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1. 发明申请

WO2018141821A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2018141821A1
公开(公告)日：2018-08-09
申请号：PCT/EP2018/052451
申请日：2018-01-31
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC. , LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
发明人： CARELL, Thomas , KOBOLD, Uwe , HEINDL, Dieter , BAECHER, Silvia , LEINENBACH, Andreas , REMPT, Martin , PFAFFENEDER, Toni , KIRCHNER, Angie , KOSMATCHEV, Olesea , RAHIMOFF, René , SCHIFFERS, Sarah , MÜLLER, Markus
IPC分类号： G01N33/68 , C12Q1/68
摘要： The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

2. 发明申请

WO2022129131A1 EVAPORATION-BASED SAMPLE PREPARATION WORKFLOW FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2022129131A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085832
申请日：2021-12-15
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HOFFMANN, Thomas , KUPSER, Peter , LEINENBACH, Andreas , MITRA, Indranil , NANDANIA, Jatin , WERNER, Cornelia
IPC分类号： G01N1/40 , G01N30/72 , G01N33/543 , G01N33/74 , G01N33/68 , G01N30/00
摘要： The present invention relates to a method for detecting and/or quantifying an analyte in a sample using mass spectrometry. The method of the invention comprises: extracting the analyte from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the analyte, concentrating the analyte, said concentrating comprising evaporating solvent from the SPE-extract; and detecting and/or quantifying the analyte in the sample using mass spectrometry.

3. 发明申请

WO2020020850A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020850A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069730
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

4. 发明申请

WO2018077783A1 IMMOBILIZED ANALYTES 审中-公开
标题翻译：固定化分析
公开(公告)号：WO2018077783A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/076961
申请日：2017-10-23
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KOBOLD, Uwe , LANG, Robert , LEINENBACH, Andreas
IPC分类号： G01N33/543 , G01N33/68
摘要： The present invention relates to a method for detecting an analyte comprising a) contacting said analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within said analyte and/or within said capture agent comprised in said capture complex and, thereby, releasing said analyte or a fragment thereof from said capture complex, and c) detecting said at least one fragment of said analyte and, thereby, detecting said analyte. The present invention further relates to a kit comprising i) a capture agent binding, in an embodiment specifically binding, to an analyte; and ii) an agent cleaving at least one covalent bond within said analyte and/or within said capture agent; and to a use of a protease for releasing fragments of an analyte for detecting said analyte, wherein said analyte is bound to a solid surface via a capture agent.
摘要翻译：本发明涉及用于检测分析物的方法，其包括a）使所述分析物，捕获剂和固体表面接触以形成附着于固体表面的捕获复合物，b）将至少一个在所述捕获复合物中包含的所述分析物内和/或所述捕获剂内的共价键，从而从所述捕获复合物释放所述分析物或其片段，以及c）检测所述分析物的所述至少一个片段，从而检测所述分析物。本发明进一步涉及一种试剂盒，其包含：i）在分析物中结合特定结合的捕获剂; 和ii）切割所述分析物内和/或所述捕获剂内的至少一个共价键的试剂; 并涉及蛋白酶用于释放分析物片段以检测所述分析物的用途，其中所述分析物通过捕获剂结合到固体表面。

5. 发明申请

WO2020148394A1 HIGH SPEED SAMPLE WORKFLOW FOR LC-MS BASED HBA1C MEASUREMENT 审中-公开
公开(公告)号：WO2020148394A1
公开(公告)日：2020-07-23
申请号：PCT/EP2020/051039
申请日：2020-01-16
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KOBOLD, Uwe , LEINENBACH, Andreas , MITRA, Indranil
IPC分类号： G01N33/72 , G01N33/68
摘要： The present invention refers to a method for determining peptide fragments of glycated hemoglobin A (HbA1c) molecules by mass spectrometry (MS), a reagent kit, and a clinical diagnostic system adapted for performing the method.

6. 发明申请

WO2019077113A1 COPY PROTECTION FOR ANTIBODIES 审中-公开
公开(公告)号：WO2019077113A1
公开(公告)日：2019-04-25
申请号：PCT/EP2018/078720
申请日：2018-10-19
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： DUEFEL, Hartmut , KOBOLD, Uwe , LEINENBACH, Andreas
IPC分类号： C07K16/00 , G01N33/68
摘要： The present invention is directed at an antibody conjugate comprising an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of said one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.

7. 发明申请

WO2022171790A1 COLUMN DEVICE 审中-公开
公开(公告)号：WO2022171790A1
公开(公告)日：2022-08-18
申请号：PCT/EP2022/053354
申请日：2022-02-11
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KUPSER, Peter , LEINENBACH, Andreas
IPC分类号： G01N30/60 , G01N30/88
摘要： A column device (116) for an automatic analyzer (100) is disclosed. The automatic analyzer (100) comprises a high performance liquid chromatography (HPLC) module (102). The HPLC module (102) comprises a fixation device (104) configured to automatically fix and release a chromatographic column (106). The column device (116) comprises a column jacket (118) and a capillary (120). The capillary comprises predetermined dimensions and is disposed within the column jacket (118). The column device (116) is configured to be installed at the HPLC module (102) by means of the fixation device (104). Further, an automatic analyzer (100) is disclosed.

8. 发明申请

WO2020148395A1 AUTOMATIC SAMPLE WORKFLOW FOR LC-MS BASED HBA1C MEASUREMENT ON INTACT PROTEIN LEVEL 审中-公开
公开(公告)号：WO2020148395A1
公开(公告)日：2020-07-23
申请号：PCT/EP2020/051041
申请日：2020-01-16
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KOBOLD, Uwe , LEINENBACH, Andreas , MITRA, Indranil , BUSSKAMP, Holger
IPC分类号： G01N33/68 , G01N33/72
摘要： The present invention refers to a method for determining intact glycated hemoglobin A (HbA1c) by mass spectrometry (MS), a kit and a diagnostic system adapted for performing the method.

9. 发明申请

WO2020020851A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020851A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069731
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

10. 发明申请

WO2020020849A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020849A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069729
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HAHN, Robert , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

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