用液体（101）灌注的移植物（100）和易于包含要灌注的液体（101）的传送室（3）的灌注室（2），灌注室 2）可以与传送室（3）紧密连接，用于允许两个室（2,3）之间的流体交换并且阻止两个室（2,3）和外部环境之间的流体交换。

9. 发明申请

WO2011064724A1 BIOMIMETIC COMPOSITE MATERIALS, PREPARATION PROCESS THEREOF AND USE THEREOF TO PRODUCE MONO-, BI- OR MULTI -LAYER STRUCTURES FOR THE REGENERATION OF BONE, CARTILAGINOUS AND OSTEOCARTILAGINOUS TISSUE 审中-公开
标题翻译：生物复合材料，其制备方法及其用于生产用于骨，骨质疏松和骨质疏松组织再生的单，双或多层结构
公开(公告)号：WO2011064724A1
公开(公告)日：2011-06-03
申请号：PCT/IB2010/055387
申请日：2010-11-24
申请人： FIN-CERAMICA FAENZA S.P.A. , PRESSATO, Daniele , DOLCINI, Laura , NICOLETTI, Alessandro , FIORINI, Mauro
发明人： PRESSATO, Daniele , DOLCINI, Laura , NICOLETTI, Alessandro , FIORINI, Mauro
IPC分类号： A61L27/46
CPC分类号： A61L27/46 , A61L27/20 , A61L27/24 , A61L2430/02 , A61L2430/06 , C08L5/08
摘要： The present invention relates to a monolithic mono-, bi- or multi-layer structure consisting of composite biomimetic materials for preparing substitutes for the treatment of bone, cartilaginous or osteocartilaginous defects. In particular, the present invention relates to a monolayer cartilaginous substitute consisting of an organic matrix comprising collagen and chitosan and a monolayer osseous substitute consisting of an organic-inorganic composite matrix comprising hydroxyapatite, collagen and chitosan. Moreover, the present invention relates to a monolithic bilayer or multilayer osteocartilaginous substitute comprising a first upper layer consisting of an organic matrix comprising collagen and chitosan and a lower layer consisting of a composite matrix comprising hydroxyapatite, collagen and chitosan. Finally, the present invention relates to the use of said monolayer or bilayer or multilayer structures to prepare said cartilaginous, osseous or osteocartilaginous substitutes for the treatment of articular chondral, bone and osteochondral defects or for the neoformation of a cartilaginous tissue and/or subchondral bone tissue.
摘要翻译：本发明涉及由用于制备治疗骨，软骨或骨软骨缺损的替代物的复合仿生材料组成的整体单，双或多层结构。特别地，本发明涉及由包含胶原和壳聚糖的有机基质和由包含羟基磷灰石，胶原和壳聚糖的有机 - 无机复合基质组成的单层骨代用品组成的单层软骨替代物。此外，本发明涉及一种整体式双层或多层骨软骨替代物，其包含由包含胶原和壳聚糖的有机基质组成的第一上层和由包含羟基磷灰石，胶原和壳聚糖的复合基质组成的下层。最后，本发明涉及所述单层或双层或多层结构用于制备用于治疗关节软骨，骨和软骨软骨缺损或软骨组织和/或软骨下骨的变形的所述软骨，骨或骨软骨替代物的用途组织。

10. 发明授权

EP1948561B1 A PLURISUBSTITUTED HYDROXYAPATITE AND THE COMPOSITE THEREOF WITH A NATURAL AND/OR SYNTHETIC POLYMER, THEIR PREPARATION AND USES THEREOF 有权转让
标题翻译：多羟基磷灰石和IT的复合材料具有天然的和/或合成聚合物及其制备方法和用途发明
公开(公告)号：EP1948561B1
公开(公告)日：2016-09-07
申请号：EP06809000.0
申请日：2006-10-12
申请人： FIN - CERAMICA FAENZA S.P.A.
发明人： LANDI, Elena , TAMPIERI, Anna , CELOTTI, Giancarlo , SPRIO, Simone , PRESSATO, Daniele , DE LUCA, Claudio
IPC分类号： C01B25/32 , C01B25/16 , A61L27/12 , A61L27/46
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16

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