专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013131567A1 MIRNA BASED TREATMENT MONITORING IN MULTIPLE SCLEROSIS 审中-公开
标题翻译： MIRNA治疗多发性硬化的疗效观察
公开(公告)号：WO2013131567A1
公开(公告)日：2013-09-12
申请号：PCT/EP2012/053944
申请日：2012-03-07
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BEIER, Markus , SCHEFFLER, Matthias , WENDSCHLAG, Anke , AKTAS, Orhan , INGWERSEN, Jens , HARTUNG, Hans-Peter , KÜRY, Patrick , PROZOROVSKI, Timour
发明人： KELLER, Andreas , BEIER, Markus , SCHEFFLER, Matthias , WENDSCHLAG, Anke , AKTAS, Orhan , INGWERSEN, Jens , HARTUNG, Hans-Peter , KÜRY, Patrick , PROZOROVSKI, Timour
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K16/2842 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient. Further, the present invention relates to the use of a polynucleotide or a polynucleotide set for detecting a miRNA to determine whether a patient responds to a therapeutic treatment of multiple sclerosis, to monitor the course of multiple sclerosis in a patient, to determine the risk of a relapse of multiple sclerosis in a patient, to adjust the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, and to identify a compound suitable for the treatment of multiple sclerosis in a patient. Furthermore, the present invention relates to a kit for determining whether a patient responds to a therapeutic treatment of multiple sclerosis, for monitoring the course of multiple sclerosis in a patient, for determining the risk of a relapse of multiple sclerosis in a patient, for adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, or for identifying a compound suitable for the treatment of multiple sclerosis in a patient comprising means for determining the level of at least one miRNA in a test sample isolated from a patient.
摘要翻译：本发明涉及确定患者是否对多发性硬化症（MS）的治疗性处理作出反应，监测患者中多发性硬化症（MS）的过程，确定患者患者中多发性硬化症（MS）的复发以及调整应用于患者中多发性硬化症的治疗性治疗的治疗药物的剂量。所述方法基于确定从患者分离的测试样品中的至少一种miRNA的水平。本发明还涉及鉴定适合于治疗患者多发性硬化症的化合物的方法。此外，本发明涉及用于检测miRNA的多核苷酸或多聚核苷酸的用途，以确定患者是否对多发性硬化症的治疗性处理作出反应，监测患者中多发性硬化的进程，以确定患者中多发性硬化症的复发，调整应用于患者中多发性硬化症的治疗性治疗的治疗药物的剂量，以及鉴定适合于治疗患者中多发性硬化症的化合物。此外，本发明涉及用于确定患者是否对多发性硬化症的治疗性处理作出反应，用于监测患者中多发性硬化症的过程，用于确定患者中多发性硬化症复发的风险的试剂盒，用于调整用于治疗性治疗患者中多发性硬化症的治疗药物的剂量，或用于鉴定适合于治疗患者中多发性硬化症的化合物的剂量，所述方法包括用于确定从患者的多发性硬化症分离的测试样品中的至少一种miRNA的水平的工具患者

2. 发明申请

WO2011095623A2 miRNA IN THE DIAGNOSIS OF OVARIAN CANCER 审中-公开
标题翻译： miRNA在OVARIAN癌症诊断中的应用
公开(公告)号：WO2011095623A2
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051734
申请日：2011-02-07
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , SCHEFFLER, Matthias , BEIER, Markus
发明人： KELLER, Andreas , SCHEFFLER, Matthias , BEIER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的确定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

3. 发明申请

WO2013050532A1 MIRNAS AS NON-INVASIVE BIOMARKERS FOR DIAGNOSIS 审中-公开
标题翻译： MIRNAS作为非侵入式生物标志物进行诊断
公开(公告)号：WO2013050532A1
公开(公告)日：2013-04-11
申请号：PCT/EP2012/069725
申请日：2012-10-05
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BACKES, Christina , BEIER, Markus
发明人： KELLER, Andreas , BACKES, Christina , BEIER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of a disease in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of a disease in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中的疾病的非侵入性方法，试剂盒和方法。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预测疾病的miRNA组的多核苷酸或引物对组。

4. 发明申请

WO2012089753A2 COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR GLIOBLASTOMA 审中-公开
标题翻译：复杂的MIRNAS集合作为GLIOBLASTOMA的非入侵生物标志物
公开(公告)号：WO2012089753A2
公开(公告)日：2012-07-05
申请号：PCT/EP2011/074127
申请日：2011-12-28
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BEIER, Markus
发明人： KELLER, Andreas , BEIER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中胶质母细胞瘤的非侵入性方法，试剂盒和装置。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预测胶质母细胞瘤的miRNA组的多核苷酸或引物对组。此外，本发明涉及用于诊断和/或预测来自受试者体液样品中胶质母细胞瘤的miRNA组。

5. 发明申请

WO2013026685A1 COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR COLON CANCER 审中-公开
标题翻译：复杂的MIRNAS集合作为结肠癌的非侵入性生物标志物
公开(公告)号：WO2013026685A1
公开(公告)日：2013-02-28
申请号：PCT/EP2012/065278
申请日：2012-08-03
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BEIER, Markus , WENDSCHLAG, Anke , MEESE, Eckart , LEIDINGER, Petra
发明人： KELLER, Andreas , BEIER, Markus , WENDSCHLAG, Anke , MEESE, Eckart , LEIDINGER, Petra
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中的结肠癌的非侵入性方法，试剂盒和方法。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预后结肠癌的miRNA组的多核苷酸或引物对组。此外，本发明涉及用于诊断和/或预测来自受试者的体液样品中的结肠癌的一组miRNA。

6. 发明申请

WO2012101219A3 COMPLEX MIRNA SETS AS NOVEL BIOMARKERS FOR LUNG DISEASES 审中-公开
公开(公告)号：WO2012101219A3
公开(公告)日：2012-08-02
申请号：PCT/EP2012/051241
申请日：2012-01-26
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BEIER, Markus
发明人： KELLER, Andreas , BEIER, Markus
IPC分类号： C12Q1/68
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.

7. 发明申请

WO2012089772A3 COMPLEX SET OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR PROSTATE DISEASES 审中-公开
公开(公告)号：WO2012089772A3
公开(公告)日：2012-07-05
申请号：PCT/EP2011/074169
申请日：2011-12-28
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BOISGUERIN, Valesca , BEIER, Markus , MEESE, Eckhart , LEIDINGER, Petra
发明人： KELLER, Andreas , BOISGUERIN, Valesca , BEIER, Markus , MEESE, Eckhart , LEIDINGER, Petra
IPC分类号： C12Q1/68
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of mi RNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject.

8. 发明申请

WO2010139811A1 miRNA FINGERPRINT IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS 审中-公开
标题翻译： miRNA指纹在多发性硬化症诊断中的应用
公开(公告)号：WO2010139811A1
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057943
申请日：2010-06-07
申请人： febit holding GmbH , KELLER, Andreas , MEESE, Eckart , BORRIES, Anne , STÄHLER, Peer Friedrich , BEIER, Markus
发明人： KELLER, Andreas , MEESE, Eckart , BORRIES, Anne , STÄHLER, Peer Friedrich , BEIER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.
摘要翻译：本发明提供了用于基于与健康对照相比在疾病状态中改变表达水平的特异性miRNA的确定来诊断疾病的新方法。

9. 发明申请

WO2012010584A1 COMPLEX MIRNA SETS AS NOVEL BIOMARKERS FOR GASTRIC CANCER 审中-公开
标题翻译：复杂的MIRNA集作为胃癌的新生物标志物
公开(公告)号：WO2012010584A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062326
申请日：2011-07-19
申请人： FEBIT HOLDING GMBH , KELLER, Andreas , BEIER, Markus
发明人： KELLER, Andreas , BEIER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of gastric cancer in a blood sample such as blood cell sample from a human patient. Further, the present invention relates to means for diagnosing and/or prognosing of gastric cancer comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of gastric cancer based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for gastric cancer. In addition, the present invention relates to a kit for diagnosing and/or prognosing of gastric cancer comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for gastric cancer and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.
摘要翻译：本发明涉及用于检测单个miRNA或miRNA组的单个多核苷酸或多组核苷酸，用于诊断和/或预测来自人类患者的血液样品中的血液样品中的胃癌。此外，本发明涉及包含所述多核苷酸或多核苷酸组的胃癌的诊断和/或预后的方法。此外，本发明涉及用于诊断和/或预后胃癌的方法，其基于单个miRNA或代表胃癌的miRNA组的表达谱的确定。此外，本发明还涉及用于诊断和/或预后胃癌的试剂盒，其包括用于确定代表胃癌的单个miRNA或miRNA集合的表达谱的方法，以及可选地至少一个参考和/或算法或数学函数，包括在至少一个数据载体上。

10. 发明申请

WO2010066884A1 METHOD FOR ANALYSIS OF NUCLEIC ACID POPULATIONS 审中-公开
标题翻译：核酸人口分析方法
公开(公告)号：WO2010066884A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066945
申请日：2009-12-11
申请人： FEBIT HOLDING GMBH , BEIER, Markus , STÄHLER, Peer F. , STÄHLER, Cord F. , SUMMERER, Daniel , LEONARD, Jack T. , BAU, Stephan , CARUSO, Anthony , SCHRACKE, Nadine , KELLER, Andreas , HANENBERG, Helmut , ECKERMANN, Olaf
发明人： BEIER, Markus , STÄHLER, Peer F. , STÄHLER, Cord F. , SUMMERER, Daniel , LEONARD, Jack T. , BAU, Stephan , CARUSO, Anthony , SCHRACKE, Nadine , KELLER, Andreas , HANENBERG, Helmut , ECKERMANN, Olaf
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12Q1/6834 , C12N15/1006 , C12Q1/6806 , C12Q2565/518 , C12Q2525/191
摘要： The invention relates to a method for isolation of target molecules from a nucleic acid population.
摘要翻译：本发明涉及从核酸群体分离靶分子的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式