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1. 发明申请

WO9924070A2 ESTER DERIVATIVES OF HYALURONIC ACID WITH VISCOELASTIC PROPERTIES AND THEIR USE IN THE BIOMEDICAL AND HEALTHCARE FIELD 审中-公开
标题翻译：粘弹性特性的透明质酸酯衍生物及其在生物医学领域的应用
公开(公告)号：WO9924070A2
公开(公告)日：1999-05-20
申请号：PCT/EP9807020
申请日：1998-11-05
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , RENIER DAVIDE , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
发明人： RENIER DAVIDE , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
IPC分类号： A61K9/00 , A61K47/36 , A61K47/00
CPC分类号： A61K47/36 , A61K9/0019
摘要： Viscoelastic compositions are described comprised of esters of hyaluronic acid which are uniquely advantageous because their viscoelastic characteristics may vary according to shearing stress and temperature.
摘要翻译：描述了由透明质酸的酯组成的粘弹性组合物，其具有独特的优点，因为它们的粘弹特性可以根据剪切应力和温度而变化。

2. 发明申请

WO02070030A8 GRAFTS FOR THE REPAIR OF OSTEOCHONDRAL DEFECTS 审中-公开
标题翻译：用于修复骨质缺损的修复
公开(公告)号：WO02070030A8
公开(公告)日：2002-12-05
申请号：PCT/EP0201224
申请日：2002-02-06
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
发明人： PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
IPC分类号： A61L27/00 , A61F2/30 , A61L27/12 , A61L27/20 , A61L27/38 , A61L27/42 , A61L27/46
CPC分类号： A61L27/3817 , A61L27/12 , A61L27/20 , A61L27/3852 , A61L27/3895 , A61L27/425 , A61L27/46 , C08L5/08
摘要： The invention concerns the preparation and use of a biocompatible, biocomponent material constituted by: (a) a three-dimensional matrix of hyaluronic acid derivatives witle a structure containing empty spaces; (b) a porous, three-dimensional matrix constituted by a ceramic material; (c) possibly containing pharmacologically or biologically active ingredients.
摘要翻译：本发明涉及生物相容性生物组分材料的制备和使用，所述生物相容性生物组分材料由以下物质构成：（a）透明质酸衍生物的三维基质，其具有包含空隙的结构; （b）由陶瓷材料构成的多孔三维基质; （c）可能含有药理学或生物活性成分。

3. 发明申请

WO9707833A3 BIOMATERIALS FOR PREVENTING POST-SURGICAL ADHESIONS COMPRISED OF HYALURONIC ACID DERIVATIVES 审中-公开
标题翻译：用于预防包含羟丙酸衍生物的手术后粘连的生物材料
公开(公告)号：WO9707833A3
公开(公告)日：1997-04-10
申请号：PCT/EP9603805
申请日：1996-08-29
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , PRESSATO DANIELE , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
发明人： PRESSATO DANIELE , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
IPC分类号： A61L31/00 , A61L17/00 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/12 , A61P41/00
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.

4. 发明申请

WO2006045836A3 TUBULAR STRUCTURE BASED ON HYALURONIC ACID DERIVATIVES FOR VASCULAR AND URETHRAL GRAFT 审中-公开
标题翻译：基于用于血管和尿酸盐的羟丙酸衍生物的管状结构
公开(公告)号：WO2006045836A3
公开(公告)日：2006-07-20
申请号：PCT/EP2005055610
申请日：2005-10-27
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , ABATANGELO GIOVANNI , CALLEGARO LANFRANCO
发明人： ABATANGELO GIOVANNI , CALLEGARO LANFRANCO
IPC分类号： A61L27/20
CPC分类号： A61L27/507 , A61L27/20 , C08L5/08
摘要： Tubular structure, whose wall has an unbroken surface consisting essentially of at least one HA derivative and optionally a further polymer of natural, synthetic or semisynthetic origin. Said tubular structure, which is prepared with a very simple process, is used for the preparation of vascular and urethral grafts.
摘要翻译：管状结构，其壁具有基本上由至少一种HA衍生物和任选的天然，合成或半合成来源的另外的聚合物组成的不间断表面。用非常简单的方法制备的所述管状结构用于制备血管和尿道移植物。

5. 发明申请

WO9503786A3 NEW PHARMACEUTICAL COMPOSITIONS FOR TOPICAL USE CONTAINING HYALURONIC ACID AND ITS DERIVATIVES 审中-公开
标题翻译：用于含有羟丙酸及其衍生物的局部用途的新药物组合物
公开(公告)号：WO9503786A3
公开(公告)日：1995-03-16
申请号：PCT/EP9402536
申请日：1994-07-29
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , BENEDETTI LUCA , CALLEGARO LANFRANCO
发明人： BENEDETTI LUCA , CALLEGARO LANFRANCO
IPC分类号： A61K9/12 , A61K31/715 , A61L26/00 , A61K31/725
CPC分类号： A61L26/0076 , A61K9/12 , A61K9/122 , A61K31/715 , A61L26/0023 , C08L5/08
摘要： Provided is a pharmaceutical composition, comprising a pharmaceutically effective amount of an acidic polysaccharide and/or a derivative thereof, a gaseous vehicle, and a pharmaceutically acceptable carrier or excipient. Said acidic polysaccharide or derivative thereof can be hyaluronic acid, a pharmaceutically acceptable salt of hyaluronic acid, a partial or total ester of hyaluronic acid with an alcohol, a partial or total intermolecular ester of hyaluronic acid, a partial or total intramolecular ester of hyaluronic acid, a cross-linked ester of hyaluronic acid, an alginic acid ester, an ester of carboxymethylcellulose, an ester of carboxymethylchitin, an ester of carboxymethyl starch, a gellan ester, a cross-linked gellan ester, a pectic acid ester, and a pectinic acid ester. The composition can contain one or more topical drugs, and can be in the form of an aerosol or liquid spray, a foam, or a dry spray. The composition is useful in the treatment of a variety of pathological situations requiring the acceleration of tissue repair, for example in the treatment of burns, sores, ulcerations, and wounds. Also provided is a therapeutic method, comprising topically administering a pharmaceutical composition comprising a pharmaceutically effective amount of an acidic polysaccharide and/or a derivative thereof in association with a gaseous vehicle and a pharmacologically acceptable excipient, and optionally, one or more topical drugs.
摘要翻译：本发明涉及药物组合物，其包含药学上有效量的酸性多糖和/或其衍生物，气态赋形剂和药学上可接受的载体或赋形剂。所述酸性多糖或其衍生物可以是透明质酸，透明质酸的药学上可接受的盐，透明质酸与醇的部分或全部酯，透明质酸的部分或全部分子间酯，透明质酸的部分或全部分子内的酯，透明质酸的交联酯，藻酸酯，羧甲基纤维素的酯，羧甲基壳氨酸的酯，羧甲基淀粉的酯，结冷胶的酯，交联的吉兰糖酯，果胶酸酯和果胶酸酯。组合物可以含有一种或多种局部药物，并且可以是气雾剂或液体喷雾剂，泡沫剂或干燥喷雾剂的形式。该组合物可用于治疗需要加速组织修复的各种病理状况，例如在治疗烧伤，疮，溃疡和伤口中。还提供了一种治疗方法，其包括与气态赋形剂和药理学上可接受的赋形剂以及任选的一种或多种局部药物相结合地局部施用包含药学有效量的酸性多糖和/或其衍生物的药物组合物。

6. 发明申请

WO2010012653A2 NEW BIOMATERIALS, THEIR PREPARATION BY ELECTROSPINNING AND THEIR USE IN THE BIOMEDICAL AND SURGICAL FIELD 审中-公开
标题翻译：新的生物材料，通过电解制备及其在生物医学和手术领域的应用
公开(公告)号：WO2010012653A2
公开(公告)日：2010-02-04
申请号：PCT/EP2009059535
申请日：2009-07-24
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , BELLINI DAVIDE , CALLEGARO LANFRANCO , ASTIER MARIE , GIUSTI FABIO
发明人： BELLINI DAVIDE , CALLEGARO LANFRANCO , ASTIER MARIE , GIUSTI FABIO
IPC分类号： A61L31/04 , A61L15/22 , A61L15/28 , A61L27/20 , A61L27/26 , A61L27/60
CPC分类号： A61L27/60 , Y10T442/3065 , Y10T442/614 , Y10T442/626
摘要： There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.
摘要翻译：描述了使用静电纺丝技术生产的新型无纺织物，以及其作为生物医学和手术领域的新型生物材料的用途。

7. 发明申请

WO0100190A3 HYALURONIC ACID DERIVATIVES FOR THE PREVENTION AND TREATMENT OF CUTANEOUS SCARS 审中-公开
标题翻译：用于预防和治疗US疮的羟丙酸衍生物
公开(公告)号：WO0100190A3
公开(公告)日：2001-08-16
申请号：PCT/EP0006087
申请日：2000-06-29
申请人： FIDIA ADVANCED BIOPOLYMERS SRL , DALLE CARBONARE MAURIZIO , CALLEGARO LANFRANCO
发明人： DALLE CARBONARE MAURIZIO , CALLEGARO LANFRANCO
IPC分类号： A61K31/715 , A61K31/728 , A61L15/28 , A61L15/44 , A61L17/00 , A61L17/10 , A61L31/04 , A61L31/16 , A61P43/00
CPC分类号： A61K31/728 , A61K31/715 , A61L15/28 , A61L15/44 , A61L17/005 , A61L17/10 , A61L31/042 , A61L31/16 , A61L2300/00 , A61L2300/236 , A61L2300/404 , A61L2300/414 , A61L2300/45 , A61K31/00 , A61K2300/00 , C08L5/08
摘要： Use of hyaluronic acid derivatives for the preparation of biomaterials for the prevention of the formation and the treatment of cutaneous scars, wherein the hyaluronic acid derivatives are optionally combined with pharmacologically or biologically active compounds.
摘要翻译：透明质酸衍生物用于制备用于预防皮肤瘢痕形成和治疗的生物材料的透明质酸衍生物，其中任选地与药理学或生物活性化合物组合。

8. 发明专利

JP2011212464A Three-dimensional prosthesis containing hyaluronic acid derivative and process for their preparation 审中-公开
标题翻译：含有羟丙酸衍生物的三维前体及其制备方法
公开(公告)号：JP2011212464A
公开(公告)日：2011-10-27
申请号：JP2011157097
申请日：2011-07-15
申请人： Fidia Advanced Biopolymers Srl , フィディアアドヴァンスドバイオポリマーズソシエタアレスポンサビリタリミタータ
发明人： PASTORELLO ANDREA , RADICE MARCO , CALLEGARO LANFRANCO
IPC分类号： A61F2/02 , C12N5/06 , A61F2/04 , A61F2/14 , A61F2/18 , A61F2/24 , A61F2/30 , A61F2/52 , A61L15/00 , A61L15/28 , A61L15/44 , A61L27/00 , A61L27/20 , A61L27/26 , A61L27/38 , A61L27/54 , C08L5/08
CPC分类号： C08B37/0072 , A61L15/28 , A61L27/20 , A61L27/3804 , C08L5/08
摘要： PROBLEM TO BE SOLVED: To provide a three-dimensional prosthesis for reconstruction of human body part.SOLUTION: The three-dimensional prosthesis of a human body part with a complex form which is selected from the group consisting of the auricula, the nose, the pharynx, the larynx, the trachea, joints, eye sockets, cardiac valves, nipples, navels, internal organs and their parts and the secondary sexual organs, comprises at least one three-dimensional matrix having an essentially fibrous or porous structure and containing at least one hyaluronic acid derivative, when containing at least two of the three-dimensional matrices, the first of the matrices, incorporating and/or being adhered to the second and possible further matrices, wherein at least the hyaluronic acid derivative is a specific hyaluronic acid derivative such as esters, cross-linked esters, cross-linked compounds, and a quaternary ammoium salt of hyaluronic acid.
摘要翻译：要解决的问题：提供用于重建人体部位的三维假体。解决方案：具有复杂形式的人体部分的三维假体，其选自由耳廓，鼻子，咽，喉，气管，关节，眼窝，心脏瓣膜，乳头，肚脐，内部器官及其部分和第二性器官，包括至少一个具有基本纤维或多孔结构并至少包含一种透明质酸衍生物，当含有至少两个三维基质时，第一个基质，并入和/或粘附到第二个和可能的另外的基质上，其中至少透明质酸衍生物是特定的透明质酸衍生物例如酯，交联酯，交联化合物和透明质酸的季铵盐。

9. 发明专利

JP2008080153A Process for coating object with hyaluronic acid, derivatives thereof, and semisynthetic polymers 审中-公开
标题翻译：用羟丙酸涂覆对象的方法及其衍生物和半聚硅氧烷聚合物
公开(公告)号：JP2008080153A
公开(公告)日：2008-04-10
申请号：JP2007313385
申请日：2007-12-04
申请人： Fidia Advanced Biopolymers Srl , フィディア・アドバンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータFIDIA ADVANCED BIOPOLYMERS,S.r.L.
发明人： MORRA MARCO , CASSINELLI CLARA , BENEDETTI LUCA , CALLEGARO LANFRANCO
IPC分类号： A61L27/00 , A61L31/00 , A61L27/34 , A61L29/00 , A61L29/08 , A61L31/10 , A61L33/00 , A61M25/00
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L5/08 , C08L5/00
摘要： PROBLEM TO BE SOLVED: To provide a process for coating a surface of an object with hyaluronic acid, its derivatives or other natural or semisynthetic polymers, for applications in the fields of surgery, health care, and diagnostics. SOLUTION: The processes make it possible to bind such polymers in a stable manner to the surface of an object made of a wide range of materials. The surface treated according to the process is characterized by a high degree of lubricity, and is able to inhibit the adhesion of cells or bacteria present in the biological fluids. COPYRIGHT: (C)2008,JPO&INPIT

10. 发明专利

JP2008302235A Biomaterial for preventing post-surgical adhesions comprising hyaluronic acid derivatives 审中-公开
标题翻译：用于预防包含羟丙酸衍生物的手术后粘连的生物材料
公开(公告)号：JP2008302235A
公开(公告)日：2008-12-18
申请号：JP2008184052
申请日：2008-07-15
申请人： Fidia Advanced Biopolymers Srl , フィディア・アドバンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータFIDIA ADVANCED BIOPOLYMERS,S.r.L.
发明人： PRESSATO DANIELE , PAVESIO ALESSANDRA , CALLEGARO LANFRANCO
IPC分类号： A61L31/00 , A61L17/00 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/12 , A61P41/00
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： PROBLEM TO BE SOLVED: To provide a new biomaterial for the field of surgery (concretely, for preventing post-surgical adhesion). SOLUTION: The biomaterial essentially comprises esterified derivatives of hyaluronic acid or cross-linked derivatives of hyaluronic acid. COPYRIGHT: (C)2009,JPO&INPIT

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