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1. 发明专利

JP2008035859A Instrument for heating and cooling 审中-公开
标题翻译：加热和冷却仪器
公开(公告)号：JP2008035859A
公开(公告)日：2008-02-21
申请号：JP2007181916
申请日：2007-07-11
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： SAROFIM EMAD , GORAN SAVATIC
IPC分类号： C12M1/00 , C12N15/09 , H05B3/00
CPC分类号： B01L7/52 , B01L7/00 , B01L2300/1827 , B01L2300/1883 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide an instrument and method for conveniently performing rapid amplification of nucleic acids. SOLUTION: The instrument 1 for the heating and cooling of an object by a controlled method contains a substantially flat temperature sensor element 4, a substantially flat and hard heat-conductive substrate 5, a substantially flat resistance heater, a substantially flat insulation layer and a cooling element 9. The method for the amplification of nucleic acids contains the heating and cooling of the instrument in an apparatus, the supply of a mixture of a liquid containing nucleic acids to the instrument in the apparatus and the temperature cycling treatment of the mixture. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供方便地进行核酸快速扩增的仪器和方法。解决方案：用于通过受控方法加热和冷却物体的仪器1包含基本上平坦的温度传感器元件4，基本平坦且硬的导热基底5，基本上平坦的电阻加热器，基本平坦的绝缘层和冷却元件9.用于扩增核酸的方法包括在装置中加热和冷却仪器，将含有核酸的液体的混合物供应到装置中的仪器和温度循环处理混合物。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2005118041A Method for isolating nucleic acid 有权
标题翻译：分离核酸的方法
公开(公告)号：JP2005118041A
公开(公告)日：2005-05-12
申请号：JP2004294245
申请日：2004-10-06
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： BERGMANN FRANK , KIRCHGESSER MICHAEL , WALTER THOMAS , WEINDEL KURT DR , ZIELENSKI RALF , SAROFIM EMAD
IPC分类号： C12N15/09 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1006 , C12N15/1003 , C12N15/1013
摘要： PROBLEM TO BE SOLVED: To provide a method for purifying a nucleic acid, by substituting a substance which is used in an aqueous adsorption solution for accelerating bonding of the nucleic acid to a substrate, such as an inorganic support material, with another substance. SOLUTION: This method for purifying the nucleic acid includes processes (a) to (d) and, optionally, a process (e) as follows: a process (a) for making the nucleic acid which is derived from a composition containing (i) an aqueous buffer solution, (ii) a salt of a high concentration, (iii) a water-miscible non-acidic organic compound having a functional group expressed by formula I (W is C or S; and Z is O or N), and (iv) the nucleic acid adsorbed on the substrate; (b) a process for, optionally, washing the substrate containing the adsorbed nucleic acid by a washing solution; (c) a process for making the nucleic acid desorbed from the substrate, by contacting the substrate containing the adsorbed nucleic acid with a solution containing the salt of which the concentration is lower when compared with the composition in the process (a); (d) a process for purifying the nucleic acid, by separating a solution containing the desorbed nucleic acid from the substrate; and (e) a process for further purifying the nucleic acid, by precipitating the desorbed nucleic acid from the solution of the process (d) and then isolating the precipitated nucleic acid. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种纯化核酸的方法，通过用在水性吸附溶液中使用的物质代替加速将核酸粘合到诸如无机载体材料的基材上，与另一种物质。解决方案：用于纯化核酸的方法包括以下方法（a）至（d）和任选方法（e）：（a）制备从含有（i）缓冲水溶液，（ii）高浓度的盐，（iii）具有由式I表示的官能团的水可混溶的非酸性有机化合物（W是C或S; Z是O或 N），和（iv）吸附在基质上的核酸; （b）任选地通过洗涤溶液洗涤含有吸附核酸的底物的方法; （c）当与方法（a）中的组合物相比时，通过使含有吸附的核酸的底物与含有浓度较低的盐的溶液接触，使核酸脱离底物的方法; （d）通过从底物中分离含有解吸的核酸的溶液来纯化核酸的方法; 和（e）通过从方法（d）的溶液沉淀解吸的核酸，然后分离沉淀的核酸，进一步纯化核酸的方法。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2006038842A Liquid reservoir connector 审中-公开
标题翻译：液体储存连接器
公开(公告)号：JP2006038842A
公开(公告)日：2006-02-09
申请号：JP2005194176
申请日：2005-07-01
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： CURCIO MARIO , SAROFIM EMAD
IPC分类号： B01L99/00 , G01N35/10 , B01L3/00 , G01N1/00 , G01N35/02
CPC分类号： B01L3/563 , B01L3/502715 , B01L2200/027 , B01L2200/16 , B01L2300/0838
摘要： PROBLEM TO BE SOLVED: To provide a simple capillary-like conduit device for interconnecting a liquid reservoir to a testing element. SOLUTION: The device (7) for interconnecting at least one liquid reservoir (3) such as a storage chamber, a liquid transport channel or a liquid transport tube to a region (9) on the test element to be supplied with liquid and/or to be brought into contact with the liquid, comprises a pre-shaped, capillary-like tube or conduit which is at least along a section that is at least nearly rigid. According to one possible design the capillary-like tube or conduit can be U-shaped, with the two ends of the capillary-like tube or conduit being at least nearly rigid. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于将液体储存器与测试元件相互连接的简单的毛细管状导管装置。解决方案：用于将诸如储存室，液体输送通道或液体输送管的至少一个液体储存器（3）互连到测试元件上的区域（9）的装置（7），以供应液体和/或与液体接触，包括至少沿着至少几乎刚性的部分的预成形的毛细管状管或导管。根据一种可能的设计，毛细管状管或导管可以是U形的，毛细管样管或导管的两端至少几乎是刚性的。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2008017843A Instrument for heating and cooling 审中-公开
标题翻译：加热和冷却仪器
公开(公告)号：JP2008017843A
公开(公告)日：2008-01-31
申请号：JP2007180812
申请日：2007-07-10
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： SAROFIM EMAD , GORAN SAVATIC
IPC分类号： C12M1/00 , C07H21/04 , C12N15/09
CPC分类号： B01L9/527 , B01J2219/00873 , B01L3/5027 , B01L7/52 , B01L2300/0816 , B01L2300/1827 , B01L2300/1838 , B01L2300/185 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide an instrument and method that conveniently allows rapid amplification of a nucleic acid. SOLUTION: The instrument for heating and cooling subject in a controlled manner comprises layers piled in the following order from top to bottom, at least one substantially flat temperature sensor element 1, a heat conducting substrate 2, and a heater layer 3, whereby the heat conducting substrate 2 comprises one or more channels permeable for fluid. The method for conducting a thermal profile, and the method for amplifying the nucleic acid, and a system for heating liquid and a system for measuring nucleic acids are also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供方便地允许快速扩增核酸的仪器和方法。解决方案：以受控方式加热和冷却受试者的仪器包括从上到下按顺序堆叠的层，至少一个基本上平坦的温度传感器元件1，导热基底2和加热器层3，由此导热基底2包括一个或多个可渗透流体的通道。还提供了用于进行热分布的方法和用于扩增核酸的方法，以及用于加热液体的系统和用于测量核酸的系统。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2008017842A Temperature sensor element for monitoring heating and cooling 审中-公开
标题翻译：温度传感器元件用于监测加热和冷却
公开(公告)号：JP2008017842A
公开(公告)日：2008-01-31
申请号：JP2007180676
申请日：2007-07-10
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： SAROFIM EMAD , GORAN SAVATIC
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/1827 , B01L2300/1844 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide a system for heating and cooling a mixture, a device for heating a cartridge, a method for conducting a thermal profile, and a method for amplifying a nucleic acid. SOLUTION: The system heats and cools the mixture in a controlled manner by sensing the temperature of the mixture in the cartridge 1 with at least one sensor element 15. A device for heating the cartridge comprises a chamber. The method executes the thermal profile in the device, and the method amplifies nucleic acids by using the system. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于加热和冷却混合物的系统，用于加热筒的装置，用于进行热分布的方法以及用于扩增核酸的方法。解决方案：系统通过用至少一个传感器元件15感测盒1中的混合物的温度，以受控的方式加热和冷却混合物。用于加热盒的装置包括室。该方法执行器件中的热分布，该方法通过使用该系统来扩增核酸。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2006082079A Method and apparatus for adjusting fluid temperature, and micro fabrication system 有权
标题翻译：用于调节流体温度的方法和装置以及微型制造系统
公开(公告)号：JP2006082079A
公开(公告)日：2006-03-30
申请号：JP2005270326
申请日：2005-09-16
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： KOPP MARTIN , SAROFIM EMAD
IPC分类号： B01J19/00
CPC分类号： G05D23/19 , B01L7/52 , B01L2300/1822 , B01L2300/1833
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for adjusting the fluid temperature in a container, and a micro fabrication system whereby a higher heat transfer rate is realized than a prior art method based on a PCR technique.
SOLUTION: The method comprises a step of installing a heat sink 4 effective for a fluid 8, a heating step wherein the fluid is heated by joule heating, and a control step wherein the heat supplied by joule heating is controlled so as to cause the fluid to reach an intended temperature. The apparatus in which the heat sink 4 effective to the fluid in container 1 can be installed, comprises container 1 which receives the fluid 8, a heating element which heats the fluid, and power source unit 3 which supplies energy to the heating element, with the heating element being equipped with an electrode for generating electric current in the fluid. Further, a micro fabrication system equipped with the apparatus is disclosed.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于调节容器中的流体温度的方法和装置，以及实现比基于PCR技术的现有技术方法更高的传热速率的微制造系统。解决方案：该方法包括安装对流体8有效的散热器4的步骤，其中通过焦耳加热来加热流体的加热步骤，以及控制步骤，其中通过焦耳加热供应的热量被控制为使流体达到预期的温度。可以安装对散装容器1中的流体有效的散热器4的装置，包括容纳流体8的容器1，加热流体的加热元件和向加热元件供应能量的电源单元3，加热元件配备有用于在流体中产生电流的电极。此外，公开了配备有该装置的微型制造系统。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2008020457A Device equipped with insert for analysis system 审中-公开
标题翻译：装备有分析系统插件
公开(公告)号：JP2008020457A
公开(公告)日：2008-01-31
申请号：JP2007182949
申请日：2007-07-12
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： SAROFIM EMAD , WAHL HANS-PETER
IPC分类号： G01N35/10
CPC分类号： B01L3/502715 , B01L3/5025 , B01L2400/0622 , B01L2400/0633
摘要： PROBLEM TO BE SOLVED: To provide a device permitting simple fluid flow, without carrying various reagents over final mixture for measuring during sample regulating stage. SOLUTION: In the analytical device possessing a main body equipped with a fluidic unit including a first chamber with a delivery aperture and a first channel exiting through the delivery aperture, the first chamber containing also an insert equipped with recesses between each limb contacting wall section of the first chamber concerned and a second channel, while the insert is prepared at a first position where the insert concerned is not engaged from the delivery aperture, is movable from the aforementioned first position to a second position in the first chamber, where the insert is engaged to the delivery aperture so as to extend the first channel into interior of the first chamber by the second channel, and has the same shape as the first chamber at a part pointing to the delivery aperture. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供允许简单流体流动的装置，而不在最终混合物中携带各种试剂以在样品调节阶段进行测量。解决方案：在具有配备有流体单元的主体的分析装置中，流体单元包括具有输送孔的第一室和通过输送孔离开的第一通道，第一室还包含在每个肢体接触之间的凹槽所述第一腔室和所述第二通道的壁部分，并且所述插入件准备在所述插入件未与所述输送孔接合的第一位置处，可从所述第一位置移动到所述第一腔室中的第二位置，其中插入件接合到输送孔，以便通过第二通道将第一通道延伸到第一室的内部，并且在指向输送孔的部分处具有与第一室相同的形状。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2006292742A Device having self-sealing fluid port 审中-公开
标题翻译：具有自密封流体端口的装置
公开(公告)号：JP2006292742A
公开(公告)日：2006-10-26
申请号：JP2006088223
申请日：2006-03-28
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： ELSENHANS OLIVIER , SAROFIM EMAD , SAVATIC GORAN
IPC分类号： G01N35/08 , B01J19/00 , B81B1/00 , B81C99/00 , G01N37/00
CPC分类号： B29C45/1676 , B01L3/502707 , B01L3/502715 , B01L3/50825 , B01L7/52 , B01L2200/027 , B01L2200/12 , B01L2300/042 , B01L2300/044 , B01L2300/0816 , B01L2300/0887 , B29C65/02 , B29C65/08 , B29C65/16 , B29C65/1606 , B29C65/1616 , B29C65/1619 , B29C65/48 , B29C65/58 , B29C66/53461 , B29K2021/003 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , G01N35/1079 , B29C66/71
摘要： PROBLEM TO BE SOLVED: To provide a device which can be manufactured economically and has a liquid port that is easy to handle and is high in reliability, and also to provide its manufacturing method.
SOLUTION: The device has a body and is provided with a cavity and fluid ports formed of heat plastic elastomer fixedly adhering to the body. The device can be used effectively automatically for analysis having high reliability.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：提供一种能够经济地制造并且具有易于处理和高可靠性的液体口的装置，并且还提供其制造方法。解决方案：该装置具有主体并且设置有由固定地粘附到主体上的热塑性弹性体形成的空腔和流体端口。该设备可以自动有效地用于具有高可靠性的分析。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2010115647A Method and device for separating component bound to magnetic particle by applying centrifugal force 有权
标题翻译：通过应用离心力分离与磁性颗粒接触的组分的方法和装置
公开(公告)号：JP2010115647A
公开(公告)日：2010-05-27
申请号：JP2009256430
申请日：2009-11-09
申请人： F Hoffmann-La Roche Ag , エフホフマン−ラロッシュアクチェンゲゼルシャフト
发明人： HEIN HEINZ-MICHAEL , SAROFIM EMAD , SCHENK LOTAR , WAHL HANS-PETER
IPC分类号： B03C1/30 , B04B5/10
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , Y10T436/111666
摘要： PROBLEM TO BE SOLVED: To provide a method for separating a component of interest bound to magnetic particles from a solution. SOLUTION: The method includes the following steps: providing a container device having one or more flat chamber(s) each composed of an angular bottom ascending to the outer part 25 of the compartment and means for trapping fluids 10, the means being positioned inside the outer part of the compartment of the container 11 and a magnet 12 for capturing the magnetic particles 21 and the component of interest bound to the magnetic particles; disposing the solution including the component of interest in the interior volume of the chamber(s), while the container is rotating around an axis 19 located outside the inner part of the container and adjacent to the magnet; adding to the solution the magnetic particles coated with a reaction component that binds the component of interest; mixing the solution with the magnetic particles to produce a mixture composed of magnetic particles and a supernatant liquid; and separating the magnetic particles and the liquid by rotating the container, wherein the liquid is trapped by centrifugal forces into the trapping means and a magnetic field is applied such that magnetic particles bind to the inner side of the inner part of the interior volume. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种从溶液中分离与磁性颗粒结合的感兴趣成分的方法。解决方案：该方法包括以下步骤：提供一种具有一个或多个平坦室的容器装置，每个平坦室由沿着隔室的外部部分25上升的角度底部构成，并且用于捕获流体10的装置位于容器11的隔室的外部部分的内部;磁体12，用于捕获与磁性颗粒结合的磁性颗粒21和感兴趣的组分; 将包含感兴趣的部件的溶液放置在室的内部容积中，同时容器围绕位于容器的内部部分外部并且与磁体相邻的轴线19旋转; 向溶液中加入涂覆有结合感兴趣组分的反应组分的磁性颗粒; 将溶液与磁性颗粒混合以产生由磁性颗粒和上清液组成的混合物; 并且通过旋转容器来分离磁性颗粒和液体，其中液体被离心力捕获到捕获装置中，并且施加磁场，使得磁性颗粒结合到内部体积的内部部分的内侧。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2011039051A Unit and method for processing of liquid sample 有权
标题翻译：液体样品处理单元和方法
公开(公告)号：JP2011039051A
公开(公告)日：2011-02-24
申请号：JP2010176299
申请日：2010-08-05
申请人： F Hoffmann-La Roche Ag , エフホフマン−ラロッシュアクチェンゲゼルシャフト
发明人： BOLLIGER JEAN-PIERRE , MIKHAIL GROSER , OLIVER GUTMANN , MIKHAIL HEINRICH , JAEGGI RAINER D , OOSTERBROEK EDWIN , SAROFIM EMAD
IPC分类号： G01N35/08 , G01N35/02 , G01N35/10 , G01N37/00
CPC分类号： G01N35/1072 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0621 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0677 , G01N2035/00158 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide a novel microfluidic processing unit for the automated processing of a liquid sample capable of mixing one or more reagents with the liquid sample. SOLUTION: A microfluidic processing unit 3 for the automated processing of a liquid sample includes: first and second main channels 110 and 111 connected to a pump 112 for generating negative or positive pressure therein; a sample channel 114 for supplying a liquid sample which is connectable to a sample vessel 102 containing the liquid sample, communicates with the first main channel, and is equipped with an on/off valve 115; one or more reagent channels 118 and 127 for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid sample, respectively, and equipped with on/off values 119 and 128; a reaction chamber 120 for the reaction of the sample and the reagent to take place, the reaction chamber connected to the first and second main channels via at least one on/off-valve 123. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于自动处理能够将一种或多种试剂与液体样品混合的液体样品的新型微流体处理单元。解决方案：用于液体样品的自动处理的微流体处理单元3包括：连接到泵112的用于在其中产生负压或正压的第一和第二主通道110和111; 用于供应可连接到容纳液体样品的样品容器102的液体样品的样品通道114与第一主通道连通，并且配备有开/关阀115; 一个或多个用于供应一种或多种试剂的试剂通道118和127，所述试剂通道可分别连接到含有用于与液体样品反应的试剂并且装备有开/关值119和128的试剂容器; 用于使样品和试剂发生反应的反应室120，反应室经由至少一个开/关阀123连接到第一和第二主通道。（C）2011年，JPO和INPIT

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