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1. 发明专利

JP2008241709A Sorption microarray 审中-公开
标题翻译： SORPTION MICROARRAY
公开(公告)号：JP2008241709A
公开(公告)日：2008-10-09
申请号：JP2008067776
申请日：2008-03-17
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： FATTINGER CHRISTOF , BERNDT PETER
IPC分类号： G01N1/10 , G01N1/00 , G01N37/00
CPC分类号： G01N1/28 , B01L3/0255 , B01L3/5023 , B01L3/5025 , B01L3/502753 , B01L3/5085 , B01L2300/069 , B01L2300/0819 , G01N2001/282 , G01N2001/2826
摘要： PROBLEM TO BE SOLVED: To provide a sorption microarray which enables chemical imaging of a relatively bigger molecule in analysis sample, especially, a biomolecule. SOLUTION: The sorption microarray (1) for sorbing a substance from the analysis sample includes a support (11) and a plurality of sorption elements (14). These sorption elements (14) are arranged in a clearly-defined shape to be connected with the support (11), where distance between each sorption element (14) and its adjacent sorption element (14) is predefined. Output of assay on the substance sorbed by individual sorption element (14) can strictly be assigned to any clearly-defined position of the analysis sample (position from which the substance is sorbed), allowing a strict chemical output image of microdistribution for the substance in analysis sample to be provided. Thus the sorption microarray enables soft fluidic acquisition of the substance in analysis sample to clearly define the position of acquisition on the analysis sample. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种吸附微阵列，其能够在分析样品，特别是生物分子中对相对较大的分子进行化学成像。用于从分析样品中吸附物质的吸附微阵列（1）包括支撑体（11）和多个吸附元件（14）。这些吸附元件（14）被布置成清楚定义的形状以与支撑件（11）连接，其中每个吸附元件（14）和其相邻的吸附元件（14）之间的距离是预定义的。由个别吸附元件（14）吸收的物质上的测定输出可以严格地分配到分析样品（物质被吸附的位置）的任何明确定义的位置，从而允许对物质进行微量分布的严格化学输出图像分析样品要提供。因此，吸附微阵列能够在分析样品中对物质进行软流体采集，以清楚地定义采集在分析样品上的位置。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2005177749A Microtiter plate for processing sample, system and method 审中-公开
标题翻译：用于处理样品，系统和方法的微孔板
公开(公告)号：JP2005177749A
公开(公告)日：2005-07-07
申请号：JP2004352374
申请日：2004-12-06
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： BERNDT PETER , DERNICK GREGOR , FATTINGER CHRISTOF , HOCHSTRASSER REMO A , VOEGELIN DIETER
IPC分类号： G01N35/02 , B01J19/00 , B01L3/00 , B04B5/02
CPC分类号： B01L3/5085 , B01L2200/026 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , Y10T436/111666
摘要： PROBLEM TO BE SOLVED: To provide a microtiter plate for processing a sample comprising a liquid ingredient, a liquid and a solid ingredients, or a liquid and a gel ingredients. SOLUTION: The microtiter plate is produced with injection molding and has a single-piece main body 12 with an array of wells 13. Each of the wells 13 is provided with a first chamber 16 for receiving the sample to be processed, a second chamber 17 and a conduit 18 which fluid-connects the chamber 16 to the chamber 17. The conduit 18 has an upper surface opening 19. The first chamber 16, the second chamber 17 and the conduit 18 respectively have an inner face of the bottom constituting a part of the inner face of the bottom of the well 13. A sector 21 in the lower part of the conduit 18 is contiguous to the bottom part 15 of the well 13. The section 21 is structured so that a liquid can pass through the section 21 from one of the chambers to the other chamber when centrifugal force is applied to the microtiter plate while not a solid nor a gel ingredients having a larger size than the width of the section 21 can pass through, and the dimensions of the section 21 are set accordingly. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供用于处理包含液体成分，液体和固体成分或液体和凝胶成分的样品的微量滴定板。
解决方案：微量滴定板用注射成型制成，并且具有单个主体12，其具有孔阵列13.每个孔13设置有用于接收待加工样品的第一室16，第二腔室17和将腔室16流体连接到腔室17的导管18.导管18具有上表面开口19.第一腔室16，第二腔室17和导管18分别具有底部的内表面构成井13的底面的一部分。导管18的下部中的扇形部21与井13的底部15邻接。部分21的结构使得液体可以通过当离心力施加到微量滴定板而不是固体时，或从具有比区段21的宽度大的凝胶成分的凝胶成分可以通过时，部分21从一个室到另一个室中，并且该部分的尺寸 21相应设置。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2005189241A Quantification by serial combinatorial dilution 有权
标题翻译：通过串联组合稀释量化
公开(公告)号：JP2005189241A
公开(公告)日：2005-07-14
申请号：JP2004367043
申请日：2004-12-20
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： BERNDT PETER , EVERS STEFAN , LANGEN HANNO
IPC分类号： G01N27/62 , C12Q1/06 , C12Q1/68 , G01N1/38 , G01N27/447 , G01N30/02 , G01N30/72 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68 , G01N33/92 , G01N35/00
CPC分类号： G01N33/6803
摘要： PROBLEM TO BE SOLVED: To provide a method for quantifications of a biomolecule in a complex mixture of biomolecules. SOLUTION: A fractionation of the mixture of biomolecules provides at least two fractions with at least one distinct component, and these fractions are then subjected to serial combinatorial dilution. Subsequently, the biomolecule is detected and identified in the fractions by a method for providing a sensitivity threshold and identify information. The quantity of the biomolecule is determined by summarizing the number of identifications of the biomolecule in each fraction on each dilution level in consideration of the respective dilution factor. For purpose of normalization, this sum may be divided by the total number of identifications of all biomolecules in all fractions on all dilution levels. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供生物分子复杂混合物中生物分子的定量方法。解决方案：生物分子混合物的分级提供至少两个具有至少一个不同组分的级分，然后对这些级分进行连续组合稀释。随后，通过用于提供灵敏度阈值和识别信息的方法在分数中检测和鉴定生物分子。考虑各自的稀释因子，通过总结每个稀释级别中每个级分中的生物分子的鉴定数来确定生物分子的量。为了归一化的目的，这个总和可以除以所有稀释水平上所有级分中所有生物分子的标识总数。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2005047895A Hcv regulated protein 审中-公开
标题翻译： HCV调节蛋白
公开(公告)号：JP2005047895A
公开(公告)日：2005-02-24
申请号：JP2004192804
申请日：2004-06-30
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： BERNDT PETER , KILBY PETER MICHAEL , RUGMAN PAUL
IPC分类号： G01N33/50 , A61K45/00 , A61P31/14 , C07K14/18 , C07K14/47 , C07K16/10 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a method that is useful for therapy and diagnosis of HCV (hepatitis C virus) infection, particularly provide a method for screening the predictive marker of the disinfection prognosis and the compound regulating the activity or expression of the target by specifying the factor originating from the host cells that can become the target of the therapeutic agent.
SOLUTION: At least one polypeptide that comprises at least one of a specific polypeptide selected from the HCV replicon regulating polypeptide originating from the host cells is useful as a target for anti-HCV and as a predictive marker of the prognosis. This invention further provide a method for evaluating in vitro a compound that regulates the activity or expression and is displayed in the form of medicines or diagnostic kits whereby they can be provided as therapeutic medicines or diagnostic agents.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了提供可用于治疗和诊断HCV（丙型肝炎病毒）感染的方法，特别提供了筛选消毒预后预测标记的方法和调节活性或表达的化合物通过指定源自可以成为治疗剂的靶标的宿主细胞的因子来实现靶标。解决方案：至少一种包含选自源自宿主细胞的HCV复制子调节多肽的特异性多肽中的至少一种的多肽可用作抗HCV的靶标和作为预后的预测标记物。本发明进一步提供一种体外评估调节活性或表达并以药物或诊断试剂盒形式显示的化合物的方法，由此可将其作为治疗药物或诊断剂提供。版权所有（C）2005，JPO＆NCIPI

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