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1. 发明申请

WO2015101586A1 BISPECIFIC ANTI-HAPTEN/ANTI-BLOOD BRAIN BARRIER RECEPTOR ANTIBODIES, COMPLEXES THEREOF AND THEIR USE AS BLOOD BRAIN BARRIER SHUTTLES 审中-公开
标题翻译：双相抗血/抗血清脑阻滞剂受体抗体，其复合物及其作为血脑屏障的SHUTTLES
公开(公告)号：WO2015101586A1
公开(公告)日：2015-07-09
申请号：PCT/EP2014/079351
申请日：2014-12-29
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BRINKMANN, Ulrich , GEORGES, Guy , MUNDIGL, Olaf , NIEWOEHNER, Jens
IPC分类号： C07K16/46 , A61K39/395 , A61K47/48
CPC分类号： A61K47/48676 , A61K47/546 , A61K47/557 , A61K47/60 , A61K47/64 , A61K47/6879 , C07K16/16 , C07K16/26 , C07K16/2881 , C07K16/40 , C07K16/44 , C07K16/468 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92 , C07K2317/94
摘要： Herein is reported a bispecific antibody comprising a first binding specificity that specifically binds to a haptenylated payload and a second binding specificity that specifically binds to a blood brain barrier receptor.
摘要翻译：本文报道了包含特异性结合半抗原载体的第一结合特异性和特异性结合血脑屏障受体的第二结合特异性的双特异性抗体。

2. 发明申请

WO2015091144A1 IMPROVED RECOMBINANT POLYPEPTIDE PRODUCTION METHODS 审中-公开
标题翻译：改进的重组多肽生产方法
公开(公告)号：WO2015091144A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/077196
申请日：2014-12-10
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： KOPETZKI, Erhard , NIEWOEHNER, Jens , MAIER, Peter
IPC分类号： C12P21/00 , C12P21/02
CPC分类号： C12P21/005 , C07K5/1019 , C07K14/475 , C07K14/48 , C07K16/2863 , C07K16/2881 , C07K2317/14 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2319/00 , C07K2319/50 , C07K2319/60 , C12P21/02
摘要： Herein is reported a method for producing a fusion-polypeptide comprising the steps of a) cultivating a mammalian cell comprising a nucleic acid encoding a variant fusion-polypeptide wherein the amino acid sequence of the fusion-polypeptide has been modified by replacing in a pro-fusion-polypeptide the endogenous protease cleavage site between the pro-peptide and the fusion-polypeptide with an exogenous (with respect to the origins of the parts of the fusion-polypeptide) or artificial protease cleavage site, and b) recovering the fusion-polypeptide or fusion-pro-polypeptide from the cell or the cultivation medium and thereby producing the (recombinant) fusion-polypeptide.
摘要翻译：本文报道了一种产生融合多肽的方法，包括以下步骤：a）培养包含编码变体融合多肽的核酸的哺乳动物细胞，其中融合多肽的氨基酸序列已被修饰，使用外源（相对于融合多肽的部分的起源）或人造蛋白酶切割位点融合多肽前体肽和融合多肽之间的内源性蛋白酶切割位点，以及b）回收融合多肽或来自细胞或培养基的融合原多肽，从而产生（重组）融合多肽。

3. 发明申请

WO2015101588A1 MONOVALENT BLOOD BRAIN BARRIER SHUTTLE MODULES 审中-公开
标题翻译：单体血液脑屏障模块
公开(公告)号：WO2015101588A1
公开(公告)日：2015-07-09
申请号：PCT/EP2014/079353
申请日：2014-12-29
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： RUEGER, Petra , TIEFENTHALER, Georg , MOESSNER, Ekkehard , NIEWOEHNER, Jens , HUGENMATTER, Adrian , SHAO, Cuiying , ROS, Francesca , XU, Gang
IPC分类号： C07K16/18 , C07K16/28
CPC分类号： C07K16/2881 , A61K2039/505 , C07K16/18 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2319/33
摘要： Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03).
摘要翻译：本文报道了包含脑效应器实体，接头和结合血脑屏障受体的一个单价结合实体的血脑屏障穿梭模块，其中所述接头将效应实体与结合血脑屏障的单价结合实体相连受体，其中所述单价结合实体不包含抗转铁蛋白受体抗体8D3（SEQ ID NO：01和SEQ ID NO：02）或变体抗转铁蛋白受体抗体8D3v（SEQ ID NO：01和 SEQ ID NO：03）。

4. 发明申请

WO2015014884A1 THERAPEUTIC FUSION PROTEIN 审中-公开
标题翻译：治疗融合蛋白
公开(公告)号：WO2015014884A1
公开(公告)日：2015-02-05
申请号：PCT/EP2014/066355
申请日：2014-07-30
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BOHRMANN, Bernd , FRESKGARD, Per-Ola , KNOETGEN, Hendrik , NIEWOEHNER, Jens
IPC分类号： A61P25/28 , C07K9/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K14/47
CPC分类号： C07K16/2881 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/31 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/60 , C07K2319/00 , C07K2319/50 , C07K2319/74 , C12N9/6494 , C12Y304/24011
摘要： The invention relates to a fusion protein comprising an antibody directed to Aβ, a monovalent binding entity which binds to a blood brain barrier receptor and a neprilysin.
摘要翻译：本发明涉及包含针对A＆bgr的抗体的融合蛋白，与血脑屏障受体结合的单价结合实体和尿丙氨酸。

5. 发明申请

WO2016207240A1 ANTI-TRANSFERRIN RECEPTOR ANTIBODIES WITH TAILORED AFFINITY 审中-公开
标题翻译：抗转铁蛋白受体抗体与定制的亲和力
公开(公告)号：WO2016207240A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064460
申请日：2016-06-22
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： DENGL, Stefan , GEORGES, Guy , GOEPFERT, Ulrich , NIEWOEHNER, Jens , SCHLOTHAUER, Tilman
IPC分类号： C07K16/28
CPC分类号： C07K16/2881 , C07K2317/24 , C07K2317/33
摘要： Herein is reported an anti-transferrin receptor antibody that specifically binds to human transferrin receptor and cynomolgus transferrin receptor, which comprises i) a humanized heavy chain variable domain derived from the heavy chain variable domain of SEQ ID NO: 01, and ii) a humanized light chain variable domain derived from the light chain variable domain of SEQ ID NO: 26, wherein the antibody has an off-rate for the human transferrin receptor that is equal to or less than (i.e. at most) the off-rate of the anti-transferrin receptor antibody 128.1 for the cynomolgus transferrin receptor, whereby the off-rates are determined by surface plasmon resonance, and whereby the anti-transferrin receptor antibody 128.1 has a heavy chain variable domain of SEQ ID NO: 64 and a light chain variable domain of SEQ ID NO: 65.
摘要翻译：本文报道了特异性结合人转铁蛋白受体和食蟹猴转铁蛋白受体的抗转铁蛋白受体抗体，其包含i）源自SEQ ID NO：01的重链可变结构域的人源化重链可变结构域，和ii）人源化衍生自SEQ ID NO：26的轻链可变结构域的轻链可变结构域，其中所述抗体对于人转铁蛋白受体的脱离率等于或小于（即，最多）所述抗体的脱离率 - 转铁蛋白受体抗体128.1用于食蟹猴转铁蛋白受体，由此通过表面等离振子共振确定脱离速率，由此抗转铁蛋白受体抗体128.1具有SEQ ID NO：64的重链可变结构域和轻链可变结构域的SEQ ID NO：65。

6. 发明申请

WO2014033074A1 BLOOD BRAIN BARRIER SHUTTLE 审中-公开
标题翻译：血脑屏障
公开(公告)号：WO2014033074A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067595
申请日：2013-08-26
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BOHRMANN, Bernd , FRESKGARD, Per-Ola , MAIER, Peter , NIEWOEHNER, Jens , TISSOT-DAGUETTE, Alain , URICH, Eduard
IPC分类号： C07K16/28 , C07K16/18 , C07K16/46 , A61K39/395 , A61P25/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K16/2881 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/64 , C07K2317/732 , C07K2317/76 , C07K2319/33
摘要： The present disclosure relates to blood brain barrier shuttles that bind receptors on the blood brain barrier (R/BBB) and methods of using the same.
摘要翻译：本公开涉及结合血脑屏障（R / BBB）上的受体的血脑屏障穿梭及其使用方法。

7. 发明申请

WO2020260326A1 NOVEL ICOS ANTIBODIES AND TUMOR-TARGETED ANTIGEN BINDING MOLECULES COMPRISING THEM 审中-公开
公开(公告)号：WO2020260326A1
公开(公告)日：2020-12-30
申请号：PCT/EP2020/067572
申请日：2020-06-24
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： DENGL, Stefan , FAUTI, Tanja , FISCHER, Jens , HABEGGER, Lucas , KLEIN, Christian , KOENIGSBERGER, Esther , NIEWOEHNER, Jens , SAM, Johannes , UMAÑA, Pablo , ZIELONKA, Joerg
IPC分类号： C07K16/28 , C07K16/30 , C07K16/40 , C12N9/64 , A61P35/00 , A61K39/00
摘要： The present invention relates to novel ICOS antibodies and tumor-targeted agonistic ICOS antigen binding molecules comprising them, pharmaceutical compositions comprising these molecules, and methods of using the same.

8. 发明申请

WO2018210898A1 REDUCTION OF APPLICATION-RELATED SIDE REACTION OF A THERAPEUTIC ANTIBODY 审中-公开
公开(公告)号：WO2018210898A1
公开(公告)日：2018-11-22
申请号：PCT/EP2018/062649
申请日：2018-05-16
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FISCHER, Jens , FRESKGARD, Per-Ola , IGLESIAS, Antonio , NIEWOEHNER, Jens , WEBER, Felix
IPC分类号： C07K16/18 , C07K16/28
摘要： Herein is reported an anti-brain target therapeutic agent, which is an anti-brain target/human transferrin receptor (1) antibody, wherein the anti-brain target/human transferrin receptor (1) antibody has two binding sites (VH/VL pairs) that specifically bind to the brain target, one binding site (VH/VL pair) that specifically binds to the human transferrin receptor (1) and an effector function competent (native) Fc-region, for use in anti-brain target treatment in an individual with reduced undesired body-temperature drop after intravenous application.

9. 发明申请

WO2018184966A1 ANTIBODIES BINDING TO STEAP-1 审中-公开
公开(公告)号：WO2018184966A1
公开(公告)日：2018-10-11
申请号：PCT/EP2018/058043
申请日：2018-03-29
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： HOFER, Thomas , KOENIG, Maximiliane , MOESSNER, Ekkehard , NIEWOEHNER, Jens , WEINZIERL, Tina , LARIVIERE, Laurent
IPC分类号： C07K16/30 , A61K47/68 , A61K39/00
摘要： The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

10. 发明申请

WO2016207245A1 HUMANIZED ANTI-TAU(PS422) ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：人类抗原（PS422）抗体和使用方法
公开(公告)号：WO2016207245A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064465
申请日：2016-06-22
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： EMRICH, Thomas , GRUENINGER, Fiona , HUGENMATTER, Adrian , MOESSNER, Ekkehard , DENGL, Stefan , GEORGES, Guy , GOEPFERT, Ulrich , JOCHNER, Anton , KETTENBERGER, Hubert , MOELLEKEN, Joerg , MUNDIGL, Olaf , NIEWOEHNER, Jens , SCHLOTHAUER, Tilman , MOLHOJ, Michael , BRADY, Kevin
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/92
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
摘要翻译：本发明提供人源化抗人Tau（pS422）抗体及其使用方法。

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