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1. 发明申请

WO0108799A9 MICROFLUID REACTION CARRIER HAVING THREE FLOW LEVELS AND A TRANSPARENT PROTECTIVE LAYER 审中-公开
标题翻译：与三种流量水平和透明层微反应载体，
公开(公告)号：WO0108799A9
公开(公告)日：2002-09-06
申请号：PCT/EP0007445
申请日：2000-08-01
申请人： FEBIT FERRARIUS BIOTECH GMBH , STAEHLER CORD FRIEDRICH , MUELLER MANFRED , STAEHLER PEER FRIEDRICH
发明人： STAEHLER CORD FRIEDRICH , MUELLER MANFRED , STAEHLER PEER FRIEDRICH
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , G01N35/00
CPC分类号： B01L3/502746 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00319 , B01J2219/00351 , B01J2219/00389 , B01J2219/0043 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00702 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00783 , B01J2219/00831 , B01J2219/00891 , B01J2219/0097 , B01J2219/0099 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0861 , B01L2300/0864 , B01L2300/0874 , B01L2300/0877 , B01L2400/084 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/14 , C40B50/14 , C40B60/08 , G01N2035/00237 , Y10T436/25 , Y10T436/2575
摘要： The present invention relates to a microfluid reaction carrier intended for the purely fluid or light-controlled synthesis or analysis of oligomers or polymers. The reaction carrier comprises a structure of flow channels for the fluids, while supply channels and discharge channels parallel to the latter form an angle relative to the plane of the structure of the flow channels (reaction areas).
摘要翻译：本发明是一种微流体反应的支持，其使得流体纯粹，或低聚物或聚合物的光指导的合成和分析。将反应载体包括用于流体，添加u的通道中的流道结构。平行于它们的衍生物插管谎言成一角度的流道结构（反应区域）的平面。

2. 发明专利

DE19922285A1 Sample vessel used for handling liquids, powders and granules has two front ends with a casing between the ends to limit a sample vessel chamber 未知
公开(公告)号：DE19922285A1
公开(公告)日：2000-11-16
申请号：DE19922285
申请日：1999-05-14
申请人： FEBIT FERRARIUS BIOTECH GMBH
发明人： STAEHLER CORD FRIEDRICH , STAEHLER PEER FRIEDRICH
IPC分类号： B01L3/00
摘要： Sample vessel (1) has two front ends (3) and a casing (5) between the ends to limit a sample vessel chamber (15). The casing is flexible in such a way that the front ends can move towards or away from each other by decreasing or increasing the volume of the sample vessel chamber. Independent claims are also included for the following: (1) a set made up of a number of sample vessels with functional elements coupled to it to form a modular system; and (2) an adapter for coupling the sample vessels.

3. 发明专利

DE19935433A1 未知
公开(公告)号：DE19935433A1
公开(公告)日：2001-03-01
申请号：DE19935433
申请日：1999-08-01
申请人： FEBIT FERRARIUS BIOTECH GMBH
发明人： STAEHLER CORD FRIEDRICH , MUELLER MANFRED , STAEHLER PEER FRIEDRICH
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , G01N35/00 , B81B7/00 , C07H21/00 , C07K1/00 , G01N33/48 , G01N21/00
摘要： Microfluid reaction carrier, with a number of reaction zones, has a flow channel structure for fluids to pass through. Feed channels and parallel outflow channels are interlinked by angled connecting channels which also act as part of the feed and outflow channels structure. Microfluid reaction carrier, with a number of reaction zones, has a flow channel structure for fluids to pass through. The flow channel structure (1) is arranged on three flow planes. The feed channels (2) are in parallel on one plane, and the parallel outflow channels (3) are on the third plane. The connecting channels (4), forming the reaction zones, are in the center plane (30), linking the channels together in the outer planes at right angles or virtually at right angles. The projections of the channels in the first and third planes intersect at an angle. Each flow channel has an individual flow control with a valve system for fluid to flow in and for the fluid to be extracted. The fluid taken from each reaction zone is removed without contact with a fluid from other reaction zones. The flow channel structure is covered by a transparent layer on one or both sides (10,20). The transparent cover is of glass or plastics, with an integrated system of micro-lenses to focus light on the reaction zones and concentrate emitted light from reactions. The transparent cover can be composed of a number of parallel and fused glass fibers, forming a transparent honeycomb structure, where incoming and outgoing light is paralleled and scattered light is blocked from spreading into the transparent cover. The walls between the feed and outflow channels are impermeable to light. The connecting channels are formed by a number of fused glass fiber bundles, where the glass fiber cores are etched out to give micro-channels, only at the reaction zones. The connecting plane can be of a silicon layer, with a number of etched channels. A number of flow planes can be assembled together, where their reaction zones do not overlap and can be exposed to light individually which is directed specifically to each reaction zone. A programmable light source matrix is integrated in the reaction carrier for synthesis and analysis. A number of different receptors are fitted to the carrier at specific zones such as nucleic acids such as DNA, RNA, matter similar to nucleic acids such as peptide nucleic acids (PNA), peptides and saccharides. The receptors are of separate synthesis components, synthesized at the carrier. A component is between the receptor and carrier, to split the receptor for a functional group to remain at the carrier for the synthesis of a new receptor.

4. 发明专利

DE19940752A1 Use of an illumination matrix that can be controlled to generate a freely adjustable illumination pattern to produce a microchip 未知
公开(公告)号：DE19940752A1
公开(公告)日：2000-04-27
申请号：DE19940752
申请日：1999-08-27
申请人： FEBIT FERRARIUS BIOTECH GMBH
发明人： MUELLER MANFRED , STAEHLER PEER FRIEDRICH , STAEHLER CORD FRIEDRICH
IPC分类号： G01J3/51 , B01J19/00 , B01L3/00 , C07H21/00 , C07K1/04 , C12M1/00 , C12N15/09 , C12N15/10 , C12P19/34 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B50/14 , G01N21/25 , G01N21/64 , G01N21/78 , G01N33/483 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/566 , G01N37/00 , G03F7/20 , G03F7/00 , C07B61/00 , C07H1/00 , B01J20/30 , C07K1/00 , C12N15/00 , C12Q1/00 , G01N33/50
摘要： An illumination matrix that can be controlled to generate a freely adjustable illumination pattern is used to produce a support coated with biologically or chemically functional materials (a biochip). Independent claims are also included for the following: (1) a process for producing a biochip, comprising: (a) preparing a support with a surface having photoactivatable groups; (b) activating the photoactivatable groups on at least one predetermined region of the surface by site-specific illumination using the illumination matrix; (c) site-specifically binding biologically or chemically functional materials, or building blocks for such materials, to at least one of the predetermined regions; and (d) optionally repeating the activation and binding steps on the same and/or different predetermined regions; (2) a process for synthesizing polymers, comprising assembling several oligomers on a support by means of parallel synthesis steps, removing the oligomers from the support, and contacting the oligomers with one another to assemble polymers; (3) an apparatus comprising: the illumination matrix; a frame for holding the illumination matrix and optionally a light source; a programmable device for controlling the illumination matrix; and a holder on the frame for receiving and positioning a biochip relative to the illumination matrix so that the light pattern generated by the illumination matrix is projected onto the relevant surface of the biochip; (4) a biochip, or a support for preparing a biochip, having an illumination matrix that can be controlled to generate a freely adjustable illumination pattern, especially a liquid crystal matrix.

5. 发明申请

WO2010139812A1 miRNA FINGERPRINT IN THE DIAGNOSIS OF DISEASES 审中-公开
标题翻译： miRNA指纹在疾病诊断中的应用
公开(公告)号：WO2010139812A1
公开(公告)日：2010-12-09
申请号：PCT/EP2010057944
申请日：2010-06-07
申请人： FEBIT HOLDING GMBH , KELLER ANDREAS , MEESE ECKART , BORRIES ANNE , STAEHLER PEER FRIEDRICH , BEIER MARKUS
发明人： KELLER ANDREAS , MEESE ECKART , BORRIES ANNE , STAEHLER PEER FRIEDRICH , BEIER MARKUS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的确定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

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