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1. 发明申请

WO2012141889A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 审中-公开
标题翻译：红血球细胞分离系统
公开(公告)号：WO2012141889A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/030869
申请日：2012-03-28
申请人： FENWAL, INC. , MIN, Kyungyoon , BROWN, Richard, I. , FOLEY, John, T. , CASE, Brian, C.
发明人： MIN, Kyungyoon , BROWN, Richard, I. , FOLEY, John, T. , CASE, Brian, C.
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

2. 发明申请

WO2012027312A1 METHODS AND SYSTEMS FOR ANTICOAGULATING BLOOD 审中-公开
标题翻译：用于抗血清的方法和系统
公开(公告)号：WO2012027312A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048721
申请日：2011-08-23
申请人： FENWAL, INC. , BROWN, Richard, I.
发明人： BROWN, Richard, I.
IPC分类号： A61M1/36
CPC分类号： A61M1/0272 , A61M1/02 , A61M1/3621 , A61M1/3672 , A61M2205/3334 , A61M2205/52
摘要： Methods and systems are provided for anticoagulating blood. Whole blood is drawn from a donor into a system at a draw flow rate. Anticoagulant from an anticoagulant source is pumped into the system at an anticoagulant flow rate to mix with the blood. The anticoagulated blood may be subsequently processed in any of a number of known ways, including separating it and removing at least a portion of one of the components of the blood. Thereafter, at least a portion of the remaining blood may be returned to the donor. The anticoagulant flow rate is independent of the draw flow rate and can be based on a number of factors, including the weight of the donor and the rate at which the donor can metabolize the anticoagulant.
摘要翻译：提供用于抗凝血的方法和系统。将全血从供体抽出到抽吸流量的系统中。来自抗凝血剂来源的抗凝血剂以抗凝血流量泵入系统以与血液混合。随后可以以许多已知方式中的任何一种处理抗凝血液，包括分离血浆并除去血液中一种成分的至少一部分。此后，剩余血液的至少一部分可以返回给供体。抗凝血剂流速与抽吸流速无关，可以基于许多因素，包括供体的重量和供体可以代谢抗凝血剂的速率。

3. 发明申请

WO2021194824A1 CONFIGURABLE SYSTEM TO AUTOMATE BLOOD COMPONENT MANUFACTURING PROCESSES 审中-公开
公开(公告)号：WO2021194824A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/022750
申请日：2021-03-17
申请人： FENWAL, INC.
发明人： KUSTERS, Benjamin, E. , BROWN, Richard, I. , MIN, Kyungyoon
IPC分类号： A61M1/02 , A61M1/36 , A61M1/0209 , A61M1/0272 , A61M1/3643 , A61M1/3693 , A61M2205/128 , A61M2205/3306 , A61M2205/3331 , A61M2205/3393 , A61M2205/505
摘要： A configurable automated blood component manufacturing system includes a durable hardware component and a single use fluid flow circuit. The hardware component includes a pump station, a centrifuge, and a controller including a touchscreen. The hardware component further includes hangers for suspending containers, a weight scale associated with each hanger, a plurality of tubing damps, and a cassette nesting module including a plurality of valves and pressure sensors. The fluid flow circuit includes a separation chamber received in the centrifuge, a fluid flow control cassette mounted in the cassette nesting module, and a plurality of containers in fluid communication with the fluid flow cassette. The controller is pre-programmed to automatically operate the system to perform one or more standard blood processing procedures selected by an operator by input to the touchscreen, and is configured to be further programmed by the operator to perform additional blood processing procedures.

4. 发明申请

WO2018053217A1 BLOOD SEPARATION SYSTEMS AND METHODS EMPLOYING CENTRIFUGAL AND SPINNING MEMBRANE SEPARATION TECHNIQUES 审中-公开
标题翻译：血液分离系统和使用离心和旋转膜分离技术的方法
公开(公告)号：WO2018053217A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051695
申请日：2017-09-15
申请人： FENWAL, INC.
发明人： MIN, Kyungyoon , KUSTERS, Benjamin, E. , BROWN, Richard, I. , BRIERTON, Mark, J.
IPC分类号： A61M1/02 , A61M1/36 , A61M1/26
摘要： Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.
摘要翻译：提供了用于将血液分离成两种或更多种成分的系统和方法。血液分离系统包括血液分离装置和被配置为安装到血液分离装置的流体流动回路。血液分离装置具备将离心分离装置和旋转膜分离驱动装置组装到通常的壳体中，通过两种不同的方法进行流体分离的装置。取决于要进行的分离程序，与血液分离装置配对的流体流动回路可以仅包括一个分离室，该分离室构造成安装到离心分离器或旋转膜分离器驱动单元或两个分离室，其中一个分离室安装到离心分离器和另一个旋转膜分离器驱动单元。该系统可用于分离和收集红细胞，血浆和血小板的任何组合。

5. 发明申请

WO2013109327A1 BLOOD BAG SYSTEMS FOR SEPARATION OF WHOLE BLOOD AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于分离全血的血液袋系统及其使用方法
公开(公告)号：WO2013109327A1
公开(公告)日：2013-07-25
申请号：PCT/US2012/061592
申请日：2012-10-24
申请人： FENWAL, INC.
发明人： BRIERTON, Mark, J. , BROWN, Richard, I. , FORD, Sean , WEASLER, Marc, N.
IPC分类号： A61J1/20 , A61J1/10 , A61M1/02 , B04B1/00 , C12M1/10
CPC分类号： A61M1/3693 , A61J1/10 , A61J1/12 , A61J1/16 , A61J1/2034 , A61J1/2037 , A61J1/2086 , A61J1/2093 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/029 , A61M1/3698 , B01L3/502715 , B04B5/0428
摘要： The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge.
摘要翻译：本公开总体上涉及当该单元仍然在离心机中时将全血单元加工成其组件的系统。该系统包括容纳全血的容器和一个或多个安装在保持器中的卫星袋或容器，然后将其插入离心机的桶中。管子将容器互连，其中一个或多个优选地安装在驻留在保持器中的夹紧机构中。保持器还优选地包括感测装置，例如光学传感器，以感测由离心机的旋转产生的全血的分离的层之间的界面的位置。

6. 发明公开

EP3512577A1 BLOOD SEPARATION SYSTEMS AND METHODS EMPLOYING CENTRIFUGAL AND SPINNING MEMBRANE SEPARATION TECHNIQUES 审中-公开
公开(公告)号：EP3512577A1
公开(公告)日：2019-07-24
申请号：EP17783614.5
申请日：2017-09-15
申请人： Fenwal, Inc.
发明人： MIN, Kyungyoon , KUSTERS, Benjamin, E. , BROWN, Richard, I. , BRIERTON, Mark, J.
IPC分类号： A61M1/02 , A61M1/36 , A61M1/26

7. 发明公开

EP4126096A1 CONFIGURABLE SYSTEM TO AUTOMATE BLOOD COMPONENT MANUFACTURING PROCESSES 审中-实审
公开(公告)号：EP4126096A1
公开(公告)日：2023-02-08
申请号：EP21718299.7
申请日：2021-03-17
申请人： Fenwal, Inc.
发明人： KUSTERS, Benjamin, E. , BROWN, Richard, I. , MIN, Kyungyoon
IPC分类号： A61M1/02 , A61M1/36

8. 发明公开

EP2804576A1 BLOOD BAG SYSTEMS FOR SEPARATION OF WHOLE BLOOD AND METHODS OF USE THEREOF 有权
标题翻译：自由之星ZUR TRENNUNG VON VOLLBLUT UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2804576A1
公开(公告)日：2014-11-26
申请号：EP12866168.3
申请日：2012-10-24
申请人： Fenwal, Inc.
发明人： BRIERTON, Mark, J. , BROWN, Richard, I. , FORD, Sean , WEASLER, Marc, N.
IPC分类号： A61J1/20 , A61J1/10 , A61M1/02 , B04B1/00 , C12M1/10
CPC分类号： A61M1/3693 , A61J1/10 , A61J1/12 , A61J1/16 , A61J1/2034 , A61J1/2037 , A61J1/2086 , A61J1/2093 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/029 , A61M1/3698 , B01L3/502715 , B04B5/0428
摘要： The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge.
摘要翻译：本公开总体上涉及当该单元仍然在离心机中时将全血单元加工成其组件的系统。该系统包括容纳全血的容器和一个或多个安装在保持器中的卫星袋或容器，然后将其插入离心机的桶中。管将容器互连，其中一个或多个优选地安装在驻留在保持器中的夹紧机构中。保持器还优选地包括感测装置，例如光学传感器，以感测由离心机的旋转产生的全血的分离的层之间的界面的位置。

9. 发明公开

EP2696912A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译： ZENTRIFUGIERSYSTEM与红细胞屏障
公开(公告)号：EP2696912A1
公开(公告)日：2014-02-19
申请号：EP12714141.4
申请日：2012-03-28
申请人： Fenwal, Inc.
发明人： MIN, Kyungyoon , BROWN, Richard, I. , FOLEY, John, T. , CASE, Brian, C.
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

10. 发明授权

EP2696912B1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译： ZENTRIFUGIERSYSTEM MIT ERYTHROZYTENBARRIERE
公开(公告)号：EP2696912B1
公开(公告)日：2017-03-08
申请号：EP12714141.4
申请日：2012-03-28
申请人： Fenwal, Inc.
发明人： MIN, Kyungyoon , BROWN, Richard, I. , FOLEY, John, T. , CASE, Brian, C.
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室容纳在离心机之间的壁之间，腔室包括用于使血液进入腔室的入口端口，用于使血浆从腔室流出的等离子体出口端口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

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