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1. 发明申请

WO2009103492A1 DRUG ADMINISTRATION DEVICE HAVING A BOLUS ADMINISTRATION PROFILE CONTROLLER 审中-公开
标题翻译：具有BOLUS管理配置文件控制器的药物管理装置
公开(公告)号：WO2009103492A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/001125
申请日：2009-02-18
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , REMDE, Axel , KALT, Lucas
发明人： REMDE, Axel , KALT, Lucas
IPC分类号： G06F19/00 , A61M5/142
CPC分类号： A61M5/14244 , A61M2005/14208 , A61M2205/502 , G06F19/00 , G06F19/3468
摘要： Administration device for the subcutaneous administration of a liquid drug over an extended period of time, comprising: a) an administration unit, the administration unit comprising a drug reservoir and a pump unit; b) a housing, the housing comprising the administration unit, the housing being adapted to be carried by a patient over an extend period of time; c) a controller unit, characterized in that the controller unit further comprises d) a bolus administration profile controller (85), the bolus administration profile controller (85) being adapted to receive a bolus volume (B) of a bolus to be administered and to determine based, at least in part, on the bolus volume (B) a bolus administration profile such that the depot volume (B_depot) of a depot is limited.
摘要翻译：用于在长时间内皮下施用液体药物的给药装置，包括：a）给药单元，所述给药单元包括药物储存器和泵单元; b）壳体，所述壳体包括所述管理单元，所述壳体适于在延长的时间段内被患者携带; c）控制器单元，其特征在于，所述控制器单元还包括d）推注管理简档控制器（85），所述推注管理简档控制器（85）适于接收要施用的推注的推注体积（B）至少部分地基于推注体积（B）来确定药剂量给药谱，使得贮库的贮库体积（B_depot）受到限制。

2. 发明申请

WO2012025388A1 ACOUSTIC WARNING LEVEL OPTIMIZATION IN AMBULATORY MEDICAL SYSTEMS 审中-公开
标题翻译：辅助医疗系统中的呼声警戒级别优化
公开(公告)号：WO2012025388A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/063809
申请日：2011-08-11
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , KALT, Lucas , REMDE, Axel
发明人： KALT, Lucas , REMDE, Axel
IPC分类号： A61M5/142 , B06B1/02 , G08B3/10
CPC分类号： A61M5/14244 , A61B5/14532 , A61M2205/186 , A61M2205/581 , A61M2205/70 , A61M2205/702 , G10K15/02 , H04R29/00
摘要： An ambulatory medical device (10) comprises a function module (18) adapted to provide the intended functionality of the device, a controller module (24) adapted to control the device, and a sound generation module (11) with an acoustic transducer (16) adapted to produce an acoustic signal (56) and a signal generator (26) adapted to drive the acoustic transducer with a certain frequency, wherein the signal generation module (11) is arranged within a housing of the device. A tuning module (28, 30) is adapted to vary the frequency used by the signal generator to drive the acoustic transducer, and to determine one or more frequencies that correspond to an optimum sound level of the acoustic signal (56) outside of the housing of the device. The optimum sound level of the acoustic signal (56) is a maximum sound level outside of the housing of the device (10), and/or a maximum perceivable sound level as determined by a user (42).
摘要翻译：移动医疗设备（10）包括适于提供设备的预期功能的功能模块（18），适于控制设备的控制器模块（24）和具有声换能器（16）的声音生成模块（11））适于产生适于以特定频率驱动所述声换能器的声信号（56）和信号发生器（26），其中所述信号发生模块（11）布置在所述装置的壳体内。调谐模块（28,30）适于改变由信号发生器使用的频率以驱动声换能器，并且确定对应于壳体外部的声信号（56）的最佳声级的一个或多个频率的设备。声信号（56）的最佳声级是设备（10）外壳之外的最大声级和/或由用户（42）确定的最大可感知声级。

3. 发明申请

WO2008092286A1 ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL 审中-公开
标题翻译：葡萄糖浓度信号的评估方法
公开(公告)号：WO2008092286A1
公开(公告)日：2008-08-07
申请号：PCT/CH2008/000025
申请日：2008-01-25
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , KÜHNI, Florian , VERING, Thomas , KALT, Lucas , CRIS, Catalin , PATTE, Caroline
发明人： KÜHNI, Florian , VERING, Thomas , KALT, Lucas , CRIS, Catalin , PATTE, Caroline
IPC分类号： A61B5/00 , G01N35/10 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/7275 , A61B5/7285 , G06F19/00 , G06F19/324 , G06F19/3456 , G16H50/20
摘要： The invention relates to an assessment method to process a signal corresponding to a glucose concentration by performing a retrospective analysis, whereas the assessment contains the steps of starting the assessment initiated by a first trigger, collecting data to be analysed, analysing the collected data initiated by a second trigger, and displaying the results of the analysis. The invention further relates to a device, which is designed and programmed to perform said assessment method, consisting of at least a measuring device (45) for collecting the data to be analysed, a computing device (52) for analysing the collected data, a storage device (50) for recording the collected data and the analysis, a display (47) for visualising the analysed data, and a communication link (51) for transmitting data between the measuring device and the computing/storage device and display, respectively. The user has the opportunity of choosing the time period the analysis is performed for. By employing a user triggered and retrospective analysis of data, collected in particular during or after a relevant event such as a meal, it is ensured that the analysis relates to a certain event-specific context and therefore enhances the usefulness of the assessment of a glucose concentration.
摘要翻译：本发明涉及通过进行回顾性分析来处理与葡萄糖浓度相对应的信号的评估方法，而评估包括开始由第一触发发起的评估的步骤，收集要分析的数据，分析由第二个触发器，并显示分析结果。本发明还涉及一种被设计和编程以执行所述评估方法的装置，至少包括用于收集待分析数据的测量装置（45），用于分析收集的数据的计算装置（52），用于记录所收集的数据和分析的存储装置（50），用于可视化分析数据的显示器（47）以及用于在测量装置和计算/存储装置之间传送数据和显示的通信链路（51）。用户有机会选择执行分析的时间段。通过采用用户触发和回顾性分析数据，特别是在相关事件（如餐）之前或之后收集的数据，确保分析与特定事件特定的上下文有关，因此增强了葡萄糖评估的有用性浓度。

4. 发明申请

WO2007131567A1 VERFAHREN UND VORRICHTUNG ZUM STIMULIEREN EINES GEWEBES FÜR DIE SUBKUTANE VERABREICHUNG VON WIRKSTOFFEN 审中-公开
标题翻译：方法和设备用于刺激组织代理商皮下注射
公开(公告)号：WO2007131567A1
公开(公告)日：2007-11-22
申请号：PCT/EP2007/002202
申请日：2007-03-13
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , SCHILTGES, Gilbert , KALT, Lucas , HAEBERLI, Michael
发明人： SCHILTGES, Gilbert , KALT, Lucas , HAEBERLI, Michael
IPC分类号： A61M5/158
CPC分类号： A61M5/158 , A61H23/02 , A61H23/0245 , A61H2201/0207 , A61H2201/0228 , A61H2201/10 , A61M5/14248 , A61M5/44 , A61M25/00 , A61M2005/1581 , A61M2025/0266 , A61M2205/058 , A61N1/0492 , A61N1/306 , A61N1/327 , A61N2005/0659
摘要： Die Erfindung betrifft ein Verfahren zum Stimulieren eines Gewebes zur Beschleunigung der Resorptionskinetik eines subkutan verabreichten Wirkstoffes, wobei um eine Einstichstelle einer Kanüle (5) herum eine Stimulation mittels Vibrationen und/oder Schwingungen und/oder Wärmestrahlungen und/oder Ultraschall und/oder chemischen Substanzen derart durchgeführt wird, dass die Durchblutung des Bereichs um die Einstichstelle erhöht wird und eine Vorrichtung (1) zum Durchführen des Verfahrens.
摘要翻译：本发明涉及一种用于刺激组织用于加速皮下施用药物的吸收动力学，其中，通过振动的装置和/或振动和/或热辐射和/或超声和/或化学物质例如插管（5）围绕一个刺激的穿刺部位被进行，使得该区域的血流增加穿刺部位和用于执行该方法的装置（1）。

5. 发明公开

EP2063935A1 VERFAHREN UND VORRICHTUNG ZUM STIMULIEREN EINES GEWEBES FÜR DIE SUBKUTANE VERABREICHUNG VON WIRKSTOFFEN 审中-公开
标题翻译：方法和设备用于刺激组织代理商皮下注射
公开(公告)号：EP2063935A1
公开(公告)日：2009-06-03
申请号：EP07723212.2
申请日：2007-03-13
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： SCHILTGES, Gilbert , KALT, Lucas , HAEBERLI, Michael
IPC分类号： A61M5/158
CPC分类号： A61M5/158 , A61H23/02 , A61H23/0245 , A61H2201/0207 , A61H2201/0228 , A61H2201/10 , A61M5/14248 , A61M5/44 , A61M25/00 , A61M2005/1581 , A61M2025/0266 , A61M2205/058 , A61N1/0492 , A61N1/306 , A61N1/327 , A61N2005/0659
摘要： The invention relates to a method for stimulating a tissue for accelerating the resorption kinetics of a subcutaneously administered active substance. Stimulation is performed about a piercing point of a cannula (5) by means of vibrations and/or oscillations and/or thermal radiation and/or ultrasounds and/or chemical substances such that the flow of blood of the area around the piercing point is increased. The invention also relates to a device (1) for carrying out said method.

6. 发明授权

EP2608819B1 ACOUSTIC WARNING LEVEL OPTIMIZATION IN AMBULATORY MEDICAL SYSTEMS 有权转让
标题翻译： VOLUME可听警告信号的门诊医疗系统优化
公开(公告)号：EP2608819B1
公开(公告)日：2014-07-16
申请号：EP11741578.6
申请日：2011-08-11
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： KALT, Lucas , REMDE, Axel
IPC分类号： A61M5/142 , G10K15/02
CPC分类号： A61M5/14244 , A61B5/14532 , A61M2205/186 , A61M2205/581 , A61M2205/70 , A61M2205/702 , G10K15/02 , H04R29/00

7. 发明公开

EP2608819A1 ACOUSTIC WARNING LEVEL OPTIMIZATION IN AMBULATORY MEDICAL SYSTEMS 有权转让
标题翻译： VOLUME可听警告信号的门诊医疗系统优化
公开(公告)号：EP2608819A1
公开(公告)日：2013-07-03
申请号：EP11741578.6
申请日：2011-08-11
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： KALT, Lucas , REMDE, Axel
IPC分类号： A61M5/142 , B06B1/02 , G08B3/10
CPC分类号： A61M5/14244 , A61B5/14532 , A61M2205/186 , A61M2205/581 , A61M2205/70 , A61M2205/702 , G10K15/02 , H04R29/00
摘要： An ambulatory medical device (10) comprises a function module (18) adapted to provide the intended functionality of the device, a controller module (24) adapted to control the device, and a sound generation module (11) with an acoustic transducer (16) adapted to produce an acoustic signal (56) and a signal generator (26) adapted to drive the acoustic transducer with a certain frequency, wherein the signal generation module (11) is arranged within a housing of the device. A tuning module (28, 30) is adapted to vary the frequency used by the signal generator to drive the acoustic transducer, and to determine one or more frequencies that correspond to an optimum sound level of the acoustic signal (56) outside of the housing of the device. The optimum sound level of the acoustic signal (56) is a maximum sound level outside of the housing of the device (10), and/or a maximum perceivable sound level as determined by a user (42).

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