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1. 发明申请

WO2008077546A1 ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗胰岛素样生长因子Ⅰ受体的抗体及其用途
公开(公告)号：WO2008077546A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011159
申请日：2007-12-19
申请人： F. HOFFMANN-LA ROCHE AG , KOLL, Hans , KUENKELE, Klaus-Peter , MOSER, Samuel , POEHLING, Sylke
发明人： KOLL, Hans , KUENKELE, Klaus-Peter , MOSER, Samuel , POEHLING, Sylke
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/71
摘要： An antibody binding to IGF-IR and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is between 20% and 50%, has improved properties in antitumor therapy.
摘要翻译：抗体结合IGF-1R并在Asn297上用糖链糖基化的抗体，所述抗体的特征在于所述糖链内岩藻糖的量在20％至50％之间，具有改善的抗肿瘤治疗性能。

2. 发明申请

WO2007068429A1 ANTIBODIES AGAINST AMYLOID BETA 4 WITH GLYCOSYLATED IN THE VARIABLE REGION 审中-公开
标题翻译：抗变态反应体系中抗糖蛋白β4
公开(公告)号：WO2007068429A1
公开(公告)日：2007-06-21
申请号：PCT/EP2006/011914
申请日：2006-12-11
申请人： F. HOFFMANN-LA ROCHE AG , LOETSCHER, Hansruedi , HUBER, Walter , SCHUHBAUER, Diana , WEYER, Karl , BROCKHAUS, Manfred , BOHRMANN, Bernd , KOLL, Hans , SCHAUBMAR, Andreas , LANG, Kurt
发明人： LOETSCHER, Hansruedi , HUBER, Walter , SCHUHBAUER, Diana , WEYER, Karl , BROCKHAUS, Manfred , BOHRMANN, Bernd , KOLL, Hans , SCHAUBMAR, Andreas , LANG, Kurt
IPC分类号： C07K16/18 , A61K39/395 , A61P25/28
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/18 , C07K2317/41 , C07K2317/56 , C07K2317/77
摘要： The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (V H ). More specifically, a pharmaceutical and a diagnostic composition comprising said antibody molecule and antibody mixtures are provided which is/are capable of specifically recognizing the β-A4 peptide/Aβ4. The present invention relates in particular to a mixture of antibodies comprising one or two glycosylated antigen binding sites with a glycosylated asparagine (Asn) in the variable region of the heavy chain, i.e. mixtures of isoforms of antibodies which comprise a glycosylated Asn in the variable region of the heavy chain (V H ). Also disclosed are compositions or antibody preparations comprising the specifically glycosylated antibody isoforms. Furthermore, the pharmaceutical and diagnostic uses for these antibodies are provided. The antibody isoforms may for example be used in the pharmaceutical intervention of amyloidogenesis or amyloid-plaque formation and/or in the diagnosis of the same.
摘要翻译：本发明涉及纯化抗体分子制剂，其特征在于至少一个抗原结合位点包含重链可变区（V H H H）中的糖基化天冬酰胺（Asn）。更具体地，提供了包含所述抗体分子和抗体混合物的药物和诊断组合物，其能够特异性识别β-A4肽/Aβ。本发明特别涉及包含一个或两个糖基化抗原结合位点与重链可变区中的糖基化天冬酰胺（Asn）的抗体的混合物，即包含可变区中的糖基化Asn的抗体同种型的混合物的重链（V H H）。还公开了包含特异性糖基化抗体同种型的组合物或抗体制剂。此外，提供了这些抗体的药物和诊断用途。抗体同种型可以例如用于淀粉样变形或淀粉样蛋白斑形成的药物干预和/或其诊断。

3. 发明申请

WO2009080278A1 STABILITY TESTING OF ANTIBODIES 审中-公开
标题翻译：抗体的稳定性测试
公开(公告)号：WO2009080278A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/010800
申请日：2008-12-18
申请人： F. HOFFMANN-LA ROCHE AG , GLYCART BIOTECHNOLOGY AG , ESER, Bianca , KOLL, Hans , REGULA, Joerg, Thomas , SONDERMANN, Peter
发明人： ESER, Bianca , KOLL, Hans , REGULA, Joerg, Thomas , SONDERMANN, Peter
IPC分类号： C07K16/06 , G01N33/68
CPC分类号： G01N33/6857 , C12Q1/34 , C12Q1/37 , G01N2333/96466
摘要： Antibodies are biological macromolecules which may be subject to modification and degradation processes. A new LC/MS-based method for separating and characterizing antibody-specific degradation products is described in the present application which comprises an enzymatic digestion step to cleave the heavy chain using the enzyme IdeS.
摘要翻译：抗体是可能经历修饰和降解过程的生物大分子。在本申请中描述了用于分离和表征抗体特异性降解产物的新的基于LC / MS的方法，其包括使用酶IdeS切割重链的酶消化步骤。

4. 发明申请

WO2011101370A1 METHOD FOR THE DETERMINATION OF SEQUENCE VARIANTS OF POLYPEPTIDES 审中-公开
标题翻译：用于确定多肽序列变异体的方法
公开(公告)号：WO2011101370A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052282
申请日：2011-02-16
申请人： F. HOFFMANN-LA ROCHE AG , KOLL, Hans , REGULA, Joerg Thomas , WIEGESHOFF, Frank , ZECK, Anne
发明人： KOLL, Hans , REGULA, Joerg Thomas , WIEGESHOFF, Frank , ZECK, Anne
IPC分类号： G01N33/68
CPC分类号： C12Q1/37 , G01N33/6848 , G01N2560/00
摘要： The current invention is directed to a method for determining amino acid sequence mutations in a produced polypeptide, comprising the following steps of a) providing a sample of a produced polypeptide, b) incubating the polypeptide in the sample with a protease, c) performing a two dimensional analysis using reversed phase chromatography coupled with a high resolution mass spectroscopy (FT-ICR / FT-orbitrap) and MS/MS analysis of the amino acid sequence fragments of the peptides, d) data evaluation by comparing the LC-MS data sets obtained for the samples side by side with the data set of a reference sample, by searching for differences in the signal intensities at given retention times and by evaluation of differential signals with respect to amino acid sequence mutations. The reference sample for data evaluation (d) can be either a well characterized standard or one of the samples to be analyzed.
摘要翻译：本发明涉及一种用于测定产生的多肽中的氨基酸序列突变的方法，包括以下步骤：a）提供产生的多肽的样品，b）将样品中的多肽与蛋白酶一起孵育，c）使用反相色谱与高分辨率质谱（FT-ICR / FT-orbitrap）相结合的二维分析和肽的氨基酸序列片段的MS / MS分析，d）通过比较LC-MS数据集进行数据评估通过在给定的保留时间上搜索信号强度的差异，并且通过评估关于氨基酸序列突变的差异信号，将样品与参考样品的数据集并排获得。用于数据评估的参考样本（d）可以是一个良好表征的标准或要分析的样品之一。

5. 发明公开

EP2102242A1 ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗体的胰岛素样生长因子受体及其用途
公开(公告)号：EP2102242A1
公开(公告)日：2009-09-23
申请号：EP07856882.1
申请日：2007-12-19
申请人： F. Hoffmann-La Roche AG
发明人： KOLL, Hans , KUENKELE, Klaus-Peter , MOSER, Samuel , POEHLING, Sylke
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/71
摘要： An antibody binding to IGF-IR and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is between 20% and 50%, has improved properties in antitumor therapy.

6. 发明申请

WO2010089126A2 IMMUNOGLOBULIN GLYCOSYLATION PATTERN ANALYSIS 审中-公开
标题翻译：免疫球蛋白糖蛋白模式分析
公开(公告)号：WO2010089126A2
公开(公告)日：2010-08-12
申请号：PCT/EP2010/000710
申请日：2010-02-05
申请人： ROCHE GLYCART AG , KOLL, Hans , REGULA, Joerg, Thomas , SONDERMANN, Peter , ZECK, Anne
发明人： KOLL, Hans , REGULA, Joerg, Thomas , SONDERMANN, Peter , ZECK, Anne
IPC分类号： G01N33/68 , C07K16/06 , C07K1/00 , C07K1/14 , C07K1/16 , C07K1/22
CPC分类号： G01N33/6854 , C07K1/20 , C07K1/34 , C07K16/00 , C07K2317/24 , C07K2317/41 , C07K2317/50 , G01N33/6848 , G01N2400/00
摘要： The current invention is directed to a method for the determination of the glycosylation pattern of a human immunoglobulin of the subclass IgG1 or IgG4 or of a murine immunoglobulin of the subclass IgG2a or IgG3 comprising the following steps: a) cleaving said immunoglobulin into fragments by enzymatic digestion with the enzyme IdeS, b) separating the fragments of said immunoglobulin obtained by the enzymatic digestion by reversed phase high performance liquid chromatography, c) subjecting the separated fragments of said immunoglobulin obtained in step b) to a mass spectrometric analysis, and d) determining the glycosylation pattern of said immunoglobulin from the mass spectrometric data obtained in step c).
摘要翻译：本发明涉及确定亚类IgG1或IgG4的人免疫球蛋白或亚类IgG2a或IgG3的鼠免疫球蛋白的糖基化模式的方法，包括以下步骤：a）通过酶促将所述免疫球蛋白切割成片段用酶IdeS消化，b）通过反相高效液相色谱法分离通过酶消化获得的所述免疫球蛋白的片段，c）将步骤b）中获得的所述免疫球蛋白分离的片段进行质谱分析，以及d）从步骤c）中获得的质谱数据确定所述免疫球蛋白的糖基化模式。

7. 发明申请

WO2011039150A1 A-FUCOSYLATION DETECTION IN ANTIBODIES 审中-公开
标题翻译：抗体中的A-FUCOSYLATION检测
公开(公告)号：WO2011039150A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064291
申请日：2010-09-28
申请人： ROCHE GLYCART AG , JAEGER, Christiane , KOLL, Hans , SONDERMANN, Peter , UMANA, Pablo
发明人： JAEGER, Christiane , KOLL, Hans , SONDERMANN, Peter , UMANA, Pablo
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K16/00 , C07K2317/41 , C07K2317/52 , C12Q1/37 , C12Q1/40 , C12Y302/01 , C12Y302/01096 , C12Y304/17002 , C12Y304/21007 , G01N33/5308 , G01N2333/924 , G01N2333/948 , G01N2333/968 , G01N2400/02 , G01N2440/38 , G01N2560/00
摘要： This invention describes a new analytical method to determine the quantity and distribution of fucose per Fc within an antibody preparation.
摘要翻译：本发明描述了一种测定抗体制剂中每个Fc岩藻糖的数量和分布的新的分析方法。

8. 发明申请

WO2004008099A2 METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES 审中-公开
标题翻译：用于鉴定用抗ErbB2抗体治疗反应的肿瘤的方法
公开(公告)号：WO2004008099A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021590
申请日：2003-07-11
申请人： GENETECH, INC. , KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： G01N
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
摘要翻译：通过检测HER2 / HER3和/或HER2 / HER1蛋白复合物的存在或肿瘤细胞样品中的HER2磷酸化，确定肿瘤对抗HER2抗体的治疗有反应。患有包含HER / 2 / HER1和/或HER2 / HER3异源二聚体和/或HER2磷酸化的肿瘤的患者用抗HER2抗体如rhuMAb 2C4处理。

9. 发明申请

WO2005113592A3 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 审中-公开
公开(公告)号：WO2005113592A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/017471
申请日：2005-05-18
申请人： MAXYGEN, INC. , F.HOFFMANN-LA ROCHE AG , PATTEN, Phillip, A. , VISWANATHAN, Sridhar , NISSEN, Torben, Lauesgaard , VOGT, Anne , KROPSHOFER, Harald , SCHUMACHER, Ralf , FISCHER, Stephan , SEEBER, Stefan , GROSSMANN, Adelbert , HESSE, Friederike, , SCHAUBMAR, Andreas , FALKENSTEIN, Roberto , KOLL, Hans , DEMBOWSKI, Markus
发明人： PATTEN, Phillip, A. , VISWANATHAN, Sridhar , NISSEN, Torben, Lauesgaard , VOGT, Anne , KROPSHOFER, Harald , SCHUMACHER, Ralf , FISCHER, Stephan , SEEBER, Stefan , GROSSMANN, Adelbert , HESSE, Friederike, , SCHAUBMAR, Andreas , FALKENSTEIN, Roberto , KOLL, Hans , DEMBOWSKI, Markus
IPC分类号： C07K14/56 , C12Q1/68 , C07H21/04 , C07K14/555 , C12P21/02 , A61K38/21
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

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