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    • 2. 发明专利
      DE102006062089A1 Molecular biology process system comprises a device for synthesis of receptor arrays, devices for performing fluidic steps, a detection unit and programmable control units 未知
    • Molecular biology process system comprises a device for synthesis of receptor arrays, devices for performing fluidic steps, a detection unit and programmable control units
    • DE102006062089A1
    • 2008-07-03
    • DE102006062089
    • 2006-12-29
    • FEBIT HOLDING GMBH
    • STAEHLER PEER , STAEHLER CORD , BEIER MARKUS , SUMMERER DANIEL
    • C12M1/34 , C12Q1/68 , C40B30/04 , G01N33/68
    • Molecular biology process system comprises a device for in-situ synthesis of receptor arrays, devices for performing fluidic steps, e.g. sample delivery, reagent delivery, washing and sample discharge, a unit for detecting an optical or electrical signal, a programmable unit for synthesis control and a programmable unit for controlling fluidics, detection and data storage and management. Independent claims are also included for: (1) analyzing the sequence of a nucleic acid analyte by synthesizing an oligonucleotide probe in a synthesis zone of a miniaturized flow cell, delivering the analyte to the flow cell, ligating or hybridizing the analyte to the probe, and performing a template-dependent nucleic acid synthesis step involving a change in an optical or electrical signal; (2) amplifying a target nucleic acid by synthesizing an oligonucleotide probe in a synthesis zone of a miniaturized flow cell, delivering a nucleic acid analyte to the flow cell, ligating or hybridizing the analyte to the probe, and performing at least one round of nucleic acid amplification; (3) producing a support (S1) for the determination of nucleic acid analytes by hybridization, by preparing a carrier and constructing an array of receptors (nucleic acids or nucleic acid analogs) on the carrier by site- and/or time-specific immobilization of receptor building blocks at predetermined positions on or in the carrier, the receptors being synthesized using several different batches of building blocks to produce asymmetric receptors; (4) determining analytes by preparing a support of type S1, contacting the support with an analyte-containing sample, and determining the analytes on the basis of their binding to the receptors, where binding causes a detectable signal change; (5) producing a support (S2) for the determination of nucleic acid analytes by hybridization, by preparing a carrier and constructing an array of receptors (nucleic acids or nucleic acid analogs) on the carrier by site- and/or time-specific immobilization of receptor building blocks at predetermined positions on or in the carrier, where the nucleotide sequences of the receptors are selected so that the receptors are present as secondary structures in the absence of a specific-binding analyte; (6) determining analytes by preparing a support of type S2, contacting the support with an analyte-containing sample, and determining the analytes on the basis of their binding to the receptors, where binding causes elimination of the secondary structure; (7) reagent kit comprising a carrier and at least two different batches of building blocks for the synthesis of receptors on the carrier.
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