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1. 发明专利

CA2756246A1 AMATOXIN-ARMED TARGET-BINDING MOIETIES FOR THE TREATMENT OF CANCER 未知
公开(公告)号：CA2756246A1
公开(公告)日：2010-10-14
申请号：CA2756246
申请日：2010-04-08
申请人： FAULSTICH HEINZ , DEUTSCHES KREBSFORSCH
发明人： FAULSTICH HEINZ , BREITLING FRANK , LUETTGAU SANDRA , MOLDENHAUER GERHARD
IPC分类号： A61K47/48 , A61P35/00 , C07K16/28
摘要： The invention relates to tumour therapy, In one aspect, the present invention relates to conjugates of target-binding moieties and toxins that are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moieties (e.g. antibodies) are directed against tumour-associated antigens, such as epithelial cell adhesion molecule (EpCAM). In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target- binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer, in particular adenocarcinoma, such as pancreatic cancer, cholangiocarcinoma, breast cancer, and colorectal cancer.

2. 发明申请

WO2008151819A3 TREATMENT OF TUMORS USING SPECIFIC ANTI-L1 ANTIBODY 审中-公开
标题翻译：使用特异抗原抗体治疗肿瘤
公开(公告)号：WO2008151819A3
公开(公告)日：2009-04-09
申请号：PCT/EP2008004773
申请日：2008-06-13
申请人： DEUTSCHES KREBSFORSCH , MEDIGENE AG , GAST DANIELA , ALTEVOGT PETER , MOLDENHAUER GERHARD , BREITLING FRANK , KRUEGER ACHIM , WOLTERINK SILKE , LUETTGAU SANDRA , MOEBIUS ULRICH , LI YI
发明人： GAST DANIELA , ALTEVOGT PETER , MOLDENHAUER GERHARD , BREITLING FRANK , KRUEGER ACHIM , WOLTERINK SILKE , LUETTGAU SANDRA , MOEBIUS ULRICH , LI YI
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
摘要翻译：本发明涉及抗L1单克隆抗体9.3以及相关抗体或结合分子，以及其用途，特别是在肿瘤治疗中。

3. 发明专利

PT1298207E PROCESSO PARA A PRODUÇÃO DE BIBLIOTECAS DE PROTEÍNAS E PARA A SELECÇÃO DE PROTEÍNAS A PARTIR DA MESMA 未知
公开(公告)号：PT1298207E
公开(公告)日：2010-11-08
申请号：PT01123596
申请日：2001-10-01
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , MOLDENHAUER GERHARD , POUSTKA ANNEMARIE , KUEHLWEIN THORSTEN , LUETTGAU SANDRA
IPC分类号： C12N15/09 , C07K16/30 , C12N15/10 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C40B40/02

4. 发明专利

DE50115580D1 Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus 未知
公开(公告)号：DE50115580D1
公开(公告)日：2010-09-16
申请号：DE50115580
申请日：2001-10-01
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , MOLDENHAUER GERHARD , POUSTKA ANNEMARIE , KUEHLWEIN THORSTEN , LUETTGAU SANDRA
IPC分类号： C12N15/09 , C12N15/10 , C07K16/30 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C40B40/02

5. 发明专利

AT476503T 未知
公开(公告)号：AT476503T
公开(公告)日：2010-08-15
申请号：AT01123596
申请日：2001-10-01
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , MOLDENHAUER GERHARD , POUSTKA ANNEMARIE , KUEHLWEIN THORSTEN , LUETTGAU SANDRA
IPC分类号： C12N15/09 , C12N15/10 , C07K16/30 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C40B40/02
摘要： Humanizing a hybridoma cell (A) so that the expressed antibody (Ab) is bound to the surface of the cell expressing it, so as to allow detection and selection of those cells that present a humanized constant Ab domain, comprises transfecting the hybridoma cell line with heavy and light chain constant domains, and expanding cells that express Ig heavy chain and kappa or lambda light chain constant regions. Humanizing a hybridoma cell (A) comprises: (a) transfecting the hybridoma cell line with a DNA sequence (I) that encodes one or more of the human constant immunoglobulin (Ig) G, M, A, D or E domains; (b) (I) is flanked by DNA sequences (II) that are homologous with chromosomal gene regions that flank the constant domains of the active heavy chain-encoding gene locus in (a); (c) one or a few cells are expanded that, on the basis of homologous recombination (HR), express an Ig heavy chain with a humanized constant region; (d) a DNA sequence (III), encoding a human constant kappa or lambda domain, is transfected into the cells, where (III) is flanked by sequences (IV) homologous with chromosomal gene regions that flank the constant domain of the active kappa or lambda gene locus in (a); and (e) one or a few cells are expanded that, on the basis of HR, express a kappa or lambda chain having a human constant region. The expressed Ab is bound to the surface of the cell expressing it, through covalent bonding of the membrane-bound splice variant of the heavy chain, making it possible to detect and select those cells that present a human constant antibody domain. Independent claims are also included for: (1) vector that contains one or more of the DNA sequences specified above; and (2) host cell that contains a vector of (1).

6. 发明专利

CA2691075A1 TREATMENT OF TUMORS USING SPECIFIC ANTI-L1 ANTIBODY 未知
公开(公告)号：CA2691075A1
公开(公告)日：2008-12-18
申请号：CA2691075
申请日：2008-06-13
申请人： DEUTSCHES KREBSFORSCH , MEDIGENE AG
发明人： GAST DANIELA , ALTEVOGT PETER , MOLDENHAUER GERHARD , BREITLING FRANK , KRUEGER ACHIM , WOLTERINK SILKE , LUETTGAU SANDRA , MOEBIUS ULRICH , LI YI
IPC分类号： C07K16/28
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.

7. 发明专利

MX2011010469A RADICALES DE ENLACE AL OBJETIVO, ARMADOS CON AMATOXINA PARA EL TRATAMIENTO DEL CANCER. 未知
公开(公告)号：MX2011010469A
公开(公告)日：2012-03-14
申请号：MX2011010469
申请日：2010-04-08
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , FAULSTICH HEINZ , LUETTGAU SANDRA , MOLDENHAUER GERHARD
IPC分类号： A61K47/48 , A61P35/00 , C07K16/28
摘要： La invención se refiere a terapia para tumores. En un aspecto, la presente invención se refiere a conjugados de radicales de enlace al objetivo y toxinas que son útiles en el tratamiento del cáncer. En particular, la toxina es una amatoxina, y los radicales de enlace al objetivo (por ejemplo anticuerpos) están dirigidos contra antígenos asociados con tumores, tales como la molécula de adhesión de células epiteliales (EpCAM). En un aspecto adicional la invención se refiere a composiciones farmacéuticas que comprenden tales conjugados de toxina de radical de enlace al objetivo y al uso de tales conjugados de toxina de radical de enlace al objetivo y al uso de tales conjugados de toxina de radical de enlace al objetivo para la preparación de tales composiciones farmacéuticas. Los conjugados de toxina de radical de enlace al objetivo y composiciones farmacéuticas de la invención son útiles para el tratamiento de cáncer, en particular adenocarcinoma, tal como cáncer pancreático, colangiocarcinoma, cáncer de seno, y cáncer colorrectal.

8. 发明专利

SG174328A1 AMATOXIN-ARMED TARGET-BINDING MOIETIES FOR THE TREATMENT OF CANCER 未知
公开(公告)号：SG174328A1
公开(公告)日：2011-10-28
申请号：SG2011065356
申请日：2010-04-08
申请人： DEUTSCHES KREBSFORSCH , HEINZ FAULSTICH
发明人： FAULSTICH HEINZ , BREITLING FRANK , LUETTGAU SANDRA , MOLDENHAUER GERHARD
摘要： The invention relates to tumour therapy, In one aspect, the present invention relates to conjugates of target-binding moieties and toxins that are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moieties (e.g. antibodies) are directed against tumour-associated antigens, such as epithelial cell adhesion molecule (EpCAM). In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target- binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer, in particular adenocarcinoma, such as pancreatic cancer, cholangiocarcinoma, breast cancer, and colorectal cancer.

9. 发明专利

PT1652920E PROCESSO PARA A PRODUÇÃO DE BIBLIOTECAS DE PROTEÍNAS E PARA A SELECÇÃO DE PROTEÍNAS A PARTIR DA MESMA 未知
公开(公告)号：PT1652920E
公开(公告)日：2010-11-08
申请号：PT06002567
申请日：2001-10-01
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , MOLDENHAUER GERHARD , POUSTKA ANNEMARIE , KUEHLWEIN THORSTEN , LUETTGAU SANDRA
IPC分类号： C12N15/09 , C07K16/30 , C12N15/10 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C40B40/02

10. 发明专利

DE50115587D1 Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus 未知
公开(公告)号：DE50115587D1
公开(公告)日：2010-09-16
申请号：DE50115587
申请日：2001-10-01
申请人： DEUTSCHES KREBSFORSCH
发明人： BREITLING FRANK , MOLDENHAUER GERHARD , POUSTKA ANNEMARIE , KUEHLWEIN THORSTEN , LUETTGAU SANDRA
IPC分类号： C12N15/09 , C12N15/10 , C07K16/30 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C40B40/02

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