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1. 发明申请

US20120115129A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权
标题翻译：包含功能性染色及其相关技术和方法的酶基质
公开(公告)号：US20120115129A1
公开(公告)日：2012-05-10
申请号：US13326009
申请日：2011-12-14
申请人： FEI MAO , HUI CEN , WAI-YEE LEUNG
发明人： FEI MAO , HUI CEN , WAI-YEE LEUNG
IPC分类号： C12Q1/37 , C12Q1/68 , C12Q1/25 , C07K17/02 , C07D413/06
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

2. 发明申请

US20080277277A1 BIOSENSOR MEMBRANES COMPOSED OF POLYMERS CONTAINING HETEROCYCLIC NITROGENS 有权
标题翻译：含有杂环化合物的聚合物的生物传感器膜
公开(公告)号：US20080277277A1
公开(公告)日：2008-11-13
申请号：US12174121
申请日：2008-07-16
申请人： FEI MAO , Hyun Cho
发明人： FEI MAO , Hyun Cho
IPC分类号： G01N27/40
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/6846 , C12Q1/002 , C12Q1/004 , C12Q1/006
摘要： Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
摘要翻译：描述了包含含有杂环氮基团的各种聚合物的新型膜。这些膜可用于电化学传感器，如电流分析生物传感器。更具体地，这些膜有效地将分析物的通量调节到电化学传感器中的测量电极，由此在显着的分析物浓度范围内改善了电化学传感器的功能。还描述了配备有这种膜的电化学传感器。

3. 发明申请

US20080197026A1 TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS 有权
标题翻译：过渡金属配合物（吡啶基）咪唑基配体
公开(公告)号：US20080197026A1
公开(公告)日：2008-08-21
申请号：US11933219
申请日：2007-10-31
申请人： FEI MAO , ADAM HELLER
发明人： FEI MAO , ADAM HELLER
IPC分类号： G01N27/26 , G01N27/28 , C07F15/00
CPC分类号： C07F15/0026 , C07F1/005
摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.
摘要翻译：描述了铁，钴，钌，锇和钒的新型过渡金属络合物。过渡金属络合物可用作酶基电化学传感器中的氧化还原介质。过渡金属络合物包括取代或未取代的（吡啶基）咪唑配体。还描述了连接到聚合物主链上的过渡金属络合物。

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