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1. 发明申请

WO2007107346A1 SUBSTITUTED INDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：取代的吲哚衍生物，其制造和用作药物代理
公开(公告)号：WO2007107346A1
公开(公告)日：2007-09-27
申请号：PCT/EP2007/002487
申请日：2007-03-21
申请人： F. HOFFMANN-LA ROCHE AG , GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
发明人： GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途，提及的化合物在控制或预防诸如癌症的疾病中。

2. 发明申请

WO2007068465A1 TRICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：三聚赖氨酸衍生物，其制造和用作药物代理
公开(公告)号：WO2007068465A1
公开(公告)日：2007-06-21
申请号：PCT/EP2006/011998
申请日：2006-12-13
申请人： F. HOFFMANN-LA ROCHE AG , GEORGES, Guy , GOLLER, Bernhard , KRELL, Hans-Willi , LIMBERG, Anja , REIFF, Ulrike , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
发明人： GEORGES, Guy , GOLLER, Bernhard , KRELL, Hans-Willi , LIMBERG, Anja , REIFF, Ulrike , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
IPC分类号： C07D487/04 , A61K31/4164 , A61P35/00
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）的化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述用途所述化合物可用于控制或预防诸如癌症等疾病。

3. 发明公开

EP2001882A1 SUBSTITUTED INDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：吲唑取代，生产与应用，药物活性成分
公开(公告)号：EP2001882A1
公开(公告)日：2008-12-17
申请号：EP07723447.4
申请日：2007-03-21
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

4. 发明申请

WO2005121177A2 ANTI-IL-13 ANTIBODIES AND COMPLEXES 审中-公开
标题翻译：抗IL-13抗体和复合物
公开(公告)号：WO2005121177A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/020334
申请日：2005-06-09
申请人： WYETH , LIN, Laura, Long , PARRIS, Kevin, D. , TAM, Amy, Sze, Pui , TAN, Xiang-Yang , SHANE, Tania , DUMAS, John , WILHELM, James, M. , STAHL, Mark , MOSYAK, Lidia , HU, Zhixiang
发明人： LIN, Laura, Long , PARRIS, Kevin, D. , TAM, Amy, Sze, Pui , TAN, Xiang-Yang , SHANE, Tania , DUMAS, John , WILHELM, James, M. , STAHL, Mark , MOSYAK, Lidia , HU, Zhixiang
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.
摘要翻译：抗IL-13抗体，抗IL-13抗体的结晶，IL-13多肽/抗IL-13抗体复合物，IL-13多肽/抗IL-13抗体复合物的结晶，IL-13Rα1多肽/ IL -13多肽/抗IL-13抗体复合物，IL-13Rα1多肽/ IL-13多肽/抗IL-13抗体复合物的晶体，以及相关方法和软件系统。

5. 发明申请

WO2006078733A2 ESTROGEN RECEPTOR STRUCTURE 审中-公开
标题翻译：雌激素受体结构
公开(公告)号：WO2006078733A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001761
申请日：2006-01-18
申请人： WYETH , MOSYAK, Lidia , XU, Zhang Bao , STAHL, Mark , HUM, Wah-tung , SOMERS, William Stuart , MANAS, Eric Steven
发明人： MOSYAK, Lidia , XU, Zhang Bao , STAHL, Mark , HUM, Wah-tung , SOMERS, William Stuart , MANAS, Eric Steven
IPC分类号： C07K14/72 , C30B29/58 , G01N33/68 , G06F19/00
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译：公开了雌激素受体配体，雌激素受体多肽/配体复合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。

6. 发明申请

WO2007092370A2 STRUCTURE LINGO-1 审中-公开
标题翻译：结构LINGO-1
公开(公告)号：WO2007092370A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003015
申请日：2007-02-01
申请人： WYETH , MOSYAK, Lidia , DWYER, Brian , JOHNSON, Mark , ZHONG, Xiaotian , PRESMAN, Eleonora , WILHELM, James M. , STAHL, Mark , SOMERS, William Stuart
发明人： MOSYAK, Lidia , DWYER, Brian , JOHNSON, Mark , ZHONG, Xiaotian , PRESMAN, Eleonora , WILHELM, James M. , STAHL, Mark , SOMERS, William Stuart
CPC分类号： C07K14/4703 , C07K14/705 , C07K2299/00
摘要： Cette invention concerne des polypeptides LINGO-1, des complexes polypeptide/ligand LINGO-1, des cristaux de polypeptides LINGO-1, des cristaux de complexes polypeptide/ligand LINGO-1, ainsi que des méthodes associées et des systèmes logiciels.
摘要翻译： Cette发明协调多肽LINGO-1，des复合物多肽/配体LINGO-1，des cristaux de多肽LINGO-1，des cristaux de complexes多肽/配体LINGO-1，ainsi que desméthodesassociéeset dessystèmeslogiciels。

7. 发明申请

WO2005097983A2 STRUCTURE OF PROTEIN KINASE C THETA RELATED APPLICATIONS 审中-公开
标题翻译：蛋白激酶C结构相关应用
公开(公告)号：WO2005097983A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/011656
申请日：2005-04-06
申请人： WYETH , MALAKIAN, Karl , XU, Zhang, Bao , OLLAND, Stephane , WOLFROM, Scott , LIN, Laura , STAHL, Mark , LEE, Julie , FITZ, Lori , GRECO, Rita , CHAUDHARY, Divya , SOMERS, William, Stuart , MOSYAK, Lidia
发明人： XU, Zhang, Bao , OLLAND, Stephane , WOLFROM, Scott , LIN, Laura , STAHL, Mark , LEE, Julie , FITZ, Lori , GRECO, Rita , CHAUDHARY, Divya , SOMERS, William, Stuart , MOSYAK, Lidia
IPC分类号： C12N9/00
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PACθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译：蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PACTA相互作用的药剂的方法。该药物可以是PKCθ活性的抑制剂。

8. 发明申请

WO2011084619A2 ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS 审中-公开
标题翻译：消灭农民动物种群中的致病性感染
公开(公告)号：WO2011084619A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060813
申请日：2010-12-16
申请人： STAHL, Mark , STAHL, John , STAHL, Richard
发明人： STAHL, Mark , STAHL, John , STAHL, Richard
IPC分类号： C12Q1/70
CPC分类号： C12Q1/702 , C12N7/00 , C12N2750/14311 , C12N2750/14321 , C12Q2600/166
摘要： Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed.
摘要翻译：畜牧业一直容易受到致病性感染的破坏。家禽流感和牛只疾病只是两个例子，它们对动物有可怕的后果，并对农民的经济命运产生不利影响。提出了一种检测和扑杀方法，可以消除感染猪群的病原体。利用PCR检测感染病原体的极低水平的核酸的灵敏度来鉴定受感染的动物。另外，已经发现对粪便样品进行PCR分析可以准确地鉴定那些出生后食用胎盘残留的物种的感染动物和后代。水貂阿留申病病毒（mADV）是几种致命的DNA细小病毒之一，可以迅速在貂群中达到流行病比例。已经开发了PCR引物，其产生扩增子来检测和鉴定mADV。此外，还发现了一种以前未经鉴定的mADV菌株，基因组测序和基本详细的。

9. 发明申请

WO2006113861A3 MAMMALIAN EXPRESSION SYSTEMS 审中-公开
公开(公告)号：WO2006113861A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014859
申请日：2006-04-20
申请人： WYETH , ZHONG, Xiaotian , KRIZ, Ronald , STAHL, Mark
发明人： ZHONG, Xiaotian , KRIZ, Ronald , STAHL, Mark
IPC分类号： C12N5/06 , C07K14/71 , C08B37/10
摘要： The present invention features mammalian expression systems with improved production yields, and method of using these systems to produce desired proteins. In one embodiment, the expression systems of the present invention comprise genetically-engineered mammalian host cells cultured in a medium that contains an effective amount of heparin or heparin-like molecules. The presence of heparin or heparin-like molecules significantly increases protein production by the cultured cells. The present invention also features the use of constitutively-active components of FGFR-I -mediated signal transduction pathways to improve protein production by cultured mammalian cells. Co-expression of such a component with a protein of interest markedly increases the production yield of the protein of interest.

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