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1. 发明申请

US20120156717A1 BIOFUEL FROM RECOMBINANT OLEAGINOUS ALGAE USING SUGAR CARBON SOURCES 审中-公开
标题翻译：来自使用糖碳源的重组脂肪酸的生物燃料
公开(公告)号：US20120156717A1
公开(公告)日：2012-06-21
申请号：US13392950
申请日：2010-08-30
申请人： F.C. Thomas Allnutt , Bradley Lynn Postier , Richard T. Sayre , Daniel A. Coury
发明人： F.C. Thomas Allnutt , Bradley Lynn Postier , Richard T. Sayre , Daniel A. Coury
IPC分类号： C12P1/00 , C12P9/00 , C12P33/00 , C12N1/13 , C12P7/64
CPC分类号： C12P7/649 , Y02E50/13
摘要： Recombinant oleaginous alga that include one or more heterologous genes that increase the ability of the alga to use one or more natural saccharides such as cellulosic or hemicellulosic sugars for algal growth are described. The recombinant oleaginous algae are transformed to include one or more genes expressing sugar metabolizing enzymes or sugar transporting proteins, along with suitable control elements. Use of natural saccharides as a carbon source can allow the algae to produce biofuel precursors in a relatively efficient manner. Processes for preparing the alga, growing the alga, and extracting the biofuel precursors from the alga are also described.
摘要翻译：描述了包含增加藻类使用一种或多种天然糖如纤维素或半纤维素糖用于藻类生长的能力的一种或多种异源基因的重组含油藻。将重组含油藻类转化为包括一个或多个表达糖代谢酶或糖转运蛋白的基因以及合适的控制元件。使用天然糖作为碳源可以使藻类以相对有效的方式生产生物燃料前体。还描述了用于制备藻类，生长藻类以及从藻类中提取生物燃料前体的方法。

2. 发明申请

US20130109098A1 BIOSECURE GENETICALLY MODIFIED ALGAE 审中-公开
标题翻译：生物基因改造的ALGAE
公开(公告)号：US20130109098A1
公开(公告)日：2013-05-02
申请号：US13808285
申请日：2011-07-06
申请人： F.C. Thomas Allnutt , Bradley Lynn Postier , Richard T. Sayre , Daniel A. Coury , Anil Kumar , Andrew Swanson , Mark Scott Abad , Zoee Gokhale Perrine
发明人： F.C. Thomas Allnutt , Bradley Lynn Postier , Richard T. Sayre , Daniel A. Coury , Anil Kumar , Andrew Swanson , Mark Scott Abad , Zoee Gokhale Perrine
IPC分类号： C12N15/79
CPC分类号： C12N15/79 , C12N1/12
摘要： Biosecure algae and methods for preparing biosecure algae that have a substantially decreased capability to survive in a natural environment are described. The methods include transforming a genetically modified alga to include an essential gene that is operably linked to a promoter system that is active only in the presence of an inducer compound, transforming the genetically modified alga to include a lethal gene that is operably linked with a promoter system that is inactive only in the presence of a repressor compound. The biosecure algae are only able to survive in an artificial algae culture that includes factors or conditions not found in a natural environment.
摘要翻译：描述了生物安全藻类和用于制备在自然环境中具有显着降低的生存能力的生物安全藻类的方法。所述方法包括转化遗传修饰的藻类以包括可操作地连接到仅在诱导物化合物存在下仅起作用的启动子系统的必需基因，将所述遗传修饰的藻类转化为包括与启动子可操作地连接的致死基因仅在存在阻遏物化合物时不起作用的系统。生物安全藻类只能在人造藻类培养物中生存，其中包括在自然环境中未发现的因素或条件。

3. 发明申请

US20130145495A1 ENHANCED CARBON FIXATION IN PHOTOSYNTHETIC HOSTS 审中-公开
标题翻译：增强碳素固定在光合作用
公开(公告)号：US20130145495A1
公开(公告)日：2013-06-06
申请号：US13641814
申请日：2011-04-25
申请人： Richard T. Sayre
发明人： Richard T. Sayre
IPC分类号： C12N15/82
CPC分类号： C12N15/8243 , C07K2319/00 , C12N9/88 , C12N15/8261 , C12P2203/00 , C12Y401/01039 , C12Y402/01001 , Y02A40/146
摘要： This invention provides genetically modified photosynthetic organisms and methods and constructs for enhancing inorganic carbon fixation. A photosynthetic organism of the present invention comprises a RUBISCO fusion protein operatively coupled to a protein-protein interaction domain to enable the functional association of RUBISCO and carbonic anhydrase.
摘要翻译：本发明提供用于增强无机碳固定的转基因光合生物和方法和构建体。本发明的光合生物包含可操作地偶联于蛋白质 - 蛋白质相互作用结构域的RUBISCO融合蛋白，以实现RUBISCO和碳酸酐酶的功能性结合。

4. 发明申请

US20120122115A1 Bacterial quorum sensing biosensor 审中-公开
标题翻译：细菌群体感应生物传感器
公开(公告)号：US20120122115A1
公开(公告)日：2012-05-17
申请号：US11789479
申请日：2007-04-25
申请人： Richard T. Sayre , Sathish Rajamani
发明人： Richard T. Sayre , Sathish Rajamani
IPC分类号： C07K19/00 , G01N21/64 , C12N1/21 , C12N15/62 , C12N15/63
CPC分类号： C07K14/28 , C07K2319/00 , C07K2319/60 , G01N2021/6441
摘要： The present invention generally relates to fluorescent resonance energy transfer protein compounds and methods for using such compounds as biosensors. The present invention also relates to one or more nucleic acids for encoding the protein compounds, vectors containing the nucleic acids, cells transformed by the vectors, and methods for making and using the foregoing compositions.
摘要翻译：本发明一般涉及荧光共振能量转移蛋白质化合物和使用这些化合物作为生物传感器的方法。本发明还涉及用于编码蛋白质化合物的一种或多种核酸，含有核酸的载体，载体转化的细胞，以及制备和使用上述组合物的方法。

5. 发明申请

US20120088279A1 ALGAL LIPID PRODUCTION 审中-公开
标题翻译： ALGAL脂生产
公开(公告)号：US20120088279A1
公开(公告)日：2012-04-12
申请号：US13319745
申请日：2010-05-11
申请人： Andrew Keith Swanson , Bradley Lynn Postler , Richard T. Sayre
发明人： Andrew Keith Swanson , Bradley Lynn Postler , Richard T. Sayre
IPC分类号： C12P7/64 , C12M1/00 , C12N1/12
CPC分类号： C12P7/6463
摘要： Methods for increasing the levels of lipids in oleaginous algae are described. Lipid levels in algae can be increased by stress, such as nutrient stress, after which the lipid can be harvested from the algae using a non-destructive extraction process. The stress may be provided in a periodic or “pulsed” fashion. Lipid levels in oleaginous algae can also be increased using simulated stress by treating the algae with a chemical inhibitor or by using recombinant technology to insert a sequence expressing a protein such as a nitrate reductase inhibitor that is expressed when a stressed state is desired. A method for maintaining the temperature and water levels of algae ponds using buoyant spheres is also described.
摘要翻译：描述了提高含油藻类脂质含量的方法。藻类中的脂质水平可以通过胁迫（如营养胁迫）增加，此后可以使用非破坏性提取过程从藻类中收获脂质。应力可以以周期性或“脉冲”的方式提供。通过用化学抑制剂处理藻类或通过使用重组技术插入表达当需要应激状态时表达的蛋白质例如硝酸还原酶抑制剂的序列，也可以使用模拟应力来增加油质藻类中的脂质水平。还描述了使用浮力球保持藻类池塘的温度和水位的方法。

6. 发明申请

US20090181438A1 OPTIMIZATION OF BIOFUEL PRODUCTION 审中-公开
标题翻译：生物油生产优化
公开(公告)号：US20090181438A1
公开(公告)日：2009-07-16
申请号：US12328695
申请日：2008-12-04
申请人： Richard T. Sayre
发明人： Richard T. Sayre
IPC分类号： C12P7/64 , C12M1/00
CPC分类号： C10G1/00 , C10G1/04 , C10L1/19 , C11B1/10 , C11B3/12 , C12M21/02 , C12M43/02 , C12M47/10 , C12P7/6463 , Y02P30/20
摘要： Embodiments of the present invention includes an apparatuses, compositions, and methods utilizing mechanical and chemical engineering strategies to achieve even greater efficiencies in biofuels production from oleaginous organisms. These increased efficiencies may be achieved through the application of targeted and well-designed chemical and mechanical engineering methods disclosed herein to achieve a non-destructive extraction process (NDEP).
摘要翻译：本发明的实施方案包括利用机械和化学工程策略从油质生物体获得甚至更高的生物燃料生产效率的装置，组合物和方法。这些提高的效率可以通过应用本文公开的目标和精心设计的化学和机械工程方法来实现，以实现非破坏性提取方法（NDEP）。

7. 发明授权

US07410637B2 Transgenic algae for delivering antigens to an animal 有权
标题翻译：用于将抗原递送至动物的转基因藻类
公开(公告)号：US07410637B2
公开(公告)日：2008-08-12
申请号：US10311741
申请日：2001-06-20
申请人： Richard T. Sayre , Richard E. Wagner , Surasak Siripornadulsil , Carlos Farias
发明人： Richard T. Sayre , Richard E. Wagner , Surasak Siripornadulsil , Carlos Farias
IPC分类号： A01N63/00 , A61K39/00 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/82
CPC分类号： A61K39/0208 , A23K10/16 , A23K20/147 , A23K50/00 , A23K50/70 , A23K50/75 , A23K50/80 , A61K9/5068 , A61K39/05 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/523 , A61K2039/54 , A61K2039/542 , A61K2039/552 , C07K14/195 , C12N1/12 , C12N7/00 , C12N15/8214 , C12N15/8257 , C12N2710/18022 , C12N2710/18034
摘要： Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal.
摘要翻译：提供递送系统和方法用于将生物活性蛋白递送至宿主动物。提供的系统和方法包括获得由表达载体转化的藻类细胞，所述表达载体包含可操作地连接于启动子的编码生物活性蛋白质的核苷酸序列。在一个所示实施方案中，生物活性蛋白质是抗原表位，并且在给予动物时，藻类细胞在宿主动物中诱导免疫应答。

8. 发明申请

US20130219560A1 REDUCTION OF POST-HARVEST PHYSIOLOGICAL DETERIORATION 审中-公开
标题翻译：减少后期生理学检测
公开(公告)号：US20130219560A1
公开(公告)日：2013-08-22
申请号：US13820613
申请日：2011-09-02
申请人： Richard T. Sayre
发明人： Richard T. Sayre
IPC分类号： C12N15/82
CPC分类号： C12N15/8243 , C12N9/0004 , C12N15/8242 , C12N15/8249 , C12N15/8266
摘要： The invention provides methods for transgenically controlling physiological post-harvest deterioration (PPD) in plants. Among other aspects, the invention also provides transgenic plants produced by the methods and constructs for creating the plants. According to the present invention, PPD is controlled by expressing one or more transgenes which modulate ROS production or cyanogen levels. Examplary transgenes include alternative oxidase, ROS scavengers, carotenoid biosynthesis genes, and cyanogen metabolism.
摘要翻译：本发明提供了用于转基因控制植物中的生理性收获后退化（PPD）的方法。除其它方面之外，本发明还提供通过用于产生植物的方法和构建体产生的转基因植物。根据本发明，通过表达一种或多种调节ROS产生或氰水平的转基因来控制PPD。示范转基因包括替代氧化酶，ROS清除剂，类胡萝卜素生物合成基因和氰代谢。

9. 发明授权

US08282915B2 Transgenic algae for delivering antigens to an animal 有权
标题翻译：用于将抗原递送至动物的转基因藻类
公开(公告)号：US08282915B2
公开(公告)日：2012-10-09
申请号：US12145249
申请日：2008-06-24
申请人： Richard T. Sayre , Richard E. Wagner , Surasak Siripornadulsil , Carlos Farias
发明人： Richard T. Sayre , Richard E. Wagner , Surasak Siripornadulsil , Carlos Farias
IPC分类号： A01N63/00 , A61K39/00 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/82
CPC分类号： A61K39/0208 , A23K10/16 , A23K20/147 , A23K50/00 , A23K50/70 , A23K50/75 , A23K50/80 , A61K9/5068 , A61K39/05 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/523 , A61K2039/54 , A61K2039/542 , A61K2039/552 , C07K14/195 , C12N1/12 , C12N7/00 , C12N15/8214 , C12N15/8257 , C12N2710/18022 , C12N2710/18034
摘要： Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal.
摘要翻译：提供递送系统和方法用于将生物活性蛋白递送至宿主动物。提供的系统和方法包括获得由表达载体转化的藻类细胞，所述表达载体包含可操作地连接于启动子的编码生物活性蛋白的核苷酸序列。在一个所示实施方案中，生物活性蛋白质是抗原表位，并且在给予动物时，藻类细胞在宿主动物中诱导免疫应答。

10. 发明申请

US20100317073A1 MOLECULAR APPROACHES FOR THE OPTIMIZATION OF BIOFUEL PRODUCTION 审中-公开
标题翻译：生物生产优化的分子方法
公开(公告)号：US20100317073A1
公开(公告)日：2010-12-16
申请号：US12743434
申请日：2008-12-04
申请人： Richard T. Sayre , Suzette L. Pereira
发明人： Richard T. Sayre , Suzette L. Pereira
IPC分类号： C12P7/40 , C12N15/63 , C07H21/04 , C12N1/13 , C12N15/74
CPC分类号： C10G1/00 , C10G1/04 , C10G2300/1014 , C10L1/19 , C11B1/10 , C11B3/12 , C12N1/32 , C12N15/8247 , C12N15/8261 , C12N15/8269 , C12N15/8281 , C12P7/6463 , Y02A40/146 , Y02P30/20
摘要： Embodiments of the present invention utilize rationale genetic and chemical engineering strategies to achieve even greater efficiencies in biofuel production from microalgae. These increased efficiencies may be achieved through the application of targeted and well-designed chemical and genetic engineering methods disclosed herein. The exemplary embodiments focus on increasing single cell oil yields, increased algal culture densities, and increased efficiencies in oil production. Individually or in combination, exemplary embodiments may reduce the cost to produce a barrel of biofuel to enable commercial viability.
摘要翻译：本发明的实施例利用合理的遗传和化学工程策略来实现微藻生物燃料生产的更高的效率。这些提高的效率可以通过应用本文公开的目标和精心设计的化学和基因工程方法来实现。示例性实施方案侧重于增加单细胞油产量，增加的藻类培养密度和提高石油生产的效率。单独地或组合地，示例性实施例可以降低生产一桶生物燃料的成本，以实现商业可行性。

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