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1. 发明申请

US20070171417A1 Methods and apparatus for reducing noise in scatterometry measurements 有权
标题翻译：用于降低散射测量中噪声的方法和装置
公开(公告)号：US20070171417A1
公开(公告)日：2007-07-26
申请号：US11336388
申请日：2006-01-20
申请人： Evan Cromwell , Steven Miller , Robert Trujillo , Paul Comita
发明人： Evan Cromwell , Steven Miller , Robert Trujillo , Paul Comita
IPC分类号： G01N21/00
CPC分类号： B01L3/50853 , B01L2200/0684 , B01L2300/0654 , B01L2300/0829 , G01N21/0303 , G01N21/49
摘要： Methods and apparatus for performing scatterometry measurements of biological samples as described herein. A substrate having formed therein one or more sample wells is provided. Each sample well is configured to hold a sample solution containing objects that are to be characterized based on their light scattering properties. One or more sample solutions are dispensed into the sample wells. A specular reflection reducing element is applied to at least some of the sample solutions in the sample wells to decrease reflections of light into one or more detectors. A light beam is directed from a light source onto the objects in the sample wells. Light scattered by the objects in the sample wells is collected and transmitted to one or more detectors. The signal from the detectors is analyzed to detect the one or more characteristics of the one or more samples.
摘要翻译：如本文所述进行生物样品的散射测量的方法和装置。提供了其中形成有一个或多个样品阱的衬底。每个样品孔构造成容纳含有根据其光散射性质进行表征的物体的样品溶液。将一种或多种样品溶液分配到样品孔中。将镜面反射减少元件应用于样品阱中的至少一些样品溶液以减少光反射到一个或多个检测器中。将光束从光源引导到样品孔中的物体上。被样品孔中的物体散射的光被收集并传输到一个或多个检测器。分析来自检测器的信号以检测一个或多个样品的一个或多个特性。

2. 发明申请

US20060003320A1 Exploring fluorophore microenvironments 有权
公开(公告)号：US20060003320A1
公开(公告)日：2006-01-05
申请号：US11173814
申请日：2005-07-01
申请人： Steven Miller , Paul Comita , Evan Cromwell , Christopher Shumate
发明人： Steven Miller , Paul Comita , Evan Cromwell , Christopher Shumate
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/582 , B82Y5/00 , B82Y10/00 , C12Q1/6816 , G01N21/6408 , G01N21/6428 , G01N21/6445 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6441 , G01N2021/6478 , G01N2021/6484 , G01N2201/067 , G01N2201/0697 , G01N2201/0833 , C12Q2563/107 , C12Q2561/119
摘要： Methods, apparatus, and system, implementing and using techniques for detecting a presence of one or more target analytes in particular regions of interest of one or more samples. One or more samples including objects and one or more target analytes are provided. Some of the target analytes are labeled with a fluorophore and are bound to some of the objects in the samples. The samples are illuminated with fluorescence inducing light and fluorescent light is collected from one or more regions of the one or more samples. At least one anisotropy measurement of the samples is performed to identify regions of interest where one or more target analytes are bound to the objects. The collected fluorescent light from the regions of interest is analyzed to determine a presence of target analytes that are bound to the objects in the one or more samples.

3. 发明申请

US20050264805A1 Methods and apparatus for scanning small sample volumes 审中-公开
标题翻译：扫描小样本量的方法和设备
公开(公告)号：US20050264805A1
公开(公告)日：2005-12-01
申请号：US11055244
申请日：2005-02-09
申请人： Evan Cromwell , Steven Miller , Christopher Shumate , Paul Comita
发明人： Evan Cromwell , Steven Miller , Christopher Shumate , Paul Comita
IPC分类号： B01L3/00 , G01N1/10 , G01N21/25 , G01N21/64 , G01N35/02
CPC分类号： G01N21/253 , B01L3/5085 , B01L2300/0806 , G01N21/6408 , G01N21/6445 , G01N21/6452 , G01N35/028
摘要： Methods and apparatus for assaying biological materials employ multi-well substrates as described herein. The substrates include a plurality of wells, typically each of several nanoliters volume or smaller having consistent dimensions and formed in a rigid substrate such as a glass disk. Each well may be provided with a circumferential lip to minimize crosstalk between wells and/or facilitate optical location of the individual wells during interrogation. Samples are provided to the individual wells and assayed by an optical technique employing fluorescence, polarization, reflectance, or the like. A scanning laser system may be employed for this purpose. The substrate may rotate during the scan to allow consistent interrogation of the wells without stopping and starting the rotation. Multiple rotations may also be employed repeatedly interrogate the samples for use in a kinetic study, for example.
摘要翻译：用于测定生物材料的方法和装置采用本文所述的多孔底物。衬底包括多个孔，通常具有一定尺寸的几个纳升体积或更小的孔，并形成在诸如玻璃盘的刚性衬底中。每个孔可以设置有圆周唇缘，以最小化井之间的串扰和/或促使询问期间各个孔的光学定位。将样品提供给各个孔，并通过使用荧光，极化，反射率等的光学技术进行测定。为此目的可以采用扫描激光系统。衬底可以在扫描期间旋转，以允许孔的一致询问，而不停止和开始旋转。例如，也可以多次旋转重复地询问用于动力学研究的样品。

4. 发明申请

US20060234279A1 Screening using polarization anisotropy in FRET emissions 审中-公开
标题翻译：在FRET排放中使用偏振各向异性进行筛选
公开(公告)号：US20060234279A1
公开(公告)日：2006-10-19
申请号：US11398496
申请日：2006-04-04
申请人： Steven Miller , Paul Comita , Christopher Shumate , Evan Cromwell
发明人： Steven Miller , Paul Comita , Christopher Shumate , Evan Cromwell
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/542 , G01N2500/00
摘要： Methods and apparatus are described for detecting specific binding between first and second chemical entities. The first chemical entity in association with a first fluorophore is immobilized. The second chemical entity is allowed to bind with the immobilized first chemical entity. The second chemical entity is or becomes coupled to a second fluorophore, which forms a FRET pair with the first fluorophore. The bound chemical entities are exposed to radiation at an excitation frequency for either the first or the second fluorophore, and polarization anisotropy of a FRET fluorescent signal from the bound chemical entities is measured to detect specific binding between the first and second chemical entities. Techniques are also disclosed for detecting whether a FRET interaction is occurring between a first chemical entity including a donor fluorophore and a second chemical entity including an acceptor fluorophore, using simultaneous anisotropy measurements at the wavelengths of the donor and acceptor fluorophores.
摘要翻译：描述了用于检测第一和第二化学实体之间的特异性结合的方法和装置。与第一荧光团相关联的第一化学实体被固定化。允许第二化学实体与固定化的第一化学实体结合。第二化学实体是或连接到与第一荧光团形成FRET对的第二荧光团。结合的化学实体以第一或第二荧光团的激发频率暴露于辐射，并且测量来自结合的化学实体的FRET荧光信号的偏振各向异性以检测第一和第二化学实体之间的特异性结合。还公开了用于检测在包括供体荧光团的第一化学实体和包括受体荧光团的第二化学实体之间是否发生FRET相互作用的技术，其使用在供体和受体荧光团的波长处的同时各向异性测量。

5. 发明授权

US11142950B2 Removably attachable platform device 有权
公开(公告)号：US11142950B2
公开(公告)日：2021-10-12
申请号：US16263796
申请日：2019-01-31
申请人： Steven Miller
发明人： Steven Miller
IPC分类号： E06C7/16 , E06C1/39
摘要： A removably attachable platform device for use with a ladder includes a base plate, a coupler, and a pair of fasteners. The coupler is coupled to a lower face of the base plate and is configured to removably couple to a respective rung of a ladder to couple the base plate to the rung. Each fastener is coupled to a respective opposing side edge of the base plate and is configured to removably couple to a respective siderail of the ladder to couple the base plate to the siderails of the ladder. The base plate is positioned substantially parallel to a substantially horizontal surface, upon which the ladder is positioned, and thus is configured to support a user.

6. 发明授权

US09809280B2 Cleat having an adjustable anchoring structure 有权
公开(公告)号：US09809280B2
公开(公告)日：2017-11-07
申请号：US14946446
申请日：2015-11-19
申请人： Steven Miller , Timo Pascal Kommerling
发明人： Steven Miller , Timo Pascal Kommerling
IPC分类号： B63B21/20 , B63B9/00 , B63B59/02
CPC分类号： B63B21/20 , B63B9/00 , B63B21/045 , B63B59/02
摘要： A cleat having an adjustable anchoring system configured to suspend a bumper. The cleat has a first horn located opposite a second horn. A support structure is connected to the cleat. A recess of the support structure has a ridge protruding from a wall surface of the recess. The ridge is configured to deform a portion of rope. A bore of the support structure is configured to receive a fastener. A base has a bore configured to receive the fastener. The bore of the support structure is oriented to align with the bore of the base. The base has two ramps that protrude from a wall surface of a recess of the base. The two ramps form a pocket that can have a protrusion configured to bind a portion of the rope when the fastener is tightened.

7. 发明申请

US20150055977A1 Imaging Cartridge Drive Having a Centered Opening 审中-公开
标题翻译：成像盒驱动器具有中心开口
公开(公告)号：US20150055977A1
公开(公告)日：2015-02-26
申请号：US14473534
申请日：2014-08-29
申请人： Steven Miller
发明人： Steven Miller
IPC分类号： G03G21/16
CPC分类号： G03G21/1647 , G03G15/0844 , G03G21/12 , Y10T74/1598
摘要： An improved drive system for transmitting rotational force between an imaging machine and an imaging cartridge. A first coupling member comprises a first mating structure configured to transfer or receive rotational force, and a second coupling member comprises a second mating structure configured to transfer or receive rotational force. The first coupling member comprising a locating cone in the center of said first coupling member, said locating cone adapted to locate in an opening of the second coupling member whereby the first coupling member is centered in relation to the second coupling member, and the first mating structure of the first coupling member is directed into contact with the second mating structure of the second coupling member.
摘要翻译：一种用于在成像机和成像盒之间传递旋转力的改进的驱动系统。第一联接构件包括构造成传递或接收旋转力的第一配合结构，并且第二联接构件包括构造成传递或接收旋转力的第二配合结构。第一联接构件包括在所述第一联接构件的中心的定位锥体，所述定位锥体适于定位在第二联接构件的开口中，由此第一联接构件相对于第二联接构件居中，并且第一配合第一联接构件的结构被引导与第二联接构件的第二配合结构接触。

8. 发明申请

US20140085662A1 Methods of Inducing an Imaging Machine 审中-公开
标题翻译：诱导成像机的方法
公开(公告)号：US20140085662A1
公开(公告)日：2014-03-27
申请号：US13624405
申请日：2012-09-21
申请人： Steven Miller , Herman Schnell
发明人： Steven Miller , Herman Schnell
IPC分类号： G06K15/00
CPC分类号： B41J29/00 , B41J29/38 , B41J2029/3932 , G06K15/407
摘要： An electronic circuit for use with a consumable imaging unit transforms the electronic circuit from a communicated state to a non communicated state, and also induces an imaging machine to read the electronic circuit's transformed information and then store the information in the imaging machine's memory. Additionally, the information of the circuit is configured to alter an identifier of the circuit. The information of the circuit is also configured to point an imaging machine to communicate with a second element of the circuit after the information determines that a first element of the circuit has been altered from its original state.
摘要翻译：用于消耗成像单元的电子电路将电子电路从通信状态转换为非通信状态，并且还引起成像机读取电子电路的变换信息，然后将信息存储在成像机的存储器中。此外，电路的信息被配置为改变电路的标识符。电路的信息还被配置为在信息确定电路的第一元件已经从其原始状态改变之后，将成像机指向与电路的第二元件通信。

9. 发明申请

US20130224271A1 Oral Compositions Containing Microaggregates 有权
标题翻译：含有微团的口服组合物
公开(公告)号：US20130224271A1
公开(公告)日：2013-08-29
申请号：US13884030
申请日：2010-11-08
申请人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
发明人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
IPC分类号： A61K8/11
CPC分类号： A61K8/11 , A61K8/0275 , A61K8/27 , A61K8/4993 , A61K8/731 , A61K8/86 , A61K2800/412 , A61Q11/00
摘要： The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.
摘要翻译：本发明涉及一种用于口腔的复合和口腔护理组合物，以阻止牙菌斑和/或结石的积聚。该复合物是包含聚合物涂覆的表面活性剂稳定的基本上不溶的金属，金属盐或金属氧化物的颗粒，例如氧化锌的微团聚物。还提供了用于延缓牙斑和/或结石积聚的方法。

10. 发明授权

US08474387B2 Method and apparatus for incineration of combustible waste 有权
标题翻译：焚烧可燃废物的方法和装置
公开(公告)号：US08474387B2
公开(公告)日：2013-07-02
申请号：US12480320
申请日：2009-06-08
申请人： Steven Miller
发明人： Steven Miller
IPC分类号： F23G5/16 , F23G5/20 , F23G7/00 , C04B11/036 , C04B7/44
CPC分类号： F23G5/006 , F23G5/008 , F23G5/16 , F23G5/20 , F23G5/24 , F23G5/46 , F23G5/50 , F23G7/001 , F23G7/006 , F23G2206/201 , F23G2209/20 , F23G2209/28 , F23G2209/281 , Y02E20/363
摘要： A method and apparatus for incinerating different types of combustible waste in a cement manufacturing process. Two combustion chambers for incinerating waste are arranged in series, with first combustion chamber being a down draft chamber in which there is a downward flow of combustion gas and waste fuel to a waste and gas outlet. The second chamber is adaptable to support waste on a supporting surface incorporated in the compartment, wherein the waste is transported through the compartment from a waste inlet to a waste outlet along a circular path.
摘要翻译：一种用于在水泥制造过程中焚烧不同类型的可燃废物的方法和装置。用于焚烧废物的两个燃烧室被串联布置，其中第一燃烧室是下进气室，其中存在燃烧气体和废燃料向废气和气体出口的向下流动。第二室适用于在结合在隔室中的支撑表面上支撑废物，其中废物沿着圆形路径从废物入口输送到废物出口。

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