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1. 发明申请

WO2010115629A3 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 审中-公开
公开(公告)号：WO2010115629A3
公开(公告)日：2010-10-14
申请号：PCT/EP2010/002205
申请日：2010-04-08
申请人： FAULSTICH, Heinz , DEUTSCHES KREBSFORSCHUNGSZENTRUM , MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MULLER, Christoph
发明人： FAULSTICH, Heinz , MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MULLER, Christoph
IPC分类号： A61K47/48 , C07K16/28 , A61P35/00 , A61P43/00
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

2. 发明公开

EP3485912A1 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 审中-公开
公开(公告)号：EP3485912A1
公开(公告)日：2019-05-22
申请号：EP18214020.2
申请日：2010-04-08
申请人： Faulstich, Heinz, Dr. , Deutsches Krebsforschungszentrum
发明人： FAULSTICH, Heinz , MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MÜLLER, Christoph
IPC分类号： A61K47/68 , A61P35/00
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

3. 发明授权

EP2416804B1 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 有权
标题翻译：麻醉剂AMATOXIN BELADENE THERAPEUTISCHEZELLOBERFLÄCHEN-BINDUNGSKOMPONENTENFÜRDIE TUMORTHERAPIE
公开(公告)号：EP2416804B1
公开(公告)日：2017-03-01
申请号：EP10713429.8
申请日：2010-04-08
申请人： Faulstich, Heinz, Dr. , Deutsches Krebsforschungszentrum
发明人： MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MULLER, Christoph
IPC分类号： A61K47/68 , C07K16/30 , A61P35/00 , A61P43/00
CPC分类号： A61K47/48492 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/92

4. 发明公开

EP3192529A1 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 有权
标题翻译：以AMATOXIN为基础的治疗性细胞表面结合成分设计用于肿瘤治疗
公开(公告)号：EP3192529A1
公开(公告)日：2017-07-19
申请号：EP17158119.2
申请日：2010-04-08
申请人： Faulstich, Heinz, Dr. , Deutsches Krebsforschungszentrum
发明人： FAULSTICH, Heinz , MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MÜLLER, Christoph
IPC分类号： A61K47/68 , C07K16/28 , A61P35/00 , A61P43/00
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.
摘要翻译：本发明涉及肿瘤治疗。在一个方面，本发明涉及毒素与靶标结合部分的缀合物，例如，抗体，其可用于治疗癌症。特别地，毒素是amatoxin，并且靶标结合部分优选针对肿瘤相关抗原。特别地，amatoxin通过接头部分与抗体缀合。具体而言，接头部分共价结合到位于阿萨木辛位置的官能团，所述官能团被证明为关于最佳抗肿瘤活性的连接物连接的优选位置。另一方面，本发明涉及包含此类靶结合部分毒素缀合物的药物组合物，并涉及这种靶结合部分毒素缀合物用于制备此类药物组合物的用途。本发明的靶结合部分毒素偶联物和药物组合物可用于治疗癌症。

5. 发明授权

EP3192529B1 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 有权
公开(公告)号：EP3192529B1
公开(公告)日：2020-03-25
申请号：EP17158119.2
申请日：2010-04-08
申请人： Faulstich, Heinz, Dr. , Deutsches Krebsforschungszentrum
发明人： FAULSTICH, Heinz , MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MÜLLER, Christoph
IPC分类号： A61K47/68 , A61P35/00 , A61P43/00 , C07K16/30

6. 发明公开

EP2416804A2 AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY 有权
标题翻译：用装有毒伞肽用于肿瘤治疗的治疗性细胞表面结合组件
公开(公告)号：EP2416804A2
公开(公告)日：2012-02-15
申请号：EP10713429.8
申请日：2010-04-08
申请人： Faulstich, Heinz, Dr. , Deutsches Krebsforschungszentrum
发明人： MOLDENHAUER, Gerhard , WERNER, Simon , ANDERL, Jan , MULLER, Christoph
IPC分类号： A61K47/48 , C07K16/28 , A61P35/00 , A61P43/00
CPC分类号： A61K47/48492 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/92
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

7. 发明申请

WO2010087847A1 DIELECTROPHORETIC DEVICE WITH ACTUATOR 审中-公开
标题翻译：具有执行器的电子设备
公开(公告)号：WO2010087847A1
公开(公告)日：2010-08-05
申请号：PCT/US2009/032622
申请日：2009-01-30
申请人： BIO-RAD LABORATORIES, INC. , NATURAL AND MEDICAL SCIENCES INSTITUTE AT THE UNIVERSITY OF TUBINGEN , HAUSMANN, Monika , MOSCHALLSKI, Meike , POSCH, Anton , STELZLE, Martin , KENTSCH, Joerg , WERNER, Simon
发明人： HAUSMANN, Monika , MOSCHALLSKI, Meike , POSCH, Anton , STELZLE, Martin , KENTSCH, Joerg , WERNER, Simon
IPC分类号： B03C5/00
CPC分类号： B03C5/026 , B03C5/005
摘要： A dielectrophoretic fractionation device having a channel defining a direction of flow therethrough for the fractionation of particles in a liquid particle suspension is disclosed. The device also has a deflector unit affixed to a wall of the channel and arranged to generate an electric field gradient in the channel to spatially separate the particles in the liquid particle suspension. The device also has an actuator mounted to the channel and positioned to deform the wall. Also provided is a method for inhibiting aggregation of particles in a liquid particle suspension of the dielectrophoretic fractionation device, the method including periodically deforming the wall with the actuator.
摘要翻译：公开了一种介电电泳分级装置，其具有限定流过其中流动方向的通道，用于液体颗粒悬浮液中颗粒的分馏。该装置还具有固定到通道的壁上的偏转器单元，并布置成在通道中产生电场梯度以在液体颗粒悬浮液中空间分离颗粒。该装置还具有安装到通道并被定位成使壁变形的致动器。还提供了抑制介电泳分离装置的液体颗粒悬浮液中的颗粒聚集的方法，该方法包括使致动器周期性地使壁变形。

8. 发明申请

WO2003087060A1 FREDERICAMYCIN-DERIVATE 审中-公开
标题翻译： Fredericamycin衍生物
公开(公告)号：WO2003087060A1
公开(公告)日：2003-10-23
申请号：PCT/EP2003/003285
申请日：2003-03-28
申请人： BIOLEADS GMBH , WERNER, Simon , ULRICH, Abel
发明人： WERNER, Simon , ULRICH, Abel
IPC分类号： C07D221/20
CPC分类号： C07D221/20 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要： Die Erfindung betrifft neue Fredericamycin-Derivate, Arzneimittel die diese oder deren Salze enthalten, und die Verwendung der Fredericamycin-Derivate zur Behandlung von Erkrankungen, insbesondere Tumorerkrankungen.
摘要翻译：本发明涉及新颖的弗雷迪霉素衍生物，含有这些或其盐的药物，以及弗雷迪霉素衍生物用于治疗疾病，特别是肿瘤的用途。

9. 发明申请

WO2008034895A2 ANSAMYCIN DERIVATIVES 审中-公开
标题翻译：阿萨米辛衍生物
公开(公告)号：WO2008034895A2
公开(公告)日：2008-03-27
申请号：PCT/EP2007/060032
申请日：2007-09-21
申请人： DISCOVERY PARTNERS INTERNATIONAL GMBH , HANSSKE, Friedrich Georg , WERNER, Simon , ECKARD, Peter , MASKEY, Rajendra-Prasad , RASSER, Hans-Falk , SONTAG, Bernd , GRUN-WOLLNY, Iris
发明人： HANSSKE, Friedrich Georg , WERNER, Simon , ECKARD, Peter , MASKEY, Rajendra-Prasad , RASSER, Hans-Falk , SONTAG, Bernd , GRUN-WOLLNY, Iris
IPC分类号： C07D225/06 , A61K31/395
CPC分类号： C07D225/06
摘要： The invention relates to novel ansamycin derivatives of Formula (I) or (II): medicinal products that contain these or salts thereof, and the use of the geldanamycin derivatives for the treatment of diseases, in particular neoplastic diseases.
摘要翻译：本发明涉及式（I）或（II）的新型安莎霉素衍生物：含有这些或其盐的药物，以及格尔德霉素衍生物用于治疗疾病，特别是肿瘤性疾病的用途。

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